Medicine and Health Sciences Commons^™

Neuro-Palliative Medicine, Shazia Faiz

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Cyclic Alternating Pattern Of Encephalopathy (Cape) In Cns Infection: A Case Report, Zaid Waqar, Soban Khan, Maryam Khalil, Bushra Khalid, Zakir Jan, Muhammad Adil, Amina Saddiqa

Pakistan Journal of Neurological Sciences (PJNS)

Cyclic Alternating Pattern of Encephalopathy (CAPE) is rare EEG phenomenon first described in 1944 in a comatose patient. It is similar to sleep EEG pattern of cyclic alternating pattern (CAP) which is a periodic electroencephalogram activity of non-REM sleep. The cyclic alternating pattern (CAP) is defined by sequences of transient electrocortical events that are different from the tonic background and repeat at intervals of up to one minute. CAPE, however, is abnormal EEG pattern. In this pattern of EEG abnormality slow wave activity of 1-2Hz alternates with fast activity of 6-10 hertz. Here we present a case of patient with …

Anti-Caspr 2 Antibody Encephalitis: A Case Report, Maryam Khalil, Zaid Waqar, Hira Badar Abbasi, Amina Saddiqa, Bushra Khalid, Soban Khan

Pakistan Journal of Neurological Sciences (PJNS)

Encephalitis is a term denoted to Inflammation in the brain which can be due to infection, autoimmunity, or can be a part of a paraneoplastic phenomenon with malignancy. Anti-CASPR 2 antibody encephalitis is a rare form of encephalitis that can be associated with malignancy, paraneoplastic phenomenon or can be an autoimmune disease. We present a case of a young boy who presented with new onset seizures and altered sensorium and was diagnosed with anti-CASPR 2 antibody encephalitis. Anti-CASPR 2 Antibody Encephalitis is a rare form of encephalitis which due to its great diverse presentation should be kept in the differential …

Xanthine Oxidase Levels And Immune Dysregulation Are Independently Associated With Anemia In Plasmodium Falciparum Malaria, Marilyn Vasquez, Margaux Sica, Ruth Namazzi, Robert Opoka, Julian Sherman, Dibyadyuti Datta, Miquel Duran Frigola, John Ssenkusu, Chandy John, Andrea Conroy

Paediatrics and Child Health, East Africa

Severe anemia is an important contributor to mortality in children with severe malaria. Anemia in malaria is a multi-factorial complication, since dyserythropoiesis, hemolysis and phagocytic clearance of uninfected red blood cells (RBCs) can contribute to this syndrome. High levels of oxidative stress and immune dysregulation have been proposed to contribute to severe malarial anemia, facilitating the clearance of uninfected RBCs. In a cohort of 552 Ugandan children with severe malaria, we measured the levels of xanthine oxidase (XO), an oxidative enzyme that is elevated in the plasma of malaria patients. The levels of XO in children with severe anemia were …

Nursing News & Views - September 2023, Joanne Miller Rn

Nursing Newsletters

No abstract provided.

From The Lung To The Finger: An Unusual Presentation Of Adenosquamous Cell Carcinoma, Preeti Badve, Md, Sussy Obando Lara, Md, Elisenda Valdez Pena, Md, Myriah Magaris, Do, Zunaira Naeem, Md, Charalambos Solomides, Md, Avnish Bhatia

Department of Medical Oncology Posters

Learning Objective

To recognize unusual presentations of metastatic lung disease.

Equine In Vivo Metabolite Profiling Of The Selective Androgen Receptor Modulator Lgd-3303 For Doping Control, Malin Nilsson Broberg, Heather Knych, Ulf Bondesson, Curt Pettersson, Börje Tidstedt, Scott Stanley, Mario Thevis, Mikael Hedeland

UK CARES Faculty Publications

LGD-3303 is a Selective Androgen Receptor Modulator (SARM) that is prohibited in both equine and human sports due to its anabolic properties. The aim of this study was to investigate the equine in vivo metabolite profile of LGD-3303 and identify drug metabolites that can be suitable as new and improved analytical targets for equine doping control. This was performed by an oral administration of 0.05 mg⋅kg 1 LGD-3303 to horses, where blood and urine samples were collected up to 96 h after administration. The in vivo samples consisting of plasma, urine and hydrolyzed urine were analyzed utilizing ultra-high performance liquid …

Seeds Of Trust Ripe As Luscious Fruits: Faculty Mentorship Forum At Aga Khan University Medical College, Rehana Rehman, Rahila Ali, Saira Khalid, Tazeen Saeed Ali

