Medicine and Health Sciences Commons^™

Newer Insights Into Mmtv Replication: The Human Retroviral Proteins Hiv-1 Tat And Htlv-1 Tax Can Transactivate The Mmtv Novel 5’ Element, Thanumol Abdul Khader

Dissertations

The mouse mammary tumor virus (MMTV) is a prototypic betaretrovirus that causes breast cancer in mice. MMTV regulates its gene expression both at the transcriptional and post transcriptional levels. It has hormonally-regulated promoters controlled by negative regulatory factors in a tissue-specific manner. Recently, we identified a novel 24-nucleotide region at the 5' end of the MMTV genome crucial for MMTV gene expression. Its deletion resulted in disruption of MMTV transcript elongation and stability, leading to a complete loss of Gag gene expression. This conserved element is present within the bifurcated stem loop 4, responsible for gRNA dimerization and encapsidation, into …

Quad Bike Injuries In The United Arab Emirates: Evidence For Injury Prevention Strategies, Preetha Menon Karuveetil

Dissertations

Quad bikes, also known as All-Terrain Vehicles (ATVs), are versatile vehicles designed for navigating uneven terrain. Originally intended for agricultural purposes, they have gained popularity for recreational use, particularly in the middle east, notably the United Arab Emirates (UAE). While these vehicles offer health benefits, they are associated with substantial safety risks, resulting in injuries ranging from lacerations to severe traumatic injuries, imposing a significant economic burden on healthcare systems.

This research addresses a critical gap in the existing literature by focusing on quad bike injuries in the unique context of the UAE, taking into account its desert environment, rider …

Effects Of Adropin On Metabolic Parameters, Oxidative Stress, And Cell Proliferation In Animal Model Of Diabetes Mellitus, Ifrah Ismail Ali

Dissertations

Diabetes Mellitus (DM) is a major health condition that has reached alarming levels, affecting around 537 million of the global adult population. DM is a group of metabolic diseases characterized by hyperglycemia with disturbance in carbohydrate, fat, and protein metabolism. The proposed therapeutic options for DM are different according to their mechanism of action, and peptide therapy is one of these options. Adropin, a peptide hormone involved in energy homeostasis, has shown promising results in the treatment of diabetes by lowering fasting blood glucose, reducing insulin resistance, and minimizing fat storage. Moreover, it has been demonstrated that adropin is engaged …

Blood Culture Versus Antibiotic Use For Neonatal Inpatients In 61 Hospitals Implementing With The Nest360 Alliance In Kenya, Malawi, Nigeria, And Tanzania: A Cross-Sectional Study, Sarah Murless-Collins, Kondwani Kawaza, Nahya Salim, Elizabeth Molyneux, Msandeni Chiume, Jalemba Aluvaala Aluvaala, William Macharia, Veronica Chinyere Ezeaka, Opeyemi Odedere, Donat Shamba

Paediatrics and Child Health, East Africa

Background: Thirty million small and sick newborns worldwide require inpatient care each year. Many receive antibiotics for clinically diagnosed infections without blood cultures, the current ‘gold standard’ for neonatal infection detection. Low neonatal blood culture use hampers appropriate antibiotic use, fuelling antimicrobial resistance (AMR) which threatens newborn survival. This study analysed the gap between blood culture use and antibiotic prescribing in hospitals implementing with Newborn Essential Solutions and Technologies (NEST360) in Kenya, Malawi, Nigeria, and Tanzania.

Methods: Inpatient data from every newborn admission record (July 2019–August 2022) were included to describe hospital-level blood culture use and antibiotic prescription. Health Facility …

Breastfeeding Support In Your Pocket: Evaluating The Impact Of A Mobile App On Maternal Success, Maygan Brandt

Nursing | Student Research Posters

No abstract provided.

The Effect Of Nursing Education On The Utilization Of Kangaroo Mother Care And Weight Gain Of Preterm And Low Birth Weight Infants, Jhenalynn Valete

Nursing | Student Research Posters

Kangaroo Mother Care (KMC), often referred to as skin-to-skin contact, is an intervention for preterm and low birth weight infants, involving the practice of the mother or caregiver holding the newborn against their bare chest (Cleveland Clinic, 2023). This is a cost-effective and natural way to enhance health outcomes such as temperature regulation, weight gain, respiratory function, pain mitigation, and facilitation of breastfeeding for the neonate (Jefferies et al., 2012).

