Medicine and Health Sciences Commons^™

Safety And Cost Effectiveness Of Immediate Sequential Bilateral Cataracts Surgery, Miles Bowman, Abbie R. Bauer

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Rush SW, Gerald AE, Smith JC, Rush AJ, Rush RB. Prospective analysis of outcomes and economic factors of same-day bilateral cataract surgery in the United States. Journal of Cataract and Refractive Surgery. 2015;41(4):732-739. https://doi.org/10.1016/j.jcrs.2014.07.034

for a patient with bilateral cataracts.

Designing Sensory Adaptive Environments To Enhance Participation In Healthcare For Autistic Children, Lady Rios-Vega, Amy Carroll, Rachel Dumont, Diane Treadwell‑Deering, Matthew Fields, Roseann Schaaf

Jefferson Autism Center of Excellence Faculty Papers

Purpose: Many autistic individuals experience sensory features that impact participation in healthcare. In this study, we aimed to identify the needs of autistic children during healthcare participation and, based on the findings, generate solutions to improve participation in healthcare. Methods: A design-thinking approach with qualitative methods was used. First, observation of the environment and journey mapping were completed as part of the empathy stage of design thinking. Next, six parents of autistic children completed semi-structured interviews. The interviews were transcribed, and thematic analysis was used to identify themes. Next, healthcare providers participated in a group session to discuss experiences caring …

The Acceptance And Use Of Digital Technologies For Self-Reporting Medication Safety Events After Care Transitions To Home In Patients With Cancer: Survey Study, Yun Jiang, Misun Hwang, Youmin Cho, Christopher R Friese, Sarah T Hawley, Milisa Manojlovich, John C Krauss, Yang Gong

Faculty, Staff and Student Publications

BACKGROUND: Actively engaging patients with cancer and their families in monitoring and reporting medication safety events during care transitions is indispensable for achieving optimal patient safety outcomes. However, existing patient self-reporting systems often cannot address patients' various experiences and concerns regarding medication safety over time. In addition, these systems are usually not designed for patients' just-in-time reporting. There is a significant knowledge gap in understanding the nature, scope, and causes of medication safety events after patients' transition back home because of a lack of patient engagement in self-monitoring and reporting of safety events. The challenges for patients with cancer in …

Evaluation Of Perioperative Care And Drivers Of Cost In Geriatric Thoracolumbar Trauma, Omar Tarawneh, Rajkishen Narayanan, Michael Mccurdy, Tariq Issa, Yunsoo Lee, Olivia Opara, Nicholas Pohl, Alexa Tomlak, Matthew Sherman, Jose Canseco, Alan Hilibrand, Alex Vaccaro, Gregory Schroeder, Christopher Kepler

Department of Orthopaedic Surgery Faculty Papers

INTRODUCTION: As the population of elderly patients continues to rise, the number of these individuals presenting with thoracolumbar trauma is expected to increase.

RESEARCH QUESTION: To investigate thoracolumbar fusion outcomes for patients with vertebral fractures as stratified by decade. Secondarily, we examined the variability of cost across age groups by identifying drivers of cost of care.

MATERIALS AND METHODS: We queried the United States Nationwide Inpatient Sample(NIS) for adult patients undergoing spinal fusion for thoracolumbar fractures between 2012 and 2017. Patients were stratified by decade 60-69(sexagenarians), 70-79(septuagenarians) and 80-89(octogenarians). Bivariable analysis followed by multivariable regression was performed to assess independent …

Isoform Alterations In The Ubiquitination Machinery Impacting Gastrointestinal Malignancies, Srimathi Kasturirangan, Derek Nancarrow, Ayush Shah, Kiran Lagisetty, Theodore Lawrence, David Beer, Dipankar Ray

Department of Medicine Faculty Papers

The advancement of RNAseq and isoform-specific expression platforms has led to the understanding that isoform changes can alter molecular signaling to promote tumorigenesis. An active area in cancer research is uncovering the roles of ubiquitination on spliceosome assembly contributing to transcript diversity and expression of alternative isoforms. However, the effects of isoform changes on functionality of ubiquitination machineries (E1, E2, E3, E4, and deubiquitinating (DUB) enzymes) influencing onco- and tumor suppressor protein stabilities is currently understudied. Characterizing these changes could be instrumental in improving cancer outcomes via the identification of novel biomarkers and targetable signaling pathways. In this review, we …

