Medicine and Health Sciences Commons^™

The Impact Of Prone Ventilation Among Patients Diagnosed With Acute Respiratory Distress Syndrome, Mary Steward, Kimberly Loomis

Nurse Residency

Background Mechanical ventilation is a commonICU intervention for patients in respiratory distress. Proning is a form of mechanical ventilation that has been recently studied which improves gas exchange and lung perfusion among patients specifically diagnosed with ARDS.

Triticale As A Source Of Resistance To Wheat Streak Mosaic Virus And Triticum Mosaic Virus, Marcos Winicius Goncalves De Souza

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV) present a great threat to wheat production in the Great Plains area of the United States due to the loss of photosynthetic area causing reductions in crop yields. Effective control of these viruses is limited to a few available strategies including controlling volunteer wheat and using currently identified resistant genes to both the vector and viruses. While effective, these genes show temperature sensitivity and yield drag, and evidence that the vectors and viruses can overcome them has been found. Thus, new methods of genetic resistance are urgently needed. Field observations …

Evaluation Of Current Redating Guidelines For Pregnancies ≤9 6/7 Weeks' Gestation, Grace Chen, Clara Choi, Allyson Nguyen, Mark Brunk-Grady, Tuan Nguyen

Conference Presentation Abstracts

Objectives: The aim was to evaluate the validity of the current redating guidelines for pregnancies ≤9 6/7 weeks’ gestation. We postulated that visually apparent discrepancies between crown-rump length (CRL) measured by ultrasound (US) and CRL by last menstrual period (LMP) were statistically significant. Methods: This is a retrospective, cross-sectional study conducted between January 2019 and June 2023 at a tertiary referral center. Individuals who had singleton gestations between ≥6 0/7 and ≤9 6/7 weeks by known LMP were reviewed. For estimated gestational age (EGA) by LMP ≥6 0/7 and ≤8 6/7 weeks, a 3–5 day discrepancy between EGA by LMP …

The Use Of Hearing Tests To Assess Otitis Media With Effusion In Children With Down Syndrome., Mackenzie O'Donnell, Nasrin Sultana, Nasreen Talib, Jason May, Michael Slogic

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Down syndrome is associated with an increased risk for otitis media with effusion (OME), a childhood condition in which fluid accumulates in the middle ear, potentially leading to hearing loss. The American Academy of Pediatrics Down syndrome guidelines and the American Academy of Otolaryngology - Head and Neck Surgery OME guidelines recommend hearing testing to assess the hearing status of children with Down syndrome diagnosed with OME.

METHODS: Through an Institutional Review Board approved retrospective chart review at Children's Mercy, this project assessed how clinical factors affect the frequency in which children with Down syndrome receive hearing testing after …

Decreasing Overall Breast Cancer Risk Through Assessment, Treatment, And Prevention Of Vitamin D Deficiency In The Adult Population, Rachel Jamison

Doctor of Nursing Practice Scholarly Project

The primary objective of this study is to examine the effectiveness of an educational initiative aimed at enhancing nurse practitioners' understanding and recognition of vitamin D deficiency. The purpose of this program is to equip them with the skills to screen, diagnose, and manage this condition to mitigate the overall risk of breast cancer in patients. Vitamin D deficiency is a prevalent global health issue that affects over one billion people, and it can manifest at any stage of life without showing any symptoms, making it challenging for healthcare providers to detect. However, even mild or prolonged deficiencies can lead …

Auxiliary Diagnosis Of Dental Calculus Based On Deep Learning And Image Enhancement By Bitewing Radiographs, Tai Jung Lin, Yen Ting Lin, Yuan Jin Lin, Ai Yun Tseng, Chien Yu Lin, Li Ting Lo, Tsung Yi Chen, Shih Lun Chen, Chiung An Chen, Kuo Chen Li, Patricia Angela R. Abu

Ateneo Laboratory for Intelligent Visual Environments

In the field of dentistry, the presence of dental calculus is a commonly encountered issue. If not addressed promptly, it has the potential to lead to gum inflammation and eventual tooth loss. Bitewing (BW) images play a crucial role by providing a comprehensive visual representation of the tooth structure, allowing dentists to examine hard-to-reach areas with precision during clinical assessments. This visual aid significantly aids in the early detection of calculus, facilitating timely interventions and improving overall outcomes for patients. This study introduces a system designed for the detection of dental calculus in BW images, leveraging the power of YOLOv8 …

