Medicine and Health Sciences Commons^™

Hyperferritinemic Sepsis, Macrophage Activation Syndrome, And Mortality In A Pediatric Research Network: A Causal Inference Analysis, Zhenziang Fan, John C Lin, Allan Doctor, Et Al.

2020-Current year OA Pubs

BACKGROUND: One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network's objective was to obtain rationale for designing anti-inflammatory clinical trials targeting hyperferritinemic sepsis.

METHODS: We assessed differences in 32 cytokines, immune depression (low whole blood ex vivo TNF response to endotoxin) and thrombotic microangiopathy (low ADAMTS13 activity) biomarkers, seven viral DNAemias, and macrophage activation syndrome (MAS) defined by combined hepatobiliary dysfunction and disseminated intravascular coagulation, and mortality in 117 children with hyperferritinemic sepsis (ferritin level > 500 ng/mL) compared to 280 children with sepsis …

Facilitators And Barriers To Optimal Home Blood Pressure Management In Patients With Hypertensive Disorders Of Pregnancy In A Tertiary Care Facility In Abuja, Nigeria: A Qualitative Research Study, Zainab Mahmoud, Adaego A Orji, Chukwuebuka F Okoye, Friday O Ameh, Erica Jamro-Comer, Aliyu Isah, Bissallah Ekele, Godwin Akaba, Dike B Ojji, Mark D Huffman

2020-Current year OA Pubs

BACKGROUND: Nigeria has one of the highest burdens of maternal deaths globally, and hypertensive disorders of pregnancy (HDP) are the leading cause of maternal morbidity and mortality in the country. There is a significant implementation gap in utilizing evidence-based practices for the management of HDP in Nigeria. This study evaluated facilitators and barriers to implementing a home blood pressure monitoring program to improve management of HDP.

METHODS: From August 2022 to September 2022, we conducted 15 semi-structured, key informant interviews and 4 focus group discussions among patients, health care workers, and administrators at University of Abuja Teaching Hospital (UATH), a …

Single Genomic Enhancers Drive Experience-Dependent Gabaergic Plasticity To Maintain Sensory Processing In The Adult Cortex, Ori Roethler, Eran Zohar, Katayun Cohen-Kashi Malina, Lidor Bitan, Harrison Wren Gabel, Ivo Spiegel

2020-Current year OA Pubs

Experience-dependent plasticity of synapses modulates information processing in neural circuits and is essential for cognitive functions. The genome, via non-coding enhancers, was proposed to control information processing and circuit plasticity by regulating experience-induced transcription of genes that modulate specific sets of synapses. To test this idea, we analyze here the cellular and circuit functions of the genomic mechanisms that control the experience-induced transcription of Igf1 (insulin-like growth factor 1) in vasoactive intestinal peptide (VIP) interneurons (INs) in the visual cortex of adult mice. We find that two sensory-induced enhancers selectively and cooperatively drive the activity-induced transcription of Igf1 to thereby …

Is Β-Lactamase Testing Acceptably Accurate For Predicting Haemophilus Influenzae Susceptibility To Β-Lactams? Epidemiological Data From Philadelphia, Usa, 2017–2023, Arianna B. Morton, Chairut Vareechon, Matthew A. Pettengill

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

No abstract provided.

The Effect Of Covid-19 On The Academic Performance Of Zayed University Students In The United Arab Emirates, Sharifa Alblooshi, Linda Smail, Alyaa Albedwawi, Mariam Al Wahedi, Maha Alsafi

All Works

The outbreak of the coronavirus (COVID-19) pandemic led to significant changes across various sectors, including the field of education. In response to the pandemic, educational institutions worldwide, including Zayed University in the United Arab Emirates (UAE), transitioned to online learning. This study aimed to investigate the impact of COVID-19 on the academic performance of students in the UAE and their satisfaction with remote learning, while also examining gender differences in these variables. This study used a quantitative research design in which a questionnaire was used to collect data. The study employed a snowball sampling method to recruit a total of …

The Intersection Between Alcohol Use And Sexual Activity Among Young Adult Male U.S. Service Members, Lindsay M. Orchowski, Bryce M. Meerhaeghe, Amber R. Lane, Donna M. Kazemi Phd, Rn, Cne, Fiaan, Brian Borsari, Cristóbal S. Berry-Cabán

