Medicine and Health Sciences Commons^™

Axodetect: An Automated Nerve Image Segmentation And Quantification Workflow For Computational Nerve Modeling, David A Lloyd, Maria Alejandra Gonzalez-Gonzalez, Mario I Romero-Ortega

Faculty, Staff and Students Publications

Objective: Bioelectronic treatments targeting near-organ innervation have unprecedented clinical applications. Particularly in the spleen, the inhibition of the cholinergic inflammatory response by near-organ nerve stimulation has potential to replace pharmacological treatments in chronic and autoimmune diseases. A caveat is that the optimization of therapeutic stimulation parameters relies on in vivo experimentation, which becomes challenging due to the small nerve diameters (2 m), complex anatomy, and mixed axon type composition of the autonomic nerves. Effective development of in silico models requires tools which allow for fast and efficient quantification of axonal composition of specific nerves. Current approaches to generate such …

Covid-19 Outbreaks Surveillance Through Text Mining Applied To Electronic Health Records, Hermano Alexandre Lima Rocha, Erik Zarko Macêdo Solha, Vasco Furtado, Francion Linhares Justino, Lucas Arêa Leão Barreto, Ronaldo Guedes Da Silva, Ítalo Martins De Oliveira, David Westfall Bates, Luciano Pamplona De Góes Cavalcanti, Antônio Silva Lima Neto, Erneson Alves De Oliveira

Faculty, Staff and Students Publications

Background: The COVID-19 pandemic has caused significant disruptions to everyday life and has had social, political, and financial consequences that will persist for years. Several initiatives with intensive use of technology were quickly developed in this scenario. However, technologies that enhance epidemiological surveillance in contexts with low testing capacity and healthcare resources are scarce. Therefore, this study aims to address this gap by developing a data science model that uses routinely generated healthcare encounter records to detect possible new outbreaks early in real-time.

Methods: We defined an epidemiological indicator that is a proxy for suspected cases of COVID-19 using the …

Attenuation Of Polycyclic Aromatic Hydrocarbon (Pah)-Induced Carcinogenesis And Tumorigenesis By Omega-3 Fatty Acids In Mice In Vivo, Guobin Xia, Guodong Zhou, Weiwu Jiang, Chun Chu, Lihua Wang, Bhagavatula Moorthy

Faculty, Staff and Students Publications

Lung cancer is the leading cause of cancer death worldwide. Polycyclic aromatic hydrocarbons (PAHs) are metabolized by the cytochrome P450 (CYP)1A and 1B1 to DNA-reactive metabolites, which could lead to mutations in critical genes, eventually resulting in cancer. Omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial against cancers. In this investigation, we elucidated the mechanisms by which omega-3 fatty acids EPA and DHA will attenuate PAH-DNA adducts and lung carcinogenesis and tumorigenesis mediated by the PAHs BP and MC. Adult wild-type (WT) (A/J) mice, Cyp1a1-null, Cyp1a2-null, or Cyp1b1-null mice were exposed …

The Remission Status Of Aml Patients After Allo-Hct Is Associated With A Distinct Single-Cell Bone Marrow T-Cell Signature, Anna Mathioudaki, Xizhe Wang, David Sedloev, Richard Huth, Aryan Kamal, Michael Hundemer, Yi Liu, Spyridoula Vasileiou, Premal Lulla, Carsten Müller-Tidow, Peter Dreger, Thomas Luft, Tim Sauer, Michael Schmitt, Judith B Zaugg, Caroline Pabst

Faculty, Staff and Students Publications

Acute myeloid leukemia (AML) is a hematologic malignancy for which allogeneic hematopoietic cell transplantation (allo-HCT) often remains the only curative therapeutic approach. However, incapability of T cells to recognize and eliminate residual leukemia stem cells might lead to an insufficient graft-versus-leukemia (GVL) effect and relapse. Here, we performed single-cell RNA-sequencing (scRNA-seq) on bone marrow (BM) T lymphocytes and CD34+ cells of 6 patients with AML 100 days after allo-HCT to identify T-cell signatures associated with either imminent relapse (REL) or durable complete remission (CR). We observed a higher frequency of cytotoxic CD8+ effector and gamma delta (γδ) T cells in …

Using Stated Preference Methods To Facilitate Knowledge Translation In Implementation Science, Whitney C Irie, Andrew Kerkhoff, Hae-Young Kim, Elvin Geng, Ingrid Eshun-Wilson