Department of Biological & Biomedical Sciences

Background & objective: Faculty members require mentoring in all stages of their professional development. Aga Khan University (AKU) has initiated mentorship programs for students and faculty at AKU Medical College (AKU- MC) and AKU School of Nursing and Midwifery (AKU-SONAM). This study aimed to explore perceptions of mentors, mentees, administrators (chairs, co-chairs, founder members and coordinators of the mentoring program) and leadership and further investigate the strengths and challenges faced by 'Faculty Mentorship Program' at AKU- MC.
Methods: We conducted a qualitative exploratory study from February till December 2021 after approval from AKU using purposive criterion sampling. Mentors, mentees, administrators …

Dental Student Report: Rotations At A Federally Qualified Health Center In North Dakota, Jordan Jaeger, Shawnda Schroeder

Indigenous Health Faculty Publications

North Dakota has no dental school to encourage student enrollment. Recognizing the need to address dental workforce shortages, and barriers to recruiting new dental professionals to the state, the North Dakota Department of Health & Human Services Oral Health Program (OHP) and the North Dakota Area Health Education Center financially support dental rotations at one Federally Qualified Health Center (FQHC) in North Dakota: Spectra Health

Submental Intubation In Oral Maxillofacial Surgery: A Case Report And Review Of Indications And Complications, Ed W. Alvarado, Jennifer Inofomoh, Mark Lavering, Diego Aleman

MEDI 9331 Scholarly Activities Clinical Years

Background: Submental intubation has emerged as a crucial alternative airway management technique within the realm of oral maxillofacial surgery, addressing scenarios where conventional intraoral or nasal intubation proves infeasible or hazardous. The landscape of oral maxillofacial surgeries is characterized by intricate fractures, extensive soft tissue damage, and anatomical deviations that render traditional intubation methods untenable. This innovative technique involves the insertion of a modified oral endotracheal tube through a submental incision, subsequently threading it into the oropharynx. This procedure ensures secure airway access while safeguarding the integrity of oral and nasal passages. This modality reaps manifold benefits, spanning augmented …

Real-World Use Of Mold-Active Triazole Prophylaxis In The Prevention Of Invasive Fungal Diseases: Results From A Subgroup Analysis Of A Multicenter National Registry, M Hong Nguyen, Luis Ostrosky-Zeichner, Peter G Pappas, Thomas J Walsh, Joseph Bubalo, Barbara D Alexander, Marisa H Miceli, Jeanette Jiang, Yi Song, George R Thompson

Faculty, Staff and Student Publications

BACKGROUND: Antifungal prophylaxis can prevent invasive fungal diseases (IFDs) in high-risk, immunocompromised patients. This study assessed the real-world use of mold-active triazoles (MATs) for the prevention of IFDs.

METHODS: This subgroup analysis of a multicenter, observational, prospective registry in the United States from March 2017 to April 2020 included patients who received MATs for prophylaxis (isavuconazole, posaconazole, and voriconazole) at study index/enrollment. The primary objective was to describe patient characteristics and patterns of MAT use. Exploratory assessments included the frequency of breakthrough IFDs and MAT-related adverse drug reactions (ADRs).

RESULTS: A total of 1177 patients (256 isavuconazole, 397 posaconazole, 272 …

A Perspective On In Vitro Developmental Neurotoxicity Test Assay Results: An Expert Panel Review, D. R. Juberg, D. A. Fox, P. A. Forcelli, S. Kacew, J. C. Lipscomb, S. A. Saghir, Catherine M. Sherwin, C. M. Koenig, S. M. Hays, C. R. Kirman

Pediatrics Faculty Publications

For decades, there has been increasing concern about the potential developmental neurotoxicity (DNT) associated with chemicals. Regulatory agencies have historically utilized standardized in vivo testing to evaluate DNT. Owing to considerations including higher-throughput screening for DNT, reduction in animal use, and potential cost efficiencies, the development of alternative new approach methods (NAMs) occurred; specifically, the advent of the DNT in vitro test battery (DNT IVB). SciPinion convened an expert panel to address specific questions related to the interpretation of in vitro DNT test data. The consensus of the expert panel was that the DNT IVB might be used during initial …

Pulmonary & Critical Care Insider: Issue 2, Bharat Bajantri Md, Sarah Ellsworth Mls

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 2

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The goal of this newsletter is to give a brief summary of the most pertinent articles to everyday practice and an attempt to keep up with literature as best as possible. Newsletters go out every 1-2 months.