Publications

AIMS: The current study explores drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior among young adult male active duty service members in the United States. BACKGROUND: Hazardous alcohol use is a significant problem among United States military service members. Whereas the association between alcohol use and sexual assault is well documented in civilian samples, less is known regarding the intersection of alcohol use and sexual activity among soldiers. OBJECTIVE: Descriptive statistics were utilized to summarize drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior. METHODS: A sample of 338 active-duty male …

Clinically Conserved Genomic Subtypes Of Gastric Adenocarcinoma, Yun Seong Jeong, Young-Gyu Eun, Sung Hwan Lee, Sang-Hee Kang, Sun Young Yim, Eui Hyun Kim, Joo Kyung Noh, Bo Hwa Sohn, Seon Rang Woo, Moonkyoo Kong, Deok Hwa Nam, Hee-Jin Jang, Hyun-Sung Lee, Shumei Song, Sang Cheul Oh, Jeeyun Lee, Jaffer A Ajani, Ju-Seog Lee

Faculty, Staff and Student Publications

Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established genomic signatures for GAC subtypes, we identified 6 clinically and molecularly distinct genomic consensus subtypes (CGSs). CGS1 have the poorest prognosis, very high stem cell characteristics, and high IGF1 expression, but low genomic alterations. CGS2 is enriched with canonical epithelial gene expression. CGS3 and CGS4 have high copy number alterations and low immune reactivity. However, CGS3 and CGS4 differ in that CGS3 has high HER2 activation, while CGS4 has high SALL4 and KRAS activation. CGS5 has the high mutation burden and moderately …

Stem-Like Cd4+T Cells In Perivascular Tertiary Lymphoid Structures Sustain Autoimmune Vasculitis, Yuki Sato, Abhinav Jain, Shozo Ohtsuki, Hirohisa Okuyama, Ines Sturmlechner, Yoshinori Takashima, Kevin-Phu C Le, Melanie C Bois, Gerald J Berry, Kenneth J Warrington, Jörg J Goronzy, Cornelia M Weyand

Faculty, Staff and Student Publications

Autoimmune vasculitis of the medium and large elastic arteries can cause blindness, stroke, aortic arch syndrome, and aortic aneurysm. The disease is often refractory to immunosuppressive therapy and progresses over decades as smoldering aortitis. How the granulomatous infiltrates in the vessel wall are maintained and how tissue-infiltrating T cells and macrophages are replenished are unknown. Single-cell and whole-tissue transcriptomic studies of immune cell populations in vasculitic arteries identified a CD4+ T cell population with stem cell-like features. CD4+ T cells supplying the tissue-infiltrating and tissue-damaging effector T cells survived in tertiary lymphoid structures around adventitial vasa vasora, expressed the transcription …

Strategies For Maintaining Brain Health: The Role Of Stroke Risk Factors Unique To Elderly Women, Melvin E Klegerman, Tao Peng, Shao-Ling Huang, Brion Frierson, Melanie R Moody, Hyunggun Kim, David D Mcpherson

Faculty, Staff and Student Publications

We have conducted a stability study of a complex liposomal pharmaceutical product, Atheroglitatide (AGT), stored at three temperatures, 4, 24, and 37 °C, for up to six months. The six parameters measured were functions of liposomal integrity (size and number), drug payload (loading efficiency), targeting peptide integrity (conjugation efficiency and specific avidity), and echogenicity (ultrasound-dependent controlled drug release), which were considered most relevant to the product's intended use. At 4 °C, liposome diameter trended upward, indicative of aggregation, while liposome number per mg lipid and echogenicity trended downward. At 24 °C, peptide conjugation efficiency (CE) and targeting efficiency (TE, specific …

Computed Tomography Tissue Characterization Of Pediatric Cardiac Tumor, Rafael Zonana Amkie, Amulya Buddhavarapu, Mehul D Patel, Bihong Zhao, Dilachew A Adebo

Faculty, Staff and Student Publications

Little is known about tissue characterization of cardiac tumors by dedicated cardiac computed tomography (CT) protocols in pediatric patients. We report using arterial and delayed CT acquisitions to characterize a large left ventricular free wall tumor in a 12-year-old female with congenital mitral insufficiency and an automatic implantable cardioverter defibrillator. (

