Medicine and Health Sciences Commons^™

Prenylated Stilbenoids As Paclitaxel Adjuvants In Triple-Negative Breast Cancer Treatment, Sepideh Mohammadhosseinpour

Student Theses and Dissertations

Triple-negative breast cancer (TNBC), the most fatal breast cancer subtype, lacks three main receptors (the human epidermal growth factor 2 receptor (ERBB2, formerly HER2), estrogen (ER) and progesterone (PR) receptors) and represents about 15% of all breast tumors. The most common treatment for TNBC is chemotherapy, being paclitaxel one of the most prescribed drugs. One of the main issues of paclitaxel is its high level of toxicity to non-cancerous cells and the development of paclitaxel resistance in the TNBC cells. Adjuvant therapy has been proposed as an alternative approach to increase the efficacy of a drug or circumvent drug resistance. …

Metastatic Papillary Thyroid Carcinoma Gone Wild, Khulood Talpur, Ambreen Soomro, Afrah Talpur

Abington Jefferson Health Papers

Thyroid cancers account for only 1.5% of all cancers in adults and 3% of all cancers in children. In females, however, thyroid cancers are the fifth most common cancer, comprising 4% of all cases. Of all thyroid cancers, 74-80% of cases are papillary cancer. The prevalence of thyroid cancer is rising worldwide. Although thyroid cancer has a favorable prognosis, up to 20% of patients experienced recurrent disease during the follow-up period. Extra-thyroidal extension occurs in 8% to 32% of cases. Local or regional recurrences occur in 5-15% of patients with papillary thyroid carcinoma (PTC). Distant metastasis occurs in only 1% …

Analyzing The Effects Of Body Mass Index In Total Hip Arthroplasty Cases. Does It Influence Patient Characteristics, Operative Planning, And Postoperative Outcomes?, Cesar A. Sevilla Jr, Vanessa Elena Lopez, Mauricio Burbano, Michael Sander

MEDI 9331 Scholarly Activities Clinical Years

Background: Total hip arthroplasty (THA) is one of the most performed orthopaedic procedures commonly used for the treatment of osteoarthritis (OA). There are several underlying factors that lead to the formation of this condition. Not only is obesity one of the main contributors, but it is also a modifiable risk factor and one of the leading causes of end-stage arthrosis of the hip. Though there have been advancements in agricultural and health technologies, rates of obesity continue to rise causing similar increases in the demands for hip replacement surgeries. Therefore, we sought to investigate the effects of BMI on …

Camkii: A Link Between Metabolic Disorders And Cardiac Arrhythmias, Marilen Federico, C.A. Valverde, L.A. Gonano, J. Palomeque, A. Matiazzi

Center for Translational Medicine Faculty Papers

The prevalence of metabolic diseases -such as obesity, prediabetes, metabolic syndrome or diabetes-has increased globally over the years. These diseases, mainly diabetes mellitus (DM), are among the leading causes of mortality and morbidity worldwide, with increased risk of diabetic cardiomyopathy (DC), cardiac arrhythmias, and heart failure (HF). In metabolic diseases several steps and proteins involved in excitation-contraction coupling (ECC) are compromised, precluding an efficient and rhythmic cardiac contraction; moreover, calcium/calmodulin-dependent protein kinase II (CaMKII) a kinase involved in ECC, is upregulated in several metabolic maladies and significantly contributes to cardiac remodeling and arrhythmias, among which are calcium (Ca2+)-triggered arrhythmias. CaMKII …

Intrinsic Disorder In Prame And Its Role In Uveal Melanoma, Michael Antonietti, David J. Taylor Gonzalez, Mak Djulbegovic, Guy W. Dayhoff, Vladimir N. Uversky, Carol L. Shields, Carol L. Karp

Wills Eye Hospital Papers

Introduction

The PReferentially expressed Antigen in MElanoma (PRAME) protein has been shown to be an independent biomarker for increased risk of metastasis in Class 1 uveal melanomas (UM). Intrinsically disordered proteins and regions of proteins (IDPs/IDPRs) are proteins that do not have a well-defined three-dimensional structure and have been linked to neoplastic development. Our study aimed to evaluate the presence of intrinsic disorder in PRAME and the role these structureless regions have in PRAME( +) Class 1 UM.