2020-Current year OA Pubs

Enhancing the arsenal of methods available to shape implementation strategies and bolster knowledge translation is imperative. Stated preference methods, including discrete choice experiments (DCE) and best-worst scaling (BWS), rooted in economics, emerge as robust, theory-driven tools for understanding and influencing the behaviors of both recipients and providers of innovation. This commentary outlines the wide-ranging application of stated preference methods across the implementation continuum, ushering in effective knowledge translation. The prospects for utilizing these methods within implementation science encompass (1) refining and tailoring intervention and implementation strategies, (2) exploring the relative importance of implementation determinants, (3) identifying critical outcomes for key …

Comparative Lipidome Study Of Maternal Plasma, Milk, And Lamb Plasma In Sheep, Soundara Viveka Thangaraj, Adel Ghnenis, Brooke Pallas, Arpita Kalla Vyas, Brigid Gregg, Vasantha Padmanabhan

2020-Current year OA Pubs

Lipids play a critical role in neonate development and breastmilk is the newborn's major source of lipids. Milk lipids directly influence the neonate plasma lipid profile. The milk lipidome is dynamic, influenced by maternal factors and related to the maternal plasma lipidome. The close inter-relationship between the maternal plasma, milk and neonate plasma lipidomes is critical to understanding maternal-child health and nutrition. In this exploratory study, lipidomes of blood and breast milk from Suffolk sheep and matched lamb blood (n = 13), were profiled on day 34 post birth by untargeted mass spectrometry. Comparative multivariate analysis of the three matrices …

Inflammatory Breast Carcinoma In The Rio Grande Valley: A Case Report, Miguel A. Lopez, Maria Villegas, Thomas Davis

Research Symposium

Inflammatory breast carcinoma (IBC) is a rare and aggressive subtype of invasive breast cancer found in a small percentage of patients in the United States. The Rio Grande Valley is a region of Texas with pockets of low socioeconomic status and increased rates of obesity, a large risk factor for IBC. The cutaneous presentation of IBC is a tender, erythematous patch or plaque that surrounds hair follicles (referred to as peau d’orange) and is frequently edematous. Diagnosis requires a high clinical index of suspicion supported by a thorough patient history and pathology consistent with invasive carcinoma. This case study discusses …

Hypermetabolic Lymphadenopathy Following The Administration Of Covid-19 Vaccine And Immunotherapy In A Lung Cancer Patient: A Case Report, Shreya Tripathy, Nathaniel Alvarez, Shubham Jaiswal, Ryan Williams, Munaf Al-Khadimi, Sarah Hackman, William Phillips, Supreet Kaur, Sherri Cervantez, William Kelly, Josephine Taverna

Research Symposium

Background: Given the current climate of the pandemic, lung cancer patients are especially vulnerable to complications from severe acute respiratory syndrome coronavirus 2 infection. As a high-risk population group, these patients are strongly advised to receive coronavirus disease 2019 vaccination in accordance with Center for Disease Control and Prevention guidelines to minimize morbidity and mortality. In recent years, immunotherapy has taken a preeminent role in the treatment of non-small cell lung cancer with dramatic improvement in overall survival. Reactive lymphadenopathy following the administration of a coronavirus disease 2019 vaccination can confound the radiographic interpretation of positron emission tomography-computed tomography or …

The Role Of Divergent Noncoding Gene In Triple-Negative Breast Cancer, Barbara Yang, Melina J. Sedano, Shrikanth S. Gadad

Research Symposium

Breast cancer is the second leading cause of cancer mortality in women after lung cancer. Breast cancer is grouped into different molecular subtypes; triple-negative breast cancer (TNBC) accounts for 20%. TNBC is a highly aggressive histologic subtype; the lack of unique therapeutic targets makes it harder to treat. Recent studies have implicated genes involved in cancers that are transcribed using a process known as divergent transcription. The expression of these genes is tightly regulated; however, many escape regulation and become aberrantly expressed in tumors. Interestingly, our genomic analysis suggests that several of these genes encode noncoding transcripts. Analysis of transcriptome …

The Role Of A Cancer Testis-Antigen In Regulating Tumor Growth And Oncogenic Pathways In Triple-Negative Breast Cancer., Melina J. Sedano, Alana L. Harrison, Victoria Reid, Subramanian Dhandayuthapani, Shrikanth S. Gadad