Insights Into Personalized Care Strategies For Wilms Tumor: A Narrative Literature Review, Salma Karam, Ahmad Gebreil, Ahmed Alksas, Hossam Magdy Balaha, Ashraf Khalil, Mohammed Ghazal, Sohail Contractor, Ayman El-Baz

All Works

Wilms tumor (WT), or nephroblastoma, is the predominant renal malignancy in the pediatric population. This narrative review explores the evolution of personalized care strategies for WT, synthesizing critical developments in molecular diagnostics and treatment approaches to enhance patient-specific outcomes. We surveyed recent literature from the last five years, focusing on high-impact research across major databases such as PubMed, Scopus, and Web of Science. Diagnostic advancements, including liquid biopsies and diffusion-weighted MRI, have improved early detection precision. The prognostic significance of genetic markers, particularly WT1 mutations and miRNA profiles, is discussed. Novel predictive tools integrating genetic and clinical data to anticipate …

Verifiable Outsourced Attribute-Based Encryption Scheme For Cloud-Assisted Mobile E-Health System, Yinbin Miao, Feng Li, Xinghua Li, Jianting Ning, Hongwei Li, Kim-Kwang Raymond Choo, Robert H. Deng

Research Collection School Of Computing and Information Systems

The cloud-assisted mobile electronic health (e-health) system facilitates e-health data sharing between healthcare providers and patients, but also raises the security and privacy concerns of e-health data. Although Ciphertext-Policy Attribute-Based Encryption (CP-ABE) has been a promising technique to achieve fine-grained access control over encrypted e-health data, it still incurs high encryption and decryption burdens on mobile users such as smartphones and sensors. In addition, malicious cloud servers may conduct incorrect operations due to various interest incentives (e.g., leaking sensitive information to illegal users, saving computation and storage costs). To solve the above issues, in this paper we first propose an …

The Effect Of Using Two Sintering Cycles On The Optical Properties Of Gradient Multi-Layered Zirconia (In Vitro Study), Fatma Makkeyah, Passent Elghalab, Maged Zohdy, Mostafa Nour

Dentistry

No abstract provided.

Parental View On Hpv Vaccination, Rebecca Elaine Rhodes

Electronic Theses and Dissertations

The human papillomavirus (HPV) is a sexually transmitted infection widely seen in the United States. Millions of Americans are affected by it each year, especially those in their late teens and early 20s. Although most infections will resolve on their own, 1 in 10 will lead to health problems such as cancer. The HPV vaccine can prevent over 90% of associated precancers and cancers. However, uptake of the HPV vaccine and its completion among adolescents are significantly lower than other recommended adolescent immunizations, falling short of the Healthy People 2030 goal of 80% coverage. Understanding parental attitudes, beliefs, and perceptions …

Dynamic Disability Measures Decrease The Clinico-Radiological Gap In People With Severely Affected Multiple Sclerosis, Alex Burnham

Emerson Authors, Researchers, & Creators

PwMS recruited from The Boston Home (TBH), a specialized residential facility for severly-affected pwMS and University at Buffalo (UB) MS Center were assessed using EDSS, MS Severity Scale, age-related MSS, Scripps Neurological Rating Scale (SNRS) and Combinatorial Weight-Adjusted Disability Score (CombiWISE). In all scores except SNRS, higher score indicates greater disability. MRI measures of T1, T2-lesion volume (LV), whole brain, gray matter, medulla oblongata and thalamic volumes (WBV, GMV, MOV, TV) and thalamic dysconnectivity were obtained.

