Medicine and Health Sciences Commons^™

Influence Of Macrophages On Vascular Invasion Of Inflammatory Breast Cancer Emboli Measured Using An In Vitro Microfluidic Multi-Cellular Platform, Manasa Gadde, Melika Mehrabi-Dehdezi, Bisrat G Debeb, Wendy A Woodward, Marissa Nichole Rylander

Faculty, Staff and Student Publications

Inflammatory breast cancer (IBC) is an aggressive disease with a poor prognosis and a lack of effective treatments. It is widely established that understanding the interactions between tumor-associated macrophages (TAMs) and the tumor microenvironment is essential for identifying distinct targeting markers that help with prognosis and subsequent development of effective treatments. In this study, we present a 3D in vitro microfluidic IBC platform consisting of THP1 M0, M1, or M2 macrophages, IBC cells, and endothelial cells. The platform comprises a collagen matrix that includes an endothelialized vessel, creating a physiologically relevant environment for cellular interactions. Through the utilization of this …

The Impact Of Modern Dietary Practices On Cancer Risk And Progression: A Systematic Review, Stephanie Nagy, Stephanie N. Petrosky, Michelle Demory Beckler, Marc M. Kesselman

HPD Articles

Cancer is a leading cause of mortality around the world, despite continued advancements in the management of cancer. Recent research efforts have shifted to evaluating the role that modifiable risk factors play in cancer risk and development, as diet and nutrition have been found to play a significant role in the onset and progression of cancer. As a result, there has been an increasing focus on the impact of dietary modifications on preventing the onset, progression, and reoccurrence of cancer. In this systematic review, data were collected on three common diets, the Mediterranean diet (MD), ketogenic diet (KD), and plant-based …

Effectiveness Of Thyme Honey In The Management Of Xerostomia In Geriatric Patients With End-Stage Renal Disease: A Randomized Controlled Clinical Trial With A Biochemical Assessment, Asmaa Ras, Dalia M. Ghalwash, Radwa R. Hussein, Suzan M. Seifallah

Dentistry

Background

Taking into consideration the value of the oral health condition in geriatric people with end-stage renal disease (ESRD) associated with xerostomia and believing that salivary stimulants or substitutes could potentially be used to manage this condition. This study aimed to evaluate the clinical effectiveness of thyme honey as oral rinse in geriatric patients with ESRD using the subjective dry mouth score as a primary objective and to assess the effect of thyme honey on the salivary nitric oxide level, salivary flow rate, and salivary ph in addition to objective dry mouth score as a secondary objective.

Methods

This was …

Metabolomic Phenotype Of Hepatic Steatosis And Fibrosis In Mexican Children Living With Obesity, Nayely Garibay-Nieto, Karen Pedraza-Escudero, Isabel Omaña-Guzmán, María José Garcés-Hernández, Eréndira Villanueva-Ortega, Mariana Flores-Torres, José Luis Pérez-Hernández, Mireya León-Hernández, Estibalitz Laresgoiti-Servitje, Berenice Palacios-González, Juan Carlos López-Alvarenga, Mauricio Lisker-Melman, Felipe Vadillo-Ortega

2020-Current year OA Pubs

No abstract provided.

Identification Of Post-Cardiac Arrest Blood Pressure Thresholds Associated With Outcomes In Children: An Icu-Resuscitation Study, Monique M Gardner, Stuart H Friess, Arushi Manga, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage prospectively collected BP data to explore the association of post-arrest BP thresholds with outcomes. We hypothesized that post-arrest systolic and diastolic BP thresholds would be higher than the currently recommended post-cardiopulmonary resuscitation BP targets and would be associated with higher rates of survival to hospital discharge.