Hiv-1 Vpu Protein Forms Stable Oligomers In Aqueous Solution Via Its Transmembrane Domain Self-Association, Saman Majeed, Lan Dang, Md Majharul Islam, Olamide Ishola, Peter P Borbat, Steven J Ludtke, Elka R Georgieva

Faculty, Staff and Students Publications

We report our findings on the assembly of the HIV-1 protein Vpu into soluble oligomers. Vpu is a key HIV-1 protein. It has been considered exclusively a single-pass membrane protein. Previous observations show that this protein forms stable oligomers in aqueous solution, but details about these oligomers still remain obscure. This is an interesting and rather unique observation, as the number of proteins transitioning between soluble and membrane embedded states is limited. In this study we made use of protein engineering, size exclusion chromatography, cryoEM and electron paramagnetic resonance (EPR) spectroscopy to better elucidate the nature of the soluble oligomers. …

The Atm-E6ap-Mastl Axis Mediates Dna Damage Checkpoint Recovery, Yanqiu Li, Feifei Wang, Xin Li, Ling Wang, Zheng Yang, Zhongsheng You, Aimin Peng

2020-Current year OA Pubs

Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage. In this study, we discovered the upregulated protein level of MASTL kinase hours after DNA damage. MASTL promotes cell cycle progression by preventing PP2A/B55-catalyzed dephosphorylation of CDK substrates. DNA damage-induced MASTL upregulation was caused by decreased protein degradation, and was unique among mitotic kinases. We identified E6AP as the E3 ubiquitin ligase that mediated MASTL degradation. MASTL degradation was inhibited upon DNA damage as a result of the dissociation of …

A Pre-Medical Student’S Reconciliation Of Feminist Narratives Regarding Women’S Health: A Consideration Of Perspectives On Childbirth In The U.S., Laura Clayton

sprinkle: an undergraduate journal of feminist and queer studies

Many feminists argue that one major negative aspect of reproductive healthcare in the U.S. is the common over-medicalization of women during childbirth, including potentially unnecessary procedures such as cesarean-section and episiotomy. As a solution, they advocate for increased involvement of midwives in childbirth practices, as midwives allow women to give birth at home with minimal medical intervention. This paper analyzes the benefits of midwifery as well as the current increased risk associated with homebirth in the U.S. Additionally, it questions the damaging stigma associated with assumptions of cesarean-section as a suboptimal outcome. A false dichotomy has developed in our culture …

Hospitalizations For Hepatitis C In Mississippi, 2014-2018 – A Hidden Epidemic, Manuela Staneva Md, Mph, Thomas Dobbs Md, Mph, Paul Byers Md, Meg Pearson Pharmd, Ms, Jonathan Hubanks Pharmd

Journal of Public Health in the Deep South

Goal: Utilizing Mississippi’s hospital discharge data (HDD), we examined trends, demographics, comorbidities, in-hospital deaths, and hospital charges for hospitalizations with diagnoses for hepatitis C virus (HCV).Methods: We conducted a retrospective study of hospitalizations with primary or secondary HCV diagnoses. We performed descriptive and inferential statistical analyses using SAS 9.4. We compared categorical variables with chi-square tests and continuous variables with t-tests.Results: Between 2014 and 2018, patients hospitalized with an HCV diagnosis were more likely to have coexisting intravenous drug use (IDU) diagnoses compared to all other hospitalized patients (20.3% versus 3.3%, p < 0.001). From 2014 to 2018, hepatitis C infections associated with IDU spiked by 53.8%, fueling the overall increase in the number of hepatitis C hospitalizations in Mississippi. Almost one-third (31.8%) of all hepatitis C stays had a severe liver condition and 48.2% had nicotine dependence. The average charges for stays with coexisting HCV and decompensated cirrhosis were $65,975.Conclusions: In Mississippi, there has been a rapid increase in HCV hospitalizations associated with IDU. In addition, HCV hospitalizations were associated with severe morbidity burden and high economic expense. These findings underscore the need for measures aimed at containing the spread of this dangerous but preventable infection.