Research Symposium

Breast cancer is the second leading cause of cancer-related deaths in women, after lung cancer. Unfortunately, it is the primary cause of death among Hispanic women. Approximately 10-20% of breast cancers are classified as basal (triple-negative) subtypes, which are challenging to treat due to the absence of specific targets. Triple-negative breast cancer is a highly aggressive and lethal type of tumor, particularly among Hispanic women, with a poor prognosis compared to other breast cancer subtypes. Therefore, it is crucial to identify new molecules with therapeutic and prognostic values to treat this evolving disease. Multiple studies have demonstrated that X-linked genes …

Role Of Trpv6 In Mitigating Alcohol-Induced Disruption Of Tight Junctions, Barrier Function, And Hepatic Injury, Avtar S. Meena, Radhakrishna K. Rao

Research Symposium

Background: Persistent alcohol consumption is widely recognized as a precursor to alcoholic liver disease. However, the intriguing observation persists that only a minority, approximately 20%, of individuals with alcohol use disorder succumb to this liver ailment. The factors contributing to this variability remain elusive. Studies indicate that individuals with alcoholic liver disease exhibit endotoxemia, with endotoxins primarily originating from colonic microflora. Moreover, these patients manifest disruptions in epithelial tight junctions, leading to compromised barrier function in the gastrointestinal tract. In this context, the transient receptor vanilloid receptor 6 (TRPV6) emerges as a crucial regulator of calcium absorption and transport, particularly …

Optimization And Characterization Of One-Step Multi-Functionalization Of Virus-Like Particles For Multimodality Nanoplatforms, Andrea Dorado Baeza, Prakhar Sengar, Rafael Vázquez-Duhalt, Kanchan Chauhan

Research Symposium

Background: Multimodality platforms integrating targeting, therapeutic and diagnostic modalities are gaining attention in the area of smart nanomedicines for cancers. However, their multi-step synthesis strategies are the major bottleneck for large-scale production with high reproducibility. Isocyanide-based multi-component reactions (IMCRs) have become popular in modern chemistry and have offered effective access to highly diverse and complex final products in a single step. Herein, isocyanide-based 4-component (4CRs) UGI reaction is optimized on virus-like particles (VLPs) to develop multimodal nanoplatforms more efficiently.

Methods: In this work, biocatalytic P22CYP nanoreactors were multifunctionalized with: (i) enzyme Glucose Oxidase (GOx) to obtain a cascade enzymatic activity …

Novel Therapeutic Strategy For Cervical Cancer Treatment, Mohammed Sikander, Shabnam Malik, John Apraku, Sonam Kumari, Parvez Khan, Daniel Zubieta, Hassan Mandil, Aditya Ganju, Bhavin Chauhan, Maria C. Bell, Man Mohan Singh, Sheema Khan, Murali M. Yallapu, Fathi T. Halaweish, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Aberrant activation of β-catenin signaling is strongly associated with cancer proliferation, invasion, migration, and metastasis, thus small molecules that can inhibit this pathway might have great clinical significance. Our molecular modeling studies suggest that Ormeloxifene (ORM), a triphenylethylene molecule docks with β-catenin, and its brominated analogue (Br-ORM) bind more effectively with relatively less energy (-7.6 kcal/mol) to the active site of β-catenin as compared to parent ORM. Herein, we report the synthesis and characterization of a Br-ORM by NMR and FTIR, as well as its anti-cancer potential in cervical cancer models in vitro and in vivo. Br-ORM treatment effectively inhibited …

Moringin, An Isothiocyanate Improves The Susceptibility Of Breast Cancer Cells To Doxorubicin, Ankit Srivastava, Anusmita Shekher, Subash Chandra Gupta

Research Symposium

Background: Breast cancer has become the most frequent tumor worldwide and is expected to have a large impact on cancer fatalities globally. Thus, the development of precise molecular diagnosis and prognosis is essential for the effective treatment of breast cancer patients. Doxorubicin (DOXO) is the widely accepted chemotherapeutic drug for the treatment of breast cancer. However, the primary challenge with current chemotherapy drugs is their toxic effects on healthy tissues. Moringin (MG), an Isothiocyanate (ITC) is produced from the seeds of Moringa oleifera. It is produced from the myrosinase-catalyzed hydrolysis of glucomoringin. Chemosensitization is a strategy used in cancer treatment …