METHODS: We performed a secondary analysis of prospectively collected BP data from the first 24 h following return of circulation from index IHCA events enrolled …

Open Structure And Gating Of The Arabidopsis Mechanosensitive Ion Channel Msl10, Jingying Zhang, Grigory Maksaev, Peng Yuan

2020-Current year OA Pubs

Plants are challenged by drastically different osmotic environments during growth and development. Adaptation to these environments often involves mechanosensitive ion channels that can detect and respond to mechanical force. In the model plant Arabidopsis thaliana, the mechanosensitive channel MSL10 plays a crucial role in hypo-osmotic shock adaptation and programmed cell death induction, but the molecular basis of channel function remains poorly understood. Here, we report a structural and electrophysiological analysis of MSL10. The cryo-electron microscopy structures reveal a distinct heptameric channel assembly. Structures of the wild-type channel in detergent and lipid environments, and in the absence of membrane tension, capture …

Eeg Functional Connectivity In Infants At Elevated Familial Likelihood For Autism Spectrum Disorder, Christian O'Reilly, Scott Huberty, Stefon Van Noordt, James Desjardins, Nicky Wright, Julie Scorah, Sara Jane Webb, Mayada Elsabbagh, Basis Team

Publications

Background

Many studies have reported that autism spectrum disorder (ASD) is associated with atypical structural and functional connectivity. However, we know relatively little about the development of these differences in infancy.

Methods

We used a high-density electroencephalogram (EEG) dataset pooled from two independent infant sibling cohorts, to characterize such neurodevelopmental deviations during the first years of life. EEG was recorded at 6 and 12 months of age in infants at typical (N = 92) or elevated likelihood for ASD (N = 90), determined by the presence of an older sibling with ASD. We computed the functional connectivity between …

The Neuroimmune Regulation And Potential Therapeutic Strategies Of Optic Pathway Glioma, Khushboo Irshad, Yu-Kai Huang, Paul Rodriguez, Jung Lo, Benjamin E Aghoghovwia, Yuan Pan, Kun-Che Chang

Faculty, Staff and Student Publications

Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.

Unreliable Findings Due To Miscalculations And Errors Comment On Nally Et Al The Effectiveness Of School-Based Interventions On Obesity-Related Behaviours In Primary School Children: A Systematic Review And Meta-Analysis Of Randomised Controlled Trials Children 2021, 8, 489, Keara Ginell, Beate Henschel, Lilian Golzarri-Arroyo, Yasaman Jamshidi-Naeini, Andrew W Brown, David B Allison

Children’s Nutrition Research Center Staff Publications

Nally et al. [...].

Contact With Caregivers Is Associated With Composition Of The Infant Gastrointestinal Microbiome In The First 6 Months Of Life, Kyle S. Wiley, Andrew M. Gregg, Molly M. Fox, Venu Lagishetty, Curt A. Sandman, Jonathan P. Jacobs, Laura M. Glynn

Psychology Faculty Articles and Research

Objectives

Little is known about how physical contact at birth and early caregiving environments influence the colonization of the infant gastrointestinal microbiome. We investigated how infant contact with caregivers at birth and within the first 2 weeks of life relates to the composition of the gastrointestinal microbiome in a sample of U.S. infants (n = 60).

Methods

Skin-to-skin and physical contact with caregivers at birth and early caregiving environments were surveyed at 2 weeks postpartum. Stool samples were collected from infants at 2 weeks, 2, 6, and 12 months of age and underwent 16S rRNA sequencing as a proxy …

Early Season Monitoring Of Tarnished Plant Bug, Lygus Lineolaris, In Wild Hosts Using Pheromone Traps, Justin George, James P Glover, Gadi V P Reddy, Chris Johnson, David R Hall

Faculty, Staff and Student Publications

Simple Summary

The tarnished plant bug, Lygus lineolaris (Hemiptera: Miridae), is a polyphagous pest and causes severe economic damage to cotton crops. Managing the weedy field edges is important in preventing early-season infestations of L. lineolaris in cotton to prevent damage to the squares and other fruiting structures. Scouting fields for L. lineolaris is time- and labor-intensive, and end-user variability associated with field sampling can lead to inaccuracies. Insect traps that combine visual cues and pheromones are more accurate, sustainable, and economically feasible in contrast to traditional insect detection methods. In this study, we investigated the application of red or …

Stabilizing Peri-Stent Restenosis Using A Novel Therapeutic Carrier, Maria P Blasco Conesa, Frank W Blixt, Pedram Peesh, Romeesa Khan, Janelle Korf, Juneyoung Lee, Gayathri Jagadeesan, Alexander Andersohn, Tushar K Das, Chunfeng Tan, Claudia Di Gesu, Gabriela Delevati Colpo, Jose Félix Moruno-Manchón, Louise D Mccullough, Robert Bryan, Bhanu P Ganesh