Nursing staff may have limited knowledge regarding KMC which creates challenges in effectively educating parents. This information prompts the following question: “Can Nurse Education about the Importance of Kangaroo Mother …

Furry Friends & Brighter Futures: Enhancing The Life Skills Of Toddlers With Autism Through Animal Assisted Therapy, Abigail Tolentino

Nursing | Student Research Posters

No abstract provided.

Culinary Medicine And The Promotion Of Plant-Based Diets: Is Caution Needed For Older Adults?, Wendy J. Dahl, Sayaka Nagao-Sato, Christina Riccardo

Nutrition Faculty Publications

Culinary Medicine (CM), which combines food, cooking, and the science of medicine1 for the management of chronic disease conditions, is an emerging practice area for health professionals, particularly physicians.2 Culinary skills and food-disease-related knowledge are enhanced by CM training3 ; however, there is much to learn regarding optimal program outcome measures.4 What cannot be gained from a CM program is the comprehensive nutrition knowledge that may be needed to ensure CM prescriptions result in benefits and minimize harm. This may be particularly important for older adults.

Assessing The Neuropsychiatric Sequelae Of Ketamine After Use For Acute Agitation, Steven Sun Md, Henry Slone, Katherine B. Martin Md, Edward R. Norris Md, Fapa, Fapm

Department of Psychiatry

No abstract provided.

Survival Of Cervical Cancer Patients At Moi Teaching And Referral Hospital, Eldoret In Western Kenya, E Mwaliko, P. Itsura, A. Keter, N. Buziba, H. Bastiaens, A. Jackie, A. Obala, V. Naanyu, P. Gichangi, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background Cervical cancer is a major health burden and the second most common cancer after breast cancer among women in Kenya. Worldwide cervical cancer constitutes 3.1% of all cancer cases. Mortality rates are greatest among the low-income countries because of lack of awareness, screening and early-detection programs and adequate treatment facilities.

The main aim was to estimate survival and determine survival predictors of women with cervical cancer and limited resources in western Kenya.

Methods Retrospective charts review of women diagnosed with cervical cancer and follow-up for two years from the date of the histologic diagnosis. The outcome of interest was …

Inflammation And Fibrosis In Orbital Inflammatory Disease: A Histopathologic Analysis., Rohan Verma, Allison J Chen, Dongseok Choi, David J Wilson, Hans E Grossniklaus, Roger A Dailey, John D Ng, Eric A Steele, Stephen R Planck, Craig N Czyz, Bobby S Korn, Don O Kikkawa, Jill A Foster, Michael Kazim, Gerald J Harris, Deepak P Edward, Azza Al Maktabi, James T Rosenbaum

Surgery Articles

PURPOSE: The purpose of this study was to compare the histopathologic inflammation and fibrosis of orbital adipose tissue in orbital inflammatory disease (OID) specimens.

METHODS: In this retrospective cohort study, inflammation, and fibrosis in orbital adipose tissue from patients with thyroid-associated orbitopathy (TAO), granulomatosis with polyangiitis (GPA), sarcoidosis, nonspecific orbital inflammation (NSOI), and healthy controls were scored by 2 masked ocular pathologists. Both categories were scored on a scale of 0 to 3 with scoring criteria based on the percentage of specimens containing inflammation or fibrosis, respectively. Tissue specimens were collected from oculoplastic surgeons at 8 international centers representing 4 …

Demonstrating The Benefits Of Antihypertensive Nighttime Dosing And Indapamide Usage In Hypertension Management, Jonathon S. Newsome

Pharmacy Faculty Publications and Presentations

Background: Uncontrolled hypertension, specifically nocturnal hypertension, increases the risk for significant clinical outcomes. Evidence on the use of nighttime antihypertensives is scant and conflicting. In addition, hydrochlorothiazide continues to be the primary thiazide used despite being the least potent. Objective: The primary purpose of this study was to evaluate instituting nighttime dosing to control hypertension and compare the short-term effectiveness of blood pressure control with indapamide versus hydrochlorothiazide. Methods: This was a retrospective, observational study. Participant inclusion criteria consisted of patients 18 years of age or older, a current diagnosis of hypertension, and hypertension that required medical therapy. The investigator …

