Medicine and Health Sciences Commons^™

A Broadly Reactive Antibody Targeting The N-Terminal Domain Of Sars-Cov-2 Spike Confers Fc-Mediated Protection, Lucas J Adams, Laura A Vanblargan, Zhuoming Liu, Pavlo Gilchuk, Haiyan Zhao, Rita E Chen, Saravanan Raju, Zhenlu Chong, Bradley M Whitener, Swathi Shrihari, Prashant N Jethva, Michael L Gross, James E Crowe Jr., Sean P J Whelan, Michael S Diamond, Daved H Fremont

2020-Current year OA Pubs

Most neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs targeting the N-terminal domain (NTD) or other non-RBD epitopes of S. A subset of NTD mAbs inhibits SARS-CoV-2 entry at a post-attachment step and avidly binds the surface of infected cells. One neutralizing NTD mAb, SARS2-57, protects K18-hACE2 mice against SARS-CoV-2 infection in an Fc-dependent manner. Structural analysis demonstrates that SARS2-57 engages an antigenic supersite that is remodeled by deletions common to emerging variants. In neutralization escape studies with SARS2-57, this NTD site accumulates mutations, including …

Autophagy Gene-Dependent Intracellular Immunity Triggered By Interferon-Γ, Michael R Mcallaster, Jaya Bhushan, Dale R Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang, Meagan E Sullender, L David Sibley, Herbert W Virgin

2020-Current year OA Pubs

Interferon-γ (IFNγ) is a critical mediator of cell-intrinsic immunity to intracellular pathogens. Understanding the complex cellular mechanisms supporting robust interferon-γ-induced host defenses could aid in developing new therapeutics to treat infections. Here, we examined the impact of autophagy genes in the interferon-γ-induced host response. We demonstrate that genes within the autophagy pathway including

Parasympathetic Activity And Bronchial Hyperresponsiveness In Athletes, Audrey Badza

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Bronchial hyperresponsiveness (BHR) is a term used to describe the bronchial constriction response to environmental stimuli. BHR is increasingly common in endurance athletes due to increased exposure to some stimuli. The purpose of this review is to evaluate Stang et al.'s (2016) article, "Parasympathetic Activity and Bronchial Hyperresponsiveness in Athletes" and discuss the significance of their results. The results concluded that BHR is related to the parasympathetic activity of the heart rather than the pupils. The study concluded that there is an association between BHR and parasympathetic activity of the heart, methacholine is associated with BHR and cardiac vagal activity, …

Review Of: Better Safe Than Sorry: Real-Life Stories, Tips, And More–A Guide To Everyday Safety—Mike Atnip, Nathan Shrock

Journal of Amish and Plain Anabaptist Studies

This book was written from an Anabaptist perspective geared towards a younger Christian Anabaptist and seems directed at an Amish audience. The book has six different sections relating to various parts of home and farm life. The goal of this book is to encourage the Anabaptist community to use more thought in what risks they take. The sections are as follows: Home and Community, Fire Safety, Farm and Logging Safety, Shop and Construction Safety, Gun/Hunting Safety, and Road Safety. I will be addressing each section individually and giving a summary of my thoughts at the end. Atnip does not specify …

Review Of: Caring For The Low German Mennonites: How Religious Beliefs And Practices Influence Health Care—Judith Kulig, Christina Klassen Jeffries

Journal of Amish and Plain Anabaptist Studies

My personal interest in reviewing this particular book is that I am a Low German speaking Mennonite involved in healthcare. As a disclaimer, I am not super fluent in the language. I was also not technically raised in the culture as described in this book, but I live in this community and know many people in this culture. As a healthcare worker, I was interested in reading this book to see what would be applicable to my practice. I was also curious how the book would apply to living in the Low German community. [First paragraph.]

Review Of: Pull Through Blessings: The Colorful Tapestry Of Hirschsprung’S Disease—Lisa Sensenig And Helen Zimmerman, Adin Stauffer

Journal of Amish and Plain Anabaptist Studies

Hirschsprung’s Disease (HD) is a genetic condition found in a child born without ganglion cells in part of the intestines. Ganglion cells send signals to intestinal muscles to contract to help pass bowel movements. No signal means no bowel movement, which results in babies not eating, becoming uncomfortable and sleepy, spitting up, and if not treated, eventually dying. [First paragraph.]