Faculty, Staff and Student Publications

Stroke is the most common cause of long-term disability and places a high economic burden on the global healthcare system. Functional outcomes from stroke are largely determined by the extent of ischemic injury, however, there is growing recognition that systemic inflammatory responses also contribute to outcomes. Mast cells (MCs) rapidly respond to injury and release histamine (HA), a pro-inflammatory neurotransmitter that enhances inflammation. The gut serves as a major reservoir of HA. We hypothesized that cromolyn, a mast cell stabilizer that prevents the release of inflammatory mediators, would decrease peripheral and central inflammation, reduce MC trafficking to the brain, and …

Extracellular Vesicles In Triple–Negative Breast Cancer: Immune Regulation, Biomarkers, And Immunotherapeutic Potential, Kaushik Das, Subhojit Paul, Arnab Ghosh, Saurabh Gupta, Tanmoy Mukherjee, Prem Shankar, Anshul Sharma, Shiva Keshava, Subhash C. Chauhan, Vivek Kumar Kashyap

School of Medicine Publications

Triple–negative breast cancer (TNBC) is an aggressive subtype accounting for ~10–20% of all human BC and is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) amplification. Owing to its unique molecular profile and limited targeted therapies, TNBC treatment poses significant challenges. Unlike other BC subtypes, TNBC lacks specific molecular targets, rendering endocrine therapies and HER2–targeted treatments ineffective. The chemotherapeutic regimen is the predominant systemic treatment modality for TNBC in current clinical practice. However, the efficacy of chemotherapy in TNBC is variable, with response rates varying between a wide range …

The Gut Microbiome As A Biomarker And Therapeutic Target In Hepatocellular Carcinoma, Betul Gok Yavuz, Saumil Datar, Shadi Chamseddine, Yehia I Mohamed, Michael Lapelusa, Sunyoung S Lee, Zishuo Ian Hu, Eugene J Koay, Hop S Tran Cao, Prasun Kumar Jalal, Carrie Daniel-Macdougall, Manal Hassan, Dan G Duda, Hesham M Amin, Ahmed O Kaseb

Faculty, Staff and Student Publications

The microbiome is pivotal in maintaining health and influencing disease by modulating essential inflammatory and immune responses. Hepatocellular carcinoma (HCC), ranking as the third most common cause of cancer-related fatalities globally, is influenced by the gut microbiome through bidirectional interactions between the gut and liver, as evidenced in both mouse models and human studies. Consequently, biomarkers based on gut microbiota represent promising non-invasive tools for the early detection of HCC. There is a growing body of evidence suggesting that the composition of the gut microbiota may play a role in the efficacy of immunotherapy in different types of cancer; thus, …

Super-Enhancer Hijacking Drives Ectopic Expression Of Hedgehog Pathway Ligands In Meningiomas, Mark W Youngblood, Zeynep Erson-Omay, Chang Li, Hinda Najem, Süleyman Coșkun, Evgeniya Tyrtova, Julio D Montejo, Danielle F Miyagishima, Tanyeri Barak, Sayoko Nishimura, Akdes Serin Harmancı, Victoria E Clark, Daniel Duran, Anita Huttner, Timuçin Avşar, Yasar Bayri, Johannes Schramm, Julien Boetto, Matthieu Peyre, Maximilien Riche, Roland Goldbrunner, Nduka Amankulor, Angeliki Louvi, Kaya Bilgüvar, M Necmettin Pamir, Koray Özduman, Türker Kilic, James R Knight, Matthias Simon, Craig Horbinski, Michel Kalamarides, Marco Timmer, Amy B Heimberger, Ketu Mishra-Gorur, Jennifer Moliterno, Katsuhito Yasuno, Murat Günel

Faculty, Staff and Students Publications

Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the most common primary brain tumor, exhibit Hedgehog signaling activation in 6.5% of cases, triggered by recurrent mutations in pathway mediators such as SMO. In this study, we find 35.6% of meningiomas that lack previously known drivers acquired various types of somatic structural variations affecting chromosomes 2q35 and 7q36.3. These cases exhibit ectopic expression of Hedgehog ligands, IHH and SHH, respectively, resulting in Hedgehog signaling activation. Recurrent tandem duplications involving IHH permit de novo chromatin …