Investigating The Association Between Mast Cell Activation Syndrome And Irritable Bowel Syndrome, Ishaan Jakhar, Maggie Urschler, Medha Singh, Suman Sahil, Hassan Ahmad

Posters

Investigating the Association between Mast Cell Activation Syndrome and Irritable Bowel Syndrome Introduction Mast Cell Activation Syndrome (MCAS) involves the inappropriate release of chemical mediators resulting in varied episodic symptoms. Irritable Bowel Syndrome (IBS) is a common functional abdominal disorder where mucosal immune alterations play a key role. Since mast cells function as gatekeepers for the intestinal interface, we examined what proportion of patients diagnosed with MCAS also had IBS along with comorbid risk factors. Methods All patients in our study were 18 years of age or older. We used Cerner Healthfacts to gather our cohorts of patients with MCAS, …

Psychosocial Factors Influencing The Mental Health And Maternal-Fetal Attachment In Pregnant Women During The Covid-19 Pandemic, Chinyere N. Reid

USF Tampa Graduate Theses and Dissertations

Background: Psychosocial distress, anxiety, depression, and reduced maternal-fetal attachment (MFA) during pregnancy can negatively affect the health of both mothers and their children. Stress during pregnancy is a significant risk factor for maternal mental health issues and low MFA. The global COVID-19 pandemic, which has resulted in millions of deaths worldwide, is a major stressor that has likely had a profound impact on maternal mental health and MFA during pregnancy.

Purpose: The purpose of this study was to examine the influence of COVID-19-related psychosocial factors on the mental health and MFA in pregnant women during the COVID-19 pandemic. This study …

Real-World Utilization Of An Intrauterine, Vacuum-Induced, Hemorrhage-Control Device., Dena Goffman, Kara M Rood, Angela Bianco, Joseph R Biggio, Paul Dietz, Kelly Drake, Erica Heilman, Maeve Hopkins, Monique De Four Jones, Tyler Katz, Courtney Martin, Mona Prasad, Marcela C Smid, Kathryn D Wine, Robert Ryan, Candice Yong, Patricia I Carney, Hyagriv N Simhan

Women’s Health Articles

OBJECTIVE: To assess the real-world effectiveness and safety of a U.S. Food and Drug Administration (FDA)-cleared intrauterine vacuum-induced-hemorrhage control device for postpartum hemorrhage (PPH) management.

METHODS: Sixteen centers in the United States participated in this observational, postmarket registry medical record review (October 2020 through March 2022). The primary effectiveness outcome was treatment success , defined as bleeding control after insertion with no treatment escalation or bleeding recurrence. Additional outcomes included blood loss, time to device insertion, indwelling time, bleeding recurrence, and time to bleeding control. Treatment success and severe maternal morbidity measures (transfusion of 4 or more units of red …

Α-Synuclein Is The Major Platelet Isoform But Is Dispensable For Activation, Secretion, And Thrombosis, Alexis N. Smith, Smita Joshi, Harry Chanzu, Hammodah Rawhi Hammodah Alfar, Kanakanagavalli Shravani Prakhya, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Platelets play many roles in the vasculature ensuring proper hemostasis and maintaining integrity. These roles are facilitated, in part, by cargo molecules released from platelet granules via Soluble NSF Attachment Protein Receptor (SNARE) mediated membrane fusion, which is controlled by several protein-protein interactions. Chaperones have been characterized for t-SNAREs (i.e. Munc18b for Syntaxin-11), but none have been clearly identified for v-SNAREs. α- Synuclein has been proposed as a v-SNARE chaperone which may affect SNARE-complex assembly, fusion pore opening, and thus secretion. Despite its abundance and that it is the only isoform present, α-synuclein’s role in platelet secretion is uncharacterized. In …

Dentistry And The Law: Problems With Referral Incentives Explained, Dan Schulte Jd

The Journal of the Michigan Dental Association

Incorporating referral incentives in dentistry, like gift cards or raffles, can present ethical and legal issues. The MDA's ethical rule 4.E prohibits rebates or fee splitting, extending to any referral source, including patients. Gift cards may be perceived as rebates. Raffle tickets are less problematic, but only the winner gains something of value. State law (MCL 333.16221) deems fee division unethical. For insurance and dental plan agreements, check for clauses mandating specific fee schedules and discouraging referral fees to ensure compliance. Federal laws might also apply if incentives are used for Medicaid or Medicare patients.