Methods

A bioinformatics study to characterize PRAME’s propensity for the intrinsic disorder. We first used the AlphaFold tool to qualitatively assess the …

Novel Diagnostic And Therapeutic Approaches To Temporomandibular Dysfunction: A Narrative Review, Brendan Moxley, William Stevens, Joel Sneed, Craig Pearl

Faculty, Staff and Student Publications

Temporomandibular dysfunction (TMD) is a burgeoning area of study within the dental field. TMD is caused by abnormalities in the temporomandibular joint or muscles of mastication and can lead to pain, loss of function, and other complications. As this area of patient care receives increased focus, the ability to accurately diagnose TMD becomes paramount. The aim of this review is to summarize novel diagnostic and therapeutic techniques that have been proposed within the last approximately 3 years in order to inform readers of the cutting-edge advances in the field of TMD diagnosis and management, while also analyzing the clinical relevance …

David Remmert Touts The Importance Of Educating The Next Wave Of Health Care Workers, Eric Stock

Interviews for WGLT

With his past experience working for public health departments, Assistant Professor of Public Health David Remmert touts the importance of educating the next wave of health care workers through the new public health program in IWU's School of Nursing and Health Sciences.

Smad8 Is Increased In Duchenne Muscular Dystrophy And Suppresses Mir-1, Mir-133a, And Mir-133b, Meghan L Royle, Eric J Connolly, Sara Nowakowski, Jeff R Temple

Faculty, Staff and Student Publications

OBJECTIVES: Studies are beginning to document an association between sleep duration and a range of adolescent delinquent behaviors, including weapon carrying. However, little is known about whether and to what extent sleep quality - another dimension of sleep for healthy adolescent functioning - is associated with weapon carrying. We address this gap in knowledge by evaluating the role of restless sleep and sleep duration in adolescent weapon carrying.

METHODS: We analyze data from a diverse sample of 994 adolescents from Texas, USA collected in 2010. Multivariate logistic regression models estimate the association of sleep duration and restless sleep on weapon …

Structures Of The Insecticidal Toxin Complex Subunit Xpta2 Highlight Roles For Flexible Domains, Cole L Martin, David W Chester, Christopher D Radka, Lurong Pan, Zhengrong Yang, Rachel C Hart, Elad M Binshtein, Zhao Wang, Lisa Nagy, Lawrence J Delucas, Stephen G Aller

Faculty, Staff and Students Publications

The Toxin Complex (Tc) superfamily consists of toxin translocases that contribute to the targeting, delivery, and cytotoxicity of certain pathogenic Gram-negative bacteria. Membrane receptor targeting is driven by the A-subunit (TcA), which comprises IgG-like receptor binding domains (RBDs) at the surface. To better understand XptA2, an insect specific TcA secreted by the symbiont

Ant-Dependent Mptp Underlies Necrotic Myofiber Death In Muscular Dystrophy, Michael J Bround, Julian R Havens, Allen J York, Michelle A Sargent, Jason Karch, Jeffery D Molkentin

Faculty, Staff and Students Publications

Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-reperfusion injury in the heart and several degenerative diseases, including muscular dystrophy (MD). MD is a family of genetic disorders characterized by progressive muscle necrosis and premature death. It has been proposed that the MPTP has two molecular components, the adenine nucleotide translocase (ANT) family of proteins and an unknown component that requires the chaperone cyclophilin D (CypD) to activate. This model was examined in vivo by deleting the gene encoding ANT1 (Slc25a4) or CypD (Ppif) in a δ-sarcoglycan (Sgcd) gene–deleted mouse model of MD, revealing …

Microglial Rev-Erbα Regulates Inflammation And Lipid Droplet Formation To Drive Tauopathy In Male Mice, Jiyeon Lee, Julie M Dimitry, Jong Hee Song, Minsoo Son, Patrick W Sheehan, Melvin W King, G Travis Tabor, Young Ah Goo, Mitchell A Lazar, Leonard Petrucelli, Erik S Musiek

2020-Current year OA Pubs

Alzheimer's disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. REV-ERBα is a core circadian clock protein which also serves as a nuclear receptor and transcriptional repressor involved in lipid metabolism and macrophage function. Global REV-ERBα deletion has been shown to promote microglial activation and mitigate amyloid plaque formation. However, the cell-autonomous effects of microglial REV-ERBα in healthy brain and in tauopathy are unexplored. Here, we show that microglial REV-ERBα deletion enhances inflammatory signaling, disrupts lipid metabolism, and causes lipid droplet (LD) accumulation specifically in male …

Genetic Modifiers Of Mendelian Monogenic Collagen Iv Nephropathies In Humans And Mice, Constantinos Deltas, Gregory Papagregoriou, Stavroula F Louka, Apostolos Malatras, Frances Flinter, Daniel P Gale, Susie Gear, Oliver Gross, Julia Hoefele, Rachel Lennon, Jeffrey H Miner, Alessandra Renieri, Judy Savige, A Neil Turner

2020-Current year OA Pubs

Familial hematuria is a clinical sign of a genetically heterogeneous group of conditions, accompanied by broad inter- and intrafamilial variable expressivity. The most frequent condition is caused by pathogenic (or likely pathogenic) variants in the collagen-IV genes,

Rapid Direct Detection Of Sars-Cov-2 Aerosols In Exhaled Breath At The Point Of Care, Dishit P Ghumra, Nishit Shetty, Kevin R Mcbrearty, Joseph V Puthussery, Benjamin J Sumlin, Woodrow D Gardiner, Brookelyn M Doherty, Jordan P Magrecki, Jane A O'Halloran, Rachel M Presti, Traci L Bricker, Adrianus C M Boon, Carla M Yuede, John R Cirrito, Rajan K Chakrabarty, Et Al.

