Medicine and Health Sciences Commons^™

A Multicenter Evaluation Of Pediatric Emergency Department Injury Visits During The Covid-19 Pandemic, Holly R Hanson, Puja Desai, Lindsay D Clukies, Et Al.

2020-Current year OA Pubs

BACKGROUND: Injuries, the leading cause of death in children 1-17 years old, are often preventable. Injury patterns are impacted by changes in the child's environment, shifts in supervision, and caregiver stressors. The objective of this study was to evaluate the incidence and proportion of injuries, mechanisms, and severity seen in Pediatric Emergency Departments (PEDs) during the COVID-19 pandemic.

METHODS: This multicenter, cross-sectional study from January 2019 through December 2020 examined visits to 40 PEDs for children < 18 years old. Injury was defined by at least one International Classification of Disease-10th revision (ICD-10) code for bodily injury (S00-T78). The main study outcomes were total and proportion of PED injury-related visits compared to all visits in March through December 2020 and to the same months in 2019. Weekly injury visits as a percentage of total PED visits were calculated for all weeks between January 2019 and December 2020.

RESULTS: The study included 741,418 PED visits for injuries pre-COVID-19 pandemic (2019) and during the COVID-19 pandemic (2020). Overall PED visits from all causes …

Introduction: Conversations On Abortion Rights And Bodily Autonomy In The Eighteenth Century And Today, Vicki Barnett Woods, Manushag N. Powell

ABO: Interactive Journal for Women in the Arts, 1640–1830

This piece serves as an introduction to the discussions of bodily autonomy and reproductive rights, revised from roundtable presentations held at ASECS 2023. This collection of essays contributes to the resounding responses of frustration and anger toward the overturning of Roe v. Wade. The collection was written and presented by eighteenth-century scholars who have a comprehensive knowledge of the eighteenth-century legal, social, and medical histories that center around reproductive rights and bodily autonomy.

Identifying Locations Of Drug Overdose In Las Vegas To Implement The Cardiff Violence Prevention Model, John Girard, Shikha Pandey, Zack Bunn, Chris Papesh, Jacquelyn Cheun Phd, Ying Zhang

SMU Data Science Review

This paper will provide an innovative approach to drug overdose prevention programs. Using data from Las Vegas emergency departments, this paper will analyze geospatial trends of drug overdoses. Leveraging the Cardiff Violence Prevention Model, the information is shared with local law enforcement agencies and decision makers to empower them to make evidence-based strategies. This paper highlights the efficacy of a data-driven model in addressing public health issues and underscoring its ability for even broader implementation in urban settings. Findings will suggest significant implications for policymaking, crime prevention, and public health initiatives, demonstrating a step towards a safer Las Vegas.

The Overture! Then Is Here-And-Now: Hindsight Is Twenty, Twenty?, Elena Kydd

Music Therapy Theses

My existence and presence as a Black woman and graduate scholar in music therapy have allowed me to share my experience of racial trauma and oppression in the hallways of GCSU’s music therapy program. Autoethnography is the method I use to write my thesis on the relationships between Blackness, pedagogy, and music therapy. Thus, I perform an evocative autoethnographic study that allows me to share my personal experience of racial trauma and oppression within the culture of music therapy and to critique the larger social structures of whiteness that disenfranchise and dominate me and other Black student music therapists (SMTs). …

Medical School Watercooler Newsletter - December 12, 2023, Lindsey Lyle

Watercooler Newsletter

This is the December 12, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Audia receives NIH grant to study antibiotic-resistant bacteria
• Reconstructive urologist joins USA Health and Whiddon COM
• Perkins awarded $16 million grant to help address national physician shortage
• Alumni, faculty participate in medical mission trip
• Doctoral students receive inaugural Godwin Emerging Scholars Endowed Awards
• USA Student-Run Free Clinic receives grant from CeraVe

The Role Of Niacinamide In Skin Cancer Risk Reduction, Britny Ruilova Tellez, Nicolas Fortes, Heather Rollins

Doctor of Medical Science (DMSc)

The contents of this article are the author’s original unpublished findings.

