Medicine and Health Sciences Commons^™

Integrating Drug Target Information In Deep Learning Models To Predict The Risk Of Adverse Events In Patients With Comorbid Post-Traumatic Stress Disorder And Alcohol Use Disorder, Oshin Miranda, Xiguang Qi, M Daniel Brannock, Ryan Whitworth, Thomas R Kosten, Neal David Ryan, Gretchen L Haas, Levent Kirisci, Lirong Wang

Faculty, Staff and Students Publications

Background/Objectives: Comorbid post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) patients are at a significantly higher risk of adverse outcomes, including opioid use disorder, depression, suicidal behaviors, and death, yet limited treatment options exist for this population. This study aimed to build on previous research by incorporating drug target information into a novel deep learning model, T-DeepBiomarker, to predict adverse outcomes and identify potential therapeutic medications.

Methods: We utilized electronic medical record (EMR) data from the University of Pittsburgh Medical Center (UPMC), analyzing 5565 PTSD + AUD patients. T-DeepBiomarker was developed by integrating multimodal data, including lab results, drug …

Cellular Trafficking And Fate Mapping Of Cells Within The Nervous System After In Utero Hematopoietic Cell Transplantation, Matthew T Grant, Hemanth Ramesh Nelvagal, Maria Tecos, Amal Hamed, Kerry Swanson, Jonathan D Cooper, Jesse D Vrecenak

2020-Current year OA Pubs

In utero hematopoietic cell transplantation (IUHCT) utilizes fetal immune tolerance to achieve durable chimerism without conditioning or immunosuppression during a unique window in fetal development. Though donor cells have been observed within the nervous system following in utero injection, the timeline and distribution of cellular trafficking across the blood-brain barrier following IUHCT is not well understood. We injected 20 × 10

3d Genome Topology Distinguishes Molecular Subgroups Of Medulloblastoma, John J Y Lee, Michael J Johnston, Hamza Farooq, Huey-Miin Chen, Subhi Talal Younes, Raul Suarez, Melissa Zwaig, Nikoleta Juretic, William A Weiss, Jiannis Ragoussis, Nada Jabado, Michael D Taylor, Marco Gallo

Faculty, Staff and Students Publications

Four main medulloblastoma (MB) molecular subtypes have been identified based on transcriptional, DNA methylation, and genetic profiles. However, it is currently not known whether 3D genome architecture differs between MB subtypes. To address this question, we performed in situ Hi-C to reconstruct the 3D genome architecture of MB subtypes. In total, we generated Hi-C and matching transcriptome data for 28 surgical specimens and Hi-C data for one patient-derived xenograft. The average resolution of the Hi-C maps was 6,833 bp. Using these data, we found that insulation scores of topologically associating domains (TADs) were effective at distinguishing MB molecular subgroups. TAD …

Targeting The Cholesterol Storage Enzyme Acat1/Soat1 In Brain Cells And Mouse Model: A Novel Approach To Address Aging And Apoe4-Related Neuroinflammation, Thao Nguyen Phuong Huynh Krumeich

Dartmouth College Ph.D Dissertations

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that significantly impacts nearly 7 million people in the United States. AD is characterized by the deposition of amyloid beta (Ab) plaque, tau neurofibrillary tangles (NFTs), lipids granules, and neuroinflammation. Age and apolipoprotein E4 (APOE4) are the two biggest risk factors for AD. Recent AD therapeutic development has mostly benefited the patient population with milder symptoms while causing serious side effects in APOE4 carriers, leaving the most impacted patients’ group - aged APOE4 carriers with no treatment option. With the increasing aging population, there is an urgent need for a …

Remotely Delivered Yoga Therapy For Chronic Pain: A Case Study, Patience Kaltenbach, Laura Edoff, Marlysa Sullivan, Steffany Moonaz

Journal of Applied Yoga Studies

Many people seek yoga as a complementary therapy for the management of chronic pain. Barriers to maintaining care for chronic pain conditions include pain with movement, fear of exacerbating symptoms, limited resources for long-term care plans, and a lack of individualized self-management instruction. In this case study, the yoga therapist implemented an integrative framework to address the needs of a client impacted by fibromyalgia primarily using video-conferencing software. This adaptive approach demonstrates the feasibility and potential benefits of remote yoga therapy for chronic pain, including improved adherence, long-term pain management, and self-efficacy for maintaining quality of life initiated by client-motivated …

Effect Of Yoga Therapy For Managing Migraine: A Case Series, Andrea Moran, Lori Rubenstein Fazzio