2020-Current year OA Pubs

Airborne transmission via virus-laden aerosols is a dominant route for the transmission of respiratory diseases, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Direct, non-invasive screening of respiratory virus aerosols in patients has been a long-standing technical challenge. Here, we introduce a point-of-care testing platform that directly detects SARS-CoV-2 aerosols in as little as two exhaled breaths of patients and provides results in under 60 s. It integrates a hand-held breath aerosol collector and a llama-derived, SARS-CoV-2 spike-protein specific nanobody bound to an ultrasensitive micro-immunoelectrode biosensor, which detects the oxidation of tyrosine amino acids present in SARS-CoV-2 viral particles. Laboratory …

Sustainable Development For Mobile Health Apps Using The Human-Centered Design Process, Qingfan An, Marjorie M Kelley, Audra Hanners, Po-Yin Yen

2020-Current year OA Pubs

Well-documented scientific evidence indicates that mobile health (mHealth) apps can improve the quality of life, relieve symptoms, and restore health for patients. In addition to improving patients' health outcomes, mHealth apps reduce health care use and the cost burdens associated with disease management. Currently, patients and health care providers have a wide variety of choices among commercially available mHealth apps. However, due to the high resource costs and low user adoption of mHealth apps, the cost-benefit relationship remains controversial. When compared to traditional expert-driven approaches, applying human-centered design (HCD) may result in more useable, acceptable, and effective mHealth apps. In …

(2018) Shaping Trauma-Responsive Schools With Relational-Cultural Theory, Sarah C. Demarais

Louisiana Journal of Counseling

Traumatized students often struggle to meet the academic and behavioral expectations of schools. Interpersonal trauma in particular can damage children’s capacities for healthy social relationships and participation in community. In this article, I explore some of the detrimental effects of interpersonal trauma on students. I then offer relational-cultural theory as a lens for conceptualizing how interpersonal trauma affects children’s relational skills and for promoting mutually empathetic relationships that foster healing. Finally, I recommend strategies for school counselors to cultivate trauma-responsive school environments by working directly with traumatized students, advocating for safe and inclusive school cultures, and training educators in skills …

(2018) Test Questions For Licensed Professional Counselors, Test Questions

Louisiana Journal of Counseling

No abstract provided.

(2018) An Exploratory Study Of Advanced Technology In Supervision: Results From A Counselor Education Program, June Williams, Josette David, Aliah Esmaeili

Louisiana Journal of Counseling

As the profession of counseling continues to develop in a technological world, the need for quality supervision and training is crucial (Aasheim, 2012). The Council for Accreditation of Counseling and Other Educational Programs (CACREP) (2016) recognizes the benefits of technology, and requires graduate programs to demonstrate evidence of the integration of technology throughout the curriculum. The authors aimed to explore if counselor educators could utilize advanced technology tools to enhance teaching and learning in counselor education and supervision. The findings from this exploratory study and grant experience suggest that the incorporation of a play analyzer software can greatly enhance the …

(2018) Editorial, Meredith Nelson, Timothy P. Winter

Louisiana Journal of Counseling

How a Counseling Degree has Helped Me

(2018) Practicing What We Preach: Faculty Level Factors Impact On Service Learning, John A. Dewell, Yu-Yun Liu

Louisiana Journal of Counseling

Service learning has theoretical and empirical support as a pedagogy that can address the need to infuse social justice advocacy into the counselor education curriculum. Unfortunately, it is not widely utilized and there is a dearth of data shedding light on why this is. This study sought to address this by investigating how faculty level factors impact the use of service learning. The data indicates that faculty perception of the importance of professional roles, perceived teaching efficacy, and epistemic beliefs significantly predict the use of service learning. The data further indicates that faculty level factors predict attitudes towards service learning. …

(2018) Entire Issue, Meredith Nelson, Peter Emerson

Louisiana Journal of Counseling

No abstract provided.

(2019) Test Questions For Licensed Professional Counselors, Test Questions

Louisiana Journal of Counseling

No abstract provided.