Results

Greatest disability differences between the TBH and UB pwMS were in SNRS (24.4 vs 71.9, p < 0.001, Cohen's d = 4.05) and CombiWISE (82.3 vs. …

Emerging Cell And Molecular Targets For Treating Mucus Hypersecretion In Asthma, Ana M Jaramillo, Eszter K Vladar, Fernando Holguin, Burton F Dickey, Christopher M Evans

Faculty, Staff and Student Publications

Mucus provides a protective barrier that is crucial for host defense in the lungs. However, excessive or abnormal mucus can have pathophysiological consequences in many pulmonary diseases, including asthma. Patients with asthma are treated with agents that relax airway smooth muscle and reduce airway inflammation, but responses are often inadequate. In part, this is due to the inability of existing therapeutic agents to directly target mucus. Accordingly, there is a critical need to better understand how mucus hypersecretion and airway plugging are affected by the epithelial cells that synthesize, secrete, and transport mucus components. This review highlights recent advances in …

A Word From The Writing Team (July 2024), Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Publication Spotlight
• Join Us for Summer Writing Time
• For FY24-25, the Open Access Publishing Fund Process is Changing
• Jefferson has Funding Agreements with Specific Publishers
• The OPWPC Canvas Page Offers Helpful Tools
• Scott Memorial Library Archive Renovations are Done!

Ai-Assisted Study In Post Pandemic Disruptions Of Operations And Supply Chain Management Practices, Raouf G. Ghattas, Andrew Burnstine

Faculty and Staff Publications & Presentations

The presentation explored the nature of the Fashion Industry group, the disruptions, the impact on the industry as a whole, in terms of Profitability, Consumer preference, Demand, Logistics and Inventory positions, then discuss the mitigations adopted by each industry group, and finally strategies for the way forward.

The presentation explored the nature of the Fashion Industry group, the disruptions, the impact on the industry as a whole, in terms of Profitability, Consumer preference, Demand, Logistics and Inventory positions, then discuss the mitigations adopted by each industry group, and finally strategies for the way forward.

Sex Differences In Spontaneous Respiratory Recovery In Chronic Hemisection, Taylor C. Holmes, Nicole M. Popp, Carley F. Hintz, Isabell Dobrzycki, Carolyn J. Schmitz, Kaylyn A. Schwichtenberg, Elisa J. Gonzalez-Rothi, Christopher W. Sundberg, Kristi A. Streeter

Physical Therapy Faculty Research and Publications

Respiratory deficits after C2 hemisection (C2Hx) have been well documented through single-sex investigations. Although ovarian sex hormones enable enhanced respiratory recovery observed in females 2 wk post-C2Hx, it remains unknown if sex impacts spontaneous respiratory recovery at chronic time points. We conducted a longitudinal study to provide a comprehensive sex-based characterization of respiratory neuromuscular recovery for 8 wk after C2Hx. We recorded ventilation and chronic diaphragm electromyography (EMG) output in awake, behaving animals, phrenic motor output in anesthetized animals, and performed diaphragm muscle histology in chronically injured male and female rodents. Our results show that females expressed a greater recovery …

Noninvasive Estimation Of Skeletal Muscle Oxygen Consumption Rate And Microvascular Reactivity In Chronic Stroke Survivors Using Near-Infrared Spectroscopy, Allison S. Hyngstrom, Jennifer N. Nguyen, David D. Gutterman, Brian D. Schmit, Emilie A. Klevenow, Matthew J. Durand

Physical Therapy Faculty Research and Publications

Understanding post-stroke changes in skeletal muscle oxidative metabolism and microvascular reactivity could help create therapeutic targets that optimize rehabilitative interventions. Due to disuse atrophy, we hypothesized that basal muscle oxygen consumption rate and microvascular endothelial function would be impaired in the tibialis anterior (TA) muscle of the affected leg of chronic stroke survivors compared with the nonaffected leg and versus matched controls. Fifteen chronic stroke survivors (10 females) and 15 matched controls (9 females) completed this study. A near-infrared spectroscopy oximeter measured tissue oxygen saturation (StO₂) of the TA in both legs of stroke survivors and the dominant …

Reduced Oxygen Desaturation In The Vastus Lateralis Of Chronic Stroke Survivors During Graded Muscle Contractions, Allison S. Hyngstrom, Jennifer N. Nguyen, Spencer A. Murphy, Stephanie C. Raab, Brian D. Schmit, David D. Gutterman, Matthew J. Durand

Physical Therapy Faculty Research and Publications

Background

Few studies have examined changes in skeletal muscle physiology post-stroke. This study examined changes in tissue oxygen saturation (StO₂) of the vastus lateralis (VL) muscle of stroke survivors and age-matched control participants during maximal and submaximal isometric contractions of the knee extensor muscles.