Metabolomic Phenotype Of Hepatic Steatosis And Fibrosis In Mexican Children Living With Obesity, Nayely Garibay-Nieto, Karen Pedraza-Escudero, Isabel Omaña-Guzmán, María José Garcés-Hernández, Eréndira Villanueva-Ortega, Mariana Flores-Torres, José Luis Pérez-Hernández, Mireya León-Hernández, Estibalitz Laresgoiti-Servitje, Juan Carlos Lopez-Alvarenga

School of Medicine Publications

Background and Objectives: Metabolic-dysfunction-associated steatotic liver disease or MASLD is the main cause of chronic liver diseases in children, and it is estimated to affect 35% of children living with obesity. This study aimed to identify metabolic phenotypes associated with two advanced stages of MASLD (hepatic steatosis and hepatic steatosis plus fibrosis) in Mexican children with obesity.

Materials and Methods: This is a cross-sectional analysis derived from a randomized clinical trial conducted in children and adolescents with obesity aged 8 to 16 years. Anthropometric and biochemical data were measured, and targeted metabolomic analyses were carried out using mass spectrometry. …

Identification Of Post-Cardiac Arrest Blood Pressure Thresholds Associated With Outcomes In Children: An Icu-Resuscitation Study, Monique M Gardner, David A Hehir, Ron W Reeder, Tageldin Ahmed, Michael J Bell, Robert A Berg, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A Carcillo, Todd C Carpenter, J Michael Dean, J Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L Fink, Deborah Franzon, Aisha H Frazier, Stuart H Friess, Kathryn Graham, Mark Hall, Monica L Harding, Christopher M Horvat, Leanna L Huard, Tensing Maa, Arushi Manga, Patrick S Mcquillen, Kathleen L Meert, Ryan W Morgan, Peter M Mourani, Vinay M Nadkarni, Maryam Y Naim, Daniel Notterman, Murray M Pollack, Anil Sapru, Carleen Schneiter, Matthew P Sharron, Neeraj Srivastava, Bradley Tilford, Shirley D. Viteri, David Wessel, Heather A Wolfe, Andrew R Yates, Athena F Zuppa, Robert M Sutton, Alexis A Topjian

Department of Medicine Faculty Papers

INTRODUCTION: Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage prospectively collected BP data to explore the association of post-arrest BP thresholds with outcomes. We hypothesized that post-arrest systolic and diastolic BP thresholds would be higher than the currently recommended post-cardiopulmonary resuscitation BP targets and would be associated with higher rates of survival to hospital discharge.

METHODS: We performed a secondary analysis of prospectively collected BP data from the first 24 h following return of circulation from index IHCA events enrolled …

Improved Super-Elastic Ti-Ni Alloy Wire (Isw) For Treatment Of Adult Angle Class Iii With Anterior Crossbite, Pin-Yu Chen, Yuan-Hou Chen, I-Jia Wang, Jian-Hong Yu

Taiwanese Journal of Orthodontics

An adult female (35 years old) came for orthodontic consultation with a chief complaint of poor dental alignment with protruded mandible. Clinical findings revealed that Class III malocclusion with functional anterior crossbite. Low Hysteresis Improved Super-elastic TieNi alloy wire (ISW), developed by Tokyo Medical and Dental University with ISW curve applied over upper arch for flaring out the upper anterior tooth. MEAW technique applied on lower arch to correct a negative overjet. Treatment was completed within 41 months and patient was pleased with the improvement of appearance and dental alignment.

Substitution Of Maxillary Central Incisor With Forced Eruption Of Impacted Maxillary Canine, Wei-Lun Lim, Huei-Mei Tsai, Yu-Ling Cheng, Yuen-Yung Tsang, Ming-Jeaun Su, Chia-Yi Pan

Taiwanese Journal of Orthodontics

This case report describes the orthodontic management of missing teeth and rehabilitation needs in a 26-year-old woman. Several missing teeth on her maxillary anterior esthetic zone, a poor prognosed left mandibular first molar and a missing right mandibular first molar was also found. The treatment plan included extraction of the unrestorable maxillary left incisor, surgical exposure and forced eruption of the impacted maxillary left canine. While on the lower arch, protraction of mandibular second and third molars was planned. A good functional occlusion was achieved after 42 months treatment duration. The transposed impacted maxillary left canine was orthodontically extruded and …