Journal of Applied Yoga Studies

Migraine is a common disabling primary headache disorder. It is characterized by symptoms lasting 4-72 hours, headache with unilateral location, pulsating quality, moderate or severe intensity, aggravation by routine physical activity, and association with nausea and/or photophobia and phonophobia. In this case series four females in the age range of 25-57 presented complaints of migraine headaches affecting their everyday lives. Additionally, they reported emotional challenges accompanying chronic pain due to migraine headaches such as stress, sleep deprivation, and anxiety. An online eight-week yoga therapy program was given for the management of migraine headaches. This program included lifestyle modifications, postures, breathing …

A Comparative Study Of Yoga And Stoicism For Achieving Mental Well-Being, Dr. R K Roshni Raj Lakshmi, Mr. Puyam Robinchandra Singh

Journal of Applied Yoga Studies

Background: The ideal way of life is a question perused upon by many thinkers. Western philosophy as well as Indian philosophy has dwelled on this. A common thread can be seen running through philosophical schools of stoicism and yoga. Evidence can be seen in both schools of philosophy to prove this similarity. The concepts of stoicism like the dual powers leading to creation, concept of eudemonia, restraint of sense organs and control of desire find their equivalent concepts in yoga texts. It can be thus, concluded that stoicism can be seen intertwined in yoga philosophy.

Aim of the philosophical study: …

A Philosophical And Spiritual Design For Prenatal Yoga Courses, Tia A. Arriola

Journal of Applied Yoga Studies

Fear and anxiety dominate much of the global birth culture, whereby approximately 80% of pregnant women report worrying with regard to the natural risks of childbirth (Rublein & Muschalla, 2022). This leads to increased rates of antenatal stress and postpartum depression. These psychosocial responses present risk factors for adverse developmental and health outcomes for the fetus, newborn, mother, and family (Shakarami et al., 2021). In the Western context, the overwhelming response is to increasingly medicalized childbirth, which, while offering life-saving support, may also pose its own set of adverse risks for mother and infant. Therefore, alterative and complementary approaches that …

Impact Of For-Credit Mindfulness Course On Student Resilience, Engagement, And Mental Health, Linda Yaron Weston

Journal of Applied Yoga Studies

This paper highlights the impact of a university for-credit introductory mindfulness course. Research compiled from student reflections, surveys, and interviews revealed that it had a notable impact on personal growth and development, including the capacity to navigate challenges, manage difficult emotions, and build resilience. This enhanced student learning, decision making, engagement, and connection to themselves, others, and the world around them. Course pedagogy and curriculum are included here alongside a narrative account of student experiences in the course. These findings indicate a promising practice for schools to include well-being supports in the student experience.

Exploring The Role Of Yoga In Improving The Quality Of Life Among Patients Diagnosed With Schizophrenia And Intellectual Disability, Laura Tolbaños-Roche

Journal of Applied Yoga Studies

Background and objectives

There is large evidence of the positive effect of yoga in mental health disorders, mainly anxiety and depression. However, the studies on the role of yoga in schizophrenia and intellectual disability are sparse and inconclusive. The objective of this study is exploring the role of a specific yoga intervention, based on the Gitananda Rishiculture Asthanga Yoga Tradition, in improving the quality of life (QoL) of patients diagnosed with schizophrenia and intellectual disability in a mental health institution of Las Palmas de Gran Canaria (Spain).

Methods

Patients diagnosed with schizophrenia (n=5) and patients diagnosed with intellectual disability (n=4) …

Editors' Note, Dr. Lori Rubenstein Fazzio, Dr. Meena Ramanathan, Dr. Praseeda Menon

Journal of Applied Yoga Studies

Welcome message from the editors.

Noda News December 2024

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Random Blood Glucose As An Alternative To Glycated Hemoglobin For Assessing Glycemic Control In Diabetes Mellitus Patients. Cross-Sectional Study In Babylon Province, Iraq, Hajir Karim Abdul-Husseein, Abeer Tariq Watife, Mustafa Karim Abdul-Husseein, Hayder Abdul-Amir Makki Al-Hindy, Karam Akram Al- Akkam

Maaen Journal for Medical Sciences

Background: Diabetes affected 171 million people worldwide one and a half decades ago, and 366 million people are expected by 2030. The relationship between glycated hemoglobin (HbA1c) and diabetes complications was established, emphasizing the importance of good glycemic management. However, due to its high cost, the HbA1c test is considered to be not affordable or not available. The high incidence of diabetes mellitus (DM) and its more risky comorbidities in most populations necessitate the requirement for regarding an alternative test.