Objectives

We hypothesized that tissue oxygen desaturation (ΔStO₂) during knee extensor muscle contractions would be less in the VL in the paretic vs. the non-paretic and control legs.

Methods

Ten chronic stroke survivors (>6 months post-stroke) with lower extremity muscle weakness and 10 age-matched controls completed this prospective cohort study. Maximum …

Genetic Correlations Between Liver Fat Content, Metabolic Health, And Adiposity Distribution In The Fels Longitudinal Study, Ariana L. Garza, Miryoung Lee, John Blangero, Cici X. Bauer, Stefan A. Czerwinski, Audrey C. Choh

School of Medicine Publications

Highlights

• Steatosis and all other related phenotypes examined were significantly heritable.

• Liver fat showed significant genetic correlation with various phenotypes.

• The strongest genetic correlation of liver fat was with insulin resistance.

• Glucose homeostasis phenotypes were also genetically correlated to adiposity traits.

Abstract

Background and aims

Hepatic steatosis is known to be heritable, but its genetic basis is mostly uncharacterized. Steatosis is associated with metabolic and adiposity features; recent studies hypothesize that shared genetic effects between these traits could account for some of the unexplained heritability. This study aimed to quantify these genetic associations in a family-based sample of non-Hispanic white …

Contraceptive Use Among Women Experiencing Intimate Partner Violence And Reproductive Coercion: The Moderating Role Of Ptsd And Depression, Jessica L. Zemlak, Lea Marineau, Tiara C. Willie, Helena Addison, Gabrielle Edwards, Trace S. Kershaw, Kamila A. Alexander

College of Nursing Faculty Research and Publications

Women experiencing reproductive coercion (RC) report more unintended pregnancies and mental health symptoms that can influence contraceptive use patterns. We examined associations between RC and contraceptive use among intimate partner violence (IPV) exposed women aged 18–35 (N = 283). We tested depression, post-traumatic stress disorder (PTSD), and co-morbid depression and PTSD as effect modifiers. Though no association was found between RC and contraception, PTSD significantly modified this relationship. Among Black women (n = 112), those reporting RC and either PTSD or comorbid PTSD and depression were less likely to use partner-independent contraception compared to those reporting RC without …

Correlations Of Physical And Psychological Health In Parents Of Individuals With Autism Spectrum Disorder, Norah L. Johnson, Abir K. Bekhet, Emily Zint, June Wang, Sylvia Peña, Amy V. Van Hecke, Mauricio Garnier-Villarreal, Alexander V. Ng

College of Nursing Faculty Research and Publications

Background: Individuals with autism spectrum disorder (ASD) have social communication difficulties and restricted, repetitive, and/or sensory behaviors or interests. The prevalence of ASD is now 1 in 36 individuals. Parents of individuals with ASD face challenges that can affect their physical and psychological wellbeing.

Objective: With the long-term goal to tailor an exercise program, the purpose of this study was 2-fold: (1) establish the baseline physical and mental health of parents of individuals with ASD and (2) estimate the relationship of physiologic variables with psychological variables of health for parents of individuals with ASD.

Methods: This descriptive, cross-sectional study (N …

Using Implementation Science To Improve Short Peripheral Intravenous Catheter Outcomes, Mary Hook, Aimee A. Woda, Kelsey Bohr, Cailin Ford, Maharaj Singh

College of Nursing Faculty Research and Publications

Short peripheral intravenous catheters (short PIVCs) are commonly used in acute care, guided by evidence-based policy with interventions to limit premature failure. Research on how nurses use evidence and change processes to optimize outcomes is needed. The study objective was to use a theory-based implementation science approach to evaluate and improve short PIVC insertion and care processes and reduce removals for adverse outcomes in acute care. This mixed-methods study was conducted with inpatient nursing units (n = 23) at a large urban quaternary medical center. Units identified and implemented one PIVC care intervention that could lower catheter removals for adverse …

No Difference In Surgical Outcomes Between Stand-Alone Devices And Anterior Plating For 1-2 Level Anterior Cervical Discectomy And Fusion: A 1:1 Exact Matched Analysis, Xu Tao, Abhijith V. Matur, Seth Street, Geet Shukla, Julia Garcia-Vargas, Jay P. Mehta, Kelly Childress, Henry Ofori Duah, Justin Gibson, Daryn Cass, Andrew Wu, Benjamin Motley, Joseph Cheng, Owoicho Adogwa

College of Nursing Faculty Research and Publications

Study Design. 