Distribution Of Different Skeletal And Dental Relations Among Orthodontic Patients In Recent 5 Years: A Retrospective Study, Zong-Zhe Tsai, Morton Chang, Yu-Chuan Tseng

Taiwanese Journal of Orthodontics

The prevalence of malocclusion differs significantly from race to race. The cause of malocclusion could be multifactorial. Previous studies have demonstrated quantitative information on skeletal and dental relations in different countries. This study focuses on patients who had received orthodontic data collection and analysis in a specific medical center. Skeletal relation and Angle’s dental classification of male and female were statisticized and analyzed. Skeletal relation of Class I was 45.4%, Class II was 29.5%, and Class III was 25.1%. Angle’s dental classification of Class I was 39.3%; Class II was 30.8%; Class III was 29.9%. There was a statistically significant …

Comparison Of Lateral Cephalometry And Cone-Beam Computed Tomography Techniques For Measuring Alveolar Bone Thickness Around Maxillary Incisors, Farzaneh Ahrari, Mostafa Shahabi, Hossein Hosseini-Zarch, Mohammad Javad Alavi

Taiwanese Journal of Orthodontics

Purpose: It is valuable to detect whether bone thickness measurements performed on lateral cephalograms reflect the values obtained from three-dimensional images. The present study compared lateral cephalometry and cone-beam computed tomography (CBCT) for evaluating alveolar bone thickness surrounding maxillary central incisors.

Methods: The study included the records of 55 patients who had both lateral cephalograms and CBCT scans of the maxilla. In cephalograms, the alveolar bone thickness was measured at the crestal, middle, and apical levels of maxillary incisors at the buccal and lingual sides. Bone thickness was also measured at the corresponding points on CBCT images, and the data …

Facial Growth: Does It Play A Role In Long-Term Stability Of Orthodontic Treatment?, Ib Leth Nielsen

Taiwanese Journal of Orthodontics

Following orthodontic treatment there is usually a period of retention to maintain the treatment result. This period can vary from a few years to even lifelong retention all depending upon the clinician, type of treatment and severity of the initial malocclusion. In most cases retention is planned for one to two years, but some clinicians routinely recommend continuous retention into adulthood. The retention planned for a patient is unfortunately often based on intuition rather than on scientific evidence. Furthermore, the retention is frequently not planned based on the initial malocclusion, the patient's facial growth pattern nor is attention paid to …

Don't Look Away

Medical Muse

No abstract provided.

Well-Being And Resilience: A Survey Of Physician Needs During Covid-19, Delta, And Omicron, Melinda M. Wilding

Research Colloquium

Background: Physician moral distress during COVID-19, Delta, and Omicron has resulted in a decrease in self-care and a reduction in empathy for patients. Determining physician well-being and resilience assists clinicians in maintaining pliancy during times of uncertainty.

Methods: An IRB quantitative survey aims to illustrate levels of moral distress, self-care tactics, and physician fortitude during the three waves of the pandemic from 2020-2022. The questionnaire elicits responses regarding how physicians have pivoted to remain healthy during the pandemic, what measures physicians have engaged in maintaining empathy and ethics towards patients, and what physicians need in the future to retain self-care. …

A Rare Case Report Of A Testicular Germ-Cell Tumor (Gct) Metastasis Mimicking Pancreatic Malignancy, Lakshman Vigneswaran, Nolan Perez, Seema B. Jabbar, Carlos T. Ramos

Research Colloquium

Introduction: Testicular germ cell tumors (TGCT), evenly divided into two histologic types, seminomas and nonseminomas, are the most common malignancy among males between ages 15 to 44 years [1, 2]. The incidence of TGCT in the U.S. has increased over the past 20 years, being attributed to chronic exposure environmental risk factors (i.e. pesticides and plastic component polyvinyl chloride) in addition to genetic predisposition [1, 3-6].