Background: Each year, approximately 6 million Americans are treated for skin cancer, resulting in a total annual medical expense of $8.9 billion 1. The two most common types of skin cancer are basal cell carcinoma (BCC) followed by squamous cell carcinoma (SCC)2. The metastatic potential of these cancers is minimal; however, their treatment may involve severe scarring and disfigurement2. In contrast, melanoma is an aggressive skin malignancy that grows rapidly and can metastasize in a quick manner2. Risk factors of these skin cancers include UV exposure, fair skin complexions, …

2023 December 12 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Beyond The Basics: Unraveling The Complexity Of Coronary Artery Calcification, Satwat Hashmi, Pashmina Wiqar Shah, Zouhair Aherrahrou, Elena Aikawa, Rédouane Aherrahrou

Department of Biological & Biomedical Sciences

Coronary artery calcification (CAC) is mainly associated with coronary atherosclerosis, which is an indicator of coronary artery disease (CAD). CAC refers to the accumulation of calcium phosphate deposits, classified as micro- or macrocalcifications, that lead to the hardening and narrowing of the coronary arteries. CAC is a strong predictor of future cardiovascular events, such as myocardial infarction and sudden death. Our narrative review focuses on the pathophysiology of CAC, exploring its link to plaque vulnerability, genetic factors, and how race and sex can affect the condition. We also examined the connection between the gut microbiome and CAC, and the impact …

How Does Information Overload Through News Consumption Impact Users’ Mental State?, Agaretha Kosasih

D.U.Quark

With the rise of technology and its accessibility, people have an increased ability to access information, which consequently escalates the chances to be more prone to information overload. However, despite the frequent use of technology and the internet, there is still a lack of awareness about the effects of information overload. One issue that arises in discussing information overload is the abundant research that confirms the negative impacts compared to those that provide positive solutions for the issue. This review discusses the way information overload impacts our mental health through our cognitive processes, influencing our mental state, and examines our …

Analisis Hubungan Tingkat Pencahayaan, Reflektansi, Dan Kekontrasan Area Kerja Terhadap Keluhan Eye Strain Pada Karyawan Office Di Pt. X Tahun 2023, Afni Fadhila, Mila Tejamaya

National Journal of Occupational Health and Safety

Eye strain is a condition where the eyes are strained due to prolonged overuse, especially in computer-based activities. NIOSH states that about 75 - 90% of computer users who spend three hours or more complaining of visual impairment. A study by Kowalska et al (2011) on office workers who use computers intensely stated that the prevalence of eye strain in female workers was 50,7% and in men was 32,6%. This study aims to determine the relationship between illuminance, reflectance, and work area contrast on eye strain complaints in office employees at PT. X. This research was conducted from April - …

Self-Care Practices For Common Acute Conditions In The Philippines: A Scoping Review, Arianna Maever Loreche, Veincent Christian F. Pepito, Manuel M. Dayrit

Ateneo School of Medicine and Public Health Publications

Purpose

This review aimed to identify and map published studies on self-care practices to manage common acute health conditions in the Philippines.

Design/methodology/approach

The authors conducted a scoping review in PubMed, Scopus, Cumulative Index of Nursing and Allied Health Literature (CINAHL), ProQuest Central, Journal Storage (JSTOR) and the Philippine Council for Health Research and Development – Health Research and Development Information Network (HERDIN). The authors included all studies on self-care practices to manage common acute conditions, namely low back pain, allergic rhinitis, general acute pain, cough, cold, diarrhea, constipation and stress, published up to 2021 in the Philippines. Information on …

Illuminating Type Iv Secretion-Mediated Dna Trafficking Through Long Filaments, Peter J Christie

Faculty, Staff and Student Publications

No abstract provided.

Bridging The Gap: Reducing Disparities In Reproductive Healthcare For Black And White Women, Emma Weiden

Population Health Research Brief Series

A woman’s reproductive healthcare experience in the United States can vary dramatically depending on her race. In 2020, the pregnancy-related mortality rate in the U.S. was 40.8 deaths per 100,000 live births for Black women, which is more than three times the rate among White women (12.7 per 100,000). This brief summarizes disparities in reproductive healthcare outcomes for Black women compared to White women in the U.S., advocates for policy changes, and provides recommendations for addressing racial disparities to create more equitable reproductive healthcare.