Prevalence Of Probable Hoarding And Associated Consequences At The Scene Of Mississippi Fires, 2009-2019, Mary E. Dozier Phd, Ben Porter Phd

Journal of Public Health in the Deep South

Background: Increased risk for fire is an often-discussed consequence of hoarding disorder; however, the source of this association has been largely through clinicians’ accounts or hoarding patients’ self-reports.Purpose: The purpose of this study was to investigate the association between probable hoarding and incidence of fires using archival data from Mississippi.Methods: Incidents of residential fires from 2009-2019 were provided by the Mississippi State Fire Marshal’s Office. Fires that were classified as having “a significant amount of fire load present” were classified as probable hoarding fires for analysis.Results: Of the 5,194 unique residential fires identified across the study period, 96 fires (1.9% …

Assessment Of Knowledge And Attitudes Toward Determinants Of Infant Mortality In Head Start Teachers, Teacher Aides, Caregivers, And Family Support Workers, Susan Mayfield-Johnson Phd, Mches, Danielle Fastring Phd, Stephanie T. Mcleod Mph

Journal of Public Health in the Deep South

IMR (11.9 infant deaths per 1,000 live births) almost twice the rate observed in (6.2 infant deaths per 1,000 live births). Objectives. The purpose of this project was to assess Head Start teachers’, teacher aides’, caregivers’, and family support workers’ perceptions, knowledge, attitudes, values and beliefs on topics (nutrition, exercise, breastfeeding, safe sleep, smoking, stress, postpartum depression, and mental health) related to infant mortality prevention in a Mississippi Gulf Coast Head Start consortium. Methods. A 47-item questionnaire was developed that focused on areas associated with primary prevention of infant mortality. Results. Participants (n=82) ages were 25 to 44 years of …

Factors Associated With History Of Unintended Pregnancy Among Mothers In Mississippi, Stephanie T. Mcleod Mph, Morgan Bradwell, Lei Zhang, Olivia Hogan Ismail, Eden Blackwell, Tanya Funchess, Jerome R. Kolbo

Journal of Public Health in the Deep South

Background: Mississippi has the highest rate of unintended pregnancy in the nation. Accessibility, availability, and affordability of women’s health services and effective contraceptive methods are key in preventing unintended pregnancies. Purpose: The purpose of this study was to identify factors associated with history of unintended pregnancy among parous women of childbearing age in Mississippi in order to improve understanding of these relationships and to fill a gap in literature about the state. Methods: Through a multi-stage, probability sample, mothers of students in childcare facilities were selected to participate in a survey about health care and contraceptive use. Chi-square tests of …

Adaptability In Community-Based Participatory Research: Comparisons Of Coalitions In The Deep South, Candace Forbes Bright Phd

Journal of Public Health in the Deep South

Background: Health inequities in the Gulf states are complex issues to resolve, and no single solution or strategy can improve the health rankings in each state. Yet, using grassroots approaches and building community partnerships are promising strategies to identify important health issues and opportunities for policy change. Purpose: This paper illustrates how the Gulf States Health Policy Center coalitions in four different locations used the same community-based participatory research model, but with distinct differences in processes, across nine projects to address issues that negatively affected population health. Methods: Recognizing that communities have unique needs, resources, and complementary health efforts, we …

Ocular Biomarkers Of Disease: Employing Routine Eye Exams To Promote Better Health Surveillance, Dawn S. Mclendon, Kenneth R. Butler Phd, Michael A. Welsch Phd, Facsm

Journal of Public Health in the Deep South

America’s burden of vision impairment, Alzheimer’s disease and related dementias (ADRD), and cardiovascular disease will continue to rise over the next 40 years. The burden of these diseases will be greater for women, Hispanics, African-Americans, and those from lower socio-economic regions. A key challenge is to develop strategies to deny the organization of the pathologies that eventually lead to the manifestation of the disease. An important feature within this battle is the development of appropriate tools and biomarkers for early reconnaissance of the enemy. Recent advances in Optical Coherence Tomography Angiography (OCTA) present a unique opportunity to examine physiological features …

Rural Medical Scholars Program: Filling The Gap For Health-Care And Public Health Leaders In Mississippi, Ann Sansing, David R. Buys, Marion W. Evans Phd, Mches, Laura Downey, Jasmine Harris-Speight

Journal of Public Health in the Deep South

The Rural Medical & Science Scholars program aims to help rising high school seniors determine if they want to pursue health-related careers. The program shapes students’ interest in and understanding of medicine, health-related disciplines, and other science, technology, engineering, and mathematics (STEM) fields. The program combines didactic, observational, and practical learning during a summer semester. Participants earn seven college credits to jumpstart a health or STEM career. We report on descriptive statistics since the program’s inception in 1998. The program has matriculated 401 students, of whom approximately 71% have chosen health-related careers in nursing, physical or occupational therapy, dentistry, pharmacy, …