Description: We report of an unusual case of retroperitoneal metastatic GCT clinically simulating a pancreatic lymphoma. A 31-year-old male presented with a 2-month history of abdominal pain in the right upper quadrant, 40-pound weight …

Supportive Care Team Challenges On The Border In The Pandemic, Meghana Rao, Andrew N. Dentino

Research Colloquium

Background: Hospice and Palliative Medicine (HPM) is a subspecialty of medicine, recognized in 2008 by the ABMS, with over 200 fellowship programs nationally. This Supportive Care Team (SCT) interprofessional paradigm of MD’s, NP’s, PA’s, MSW’s, Pharm.D.’s, chaplains, RN’s and therapists holistically cares for persons with advanced life-limiting illnesses.

UTRGV SOM and DHR Health, in extreme south Texas on the border with Mexico, inaugurated the HPM fellowship in 2019. Its current fellow began in 2021.

The intent of the fellowship was for care and services to flow uninterruptedly throughout the RGV. However, in early 2020 the world changed indelibly due to …

Euglycemic Diabetic Ketoacidosis In A Patient Using Sodium-Glucose Cotransporter-2 Inhibitor (Sglt 2 Inhibitor), Mays F. Abdulazeez, Alain Velazquez, Daniel Ibarias Paz, Aileen Aguilar, Baldemar Gonzalez, Heidi Pareja, Sunand Kallumadanda

Research Colloquium

Background: Diabetic Ketoacidosis (DKA) is a life-threatening complication of Diabetes Mellitus type-1 and occasionally type-2 diabetes, associated with high blood glucose levels>250 mg/dl. Normal glucose levels in all diabetic patients may delay diagnosis and management of DKA and result in increased morbidity and mortality.

Case Presentation: A 68-year-old male having a medical history of Diabetes Mellitus type-2, atrial fibrillation, aortic stenosis status post total valve replacement, coronary artery disease, gastric bypass surgery, and previous stroke presented with two episodes of hematemesis a few hours prior to admission. The patient denied using drugs or ingestion of methanol, ethylene glycol, and …

Rate Control Is The Key-Tachycardia Induced Cardiomyopathy, Maria Najam, Shadi Jafari-Esfahani, Nevin Varghese

Research Colloquium

Introduction: Tachycardia-induced cardiomyopathy is the systolic dysfunction that results from tachyarrhythmias. It presents symptoms of heart failure and can be reversed with rate control or normalization to sinus rhythm. The aim of presenting this case report is to the awareness of tachycardia-induced cardiomyopathy, which if recognized early can be reversed by the treatment.

Case Presentation: A 62-year-old male with a history of tobacco use presented with orthopnea, palpitations, and exertional dyspnea. A month ago, he was seen by his primary care physician for palpitations and was diagnosed with new-onset atrial fibrillation. There was a gradual progression of his exertional symptoms …

Development Of A Novel Fluorescent Nir Probe For Cancer Bioimaging, Neeraj Chauhan, Marco A. Cabrera, Silverio A. Lopez, Karen S. Martirosyan, Meena Jaggi, Subhash C. Chuahan, Murali M. Yallapu

Research Colloquium

Background: Optimal cancer bioimaging is imperative and come in various forms, ranging from screening to detection and surgical guidance. Current imaging tools being used are not cancer-specific and tend to expose patients to radiation. Therefore, there is a crucial need to develop newer and safer imaging modalities. Near InfraRed fluorescence (NIRF) agents have been gaining great attraction for cancer imaging in the past years, because of their high resolution/sensitivity, low cost, and real-time visualization/imaging capabilities without ionizing radiation. Hence, NIRF-based cancer imaging counterpoises some of the obstacles elicited by traditional imaging. Indocyanine green (ICG) is the only FDA approved NIR …

Inpatient Palliative Care Utilization In Sickle Cell Disease: Temporal Trends And Factors Associated With Usage, Lois C. Akpati

Research Colloquium

Background: Sickle cell disease (SCD) is a highly morbid condition notable for recurrent hospitalizations due to vaso-occlusive crises and complications of end-organ damage. Palliative care (PC) aims to provide holistic care to patients with serious chronic illnesses. Little is known about the use of inpatient palliative care services in adult patients with SCD.

Methods: We conducted a retrospective cross-sectional study utilizing data from the National Inpatient Sample (NIS) from 2008-2017. Patients >18 years old hospitalized with a primary or secondary ICD-9-CM and ICD-10-CM diagnosis of SCD were included. Outcome of interest was PC service utilization using ICD-9-CM and ICD-10-CM diagnosis …