Objective: The aim of the current study was to assess if there is a relationship between HbA1c and …

6th Annual Occupational Therapy Program Research Conference, Kelly L. Taylor Otd, Ms, Otr/L, Cbis

Student Scholarship & Creative Works

Occupational Therapy Program RESEARCH CONFERENCE

6TH OT COHORT | CLASS OF 2025

OT Program Student Presentations Graduate Students from the Class of 2025

Sk609, A Novel Dopamine D3 Receptor Agonist And Norepinephrine Transporter Blocker With Putative Pro-Cognitive Actions, Does Not Induce Psychostimulant-Like Increases In Risky Choice During Probabilistic Discounting, Christopher P. Knapp, Brooke Fallon, Sandhya Kortagere, Barry D. Waterhouse, Stan B Floresco, Rachel L Navarra

Rowan-Virtua School of Osteopathic Medicine Departmental Research

RATIONALE: Psychostimulants, such as amphetamine (AMPH) and methylphenidate (MPH), non-selectively elevate extracellular concentrations of the catecholamine neurotransmitters, dopamine (DA) and norepinephrine (NE), and are common pharmacological strategies used to improve prefrontal cortex (PFC)-dependent cognitive dysfunction. However, this approach can be problematic given AMPH has been shown to increase preference for risky choices in a rodent assay of risk/reward decision making. SK609 is a novel NE reuptake blocker that selectively activates DA D3 receptors without affinity for the DA transporter. SK609 has been shown to improve cognitive performance without increasing psychostimulant-like spontaneous locomotor activity, suggesting SK609 may benefit neurocognitive function without …

Impact Of Patient Psychoeducation On Medication Adherence In Bipolar Depression, Mary Nse Wellington

Walden Dissertations and Doctoral Studies

The quality improvement (QI) project targeted patients with bipolar depression, aged 20–50 years, in an outpatient mental health setting who had the problem of nonadherence to medication. Medication nonadherence is a major concern in nursing practice that impacts clinical effectiveness, overall treatment outcomes, and healthcare cost implications. The project evaluated whether the outcome, timely refill rates of prescription medication, was impacted by the psychoeducation that was conducted outside the scope of the project. The project question was, “What is the impact of patient psychoeducation to improve timely refill rates among patients with bipolar depression aged 20–50 years in an outpatient …

Perceptions And Attitudes Of Western Michigan University Students On Antibiotic Medications, Emily Boask

Honors Theses

On a global scale, antibiotic resistance is a threat to public health. The causes of antibiotic resistance are multifaceted, including healthcare providers overprescribing antibiotics, antibiotic overuse in farming and food production, and antibiotic misuse or malpractices. The public recognizes antibiotic resistance as a significant problem but there are serious knowledge gaps regarding antibiotic resistance and antibiotic stewardship.

University students are a particularly important subpopulation of the public to understand appropriate antibiotic use because many of these individuals are navigating their health concerns on their own for the first time. Many individuals believe that antibiotics can improve cold symptoms, upper respiratory …

Interaction Between Type 2 Diabetes And Past Covid-19 On Active Tuberculosis, Liz E. Calles-Cabanillas, Genesis P. Aguillón-Durán, Doris Ayala, Jose A. Caso, Miguel Garza, Mateo Joya-Ayala, Raúl Loera-Salazar, America Cruz-González, John M. Thomas Iii, Blanca I. Restrepo

School of Medicine Publications

Background

The global setback in tuberculosis (TB) prevalence and mortality in the post-COVID-19 era has been partially attributed to pandemic-related disruptions in healthcare systems. The additional biological contribution of COVID-19 to TB is less clear. The goal of this study was to determine if there is an association between COVID-19 in the past 18 months and a new TB episode, and the role played by type 2 diabetes mellitus (DM) comorbidity in this relationship.

Methods

A cross-sectional study was conducted among 112 new active TB patients and 373 non-TB controls, identified between June 2020 and November 2021 in communities along …

Age-Related Differences In Behavioral Outcomes Of Bimanual Functional Motor Tasks In Children And Adolescents With Cerebral Palsy: A Scoping Review, Hubert D. Gascon, Sahian Alicia Maldonado Numata, Sandrine Emond, Samuel Nemanich, Maxime T. Robert

Occupational Therapy Faculty Research and Publications

Aim: The objective of this review is to determine age-related differences in behavioral outcomes of bimanual motor tasks in children and adolescents with cerebral palsy (CP). Method: This review followed the 6-stage Joanna Briggs institute methodology. The embase, EBSCO CINAHL, and PubMed databases were searched on May 2024. we included studies that employed instrumented measures to assess bimanual tasks in individuals with CP aged between 3 and 19 years.Results: Twenty-eight studies were included after full-text screening. This review reported on 544individuals with CP. Bimanual tasks were grouped in seven categories and their varying complexities were listed and analyzed. There are …