Metabolic Reprogramming In Breast Cancer Patients As Revealed By 1h Nmr Spectroscopy, Anusmita Shekher, Ankit Srivastava, Puneet, Nikee Awasthee, Dinesh Kumar, Subash Chandra Gupta

Research Symposium

Background: Breast cancer is a global health concern among women. Several metabolic pathways are dysregulated in breast cancer cells, including alterations in energy metabolism, amino acid metabolism, and lipid metabolism. Reprogramming of metabolic pathways may facilitate inappropriate proliferation of cancer cells and adaptation to the tumor microenvironment. Long non-coding RNAs (lncRNAs) have emerged as important regulatory targets in the process of tumorigenesis. However, the role of lncRNAs in the process of metabolic reprogramming is not properly known. Exploring metabolic alterations and its association with lncRNAs expression might be helpful for developing new biomarkers and therapeutic targets for cancer management.

Objectives: …

Lncrna Malat1 As A Novel Stress Related Factor In Hepatocellular Carcinoma, Amayrani Sanchez, Kyle Doxtater, Mohammad Shabir Hussain, Sophia M. Leslie, Subhash C. Chuahan, Elias George, Manish Kumar Tripathi

Research Symposium

As a result of the fast life pace, stress, and a major dietary shift toward preserved food, hepatocellular carcinoma (HCC) incidence and mortality are on rising trend, thus posing severe concerns. Texas is expected to have the second highest number of deaths related to liver cancer, with Hispanics having the highest mortality rate. HCC accounts for 85% to 90% of liver cancers. The Rio Grande Valley (RGV) region, where a predominantly (~90%) Latino/Hispanic population resides, has ~4-fold higher prevalence of liver cirrhosis and is a major hotspot of HCC in the nation. In addition, it was found to be positively …

Clinical Significance Of Targeting Ribosome Biogenesis In Pancreatic Cancer Therapy, Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez, Muhammad Bangash, Andrew Massey, Emmanuel Anning, Aun A. Bangash, Manu Sebastian, Manish Tripathi, Dae Joon Kim, Subhash Chauhan, Bilal B. Hafeez

Research Symposium

Pancreatic cancer (PanCa) is the third leading cause of cancer-related deaths in the United States with limited therapeutic options available. Gemcitabine (GEM), a deoxycytidine nucleoside analog is currently considered the most effective therapy for PanCa. However, it shows only a marginal survival benefit of six months. Aberrant ribosome biogenesis occurs in most tumor types. We observed that PanCa cells are addicted to ribosome biogenesis (RiBi), which supports their highly aggressive metastatic phenotypes. Thus, strategically targeting RiBi process could be one of the ideal strategies for the prevention and treatment of PanCa. In this study, we elucidated the molecular mechanisms of …

Ceacam7 Emerges As A Promising Early Detection Biomarker In Pancreatic Cancer., Anupam Dhasmana, Swati Dhasmana, Iris A. Enriquez-Perez, Sheema Khan, Murali M. Yallapu, Subhash C. Chauhan

Research Symposium

Background: According to the key statistics from the American Cancer Society in 2021, Pancreatic Cancer (PanCa) impacts approximately 60,430 individuals annually in the U.S., affecting 31,950 men and 28,480 women. Diagnosis and treatment of PanCa pose significant challenges. It stands as the fourth leading cause of cancer-related deaths, boasting a mere 9% 5-year survival rate and an overall grim prognosis. Adenocarcinomas, particularly PDAC, constitute the majority (around 85-90%) of PanCa cases, contributing to its highly aggressive nature and low survival rates. The absence of an early tumor-specific biomarker for PDAC underscores the urgent need for a novel strategy to enhance …

Antidiabetic Drug Jardiance (Empagliflozin) Effectively Attenuated The Weight Gain Induced By The Antipsychotic Drug Zyprexa (Olanzapine) In Female Wistar Rats, Ghulam Md Ashraf

Research Symposium

Atypical antipsychotic drugs are commonly associated with undesirable side effects including body weight gain (BWG) and metabolic deficits. Many pharmacological interventions have been tested to minimize or prevent these side effects. Preliminary evidence suggested that antidiabetic drugs may be effective in attenuating the BWG induced by antipsychotic drugs. In the first phase, we carried out a 28-day study to standardize the correlated effective dosage of the antidiabetic drug empagliflozin (EMPA) and the antipsychotic drug olanzapine (Ola). Rats were divided into control (vehicle), Ola-4 and Ola-8 (4 and 8 mg/kg/OD, IP, respectively), and EMPA-10 and EMPA-20 (10 and 20 mg/kg/OD, IG, …

Analysis Of Serum Cytokines-Chemokines In Association With Prostate Cancer Disparity., Dev Karan

Research Symposium

Background: Cancer health disparities represent a significant public health concern in the United States. Prostate cancer is one such disease with a higher incidence and death rate in African American (AA) men than in Whites. This study aimed to understand the role of systemic inflammation in association with prostate cancer disparity among AA and White men.