Oral Small Molecule Agents In Management Of Ulcerative Colitis: Fact Or Fancy, Benan Kasapoğlu, Ati̇lla Ertan

Turkish Journal of Medical Sciences

Ulcerative colitis is a chronic, immune-mediated disease characterized by recurring episodes of mucosal inflammation in the colon and rectum. The primary pathogenic mechanism of ulcerative colitis is the dysregulation of the mucosal immune response. The disease follows a relapsing-remitting course, and the goal of management is to successfully induce and then maintain remission. Effectively managing this chronic disease requires addressing all aspects of it. Currently, we have various antitumor necrosis factor agents and novel biologics available for treating ulcerative colitis patients with moderate-to-severe disease. However, none of the existing treatments are considered entirely satisfactory or ideal in these cases. After …

Musculoskeletal Ultrasonography In Rheumatic Diseases, Erhan Çapkin

Turkish Journal of Medical Sciences

Ultrasonography is an imaging technique based on sound waves used for the evaluation of soft tissues. Sound waves have been used for a long time in nonmedical fields, including military defense systems, radar systems, and detection of icebergs. Technological advances resulted in new techniques becoming available for medical imaging, including ultrasonography, magnetic resonance imaging, and computed tomography. Nowadays, the use of imaging has become a gold standard protocol in the diagnosis of many diseases, and recently developed diagnosis and therapy options provide more efficient treatment of rheumatic diseases. Thus, it has become possible to prevent structural damage and disability in …

Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç

Turkish Journal of Medical Sciences

Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are …

Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler

Turkish Journal of Medical Sciences

Background/aim: Type 1 diabetes mellitus (T1DM) is caused by the autoimmune-mediated destruction of insulin-producing cells (IPCs) and still has no effective cure. Better understanding of the molecular mechanisms involved in the differentiation of embryonic stem cells (ESCs) into IPCs may help us improve the therapeutic strategies for treating T1DM. 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatases (Pfkfb1-4) are key regulators of glucose metabolism. Although Pfkfb3 has been shown to be required for the growth of early differentiated mouse ESCs (mESCs), more studies are needed to further assess the roles of Pfkfb isoenzymes in embryonic development and differentiation, particularly into specific cell types. In this study, …

Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal

Turkish Journal of Medical Sciences

Background/aim: Due to the increasing mortality and morbidity rates in diabetes mellitus (DM), which is one of the biggest health problems of our age, many treatment modalities are still being tried. The positive effects of metformin (MET) and physical exercise (EXE) on the pathophysiology of diabetes are well known. In this study, it was aimed to detail these positive effects of MET and EXE in combination on the basis of inflammation, apoptosis mechanisms, and endogen nesfatin-1 (NES-1) synthesis. Materials and methods: Twenty-seven type 2 DM (DM-2) male Wistar Albino rats were divided into 4 groups, as the high-fat diet (HFD), …

[6]-Shogaol And [6]-Gingerol Active Ingredients May Improve Neuropathic Pain By Suppressing Cytokine Levels In An Experimental Model, Fi̇kri̇ Özdemi̇r, Güven Akçay, Sevi̇l Özkinali, Çağla Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: Neuropathic pain (NP) is a type of chronic pain usually caused by damage to the somatosensory system. Bioactive antioxidant compounds, such as curcumin and ginger, are widely preferred in the treatment of NP. However, the ingredient-based mechanism that underlies their pain-relieving activity remains unknown. The aim of this study was to investigate the therapeutic effects of trans-[6]-Shogaol and [6]-Gingerol active ingredients of the Zingiber officinale Roscoe extract on the spinal cord and cortex in the neuroinflammatory pathway in rats with experimental sciatic nerve injury. Materials and methods: Forty-six volatile phenolic components were identified in ginger samples using gas chromatography-mass …

Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru

Turkish Journal of Medical Sciences

Background/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO4) used separately and together on feto-maternal outcomes. Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy. Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, …

Ss-D-Glucan Promotes Nf-Κb Activation And Ameliorates High-Let Carbon-Ion Irradiation-Induced Human Umbilical Vein Endothelial Cell Injury, Fang Liu, Yanting Wei, Zhuanzi Wang