The Implementation Of Ketamine-Assisted-Psychotherapy On Healthcare Workers Suffering From Workplace-Related Ptsd Due To Covid-19, Ziluolan Zou

Nursing | Student Research Posters

During the coronavirus disease 2019 (COVID-19) pandemic, healthcare workers were exposed to a deadly disease with limited knowledge and personal protective equipment, subjected to long hours, forced to ration care due to limited critical care resources and ventilators, and isolated from their families due to fear of spreading the virus. These factors further compounded the occupational stress associated with being a healthcare worker. The literature shows that the physical, mental, and emotional challenges frontline healthcare workers faced during the COVID-19 pandemic had lasting impacts on their mental health. The prevalence of mental health illnesses, such as post-traumatic stress disorder, among …

Robotics And A.I In Oncological Surgery, Ian Ngo

Nursing | Student Research Posters

Throughout the decades, advancements in

technology have been surpassing limits that

were thought impossible. Every day these

breakthroughs are improving modern

surgery whether it be enhancing precision

on surgical sites, increasing accuracy of

procedure, or reducing recovery rates for

patients. Among the newly increasing

innovations, the implementation of robotics

systems and artificial intelligence (AI) into

the surgical field has emerged into

becoming a transformative force, especially

within a context as delicate as tumor removal.

This study explores the numerous benefits

of incorporating robotics and artificial

intelligence (AI) in tumor removal surgeries.

We investigate how these innovations

improve surgical accuracy, reduce …

The Effects Of Music Therapy On Pediatric Patients With Congenital Heart Defects In The Pre And Postoperative Setting, Janelle Marie Choy

Nursing | Student Research Posters

Congenital heart defects is a prominent medical occurrence especially in pediatrics. These defects often require surgeries and extensive treatment plans. These treatment plans often include invasive surgeries and extensive treatment plans which can require long recovery times along with potential surgical complications. This study aims to evaluate the effectiveness of music therapy on pediatric patients with congenital heart defects in the pre and postoperative setting and how music therapy can be implemented in treatment plans to yield effective recovery results for these patients. This research is significant as elevated vital signs and preoperative anxiety are associated with an increased need …

Educational Program On Depression And Anxiety For Low Socioeconomic Postpartum Latina Mothers, Lizbeth Valdez Duran

Nursing | Student Research Posters

Postpartum depression (PPD) and postpartum anxiety are common mental health conditions that women experience after childbirth. PPD involves intense feelings of extreme sadness, and diminished interests in activities that once brought them happiness. Postpartum anxiety involves constant worry and fear, often centered on the well-being of the baby. Symptoms may include restlessness or irritability, panic attacks, and trouble concentrating or sleeping. Barriers to treating depression and anxiety among Latinas include a lack of awareness or understanding of mental health issues. (Lopez et al., 2018).

Health Literacy refers to the individual's ability to understand and process health-related information. By assessing a …

Prepared To Protect: Improving Cardiac Emergency Response In Youth Club Sports, Melissa Garcia

Nursing | Student Research Posters

Sudden cardiac arrest (SCA) is a medical emergency where the heart unexpectedly stops beating due to an electrical malfunction. A person experiencing a cardiac arrest collapses, loses consciousness, and ceases breathing (American Heart Association, 2022).

Exercise offers numerous benefits to the cardiovascular system and a person’s overall health. However, there are incidents of sports-related cardiac arrest in apparently healthy athletes, including children and young adults. Athletes may be exposed to dehydration, adrenic surges, electrolyte imbalances, acid/base disturbances, and trauma which increases their risk of experiencing a cardiac event (Wasfy et al., 2016).

Sudden cardiac arrest is the leading cause of …

Racial Concordance Perceptions Of Post-Op African-American Patients, John-Ezekiel Moya

Nursing | Student Research Posters

African-Americans have historically faced significant health disparities, which persist due to implicit racial biases and a lack of cultural competency among non-Black healthcare providers. These disparities often result in poorer health outcomes and diminished patient satisfaction. One potential factor in mitigating these issues is racial concordance, the alignment of racial identity between patients and providers (Jetty et al., 2022). However, only 6.3% of the nursing workforce identifies as Black or African-American (Smiley et al., 2023), limiting opportunities for racially concordant care. While racial concordance may foster trust, communication, and comfort in healthcare settings, research on its importance to African-American Patients—especially …