Retrospective cohort.

Objective. 

To compare rates of all-cause surgical and medical complications between zero-profile (ZP; stand-alone) implants versus any graft type with an anterior plate in patients undergoing 1-2 level anterior cervical discectomy and fusion (ACDF) for treatment of degenerative cervical myeloradiculopathy.

Summary of Background Data. 

Degenerative cervical myeloradiculopathy is increasingly prevalent in older adults. ACDF is a common surgical procedure for decompression of neural structures and stabilization and has been shown to have excellent outcomes. Although ACDFs performed with graft and plate have been the gold standard, more recently, ZP implants were developed to decrease implant-related complications, …

A Guide To Understanding Big Data For The Nurse Scientist: A Discursive Paper, Henry Ofori Duah, Samantha J. Boch, Sara Arter, Nichole Nidey, Joshua Lambert

College of Nursing Faculty Research and Publications

Big data refers to extremely large data generated at high volume, velocity, variety, and veracity. The nurse scientist is uniquely positioned to leverage big data to suggest novel hypotheses on patient care and the healthcare system. The purpose of this paper is to provide an introductory guide to understanding the use and capability of big data for nurse scientists. Herein, we discuss the practical, ethical, social, and educational implications of using big data in nursing research. Some practical challenges with the use of big data include data accessibility, data quality, missing data, variable data standards, fragmentation of health data, and …

Sex Workers’ Experiences Of Screening For Intimate Partner Violence, Jessica L. Zemlak, Kamila A. Alexander, Deborah Wilson, Randi B. Singer, Joni S. Williams, Susan G. Sherman

College of Nursing Faculty Research and Publications

Objective

To examine experiences of intimate partner violence (IPV) screening among women who sell sex.

Design

A qualitative descriptive study.

Setting

Telephone interviews during the COVID-19 pandemic (June 2020 to October 2020).

Participants

Women aged 18 to 49 years who sold or traded sex for food, drugs, money, or shelter at least three times during the past 3 months before recruitment (N = 22).

Methods

We used individual, semistructured telephone interviews to collect data about participants’ experiences with IPV and IPV screening during health care encounters. We used reflexive thematic analysis to examine these data.

Results

We identified two …

Efect Of Conventional Cigarette Smoking And Recent Heated Tobacco Products On Cad/ Cam Restorative Materials, Fatma Makkeyah, Omar Elsergany, Mohamed Shamel, Mahmoud Al Ankily

Dentistry

No abstract provided.

Trans-Ancestral Genetic Risk Factors For Treatment-Related Type 2 Diabetes Mellitus In Survivors Of Childhood Cancer, Cindy Im, Achal Neupane, Jessica L Baedke, Brian Lenny, Angela Delaney, Stephanie B Dixon, Eric J Chow, Sogol Mostoufi-Moab, Tianzhong Yang, Melissa A Richard, M Monica Gramatges, Philip J Lupo, Noha Sharafeldin, Smita Bhatia, Gregory T Armstrong, Melissa M Hudson, Kirsten K Ness, Leslie L Robison, Yutaka Yasui, Carmen L Wilson, Yadav Sapkota

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Type 2 diabetes mellitus (T2D) is a prevalent long-term complication of treatment in survivors of childhood cancer, with marked racial/ethnic differences in burden. In this study, we investigated trans-ancestral genetic risks for treatment-related T2D.