Plain Anabaptists And Covid-19: A Distinct Response To Government Restrictions?, Michael Sauder

Journal of Amish and Plain Anabaptist Studies

Plain Anabaptists have a distinct way of relating to the government. Does that mean they would have distinct decision making processes in relation to government-promulgated public health restrictions regarding COVID-19? This essay argues that plain Anabaptist populations did not exhibit particularly unique decision-making and responses to COVID-19.

Promoting Culturally Accessible, Community-Centered, Midwifery Care In The Rural Anabaptist Population Of Southwestern Ontario, Canada, Cynthia Soulliere

Journal of Amish and Plain Anabaptist Studies

The experience of providing midwifery care in a rural Southwestern Ontario community is discussed, highlighting specific approaches to providing culturally accessible and community-centered care among the Old Order Anabaptists. Midwives in Ontario are primary care providers for perinatal care and the clinic described in this paper works primarily with families from Anabaptist communities. Success in providing culturally accessible care has come from community engagement and responsiveness to ways to improve access to healthcare in this region. Highlighted in this article are the scope of midwifery care in Ontario, home and hospital births, collaboration with other community agencies, and community-based genetic …

Mother’S Hope: A Residential Program Caring For Plain Mothers With Mental Health Challenges, Renee Bright, Naomi Raber

Journal of Amish and Plain Anabaptist Studies

Mother’s Hope is a culturally sensitive residential program of hope and healing for plain Anabaptist mothers struggling with postpartum depression and anxiety. The home is situated in central Ohio and run by paid staff and Amish volunteers. While in residence, mothers get intensive attention from professional counseling and medical staff at nearby SpringHaven Counseling Center. This home is unique in that mothers are permitted to keep their infants with them in the home so that mother-child bonding is not interrupted while they receive mental health treatment. Several women, former residents at Mother’s Hope, shared their stories, which are included in …

Oil Therapy Massage As Complementary Care Of Burns And Wounds, Tristate Burn Care Team, Rosanna Hess

Journal of Amish and Plain Anabaptist Studies

Oil therapy massage is a part of the care of burns and wounds done by plain, lay caregivers in Amish and Mennonite communities across the United States and Canada. Oil therapy massage is used to manage scarring and to improve joint functionality and skin and tissue integrity. The purpose of this article is to describe oil therapy massage as a complementary part of after-burn care in the context of sociocultural values of plain populations in which caregivers are a part of the B&W movement. This article includes a brief description of the caring and sharing culture of plain peoples; a …

Attitudes Toward The Amish Held By Nursing And Social Work Students At A Midwestern University, Lora Wyss, Rosanna Hess

Journal of Amish and Plain Anabaptist Studies

As Amish populations increase and move across North America, the likelihood grows that healthcare professionals will come into contact with them. No studies have been conducted to examine contact frequency with or attitudes of healthcare providers toward the Amish. The aims of this study were to examine attitudes toward the Amish among nursing and social work students attending a Christian liberal arts university in a Midwestern state, and, to determine the relationship between students’ cultural awareness, their knowledge of the Amish, their contact with the Amish, and their attitudes toward the Amish. The participants were anonymously surveyed using the Revised …

Partnering With The Old Order Mennonites In The Finger Lakes Region Of New York State To Identify The Mechanisms Of Protective Immunity Against Atopic Disease Development, Alexandra N. Kaplan, Camille A. Martina, Elizabeth R. Catlin, John Looney, Kirsi M. Järvinen

Journal of Amish and Plain Anabaptist Studies

Old Order Mennonites (OOM) follow a traditional agrarian lifestyle; key aspects include home births, large families, limited antibiotic usage, consumption of whole foods and unpasteurized milk, and early exposure to soil, stables, and farm animals. There is evidence that a farming lifestyle protects against asthma and allergies, yet the biological mechanisms behind this protective effect remain unknown. The “Zooming into Old Order Mennonites” (ZOOM) cohort study was established to further explore protective factors and mechanisms. This study compares immune development among OOM children from the Finger Lakes Region of New York to those residing 65 miles northwest in Rochester, NY. …

Vitamin D Status Of Anabaptist Children In Southwestern Ontario, Canada, Janis A. Randall Simpson, Natalee Miller, Taylor Hartwig, Jane Leach, Melissa Purdy, Emily Roth, Victoria Mok Siue, Cynthia Soulliere, Jacqui Tam, Ann Watt