(2019) The Relationship Between Hegemonic Masculinity And Multicultural Competence In Male Counselors, Erik Braun, Madeline Clark, George Armitage

Louisiana Journal of Counseling

The purpose of this study was to explore hegemonic masculinity, an expression of the male identity whereby value is placed on attitudes and behaviors which may be destructive, and Multicultural Competence (MCC) in male counselors. Data were collected using the Multicultural Counseling Knowledge and Awareness Scale (MCKAS; Ponterotto, et al., 2002) and the Male Norm Roles Inventory (MRNI-SF; Levant, Hall, & Rankin, 2013). Hierarchical Linear Regression (HLR) and correlational analyses were used. Results support that hegemonic masculine attitudes are negatively related to MCC, and sexual identity is related to hegemonic masculine attitudes and MCC.

(2019) A Silent Epidemic: Prevalence Of Suicide Among Asian American Adolescents, Kacie Blalock, Ashton Nance, Anna-Katrina Keco, Britney Cubley

Louisiana Journal of Counseling

The suicide rate among Asian American adolescents has sharply increased in recent years. This article examines the factors which influence suicidal ideation, predictors of suicide, and treatment approaches for Asian American adolescents. It is imperative that mental health professionals understand the risk factors which may predict suicidal ideation. Predictors of suicide for Asian American adolescents include mental health issues, family dynamics, and academic and societal expectations and perceived pressures. Asian American adolescents report higher levels of depression and anxiety than their European American counterparts. The risk of suicide is likely to decrease when Asian American adolescents have supportive families. In …

(2019) Flipped Classroom Methodology Applied To Counselor Development, Ariel E. Mitchell

Louisiana Journal of Counseling

Incorporating the flipped classroom model has been suggested from scholars in various fields of study. More recently, this model has been linked to suggested advantages within counseling (Moran & Milsom, 2015). An overview of the implemented flipped classroom model along with the educational and personal benefits are presented.

(2019) From The Editors, Meredith Nelson, Peter Emerson

Louisiana Journal of Counseling

A Call for Quality Research

(2019) The Corrective Feedback Microlab: An Experiential Group Exercise To Facilitate The Giving And Receiving Of Corrective Feedback, Christian J. Dean

Louisiana Journal of Counseling

Counseling students and trainees often participate in different group activities where feedback exchange occurs. Barriers to receiving corrective feedback, in particular, may make such exchanges difficult. The purpose of this article is to explore the use of the Corrective Feedback Microlab as a group pretraining exercise to help increase the healthy exchange of corrective feedback.

(2019) Entire Issue, Meredith Nelson, Peter Emerson

Louisiana Journal of Counseling

No abstract provided.

Leiomyosarcoma Of The Inferior Vena Cava Extending To The Right Atrium And Ventricle, Naif Saad Alghasab, Mohammad Alruwayeh, Abdulaziz A. Algharras, Amin Mulji

Journal of the Saudi Heart Association

Primary tumors originating from the inferior vena cava (IVC), namely leiomyosarcoma, present significant challenges due to their poor prognostic features, including extensive extension and a substantial tumor burden. In this case, we present a 55-year-old female patient complaining of abdominal discomfort and vague abdominal pain. Additionally, we provide a comprehensive summary encompassing key aspects related to symptomatology, diagnostic approaches, treatment, and prognostic indicators. We also discuss the complexities involved in managing primary tumors of the inferior vena cava, emphasizing the critical significance of adopting a multidisciplinary team-based approach.

Medical School Watercooler Newsletter - August 24, 2023, Lindsey Lyle

Watercooler Newsletter

This is the August 24, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Basic medical sciences student discusses ongoing tick research at national conference
• Meet a Med student: Jada Ashford
• Medical students receives awards for summer research

Machine Learning-Based Classification Of Chronic Traumatic Brain Injury Using Hybrid Diffusion Imaging, Jennifer Muller, Ruixuan Wang, Devon Middleton, Mahdi Alizadeh, Kichang Kang, Ryan Hryczyk, George Zabrecky, Chloe Hriso, Emily Navarreto, Nancy Wintering, Anthony J. Bazzan, Chengyuan Wu, Daniel A. Monti, Xun Jiao, Qianhong Wu, Andrew B. Newberg, Feroze Mohamed

Marcus Institute of Integrative Health Faculty Papers

BACKGROUND AND PURPOSE: Traumatic brain injury (TBI) can cause progressive neuropathology that leads to chronic impairments, creating a need for biomarkers to detect and monitor this condition to improve outcomes. This study aimed to analyze the ability of data-driven analysis of diffusion tensor imaging (DTI) and neurite orientation dispersion imaging (NODDI) to develop biomarkers to infer symptom severity and determine whether they outperform conventional T1-weighted imaging.

MATERIALS AND METHODS: A machine learning-based model was developed using a dataset of hybrid diffusion imaging of patients with chronic traumatic brain injury. We first extracted the useful features from the hybrid diffusion imaging …