Patients and methods: Leveraging whole-genome sequencing data from the St Jude Lifetime Cohort (N = 3,676, 304 clinically ascertained cases), we conducted ancestry-specific genome-wide association studies among survivors of African and European genetic ancestry (AFR and EUR, respectively) followed by trans-ancestry meta-analysis. Trans-/within-ancestry replication including data from the Childhood Cancer Survivor Study (N = 5,965) was required for prioritization. Three external general population T2D polygenic …

Cost Effectiveness Analysis Of A Fixed Dose Combination Pill For Primary Prevention Of Cardiovascular Disease From An Individual Participant Data Meta-Analysis, Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, Mark D Huffman, Gholamreza Roshandel, Reza Malekzadeh, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, Alvaro Avezum, Antonio L Dans, Habib Gamra, Salim Yusuf

2020-Current year OA Pubs

BACKGROUND: Cardiovascular disease (CVD) continues to impart a large burden on the global population, especially in lower income countries where affordability limits the use of cardiovascular medicines. A fixed dose combination strategy of at least 2 blood pressure lowering medications and a statin with aspirin in a single pill has been shown to reduce the risk of incident CVD by 38% in primary prevention in a recent meta-analysis. We report the in-trial (median follow-up: 5 years) cost-effectiveness of a fixed dose combination (FDC) pill in different income groups based on data from that meta-analysis.

METHODS: Countries were categorized using World …

Tumor-Informed Deep Sequencing Of Ctdna Detects Minimal Residual Disease And Predicts Relapse In Osteosarcoma, Yiwei Fu, Albert H Kim, Dimitrios Mathios, Et Al.

2020-Current year OA Pubs

BACKGROUND: Current surveillance modalities of osteosarcoma relapse exhibit limited sensitivity and specificity. Although circulating tumor DNA (ctDNA) has been established as a biomarker of minimal residual disease (MRD) in many solid tumors, a sensitive ctDNA detection technique has not been thoroughly explored for longitudinal MRD detection in osteosarcoma.

METHODS: From August 2019 to June 2023, 59 patients diagnosed with osteosarcoma at the First Affiliated Hospital of Sun Yat-sen University were evaluated in this study. Tumor-informed MRD panels were developed through whole exome sequencing (WES) of tumor tissues. Longitudinal blood samples were collected during treatment and subjected to multiplex PCR-based next-generation …

Open-Label, Dose-Escalation Fight-101 Study Of Pemigatinib Combined With Targeted Therapy, Chemotherapy, Or Immunotherapy In Patients With Advanced Malignancies, M Saleh, M Barve, V Subbiah, K P Papadopoulos, D Morgensztern, N B Mettu, S Roychowdhury, I Spanggaard, M L Veronese, C Tian, I M Silverman, M Gutierrez

2020-Current year OA Pubs

BACKGROUND: Pemigatinib is an oral, potent, selective fibroblast growth factor receptor (FGFR) 1-3 inhibitor. FIGHT-101, a three-part, open-label, first-in-human, phase I/II study (NCT02393248), evaluated pemigatinib in patients with advanced solid tumors. In parts 1 and 2, pemigatinib monotherapy had a manageable safety profile and antitumor activity in FGFR-altered tumors. Part 3 (pemigatinib combination therapies) results are presented here.

PATIENTS AND METHODS: Patients received 9, 13.5, or 20 mg oral once-daily pemigatinib on continuous or intermittent schedules with gemcitabine and cisplatin (pemi/gem/cis), docetaxel (pemi/doc), trastuzumab (pemi/tras), pembrolizumab (pemi/pembro), or retifanlimab (pemi/reti) irrespective of whether the tumor was confirmed as FGFR altered. …

Clinician-Perceived Barriers To Cervical Cancer Screening Before And During The Covid-19 Pandemic At Three Us Healthcare Systems, Veronica M Boratyn, Gaia Pocobelli, Steven J Atlas, Cheryl R Clark, Sarah Feldman, Gina Kruse, Anne Marie Mccarthy, Meghan Rieu-Werden, Michelle I Silver, Noel O Santini, Jasmin A Tiro, Jennifer S Haas

2020-Current year OA Pubs

INTRODUCTION: The COVID-19 pandemic posed serious challenges to cancer screening delivery, including cervical cancer. While the impact of the pandemic on deferred screening has been documented, less is known about how clinicians experienced barriers to screening delivery, and, in particular, the role of pre-pandemic barriers to changes reported during the pandemic.

METHODS: Survey of clinicians who performed ≥ 10 cervical cancer screening tests in 2019 from Mass General Brigham, Kaiser Permanente Washington, and Parkland Health, the healthcare systems participating in the Population-based Research to Optimize the Screening Process (PROSPR II) consortium (administered 10/2020-12/2020, response rate 53.7 %).

RESULTS: Prior to …