Activator Protein Transcription Factors Coordinate Human Il-33 Expression From Noncanonical Promoters In Chronic Airway Disease, Heather E. Raphael, Ghandi F. Hassan, Omar A. Osorio, Lucy S. Cohen, Morgan D. Payne, Ella Katz-Kiriakos, Ishana Tata, Jamie Hicks, Derek E. Byers, Bo Zhang, Jen Alexander-Brett

2020-Current year OA Pubs

IL-33 is a cytokine central to type 2 immune pathology in chronic airway disease. This cytokine is abundantly expressed in the respiratory epithelium and increased in disease, but how expression is regulated is undefined. Here we show that increased IL33 expression occurs from multiple noncanonical promoters in human chronic obstructive pulmonary disease (COPD), and it facilitates production of alternatively spliced isoforms in airway cells. We found that phorbol 12-myristate 13-acetate (PMA) can activate IL33 promoters through protein kinase C in primary airway cells and lines. Transcription factor (TF) binding arrays combined with RNA interference identified activator protein (AP) TFs as …

Graduate Medical Education Well-Being Directors In The United States: Who Are They, And What Does The Role Entail?, Larissa R Thomas, Jonathan A Ripp, Jennifer G Duncan

2020-Current year OA Pubs

BACKGROUND: Institutional Graduate Medical Education (GME) Well-being Director (WBD) roles have recently emerged in the United States to support resident and fellow well-being. However, with a standard position description lacking, the current scope and responsibilities of such roles is unknown. This study describes the scope of work, salary support, and opportunities for role definition for those holding institutional leadership positions for GME well-being.

METHODS: In November 2021, 43 members of a national network of GME WBDs in the United States were invited to complete a cross-sectional survey that included questions about job responsibilities, percent effort, and dedicated budget, and a …

Treatment Of Gastrointestinal Bleeding In The Biliopancreatic Limb With Embolization In A Patient With Duodenal Switch Anatomy, Alice S. Pang, Robert Adamo, Robert Coben

Division of Gastroenterology and Hepatology Faculty Papers

INTRODUCTION: Biliopancreatic diversion with duodenal switch (BPD/DS) is an uncommon type of bariatric surgery that can rarely lead to bleeding in the biliopancreatic limb. The altered anatomy poses significant diagnostic and therapeutic challenges.

CASE PRESENTATION: We present an unusual case of a woman status post-BPD/DS nearly a decade ago who presented with gastrointestinal bleeding in the duodenum of the biliopancreatic limb, a rare phenomenon given the unique surgery.

CONCLUSION: We illustrate a promising minimally invasive option of successfully treating the bleeding by interventional radiology (IR) embolization as an alternative to more invasive and challenging options of balloon-assisted enteroscopy, lumen-apposing metal …

Observation On Efficacy And Underlying Mechanism Of Cheek Acupuncture On Ovulation Induction For Infertile Women With Pcos: Case Series, Yi Yang, Lihua Jin, Shasha Xu, Huijun Ye, Xi Luo, Ruilan Li, Yuebing Yue

Faculty, Staff and Student Publications

RATIONALE: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder among women of childbearing age and is the primary cause of anovulatory infertility, accounting for 70% to 80% of cases. Ovulation induction is the main treatment approach for infertile patients with PCOS. Commonly utilized medications for this purpose are clomiphene citrate (CC) and letrozole (LE). Clomiphene citrate administration results in an ovulation rate ranging from 60% to 85%, while the pregnancy rate is limited to 35% to 40%, and a further reduction is observed in live birth rates. Letrozole demonstrates a slightly higher pregnancy rate and live birth …

Transmembrane Domain-Driven Pd-1 Dimers Mediate T Cell Inhibition, Elliot A Philips, Jia Liu, Audun Kvalvaag, Alexander M Mørch, Anna S Tocheva, Charles Ng, Hong Liang, Ian M Ahearn, Ruimin Pan, Christina C Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R Littman, Michael L Dustin, Jun Wang, Xiang-Peng Kong

Faculty, Staff and Student Publications

Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers, but PD-1 has been considered monomeric. Here, we show that PD-1 and its ligands form dimers as a consequence of transmembrane domain interactions and that propensity for dimerization correlates with the ability of PD-1 to inhibit immune responses, antitumor …