Policies On Hand-Held Mobile Device Use While Driving: Considerations For Mississippi, Amy Radican-Wald

Journal of Public Health in the Deep South

Background: Mississippi enacted a texting/accessing social networking sites ban for all drivers in 2015; this ban is due for reauthorization in 2018. Purpose: Examine state policies prohibiting mobile device use while driving and changes in behaviors, attitudes, and opinions over time for Mississippi adults regarding distracted driving. Methods: Review literature and enacted policies. Analyze traffic, death, and survey data statewide from 2010 to 2017. Results: Mississippi’s crash death rate rose significantly (22.7 to 25.6 per 100,000; p < .01) from 2010 to 2015. Mississippi adults surveyed said they had talked on a mobile device (75.4%), texted (45.5%), or emailed (10.1%) while driving in 2017. Each reported risky driving behavior increased significantly (p < 0.05) from 2010. Most Mississippians support bans on texting (95%) and hand-held device use (89%) while driving. Support for these types of bans significantly (p < 0.05) increased from 2010 to 2017. Enacted policies vary among states and include mobile device use bans for novice drivers (n = 38) and texting (n = 47) and hand-held (n = 14) bans for all drivers. While safety campaigns coupled with aggressive enforcement are found effective, officials cite enforcement difficulties. Only three texting citations were issued to Mississippi drivers during 2016. Conclusions: Enforcement of policies addressing drivers’ mobile device use is a key factor to consider in reducing crash-related deaths.

Training The Next Generation Of Primary-Care Physicians: Are Student-Run Free Clinics (Srfcs) The Way To Go?, Tobe Momah

Journal of Public Health in the Deep South

Background: The consensus over the last 20 years is that increased availability of primary care reduces the overall cost of healthcare and improves mortality and morbidity rates by as much as 1.44 fewer deaths per 10,000 people (American College of Physicians, 2008; Shi, Starfield, Kennedy, & Kawachi, 1999). However, not enough physicians are going into primary care to meet the need for improved and increased access. By 2020, the expanded Title VII program goal is to produce a physician workforce that is at least 40 percent primary care (Jackson et al., 2014). Estimates show that 74% of U.S. medical school …

Maternal, Child, And Parenting Factors Associated With Obesity Among Pre-Kindergarten Children In Mississippi, Jerome R. Kolbo

Journal of Public Health in the Deep South

Background: Obesity among children and youth has been consistently assessed among public school students in Mississippi since 2005. Significant declines in the prevalence of obesity among elementary students over the past decade suggest that changes may be occurring prior to entry into public school. Purpose: The purpose was to collect anthropometric data on a weighted, representative sample of children ages 3 to 5 years in licensed childcare facilities across Mississippi, and to correlate maternal, child, and parenting characteristics to obesity. Methods: The Body Mass Index was calculated using measured height and weight data. Results: A total of 14.12% of the …

Speech-Language Pathologists And Respiratory Therapists: Team Approach To Caring For Patients With Long-Term Tracheotomy, Javis M. Knott

Journal of Public Health in the Deep South

Background: Recent technological advances, together with growing social acceptance of patients with disabilities, has led to a realization of the importance of long-term management of technologically dependent and chronically ill patients with tracheostomies. This includes tracheostomy patients who are ventilator dependent, neurological patients, patients with severe illness such as stroke, and so forth. These patients are able to have a higher quality of life and communicate verbally due to advances in health care. One of the major advancements is communicating via a tracheostomy. Hence, this study will provide ways in which respiratory therapists (RTs) and speech-language pathologists (SLPs) can work …

Remaining In The Workforce After Motherhood: Does The Family Medical Leave Act Play A Role In The Decisions Of Mississippi Mothers?, Danielle Fastring

Journal of Public Health in the Deep South

Background: Increased maternity leave has been shown to have a positive impact on maternal and child health, and to increase the length of time mothers breastfeed their infants. After childbirth, working women must decide if and when they will return to the workforce. Purpose: To determine the impact of current U.S. family leave policies on Mississippi mothers’ decisions to return to work after the birth of their first child. Methods: A survey was developed to collect information about factors influencing mothers’ decisions to return to work after the birth of their first child. The survey collected study eligibility information, demographics, …