Dean's Research Newsletter, November 2023, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

Sar Study Of Niclosamide Derivatives For Neuroprotective Function In Sh-Sy5y Neuroblastoma, Shizue Mito, Benxu Cheng, Benjamin A. Garcia, Xin Yee Ooi, Daniela Gonzalez, Tess C. Ruiz, Francisco X. Elisarraras

School of Medicine Publications

Neurodegenerative disease is a debilitating and incurable condition that affects millions of people around the world. The loss of functions or malfunctions of neural cells are the causes of mortality. A proteosome inhibitor, MG132, is well known to cause neurodegeneration in vitro when model neuronal-derived cell lines are exposed to it. Niclosamide, an anthelmintic drug, which has been used to treat tapeworm infections for more than 50 years, has recently attracted renewed attention in drug repurposing because it has been found to be a good candidate in many drug development screenings. We recently found that all markers of MG132-induced neuronal …

12-Month Substance Use Disorders Among First-Year University Students In Kenya, Florence Jaguga, Muthoni Mathai, Caroline Ayuya, Ongecha Francisca, Catherine Mawia Musyoka, Jasmit Shah, Lukoye Atwoli

Brain and Mind Institute

Objectives: The period of entry into university represents one of vulnerability to substance use for university students. The goal of this study is to document the 12-month prevalence of substance use disorders among first year university students in Kenya, and to test whether there is an association between substance use disorders and mental disorders.

Methods: This was a cross-sectional online survey conducted in 2019 and 2020 as part of the World Health Organization’s World Mental Health International College Student (WMH-ICS) survey initiative. A total of 334 university students completed the survey. Descriptive statistics were used to summarize the demographic characteristics …

Effect Of 24-H Blood Pressure Dysregulations And Reduced Ocular Perfusion Pressure In Open-Angle Glaucoma Progression, Jesus D. Melgarejo, Jan V. Eijgen, Dongmei Wei, Gladys E. Maestre, Lama A. Al-Aswad, Chia-Te Liao, Luis J. Mena, Thomas Vanassche, Stefan Janssens, Peter Verhamme

School of Medicine Publications

Background:

Low ocular perfusion pressure (OPP), which depends on the mean arterial pressure (MAP) and intraocular pressure (IOP), is associated with glaucoma. We studied 24-h MAP dysregulations and OPP in relation to the progression of glaucoma damage.

Methods:

We retrospectively analyzed 155 normal-tension glaucoma (NTG) and 110 primary open-angle glaucoma (POAG) patients aged 18 years old followed at the University Hospital Leuven with repeated visual field tests (n = 7000 measures, including both eyes) who underwent 24-h ambulatory blood pressure monitoring. Twenty-four-hour MAP dysregulations were variability independent of the mean (VIM), and the five lowest dips in MAP readings …

Invisible In Plain Sight: A Qualitative Analysis Of The U.S. Public Health Service Syphilis Study And Contemporary Issues Of Iatrophobia In Black Women, Krystal Morgan

Undergraduate Student Research Fellowship

The U.S. Public Health Service Syphilis Study (USPHSSS) is the nation’s most infamous example of biomedical misconduct in the United States. Using the wives and the descendants of the USPHSSS as a case study, this project examines and conceptualizes how the lack of healthcare access and secondhand healthcare the wives and descendants received has had a cumulative impact on Black women and contemporary iatrophobia, using a Black feminist ethical and constructivist theoretical framework. Findings reflect two major themes for contemporary iatrophobia: systemic racism and what Muhjah Shakir terms the cultural constellation of silence.

Les Effets Du Changement Climatique Sur La Santé : Expériences Vécues Par Des Jeunes Du Bangladesh, Du Guatemala Et Du Nigeria, Population Council, Women Deliver

Adolescents and Young People

No abstract provided.

El Impacto Del Cambio Climático En La Salud: Experiencias De La Juventud De Bangladesh, Guatemala Y Nigeria, Population Council, Women Deliver

Adolescents and Young People

No abstract provided.