Journal of Amish and Plain Anabaptist Studies

The objective was to determine vitamin D status of Old Order Anabaptist children in rural Southwestern, Ontario, Canada, given concerns of community healthcare professionals. Fifty-two children (2.5 months - 6.5 years) (56% female) were recruited. Finger prick blood spot (BSp) samples were analyzed for 25-hydroxy (OH) vitamins D2 & D3 (BSp25(OH)D). Three-day food records were evaluated using Dietary Reference Intakes and Canada’s Food Guide (CFG) (Bush, et al. 2007). Compared to national Canadian data: mean BSp25(OH)D concentrations (78±31 nmol/L) were similar; a slightly smaller proportion (0% vs 2%) were at risk of deficiency (<30 nmol/L) or had inadequate status (4% vs 7%) (<40 nmol/L); and 10% vs 1% had BSp25(OH)D higher than 125 nmol/L. BSp25(OH)D was significantly associated (r2=0.358; p=0.001) with total vitamin D intake. From food alone, vitamin D intake was 68±39 IU/day, lower than the Recommended Dietary Allowance (RDA) of 600 IU/day, and intakes were all below the Estimated Average Requirement (EAR) of 400 IU. Even including supplemental vitamin D, 87% were below the EAR (total intake=213±194 IU/day). No children had vitamin D intakes greater than the Upper Limit. Servings of milk and alternates were 1.6±0.8/day (CFG=2/day). Unfortified farm milk was consumed by 88% of children and 89% received a vitamin D supplement. Results were comparable to recent Canadian data suggesting that most children have adequate vitamin D status. Nevertheless, these findings support the need to encourage appropriate vitamin D intake (from food and supplements) to achieve the RDA for Old Order Anabaptist children in these communities. [Abstract by authors.]

Health Beliefs, Health Practices, And Health-Seeking Behaviors Among Swartzentruber Amish In Clark County, Wisconsin, Courtney J. Schoessow

Journal of Amish and Plain Anabaptist Studies

Although the literature contains valuable information about Amish culture, few qualitative studies have been conducted on the health beliefs, health practices, and health-seeking behaviors of the Swartzentruber Amish, the most conservative group of Old Order Amish. The purpose of this study was to describe these dynamics for the Swartzentruber Amish of Clark County, Wisconsin. Utilizing the grounded theory approach, 25 participants were interviewed and seven themes were identified: shared decision-making is common in families; causes of illness are believed to be etiological or the will of God; home remedies are the first choice; preventive medicine is an unfamiliar concept; health …

Assessing The Attitudes And Perceptions Of The Old Order Amish Toward Genetic Testing For Familial Defective Apolipoprotein B-100, Erin Sutcliffe, Laura J. Conway, Alan Shuldiner, Toni Pollin

Journal of Amish and Plain Anabaptist Studies

Through a founder effect, one in eight Lancaster County, PA, Amish harbors the pathogenic APOB variant R3527Q, causing Familial Defective Apolipoprotein B-100 (FDB) that is rare in the general population. Affected individuals are at increased risk for high low density lipoprotein (LDL) cholesterol levels and cardiovascular disease and may benefit from early screening and treatment. A qualitative interview approach was used to investigate the genetic risk perceptions of the Amish and their attitudes towards genetic testing for FDB. The goal was to identify elements necessary for a successful program that would identify high risk individuals in the Lancaster County Amish …

Health And Healthcare Among The Plain Anabaptist People, Rosanna Hess, Braxton Mitchell

Journal of Amish and Plain Anabaptist Studies

This issue of the Journal of Amish and Plain Anabaptist Studies (JAPAS) marks the eleventh year of publication of this journal, the flagship journal of the Amish & Plain Anabaptist Studies Association (APASA). In the past we have devoted entire issues to specific topics, including Beachy Amish-Mennonite churches [2017 5(1)], past and future directions of Amish studies [2017 5(2)], Ohio Amish schisms [2019 7(2)], gender-focused research [2020 8(2)], agriculture and the environment [2021 9(2)], and the plain people at midcentury [2023 11(1)]. In addition, the 2018 6(2) issue included a special section on health among the Amish. This …