Identification Of Novel Small Molecule Inhibitors Of Twin Arginine Translocation (Tat) Pathway And Their Effect On The Control Of Campylobacter Jejuni In Chickens, Loïc Deblais, Mary Drozd, Anand Kumar, Janet Antwi, James Fuchs, Rahul Khupse, Yosra A. Helmy, Gireesh Rajashekara

School of Veterinary and Biomedical Sciences: Faculty Publications

Introduction: Control of Campylobacter from farm to fork is challenging due to the frequent emergence of antimicrobial-resistant isolates. Furthermore, poultry production systems are known reservoirs of Campylobacter. The twinarginine translocation (Tat) pathway is a crucial bacterial secretion system that allows Campylobacter to colonize the host intestinal tract by using formate as the main source of energy. However, Tat pathway is also a major contributing factor for resistance to copper sulfate (CuSO₄).

Methods: Since mammals and chickens do not have proteins or receptors that are homologous to bacterial Tat proteins, identification of small molecule (SM) inhibitors …

An Mhealth Intervention To Address Depression And Improve Antiretroviral Therapy Adherence Among Youths Living With Hiv In Uganda: Protocol For A Pilot Randomized Controlled Trial, Proscovia Nabunya, Patricia Cavazos-Rehg, James Mugisha, Erin Kasson, Olive Imelda Namuyaba, Claire Najjuuko, Edward Nsubuga, Lindsey M Filiatreau, Abel Mwebembezi, Fred M Ssewamala

2020-Current year OA Pubs

BACKGROUND: People living with HIV often struggle with mental health comorbidities that lower their antiretroviral therapy (ART) adherence. There is growing evidence that depression treatment may improve ART adherence and result in improved HIV outcomes. Given that mental health services are severely underequipped in low-resource settings, including in Uganda, new solutions to increase access to mental health care and close the treatment gap are urgently needed. This protocol paper presents the Suubi-Mhealth study, which proposed to develop a mobile health (mHealth) intervention for use among Ugandan youths (14-17 years) with comorbid HIV and depression, taking into account their unique contextual, …

A Structured, Journal-Led Peer-Review Mentoring Program Enhances Peer Review Training, Ariel Maia Lyons-Warren, Whitley W Aamodt, Kathleen M Pieper, Roy E Strowd

Faculty, Staff and Students Publications

BACKGROUND: Peer review is essential to the advancement of knowledge. However, training on how to conduct peer review is limited, unorganized, and not well studied. Thus, we sought to determine if a structured mentored peer-review program improved peer review training as measured by multiple quantitative and qualitative assessments.

METHODS: This pre-post intervention study enrolled 55 mentees across 5 cohorts from 2020 to 2023. Each cohort completed pre-program evaluations, participated in 2 mentored reviews, and completed post-program evaluations over 6 months. Mentors and mentees completed pre-program demographic and review experience questionnaires. Outcome measures included (1) total and sub-scores on the modified …

Antioxidant Responses And Phytochemical Accumulation In Raphanus Species Sprouts Through Elicitors And Predictive Models Under High Temperature Stress, María-Trinidad Toro, Roberto Fustos-Toribio, Jaime Ortiz, José Becerra, Nelson Zapata, María Dolores López-Belchí

Faculty, Staff and Students Publications

Crop production is being impacted by higher temperatures, which can decrease food yield and pose a threat to human nutrition. In the current study, edible and wild radish sprouts were exposed to elevated growth temperatures along with the exogenous application of various elicitors to activate defense mechanisms. Developmental traits, oxidative damage, glucosinolate and anthocyanin content, and antioxidant capacity were evaluated alongside the development of a predictive model. A combination of four elicitors (citric acid, methyl jasmonate—MeJa, chitosan, and K2SO4) and high temperatures were applied. The accumulation of bioactives was significantly enhanced through the application of two elicitors, K2SO4 and methyl …

Grb2 Stabilizes Rad51 At Reversed Replication Forks Suppressing Genomic Instability And Innate Immunity Against Cancer, Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed

Faculty, Staff and Student Publications

Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase signaling and a nuclear adapter for homology-directed-DNA repair. Here we find nuclear GRB2 protects DNA at stalled replication forks from MRE11-mediated degradation in the BRCA2 replication fork protection axis. Mechanistically, GRB2 binds and inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks. In GRB2-depleted cells, PARP inhibitor (PARPi) treatment releases DNA fragments from stalled forks into the cytoplasm that activate the cGAS-STING pathway to trigger pro-inflammatory cytokine production. Moreover in a syngeneic mouse metastatic ovarian cancer model, GRB2 depletion in the context of PARPi treatment …