Summaries/Topics in this issue:

• Spontaneous Breathing Trials
• Enteral feedings
• EFFORT Protein trial
• The NUTRIREA-3 trial
• Veno-venous extracorporeal carbon dioxide removal (vv-ECCO2 R)
• Acute hypoxemic respiratory failure (AHRF)
• Penicillin allergy
• PEN-FAST score
• Etomidate increases mortality …

Adolescent Hope And Optimism: A Scoping Review Of Measures And Their Psychometric Properties, Esther Chongwo, Ezra Too, Adam Mabrouk, Amina Abubakar

Institute for Human Development, East Africa

There is much research examining adolescent hope and optimism, but there is limited information on the available measures, particularly the most frequently used measures and their psychometric properties. We conducted a scoping review to: (1) identify measures of hope and optimism for use among adolescents; (2) determine the most frequently used measures of adolescent hope and optimism; (3) document the psychometric properties of the identified measures. We searched five bibliographic databases and Open Grey for relevant articles published from database inception to 03 May 2023. The search included the key terms ‘adolescents’, ‘optimism’, ‘hope’ and ‘measures’. We targeted adolescents aged …

The Team Nursing Model: Decreasing Patient Safety Issues, Caitlin Alizieri Bsn, Rn, Kayla Shane Bsn, Rn, Tiffany Lopez And, Rn, Reina Cerrato-Jimenez Adn, Rn, Steph Setar Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Microlearning Impact On Arterial Line Set-Up And Management, Michaeleen Farley Rn, Adn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

From Crisis Management To Multi-Level Interinstitutional Partnerships: Development Of The Southeastern Conference Deans Nursing Coalition, Jeannette O. Andrews Phd, Rn, Faan, Victoria Niederhauser, Julie Sanford, Suzanne Prevost, Demetrius Porche, Janie Heath, Pamela Jeffries, Nancy Fahrenwald

Faculty Publications

The Southeastern Conference (SEC) Nursing Dean's Coalition is a purposeful alliance organized to collaboratively address several challenges that arose during the COVID-19 pandemic. Over the last three years, this strategic team of academic leaders has evolved from a crisis response team to a multidimensional support team, leveraging both individual and collective strengths, to provide several benefits to the dean members, as well as other SEC nursing faculty members, students, and institutions. Participation has grown from the original 12 deans to engage a broader team of associate deans and nurse leaders in faculty development, research, service, and diversity, equity, and inclusion. …

Intra-Operative Guidelines For The Prevention Of Uterine Niche Formation In Cesarean Sections: A Review, Sean Backer, Deepesh Khanna, Sonia Sadr, Ali Khatibi,

HPD Articles

Formation of a uterine niche following a C-section can predispose the patient to future obstetric complications such as dehiscence, uterine rupture, ectopic pregnancy, and placenta accreta. The significant morbidity and mortality of these complications along with increasing C-section rates emphasizes the importance of prevention. However, there are no clear guidelines on intra-operative protocol to prevent postpartum niche formation. Besides surgical technique, the novel use of platelet-rich plasma (PRP) and mesenchymal stem cell (MSC) injections has demonstrated promising potential and may have applications in hysterotomy closures. The objective is to examine current research on optimal C-section procedures to prevent uterine niche …

Poor Oral Health In Trauma Intensive Care Unit Patients: Application Of A Novel Oral Health Score, Kayli Quinton, Chelsea J Guy-Frank, Sophia Syed, James M Klugh, Naila H Dhanani, Shawn S Adibi, Lillian S Kao

Faculty, Staff and Student Publications

Background: Although oral hygiene in patients in the intensive care unit (ICU) has been shown to reduce hospital-associated infections, baseline and progressive oral health are often not reported because of lack of a standardized tool. The Oral Health Risk Assessment Value Index (OHRAVI) is a comprehensive oral assessment validated by dental providers. This study hypothesizes that non-dental providers can use OHRAVI in trauma ICU patients with minimal training and acceptable inter-rater reliability (IRR). 

Patients and Methods: Dentulous adult patients in the ICU at a level 1 trauma center were scored, excluding those with severe orofacial trauma. The eight categories of …

Renin As A Biomarker Of Acute Kidney Injury And Mortality In Children With Severe Malaria Or Sickle Cell Disease, Daniel Adan, Anthony Batte, Ruth Namazzi, Ivan Mufumba, Caroline Kazinga, Kagan Mellencamp, Caitlin Bond, Robert Opoka, Chandy John, Andrea Conroy

Paediatrics and Child Health, East Africa

Background: Globally, a very high percentage of acute kidney injury (AKI) occurs in low- and middle-income countries (LMICs) where late recognition contributes to increased mortality. There are challenges with using existing biomarkers of AKI in LMICs. Emerging evidence suggests renin may serve as a biomarker of kidney injury that can overcome limitations in creatinine-based diagnostics.