Methods: We used a 40-plex human chemokine assay kit to determine the differential level of cytokines-chemokines associated with prostate cancer disparity among AA and White men. A total of 211 serum samples from prostate cancer patients and healthy donors were tested. Differential expression …

The Impact Of Physique On Strategy And Performance In The 400 M Hurdles Race Among Elite Male Athletes, Janusz Iskra, Subir Gupta, Krzysztof Przednowek, René V. Best, Arkadiusz Stanula

Baltic Journal of Health and Physical Activity

Introduction: the objective of this study was to assess the impact of physique on the stride pattern and performance of elite male 400-m hurdles runners. Materials and Methods: this study is based on the analysis of the performance of 297 male 400-m hurdlers in 13 Olympic games, 16 world championships, and 15 European championships. The hurdlers were divided into 4 groups, based on their height and body mass index (BMI) – taller and heavier (TH), taller and lighter (TL), shorter and heavier (SH), and shorter and lighter (SL). Times taken to complete various phases of the 400-m hurdles race – …

1) Comprehensive Body Composition Assessments In College Aged Students, Erica Chapman, Marshuna Dalton, Natalie Izevbigie, Maddison Wilkes

Graduate Research Showcase

Introduction: According to the spring 2023 American College Health Association health survey, 5.5%, 22.8%, and 16% of college students self-reported being underweight, overweight, and obese, respectively. These statistics align with CDC figures suggesting 35-40% of college students are overweight and/or obese. Unfortunately, the vast majority of college students are not meeting national physical activity or nutritional standards. This trend towards unhealthy body composition, a sedentary lifestyle, and poor dietary habits has the potential to promote the development of chronic health conditions such as heart disease, cancer, diabetes, and osteoporosis. These risk-factors are avoidable and hold substantial physical, social, and economic …

1) Early Onset Osteopenia Assessments In College Aged Students, Elizabeth Czarick, Paul Grazzini, Emily Long, Natalie Stampfly, Kaitlin Vanvoorhis

Graduate Research Showcase

Introduction: Osteopenia and osteoporosis are diseases of severe bone mineral density loss. Approximately fifty-million individuals in the United States over the age of fifty suffer from osteopenia or osteoporosis; with seventy-five percent of cases effecting women. There has been a noted thirty-five percent increase in diagnoses of osteopenia and osteoporosis since 2008, with a dramatic increase in cases regarding women under thirty years of age. Typically, the onset of osteopenia and osteoporosis in women has occurred around fifty years of age, making these recent diagnoses of osteopenia and osteoporosis in young females quite alarming. As early onset osteopenia and osteoporosis …

Molecular Detection Of Human And Dog Fecal Pollution In Pensacola, Florida, Logan Mccullers, Jodel Nicholas, Dave Bachoon

Graduate Research Showcase

Pensacola, Florida (USA), has a thriving coastal community that depends on its coastal areas for recreation, shellfish harvesting, and fisheries. However, increasing levels of fecal pollution pose a potential threat to the water quality of these coastal systems. Identifying the source and abundance of contaminants in these environments is critical to controlling fecal pollution in these areas. This study aimed to use Microbial Source Tracking techniques to determine the source of pollution in five sites (Bayou Texar Lower, Willard Norris Road Creek, Clear Creek Boat Ramp @ 87, Quinette River Boat Ramp and Pensacola Bay Bridge) in the Pensacola area. …

Evaluation Of Vascular Aging On Measures Of Cardiac Function And Mechanical Efficiency: Insights From, Lawrence J Mulligan, Julian Thrash, Ludmil Mitrev, Douglas Folk, Alyssa Exarchakis, Daniel Ewert, Jeffrey C Hill

Cooper Medical School of Rowan University Departmental Research

INTRODUCTION: This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct.