A Case Report : Rosai-Dorfman Disease Of The Breast, Jenjeera Prueksadee

Chulalongkorn Medical Journal

Abstract

A case report of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) of the breast is one of the rare diseases, characterized by benign proliferative disorder of histiocyte. Most occur within lymph nodes whereas the rest involve extranodal sites. Breast involvement is considered extremely rare but considerable because of radiological findings simulating breast cancer. We report the case of a 59-year-old Thai woman who underwent screening mammography. Her biopsy resulted in abnormal histiocytes with S-100 protein expression, some of them with emperipolesis (lymphophagocytosis). Recognition of Rosai-Dorfman disease leads to correct diagnosis and further appropriate proper treatment strategy.

Primary Lung And Pleural Malignancies In Children: Imaging Of A Case Series, Teerasak Phewplung, Tanitha Phruksahirun

Chulalongkorn Medical Journal

Early diagnosis of primary lung and pleural malignancies is a challenge because it is extremely rare in children. The patient often presents with metastatic disease and non-neoplastic lesions. Clinical detection and imaging studies are nonspecific findings and may be indistinguishable from other lung malformations, resulting in a delay in diagnosis and treatment and an increase in tumor morbidity and mortality.

We present four cases of children whose clinical presentation and initial imaging had suspicious abnormalities and were eventually revealed to be primary lung and pleural malignancies. The literature on primary lung and pleural malignancies is also reviewed.

Comparison Study Of Endoscopic-Guided Versus Electromyography-Guided Botulinum Toxin Injection Treatments In Adductor Spasmodic Dysphonia, Manintorn Praditthum, Premsuda Sombuntham

Chulalongkorn Medical Journal

Background: Electromyography (EMG)-guided botulinum injection is recommended in clinical practice guideline for spasmodic dysphonia. However, other alternative techniques have been practiced in absence of EMG machine. Comparison of techniques is limited in the literatures.

Objective: This pilot study aims to compare the effectiveness of treatment between the EMG-guided technique and the endoscopic-guided technique in adductor spasmodic dysphonia.

Method: Five patients who were diagnosed with Adductor spasmodic dysphonia (AdSD) were enrolled and then randomized into 2 groups. Patient data (before and after treatment) were collected. The outcome measurement included voice analysis, voice handicap index (VHI), duration aspiration, duration of breathiness, mean …

The Effect Of Fluid Replacement During 60 Minutes Of Moderate-Intensity Running On Splanchnic Blood Flow., Warot Rangsimahariwong, Onanong Kulaputana, Tanat Tabtieang, Sompol Sanguanrungsirikul, Natthaya Chuaypen

Chulalongkorn Medical Journal

Background: Exercise-induced splanchnic hypoperfusion has been linked to impaired gastrointestinal function and associated symptoms. The effectiveness of fluid replacement in protecting against splanchnic hypoperfusion is less clear.

Objectives: To evaluate the effects of fluid replacement during 60 minutes of moderate-intensity running on the splanchnic blood flow (SBF) using non-invasive Doppler ultrasound.

Methods: Seven healthy men aged 35 ± 7 years participated in two 60-minute running trials at moderate-intensity: the first trial with no water replacement (NW) followed by the second trial with ambient temperature water (28-29oC) replacement (AW). A minimum interval of 48 hours was introduced for the washout period …

Does Asymptomatic Generalized Joint Hypermobility Influence Musculotendinous Extensibility And Knee Joint Proprioception?, Pawan Chaiparinya, Sujitra Boonyong, Chitanongk Gaogasigam

Chulalongkorn Medical Journal

Background: It is unclear whether generalized joint hypermobility (GJH) influences the musculotendinous unit (MTU) extensibility or proprioception of the knee joint in individuals with asymptomatic GJH.

Objectives: To compare the quadriceps and hamstring MTU length as well as knee joint force sense (FS) and joint position sense (JPS) between individuals with asymptomatic GJH and non-GJH controls.