Bi-Negativity: An Assessment Of Negativity Surrounding Bisexuality From The Lgbtq+ And Heterosexual Communities, Whitney R. Ford

The Confluence

This study was conducted to test the hypothesis that negative attitudes towards bisexual people (bi-negativity) exists within the LGBTQ+ and heterosexual communities and to determine if levels of bi-negativity are higher within the LGBTQ+ group. I administered the Gender-Based Attitudes Towards Bisexuality (GBAB) Scale by Nielsen et al. (2022) to measure bi-negativity using an online survey. The results, obtained from 87 participants who identify as LGBTQ+ and 121 participants who identify as heterosexual between the ages of 18 and 80, support my hypothesis that bi-negativity exists within both groups. However, contrary to my second hypothesis, higher levels of bi-negativity were …

Regulation Of Mirnas In Obesity And Diabetes, Eva Maher, Ava O'Meara, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The prevalence of obesity and obesity-related secondary disorders has increased dramatically in recent years. Dysregulated microRNA (miRNA) expression has been linked to the development of obesity and its associated disorders. Adipose derived stem cells (ADSCs) are promising cell models of obesity, obesity-related inflammation and diabetes. Furthermore, miRNA expression profiles have emerged as promising targets for the novel treatment of diseases such as obesity. In order to enhance miRNA-based therapies, the miRNA expression profile of obesity and its related disorders must be monitored to further understand the underlying mechanisms of obesity and to identify novel targets.

Aim: The aim of …

The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. Symptoms of Multiple Sclerosis include sensory loss, fatigue, cognitive dysfunction, spasticity, depression, optic neuritis, gait ataxia, diplopia, and loss of bladder control. Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. Stem cells have emerged as promising approaches for Multiple Sclerosis therapeutics. Clinical trials primarily focus on mesenchymal stem cell-based therapies for Multiple Sclerosis. Furthermore, …

Tiny But Mighty, An Exploration Of Microbes And Plants As Sources Of Small Novel Bioactive Compounds Against Invasive Mycoses., Hannah Mai Peacock, James Anthony O'Connor

SURE Journal: Science Undergraduate Research Experience Journal

Despite the high mortality rate involved with invasive cerebral mycoses, there is a relative lack of research available around antifungals capable of crossing the blood brain barrier.

In this study the metabolites of four plants (Crocus vernus, Miniature Narcissus (daffodil), Osmanthus delavayi and Taraxacum officinale (common dandelion)) and two bacteria (Lacticaseibacillus paracasei and Staphylococcus epidermidis) were extracted and assayed for antifungal activity against Candida albicans and Saccharomyces cerevisiae. Thin layer chromatography and bioautography were then employed to assess the activity of the constituent components of sources showing antifungal activity.

Metabolites of S.epidermidis, and extracts …

Editorial - Sure Journal Vol 5, Anne M. Friel

SURE Journal: Science Undergraduate Research Experience Journal

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Listening – A Possibility For Improved Healthcare, Sam Katzif

Turning Toward Being: The Journal of Ontological Inquiry in Education

The conversation between a healthcare provider and a patient is one component of obtaining information for diagnosis and treatment. Responsibility rests with healthcare providers to actively lead this conversation so this exchange of information is accurate and complete with nothing added to and nothing left out. The question then becomes, “Do the words of the patient land word for word with their practitioner?”. In the world of “being” or ontology the answer is no. This article will focus on an ontological perceptual constraint known as Already-Always-Listening and introduce the practice of Authentic Listening as access to a transformation in healthcare …

Efficacy Of Modified Psychotherapy To Mitigate Depression Among African American Adults And Older Adults: A Systematic Review, Bridget Ashaolu, Nassrine Noureddine

Pacific Journal of Health

It has been established that due to several factors, African American adults and older adults in the United States respond poorly to pharmacologic intervention in treating depression. The study will help to provide evidence and raise awareness on how to better serve the African American population with depression. This systematic review of the literature examines the effectiveness of using modified evidence-based psychotherapy and faith-based resources in improving depression among older African American adults over the use of conventional pharmacological intervention. 21 studies that recommended utilizing psychotherapy intervention to improve depression in this population were reviewed to better understand the need …

Nucleus Accumbens Core Single Cell Ensembles Bidirectionally Respond To Experienced Versus Observed Aversive Events, Oyku Dinckol, Noah Harris Wenger, Jennifer E Zachry, Munir Gunes Kutlu