METHODS: A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases. In phase I, the CM included five settings of aortic compliance (CA) from normal to stiff, studied at a heart rate of 80 bpm, and phase II included the normal to stiff CA settings evaluated at 60, 100, and 140 bpm. The PV construct provided steady-state and transient data through a simulated vena caval occlusion (VCO). …

Treating Your Child's Springtime Allergies, Maggie Mckay, Jay Portnoy

Parent-ish Podcast

The warmer weather is here...but for some, along with it comes seasonal allergies that can make you child feel a little crummy. Dr. Jay Portnoy discusses the cause of seasonal allergies, the pollens and how you can help your child feel better so they can enjoy springtime.

Click here to stream the podcast episode.

Nonpharmacologic Rate Control Of Postoperative Atrial Fibrillation In The Canine Sterile Pericarditis Model, Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan

Faculty Scholarship

Introduction: Postoperative atrial fibrillation (POAF) is common following open heart surgery, and is associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid ventricular rates during the postoperative period because of increased sympathetic tone. The purpose of this study was to develop nonpharmacologic rate control of POAF by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires in the canine sterile pericarditis model. Methods: We studied 10 sterile pericarditis dogs in the closed-chest state on postoperative days 1−3. The AVN fat pad stimulation (amplitude 2–15 mA; frequency 20 …

Frailty Assessment In Prospective Lvad Candidates: An International Survey, Malachy Clancy, Phd, Otr/L, Bcpr, Sarah Schroeder, Phd, Acpn-Bc, Msn, Rn, Aacc, Yu Wu, Dnp, Agacnp

Department of Occupational Therapy Posters and Presentations

Introduction

• The concept of frailty, initially developed in geriatrics, has recently been applied to individuals with heart failure (HF) and is recognized as an essential measure for prognostication of health status and predicting health outcomes
• Frailty remains highly prevalent, ranging between 56-79% in those undergoing left ventricular assist device (LVAD) evaluation¹ and is associated with poor postoperative outcomes.²
• Since little is known about frailty assessment and instruments used, this study aimed to evaluate institutional assessment processes of frailty during evaluation and the implications of frailty in LVAD eligibility.

S100a8/A9 As A Prognostic Biomarker With Causal Effects For Post-Acute Myocardial Infarction Heart Failure, Jie Ma, Yang Li, Ping Li, Xinying Yang, Shuolin Zhu, Ke Ma, Fei Gao, Hai Gao, Hui Zhang, Xin-Liang Ma, Jie Du, Yulin Li

Department of Emergency Medicine Faculty Papers

Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, respectively. The outcomes are in-hospital and long-term heart failure events. S100A8/A9 is screened out through proteomic analysis, and elevated circulating S100A8/A9 is independently associated with heart failure in discovery and validation cohorts. Furthermore, the predictive value of S100A8/A9 is superior to the traditional biomarkers, and the addition of S100A8/A9 improves the risk estimation using traditional risk factors. We finally report …

Green Synthesis Of Zinc Oxide Nanoparticles From Althaea Officinalis Flower Extract Coated With Chitosan For Potential Healing Effects On Diabetic Wounds By Inhibiting Tnf-Α And Il-6/Il-1Β Signaling Pathways, Sammar F. Elhabal, Nashwa Abdelaal, Saeed A.K.S. Al-Zuhairy, Mohamed F. Mohamed Elrefai, Ahmed M.E. Hamdan, Mohamed M. Khalifa, Sandra Hababeh, Mohammad A. Khasawneh, Gehad M. Khamis, Jakline Nelson, Passant M. Mohie, Rania A. Gad, Amira Rizk, Soad L. Kabil, Mohamed K. El-Ashery, Bhaskara R. Jasti, Nahla A. Elzohairy, Tayseer Elnawawy, Fatma E. Hassan, Mohamed A. El-Nabarawi

Pacific Faculty Work

Background: Diabetes Mellitus is a multisystem chronic pandemic, wound inflammation, and healing are still major issues for diabetic patients who may suffer from ulcers, gangrene, and other wounds from uncontrolled chronic hyperglycemia. Marshmallows or Althaea officinalis (A.O.) contain bioactive compounds such as flavonoids and phenolics that support wound healing via antioxidant, anti-inflammatory, and antibacterial properties. Our study aimed to develop a combination of eco-friendly formulations of green synthesis of ZnO-NPs by Althaea officinalis extract and further incorporate them into 2% chitosan (CS) gel. Method and Results: First, develop eco-friendly green Zinc Oxide Nanoparticles (ZnO-NPs) and incorporate them into a 2% …