Methods: Two study populations in Uganda were assessed. Cohort #1 was a two-site, prospective cohort study enrolling 600 children with severe malaria (SM). Cohort #2 was a prospective cohort study enrolling 185 children with sickle cell disease (SCD) hospitalized with a vaso-occlusive crisis. Plasma or …

Outpatient Management Of Urinary Tract Infections By Medical Officers In Nairobi, Kenya: Lack Of Benefit From Audit And Feedback On Adherence To Treatment Guidelines, Florence Mbatia, James Orwa, Mary B. Adam, Gulnaz Mohamoud, Rodney Adam

Family Medicine, East Africa

Introduction: Acute uncomplicated urinary tract infections are common in outpatient settings but are not treated optimally. Few studies of the outpatient use of antibiotics for specifc diagnoses have been done in sub-Saharan Africa, so little is known about the prescribing patterns of medical ofcers in the region.

Methods: Aga Khan University has 16 outpatient clinics throughout the Nairobi metro area with a medical ofcer specifcally assigned to that clinic. A baseline assessment of evaluation and treatment of suspected UTI was performed from medical records in these clinics. Then the medical ofcer from each of the 16 clinics was recruited from …

Membrane Functionalization Approaches Toward Per- And Polyfluoroalkyl Substances And Selected Metal Ion Separations, Francisco Cecil Léniz-Pizarro, Holly E. Rudel, Nicolas J. Briot, Julie B. Zimmerman, Dibakar Bhattacharyya

UK CARES Faculty Publications

Adsorption and ion exchange technologies are two of the most widely used approaches to separate pollutants from water; however, their intrinsic diffusion limitations continue to be a challenge. Pore functionalized membranes are a promising technology that can help overcome these challenges, but the extents of their competitive benefits and broad applicability have not been systematically evaluated. Herein, three types of adsorptive/ion exchange (IX) polymers containing strong/weak acid, strong base, and iron-chitosan complex groups were synthesized in the pores and partially on the surface of microfiltration (MF) membranes and tested for the removal of organic and inorganic cations and anions from …

Wound Warriors, Victoria Gordon Bsph, Adn, Rn, Krystal Nelson Bsn, Rn, Angela Knight-Williams Adn, Rn, Taylor Rinaldi Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Early Mobilization In Open Heart Patients, Jon Platia Bsn, Rn, Morgan Kreider Bsn, Rn, Jie Min Lee Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Ur-Ine Trouble!, Vera Barros Bsn, Rn, Madison Bleiler Bsn, Rn, Joseph Gengarelly Bsn, Rn, Jackie Ni Bsn, Rn, Jessie Scott Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

The Impact Of Orthostatic Vital Signs On Patient Fall Risk, Rachael Christy Bsn, Rn, Mike Joseph Bsn, Rn, Emily Lunny Bsn, Rn, Samantha Razzi Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Re-Education For Rns On Clabsi Prevention And The Use Of Chg Wipes, Everlyn Sauzo Lopez Bsn, Rn, Niloufar Hobbollahi Rn, Bsn, Samantha Johnson Bsn, Rn, Victoria Delande Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Young Professionals, Lehigh Valley Health Network

Young Professionals

No abstract provided.

Transitioning From Medicaid To Private Health Insurance: Informing Public And Private Sector Outreach, Amy S. White

Publications and Research

This study explored the lived experiences of transitioning from Medicaid to private health insurance upon college graduation. Fifteen recent graduates of an urban, commuter, public college in the Mid-Atlantic were interviewed via Zoom® to understand what they regard as crucial aspects of the transition experience, especially during the COVID pandemic. The subjects all identified as being members of a minority racial or ethnic group, the average age was 33 years (SD = 10.96), and all but one interview subject majored in the health sciences. Every recent graduate reported experiencing difficulty in the transition. Subjects felt unprepared for the transition, alone, …

Simtutor Module: Antibodies, Heather Gilbert

Teaching, Learning, and Scholarship (TLAS) Academy Projects

Antibody simulation module developed for use in MLS 226: Introduction to Clinical Immunology and Molecular Diagnostics. The module was designed to reinforce lecture material and was developed utilizing SimTutor software.

Learning outcomes:

1. Define antibody.
2. Differentiate between innate and adaptive immunity.
3. Differentiate between cellular and humoral immunity.
4. Describe the four pathways of antibody acquisition.
5. Identify the three functions of an antibody.
6. Identify and describe the structure of an antibody including the following components and regions: light chain, heavy chain, constant region, variable region, Fc Fragment, Fab Fragment, and hinge region.
7. List the antibody classes and their key features.
8. Differentiate between the …