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Fear learning is a critical feature of survival skills among mammals. In rodents, fear learning manifests itself through direct experience of the aversive event or social transmission of aversive stimuli such as observing and acting on conspecifics' distress. The neuronal network underlying the social transmission of information largely overlaps with the brain regions that mediate behavioral responses to aversive and rewarding stimuli. In this study, we recorded single cell activity patterns of nucleus accumbens (NAc) core neurons using in vivo optical imaging of calcium transients via miniature scopes. This cutting-edge imaging methodology not only allows us to record activity patterns …

Distance From A Cultural Model Of Substance Use Risk, Internalization, And Self-Stigma In Urban Brazil, Nicole L. Henderson, William W. Dressler, Natalia Priolli Jora Pegoraro, Ana Falcao, Sandra Cristin Pillon

APC Fund

Introduction: A cognitive theory of culture as socially distributed cultural models has proven useful in research. Cultural models exist in two forms: the model shared by individuals in a social group, and individual versions of that model modified by personal experience. In previous research we documented a shared cultural model of substance use risk among a general population sample in urban Brazil. Here we examine how this model is distributed among persons under treatment for substance use/misuse and the implications for perceived and self-stigma.

Methods: A convenience sample of 133 persons under treatment rated the influence of risk factors for …

Intouch Week Of December 18, 2023, New York Medical College

InTouch

• Future Healers: 2023 Forum Highlights Medical Student Research
• Dr. Mitchell Cairo Awarded $2.6 Million Grant from Department of Defense for Pediatric Cancer Research
• Long COVID Patients at Greater Risk for Anxiety and PTSD New Study Finds
• NYMC Unveils the Portrait and Diploma of Alumnus Meyer J. Simon, M.D. ’25
• NYMC AMWA Chapter Hosts Medical Mavens Workshop
• Student Spotlight: Mentorship Propels Medical Student on Successful Research Path

Covid-19’S Current Impact On Telehealth Usage, Omar Saadi, Muhammed El Shanatofy

URGENT Matters

No abstract provided.

Cross-Cultural Dyads In The Psychotherapy Room, Sebastian Del Corral Winder, Katrina Spontak, Mixalis Poulakis

Midwest Social Sciences Journal

Therapeutic outcome is often impacted by the psychotherapeutic relationship throughout treatment. These outcomes are mediated by the client’s belief in the psychotherapist’s trust, comfort, and competency while navigating mental health concerns. Cultural differences can impact a client’s perspective on all three factors and thus impact the psychotherapeutic relationship and success of treatment. The Accent Prestige Theory has noted that individuals who speak English with a Latin American Spanish accent are perceived as less competent, friendly, and trustworthy by White individuals in the United States. While this theory has been examined in select contexts, there is no previous work related to …

Editorial; Biophysics Approaches To Investigate Multi-Organ Alcohol-Induced Damage, Janos Paloczi, Youngchan Kim

School of Graduate Studies Faculty Publications

No abstract provided.

Safety And Immunogenicity Of An In Vivo Muscle Electroporation Delivery System For Dna-Hsp65 Tuberculosis Vaccine In Cynomolgus Monkeys, Monique Ribeiro De Lima, Ana C. Leandro, Andreia Lamoglia De Souza, Marcio Mantuano Barradas, Eric Henrique Roma, Ana Teresa Gomes Fernandes, Gabrielle Galdino-Silva, Joyce Katiuccia M. Ramos Carvalho, Renato Sergio Marchevsky, John L. Vandeberg

School of Medicine Publications

A Bacille Calmette–Guérin (BCG) is still the only licensed vaccine for the prevention of tuberculosis, providing limited protection against Mycobacterium tuberculosis infection in adulthood. New advances in the delivery of DNA vaccines by electroporation have been made in the past decade. We evaluated the safety and immunogenicity of the DNA-hsp65 vaccine administered by intramuscular electroporation (EP) in cynomolgus macaques. Animals received three doses of DNA-hsp65 at 30-day intervals. We demonstrated that intramuscular electroporated DNA-hsp65 vaccine immunization of cynomolgus macaques was safe, and there were no vaccine-related effects on hematological, renal, or hepatic profiles, compared to the pre-vaccination parameters. No tuberculin …