Telogen Effluvium Incidence In Women Wearing Hijab Compared To Non-Hijab: A Cross-Sectional Study, Sondang Pandjaitan Sirait, Sandra Widaty, Lili Legiawati, Lis Surachmiati Suseno, Roro Inge Ade Krisanti, Windy Keumala Budianti, Eliza Miranda, Rahadi Rihatmadja, Caroline Oktarina, Paulus Anung Anindita Pandelaki, Irhen Situmeang

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Hair loss is a normal experience, but if the amount of hair loss exceeds what is considered normal, it will usually cause anxiety for the patient. In Indonesia, almost every Muslim woman wears a hijab. The hijab is one of many factors believed to cause hair loss. Telogen effluvium (TE) itself is a hair cycle disorder in which the anagen phase terminates prematurely, resulting in diffuse club hair loss without scarring, and TE itself has many risk factors. The purpose of this study was to determine the relationship between the incidence of TE in women who wear hijabs …

Accuracy In Measurement Of Infant Formula Powder And Water With And Without A Crying Baby Present, Richard R. Rosenkranz, Chris Acosta, Ana Gonzalez-Alvarez, Andrew Hooyman, Jose R. Hidalgo, Romina Ballasteros-Paniagua, Sara K. Rosenkranz

Physical Therapy Faculty Articles and Research

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Infant formula provides a safe, nutritious alternative to breastfeeding but caregivers may use unsanitary methods or make substantial errors with formula dilution and jeopardize infant health.1 Underdiluting formula can result in health problems, such as hypernatremic dehydration, gastroenteritis, other digestive problems, or long-term excess weight gain.2 Overdiluting infant formula, sometimes used to reduce expense by low-income caregivers,2 can also lead to serious health problems for babies, including diarrhea, water intoxication, nutrient deficiencies, malnutrition, and even death.2,3

Previous studies have assessed common measurement inaccuracy of infant formula preparations in relation to bottle characteristics, package instructions, caregiver experience, and target amount, …

Multicenter Clinical Performance Evaluation Of The Neumodx™ Ct/Ng Assay 2.0, B. Van Der Pol, A. Avery, Stephanie N. Taylor, J. Miller, C. L. Emery, A. English, G. B. Lazenby, Rebecca Lillis, J. Ruth, D. Young, S. Young, S. Chavoustie, L. Crane, V. Reid, G. Wall, S. Johnson

School of Medicine Faculty Publications

Background: Given the continued increases in rates of both Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection, additional diagnostic assays may be useful in increasing access to testing for these sexually transmitted infections. We evaluated the performance of the NeuMoDx™ CT/NG Assay 2.0 on the NeuMoDx-96 and NeuMoDx-288 Molecular Systems. Methods: The clinical sensitivity and specificity of the assay was assessed when used with: 1) endocervical swabs; 2) self-, and clinician-collected vaginal swabs; and 3) first-catch urine specimens (female and male). Results were compared to a patient infection status based on US Food and Drug Administration (FDA)-cleared assays. Results: The …

A Review Of The Association Between Dietary Intake And Brain Iron Levels In Older Adults: Preliminary Findings And Future Directions., Valentinos Zachariou, Christopher E. Bauer, Colleen A. Pappas, Brian T. Gold

Behavioral Science Faculty Publications

Background/Objectives: Non-heme iron is essential for critical neuronal functions such as ATP generation, synaptogenesis, neurotransmitter synthesis, and myelin formation. However, as non-heme iron accumulates with age, excessive levels can contribute to oxidative stress, potentially disrupting neuronal integrity and contributing to cognitive decline. Despite growing evidence linking high brain iron with poorer cognitive performance, there are currently no proven methods to reduce brain iron accumulation in aging or to protect cognitive function from iron’s negative effects. Recent studies suggest that nutrition may influence brain iron levels, though the evidence remains limited and mixed. Methods: In this review, we explore recent findings, …

A Prospective Study In The Treatment Of Androgenic Alopecia Using Combination Of Procapil, Capixyl, Redensyl, Garima Bansal, Rishi Bansal

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Androgenic alopecia is characterized by its diffuse loss and the miniaturization of the hair. The study aimed to assess the safety and efficacy of procapil, redensyl, capixyl, bicapil, and anagain in topical hair growth serum in androgenic alopecia.

Methods: A prospective study was conducted on 110 healthy subjects aged 18-60 with androgenic alopecia in the Department of Dermatology, Tundla, Etmadhpur. Each subject applied 1 ml of serum on a dry scalp and was followed up on the 4^th, 8^th, 12^th, and 16^th week. Mean, median, and standard deviation were calculated. A repeated measure …