Turkish Journal of Medical Sciences

Background/aim: Heavy-ion irradiation seriously perturbs cellular homeostasis and thus damages cells. Vascular endothelial cells (ECs) play an important role in the pathological process of radiation damage. Protecting ECs from heavy-ion radiation is of great significance in the radioprotection of normal tissues. In this study, the radioprotective effect of ß-D-glucan (BG) derived from Saccharomyces cerevisiae on human umbilical vein endothelial cell (EA.hy926) cytotoxicity produced by carbon-ion irradiation was examined and the probable mechanism was established. Materials and methods: EA.hy926 cells were divided into seven groups: a control group; 1, 2, or 4 Gy radiation; and 10 µg/mL BG pretreatment for 24 …

Smpdl3b Contributes To Gastric Adenocarcinoma Cells Progression By Promoting The Infiltration Of M2 Macrophages, Li Su, Jian Hao, Na Zhang, Shan Wu, Xiuhua Wu, Wei Wei

Turkish Journal of Medical Sciences

Background/aim: The common disease gastric adenocarcinoma (GAC) has a high morbidity and mortality, so there is an urgent need for research to explore new diagnostic markers and therapeutic targets. This investigation was carried out to investigate the expression of sphingomyelin phosphodiesterase acid-like 3b (SMPDL3B) in GAC and its effects on tumor progression. Materials and methods: Samples were collected from patients who underwent radical gastrectomy from January 2021 to December 2022. Along with the normal gastric epithelial cell lines GES-1 and SGC-7901, the AGS, MGC-803, and MSN-45 human gastric cancer cell lines were used to confirm SMPDL3B expression. RT-qPCR, Western blot, …

Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu

Turkish Journal of Medical Sciences

Background/aim: Titanium dioxide nanoparticles are widely used in a variety of products, including sunscreens, paints, and ceramics. However, their increasing use has raised concerns about their potential health risks. Titanium dioxide nanoparticles have been shown to have the ability to enter the bloodstream and accumulate in various tissues, reaching the fetus via the placenta. The aim of this study was to investigate the cytotoxic effects of titanium dioxide nanoparticles on a human embryonic lung cell line (HEL 299/An1) and the formation of oxidative DNA damage. Materials and methods: The cytotoxic effects of brookite-based titanium dioxide nanoparticles (<100 nm) were assessed using the 3-(4,5-dimethyldiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay for 24 and 48 h. Cell titanium levels were determined using inductively coupled plasma mass spectrometry. Oxidative DNA damage was assessed by measuring the levels of 8-hydroxy-2- deoxyguanosine (8-OHdG) as a biomarker. Results: Titanium dioxide nanoparticles caused dose-dependent cytotoxicity in HEL 299/An1 cells. The IC50 values were 25.93 μM and 0.054 μM after 24 h and 48 h of exposure, respectively. Cell titanium levels were found to be 25,967 ppb after 24 h and 210,353 ppb after 48 h (p < 0.01). 8-OHdG was detected at 32.96 ng/mL after 24 h of exposure and 17.89 ng/mL after 48 h of exposure. Conclusion: In our study, it was shown that titanium nanoparticles caused dose-dependent cytotoxicity and oxidative DNA damage in human embryonic lung cells. The nanoparticles also accumulated in cells and were taken up in higher amounts after 48 h of exposure. These findings suggest that titanium dioxide nanoparticles may pose a health risk, especially for pregnant women who may not be aware of their pregnancy. Therefore, it is important to take preventive measures to reduce exposure to these nanoparticles.

Effect Of Humanine On The Notch Signaling Pathway In Myocardial Infarction, Eli̇f Onat, Ebru Önalan, Berna Özdem, Merve Kavak Balgeti̇r, Tuncay Kuloğlu

Turkish Journal of Medical Sciences

Background/aim: By applying humanin (HN) before myocardial infarction (MI), its protection in myocardial injury and the possible roles of its cellular mechanism in the Notch pathway were investigated. Materials and methods: The study was carried out at Fırat University Experimental Research Center (12/24/2018-12/23/2019). Spraque-Dawley rats were divided into 10 groups: I (control) (n = 6), II (HN 6 h) (n = 6), III (HN 24 h) (n = 6), IV (HN day 7) (n = 6), V (MI 6 h) (n = 7), VI (MI 24 h) (n = 7), VII (MI day 7) (n = 7), VIII (MI+HN 6 …

Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian

Turkish Journal of Medical Sciences

MDABackground/ aim: Atherosclerosis is significantly influenced by endothelial cell activation and dysfunction. Studies have demonstrated the substantial presence of fibronectin (Fn) within atherosclerotic plaques, promoting endothelial inflammation and activation. However, cellular Fn (cFn) secreted by various cell types, including endothelial cells and smooth muscle cells, and plasma Fn (pFn) produced by hepatocytes. They are distinct forms of Fn that differ in both structure and function. The specific contribution of different types of Fn in promoting endothelial cell activation and dysfunction remain uncertain. Therefore, this study aimed to investigate the respective roles of pFn and endothelial cell-derived Fn (FnEC) in promoting …

Csrp1 Expression Is Associated With A Mesenchymal, Stroma-Rich Tumor Profile And Poor Prognosis In Colon Cancer, Seçi̇l Demi̇rkol Canli

Turkish Journal of Medical Sciences

Background/aim: Cysteine and glycine-rich protein 1 (CSRP1) is involved in the cysteine-rich protein family and is a marker of smooth muscle lineages. In colon cancer, the expression of this gene is associated with poor prognosis. In this study, the aim was to reevaluate its prognostic relationship in independent cohorts and explore potential underlying biological processes that are linked to aggressive behavior in tumors with high CSRP1 expression, such as epithelial-to-mesenchymal transition (EMT), stromal fractions in the tumor microenvironment, and consensus molecular subtypes (CMSs). Materials and methods: RNA sequencing (RNAseq)-, microarray-, and single-cell RNAseq (scRNAseq)-based transcriptomic data were obtained from public …

The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca

Turkish Journal of Medical Sciences

Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …

Evaluation Of Sestrin 2 And Tribbles Homolog 3 Levels In Obese And Nonobese Women With Polycystic Ovary Syndrome, Ayşegül Çatal, Evri̇m Ebru Kovalak

Turkish Journal of Medical Sciences

Background/aim: This study was designed to evaluate the relationship of two new biomarkers [tribbles homolog 3 (TRB3) and sestrin 2 levels], which were previously associated with obesity, with metabolic parameters in obese and nonobese women with polycystic ovary syndrome (PCOS). Materials and methods: This cross-sectional case control study was conducted between September 2017 and August 2019 in the gynecology department of a tertiary referral hospital. The values of the plasma sestrin 2, TRB3, insulin, fasting plasma glucose, lipid profile, and homeostasis model assessment of insulin resistance (HOMA-IR) were compared in 90 obese women with PCOS (BMI > 30), 90 women with …

Efficacy Of Rituximab On Disease Activity, Severity, And Disease-Related Damage In Patients With Immunosuppressive-Resistant Systemic Sclerosis, Yasemi̇n Yalçinkaya, Bahar Artim Esen, Shirkhan Amikishiyev, Numune Aliyeva, Ahmet Gül, Mahdume Lale Öçal, Murat İnanç

Turkish Journal of Medical Sciences

Background/aim: B-cell depletion with rituximab (RTX) is widely used as a rescue therapy in patients with systemic sclerosis (SSc). The aim herein was to analyze the progress of disease-related outcomes after RTX therapy in severe SSc patients. Materials and methods: Included in this study were 27 SSc patients who were followed-up between 2012 and 2020 and received at least 1 cycle of RTX for active disease, despite receiving standard immunosuppressives (ISs). In addition to the European Scleroderma Study Group and European Scleroderma Trials and Research Group activity scores, Medsger's severity, and the recently developed Scleroderma Clinical Trials Consortium Damage Index …

Craniocervical Junction Involvement In Inflammatory Arthritis: A Single-Center Radiologic Study, Fatma Yalçinkaya, Şafak Parlak Sağol, Aynur Azizova, Emre Bi̇lgi̇n, Kader Karli Oğuz, Umut Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: Craniocervical junction (CCJ) can be involved in inflammatory arthritis. We aimed to define types of CCJ involvement in rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) and compare them with patients without inflammatory arthritides. Materials and methods: In this retrospective analysis, cervical CT or MRIs of patients with RA, SpA, or PsA, taken for any reason between 2010 and 2020, according to ICD-10 codes, were scanned. Demographic data of the patients were recorded. CCJ involvements (atlantoaxial, vertical, or subaxial subluxation, odontoid process involvement) were reevaluated by an experienced radiologist. The control group consisted of consecutive patients without inflammatory …