Using Medicaid Data To Identify Factors That Predict Reinstitutionalization Of Mississippians With Disabilities And Elderly People, Hwanseok Choi

Journal of Public Health in the Deep South

Background: Mississippi Bridge to Independence (B2I) was Mississippi’s Money Follows the Person (MFP) program seeking to rebalance the state’s long-term care system by transitioning Medicaid beneficiaries from institutional living to home- and community-based settings (HCBS). Success of initial transitions has been documented in state cost-savings and participants’ quality of life increases. However, reinstitutionalization poses a challenge to sustaining a positive outcome for the initiative. Purpose: Therefore, the purpose of this research is to identify the underlying causes of participants’ reinstitutionalization. Methods: The Quality of Life (QoL) survey designed by Mathematica Policy Research was used to measure variables in 7 categories. …

The Relationship Between Obesity And Depression Among Federally Qualified Health Center Patients, Hwanseok Choi

Journal of Public Health in the Deep South

Background: Obesity has reached epidemic levels in Mississippi. In the shadow of these skyrocketing obesity levels, there are comorbid high levels of depression. Both obesity and depression complicate and, in many cases, compromise critical health outcomes. A significant association between obesity and depression has been suspected for decades. Purpose: The purpose of this study is to examine the relationship between obesity and depression among patients receiving medical care from a Federally Qualified Health Center (FQHC) in a southern state. Methods: The sample was comprised of 3,272 subjects. The Patient Health Questionnaire (PHQ-9) was used to measure the severity of depression, …

The Col27a1 And Col11a1 Gene Variants Are Not Associated With The Susceptibility To Anterior Cruciate Ligament Rupture In Polish Athletes, Zhuo Sun, Aleksandra Bojarczuk, Pawel Cieszczyk

Baltic Journal of Health and Physical Activity

Introduction: Sports injuries are the most common cause of anterior cruciate ligament (ACL) ruptures. Previous research has demonstrated links between some of the COL27A1 and COL11A1 genetic variants and musculoskeletal soft tissue injuries. However, no previous research has investigated the COL27A1 rs1570460 and the COL11A1 rs3753841 in the context of ACL rupture in any population. Thus, our study aimed to assess the association between specific single nucleotide polymorphisms (SNPs), i.e., COL27A1 rs946053 and COL11A1 rs3753841, and the occurrence of ACL injury (ACL-I) in a cohort of Polish athletes. Methods: The study enrolled 233 athletes with ACL-I (161 males and …

The Prevention And Cardiac Rehabilitation Group Of The Saudi Heart Association Recommendations Regarding Establishing A Cardiac Rehabilitation Service, Abdulhalim Jamal Kinsara, Raghdah Aljehani, Jadwiga Wolszakiewicz, Adam Staron, Muteb A. Alsulaimy

Journal of the Saudi Heart Association

Cardiac rehabilitation (CR) is a cornerstone in the secondary prevention of cardiovascular disease (CVD). Comprehensive cardiac rehabilitation has obtained the highest class of recommendation and the level of evidence for the treatment of patients with ST-segment elevation myocardial infarction, after myocardial revascularization, with chronic coronary syndromes, and in patients with heart failure (HF). Comprehensive cardiac rehabilitation should be implemented as soon as possible, be multi-phasic, and adjusted to the individual needs of the patient. CR is still suboptimally used, and many cardiac centers do not have such services (2). The provision of CR services should be based on standards and …

An Unusual Case Of Nonbacterial Thrombotic Endocarditis Attributable To Malignancy, Luis E. Santiago, Winy Kujundzic, Stephanie Wong, Samyukta Swaminath, Pallavi Aneja

HPD Articles

Nonbacterial thrombotic endocarditis (NBTE), also known as marantic endocarditis, is a condition characterized by the deposition of thrombi and fibrin on normal or degenerated cardiac valves in the absence of microorganisms. We report a case of a 60-year-old male with nonbacterial thrombotic endocarditis found on transesophageal echocardiogram (TEE) after a normal TEE just one month prior. Our patient presented with abdominal pain associated with poor appetite and unintentional 20-pound weight loss for one month. Chest computed tomography revealed the presence of a mass-like opacification in the right lung middle lobe with moderate pericardial effusions. A biopsy of the mass confirmed …