Methods: Thirty-two female subjects were recruited, with 16 subjects in the GJH and non-GJH groups. The angles measured from modified prone knee bend (mPKB) and straight leg raising (SLR) tests were used to identify the quadriceps and hamstrings MTU extensibility using photographic-based angle measurements. …

The Electrical Conductivity Of 24-H Urine Is Decreased In Patients With Calcium Oxalate Urolithiasis., Kamonchat Boonkam

Chulalongkorn Medical Journal

Background: Electrical conductivity (EC) of urine depends on the ionic substance-to-water ratio. Calcium oxalate (CaOx) is the most common type of urinary stone, and its formation is driven by decreased urine volume, increased lithogenic substances, and decreased stone inhibitory compounds (specifically citrate). Low urinary citrate excretion (hypocitraturia) is a prominent risk factor in Thai urolithiasis patients.

Objective: To measure the urinary EC, urinary calcium, and urine specific gravity in CaOx stone patients compared with non-stone forming (NSF) subjects.

Method: The urinary EC was measured in 24-h urine samples obtained from 42 CaOx stone patients and 121 NSF subjects. Urinary calcium …

Pediatric Appendicitis Or Not? A Retrospective Cohort Study From A Single Institution - Our Management And Factors Determining The Disease, Nimmita Srisan, Teerasak Phewplung, Katawaetee Decharun, Prapapan Rajatapiti, Paisarn Vejchapipat

Chulalongkorn Medical Journal

Purpose: The aims were to assess our treatment guidelines and to determine factors in differentiating children with acute appendicitis from other diseases.

Methods: Pediatric surgery consultations for suspected appendicitis from October 2019 to October 2021 was retrospectively studied. The treatment guidelines of children with suspected appendicitis were elucidated. Moreover, factors identifying the diagnosis of appendicitis were analyzed using multi-variate logistic regression.

Results: Ninety-one children were consulted for suspected appendicitis. Forty-one children (45.1%) were promptly successfully treated without observation or ultrasonography, except one negative appendectomy (2.4%). The other 50 children (54.9%), showed equivocal clinical symptoms and signs, requiring further management either …

Analysis Of Breast Mri Performed On Patients With Axillary Nodal Metastasis And Negative Mammogram And Ultrasound, Pakpawee Pichayakul, Palita Hansakul

Chulalongkorn Medical Journal

Background: Occult breast cancer is a rare type of breast cancer which magnetic resonance imaging (MRI) has an immense role to confirm diagnosis and disclose non-demonstrable finding on initial modality.

Objective: To analysis breast MRI findings in patients with axillary nodal metastasis and negative mammogram and ultrasound, and retrospective review of the initial mammography and second-look ultrasound.

Methods: From January 2010 to January 2023, women who diagnosed occult breast cancer by presenting metastatic axillary lymph node on pathological report with negative mammography and ultrasonography, underwent breast MRI to identify occult breast carcinoma. Their breast MRI were retrospectively reviewed …

Postoperative Intussusception After Congenital Diaphragmatic Hernia Repair: A Report Of 2 Cases, Saralee Matanaromyakit, Nimmita Srisan, Somboon Roekwibunsi, Paisarn Vejchapipat

Chulalongkorn Medical Journal

Background: A postoperative intestinal intussusception is one of complications after abdominal surgery. However current evidence of intussusception after congenital diaphragmatic repair still received little attention. Previous literature reported possible cause from atony of the herniated bowel that could be a functional leading point of intussusception.

Case report: A 7-month-old female with history of respiratory distress in newborn, with no obvious abdominal signs was scheduled for diaphragmatic hernia repair. The chest X ray showed the presence of large soft tissue density at the posterior aspect of the left hemothorax. She early came to OPD due to many episodes of non-bilious vomiting …

Exonic Variants Of Gpihbp1 Gene In Thai Subjects With Severe Hypertriglyceridemia, Wanee Plengpanich

Chulalongkorn Medical Journal

Background: Hypertriglyceridemia (HTG) is one of the risk factors for cardiovascular disease and acute pancreatitis. It is associated with genetic variations in various genes involved in triglyceride metabolism. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) encodes a membrane protein involved in an intravascular triglyceride hydrolysis. Objective: The purpose of this study was to examine the genetic variants in the exons of GPIHBP1 gene in Thai subjects with severe HTG. Methods: All 4 exons of the GPIHBP1 gene were sequenced in 101 Thai subjects with severe HTG. All subjects had triglyceride levels e” 10 mmol/L or 886 mg/dL. Subjects with normolipidemia (n …