El Impacto Del Cambio Climático En Los Medios De Subsistencia Y En Las Oportunidades Educativas De La Juventud, Population Council, Women Deliver

Adolescents and Young People

No abstract provided.

En Quoi Le Changement Climatique Contribue-T-Il À Façonner Les Moyens De Subsistance Et Les Possibilités D'Éducation Des Jeunes?, Population Council, Women Deliver

Adolescents and Young People

No abstract provided.

Diverse Clinical Manifestations And Challenges Of Mucormycosis: Insights From Serial Cases, Marisa C Nielsen, Filipe M Cerqueira, Sri Bharathi Kavuri, Caitlin M Raymond, Aeman Muneeb, Andrzej S Kudlicki, Shafaq Tariq, Mingru Liu, Andrew L Routh, Suimin Qiu, Ping Ren

Faculty, Staff and Student Publications

Background: Regulation of mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in aging and nutrition. For example, caloric restriction reduces mTORC1 signaling and extends lifespan, whereas nutrient abundance and obesity increase mTORC1 signaling and reduce lifespan. Skeletal muscle-specific knockout (KO) of DEP domain-containing 5 protein (DEPDC5) results in constitutively active mTORC1 signaling, muscle hypertrophy and an increase in mitochondrial respiratory capacity. The metabolic profile of skeletal muscle, in the setting of hyperactive mTORC1 signaling, is not well known.

Objectives: To determine the metabolomic and lipidomic signature in skeletal muscle from female and male wild-type (WT) and DEPDC5 …

Collaborative Practices Between General Education Teachers And Teachers Of The Deaf/Hard Of Hearing: A Narrative Inquiry, Kayla Power

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The US Individuals with Disabilities Education Act (2004) states that students with disabilities should receive instruction in the general education classroom as much as possible. This move has resulted in Deaf/Hard of Hearing (DHH) students spending more of their time in the general education classroom which has increased the need for collaboration between Teachers of the Deaf (TODs) and general education teachers. The purpose of this qualitative study is to examine what collaboration between TODs and general education teachers looks like in an elementary school setting. Data consisted of individual interviews and observations. Using a narrative inquiry approach, I restory …

The Application Of Electrosprayed Minocycline-Loaded Plga Microparticles For The Treatment Of Glioblastoma, Marco Antonio Arriaga, Juan A. Amieva, Jaqueline Quintanilla, Angela C. Jimenez, Julio Ledezma, Silverio A. Lopez, Karen S. Martirosyan, Sue Anne Chew

Health & Biomedical Sciences Faculty Publications

The survival of patients with glioblastoma multiforme (GBM), the most common and invasive form of malignant brain tumors, remains poor despite advances in current treatment methods including surgery, radiotherapy, and chemotherapy. Minocycline is a semi-synthetic tetracycline derivative that has been widely used as an antibiotic and more recently, it has been utilized as an antiangiogenic factor to inhibit tumorigenesis. The objective of this study was to investigate the utilization of electrospraying process to fabricate minocycline-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles with high drug loading and loading efficiency and to evaluate their ability to induce cell toxicity in human glioblastoma (i.e., U87-MG) …

Whole Genome-Based Dna Methylation Profiling In Covid-19 Patients Reveals Alterations In Pathways Linked To Neurological Dysfunctions, Syed Zameer, Juozas Gordevicius, Eman Anis, Qiong Sha, Martha L. Escobar Galvis, Michael Henderson, Andrew Pospisilik, Patrik Brundin, Stewart Graham

Conference Presentation Abstracts

The sever acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a highly transmissible viruswhich causes a life-threatening illness called coronavirus (COVID-19). It has cost millions ofdeath worldwide. This novel RNA betacorona virus is manifested by varying clinical symptomsranging from asymptomatic to mild to severe systemic illness with deadly outcomes. Muchevidence revealed the differences in the severity of COVID-19 infection varied widely accordingto host factors and comorbidities. It is critical to understand the interplay of genetic and epigeneticfactors and host response to this fatal virus. A substantial number of epigenome-wide associationstudies acknowledged that SARS-CoV-2 manipulate the host epigenome via DNA methylation …