Association Of Pnpla3, Tm6sf2 And Hsd17b13 Variants With Nafld Risk In Hiv And Non-Hiv Individuals, Varis Ruamviboonsuk

Chulalongkorn Medical Journal

Background: Non-alcoholic fatty liver disease (NAFLD) has multiple risk factors, including genetic risk factors. Patients with certain genetic variants are more susceptible to the disease. People living with human immunodeficiency virus (PLWH) have higher prevalence of NAFLD compared to those without human immunodeficiency virus (HIV) infection. However, the evidence on genetic factors in PLWH with NAFLD is limited. Objectives: This study aimed to investigate whether carriers of PNPLA3 rs738409, TM6SF2 rs58542926, and HSD17B13 rs6834314 had association with the risk of NAFLD, and whether PLWH with NAFLD also had similar genetic risk factors as those with NAFLD alone. Methods: These single …

Anopheles Population Belonging To Barbirostris Complex In Narathiwat Province And Its Vectorial Status For Human And Simian Malaria, Surasuk Yanmanee, Sunee Seethamchai, Napaporn Kuamsab, Taweesak Tia, Somchai Jongwutiwes, Chaturong Putaporntip

Chulalongkorn Medical Journal

Background: Besides well-perceived species of Plasmodium infecting humans, at least four simian malaria species including P. knowlesi, P. cynomolgi, P. inui and P. fieldi have been incriminated in human infections in Thailand. The vectors of simian malaria in this country have been recently identified to be Anopheles latens and An. introlatus.

Objectives: To address whether mosquitoes in Barbirostris complex in Narathiwat Province could vector simian malaria and to analyze species distribution of Anopheles in this complex from the sampled population.

Methods: A total of 115 mosquitoes from Sukhirin and Waeng Districts in Narathiwat Province morphologically assigned to …

Attitudes Toward End-Of-Life Care And Advance Directives: A Prospective Survey In A Family Medicine Clinic, Bangkok, Thailand, Basmon Manomaipiboon

Chulalongkorn Medical Journal

Background: Advance directives (ADs) have long been legalized and advocated, still few patients complete ADs in Thailand. In our setting, advance directive information will be provided to interested patients and palliative care patients. Objectives: This study examined the attitude toward end-of-life care and ADs, the prevalence of ADs completion and identified the factors associated with advance care planning among patients who attended a family medicine clinic, Faculty of Medicine, Vajira Hospital, Navamindhradhiraj university, Bangkok, Thailand. Methods: A total of 300 subjects completed a self-administered structured questionnaire, including sociodemographic factors, individuals’ health status, healthcare experiences, and other factors influencing advance care …

Factors Related To Positive Airway Pressure Adherence In Patients With Obstructive Sleep Apnea At King Chulalongkorn Memorial Hospital, Puntarik Srisawart

Chulalongkorn Medical Journal

Background: Positive airway pressure (PAPs) is a standard and efficacious treatment for obstructive sleep apnea (OSA). Poor adherence could lead to impaired daytime performance, increasing risk of traffic accidents, hypertension, cardiovascular events, and neuropsychological disturbances. Previous studies reported rates and factors influencing PAPs adherence, but the data in Thailand was still lacking.

Objectives: To investigate the rate of PAPs adherence, the prevalence of depressive and anxiety symptoms, and the factors associated with PAPs adherence among patients with OSA.

Methods: This is a cross-sectional descriptive study that was conducted during June 2021 to September 2022. The data was collected from patients …

Effect Of Exergame Training With Motor Imagery On Balance, Cognitive Functions And Motor Learning In Healthy Adults: Preliminary Study, Kanokwan Srisupornkornkool

Chulalongkorn Medical Journal

Background: Previous studies reported that exergames could improve balance and cognitive function. Also, motor imagery (MI) applied with actual movements cloud increase balance control. If both are combined, balance and cognitive function may increase more.

Objectives: To investigate the effect of exergame training with MI on balance, cognitive function and motor learning in healthy adults.

Methods: Twelve participants were divided into 2 groups, the exergame training (ET, n = 6) and the exergame with MI training (ET + MI, n = 6). Both groups practiced exergame for 20 minutes. Then, the ET + MI group imagined exergame for 10 minutes. …