Medicine and Health Sciences Commons^™

Pre-Visit Planning In Primary Care, Suzanne Allman, Melissa Tillman, Breanne Thielges, Melissa Diaz, John Frewing, Susan Bopp, Ozlem Kadar

Nursing Research and EBP Day 2023

Pre-visit planning is the process of collecting and organizing data prior to a patient appointment. The pre-visit planning process requires a team member to call the patient a week before the appointment through the use of a questionnaire form. This helps identify incomplete tests, screenings, immunizations and referrals that are currently outstanding. The pre-visit process results in scheduling needed appointments and lab work as well as gathering necessary information from the patient to streamline their upcoming visit. The use of pre-visit planning may result in improved patient satisfaction and decreased physician time with each patient visit.

Re-Evaluating Mobilization Practices And Their Impact On Hapis, Erin Christopher, Mary Prochaska, Luna Pierre, Lindsay Santucci, Kenny Van Ryn, Francheska Santiago

Nursing Research and EBP Day 2023

Hospital acquired pressure injuries (HAPIs) contribute to longer length of stay, poor clinical outcomes and increased healthcare costs.

A literature review showed that the implementation of visual cues to identify patients who require assistance with mobility and positioning in addition to the implementation of scheduled turn teams could have a positive health impact for the patients at RGH and reduce HAPIs incidence. Research suggests that educating unlicensed staff to recognize patient Braden Scale scores and to provide daily care based on risk factors for skin breakdown may lead to improved clinical outcomes.

The Big Picture: Use Of Photography As Standard Documentation, Megan Tebo, Rhianon Lester

Nursing Research and EBP Day 2023

Photos of surgical wounds when included in documentation can assist the clinician in providing appropriate care and help engage the patient in their care. Incorporating photos into documentation provides a consistent timeline of wound changes and can help the clinician identify issues in a timely manner and may provide a method to involve the patient in their care. An additional benefit of wound photos is the prevention of potential legal issues as it demonstrates that the quality of care received is appropriate. If medical malpractice were to result, photos add to proper documentation.

When the decision is made to include …

Nurse Led Mobility/Exercise Program, Elizabeth Schneider, Sarah Koopman, Marissa Sharp, Victoria Dempsey, Elizabeth Rudy, Melissa Combs, Dena Chapman

Nursing Research and EBP Day 2023

Question: Can an individualized nurse led exercise/mobility program in hospitalized elderly, age 75 and older prevent functional decline, decrease LOS and prevent institutionalization to SNF?

Hypothesis: Current practice is one mobility champion for 3 or 4 inpatient medical surgical units to ambulate or mobilize patients in a 262/300 bed hospital (NWH/CSH). No formal exercise program is in place unless there is an order for PT. This current practice leaves elderly age 75 and older at risk for functional decline and adverse outcomes. It was hypothesized that a nurse driven mobility program in the patients care plan for mobile, non- mobile …

Postoperative Deep Vein Thrombosis Prevention, Jaidin Degraw, Carrie Elliott, Cailey Jeffery, Melina Leone, Amber Mallory

Nursing Research and EBP Day 2023

The prevention of deep vein thrombosis (DVT) remains a primary concern for providers. While prophylactic heparin has been routinely prescribed, other forms of prevention such as early ambulation and pneumatic compression are now being used. This project sought to identify which method of DVT prophylaxis is more effective in providing safe patient care and reducing hospital stay. Based on the literature that was reviewed, the use of dual prophylactic measures may be more beneficial than a single preventative measure. As always, more research is warranted.

“My Mummy Has A Hole In Her Face”: Living With Facial Eye Disfigurement, Zali O'Dea, Jane Southcott

The Qualitative Report

People living with facial eye disfigurements (LwFED) are often shunned by a society that makes spontaneous judgements based on appearance. This article is a case study of the lived experience of Toni, a 27-year-old woman LwFED, the result of her treatment for ocular cancer. Semi-structured interviews facilitated the exploration of her experiences. We present the findings chronologically but interwoven with themes such as: being strong for others; responding to her partner’s abuse; dealing with strangers; and reinventing her sense of identity and supporting others. We identified institutional perspectives of work, hospital, and family within the prevailing UK that impacted Toni’s …

Virtual Delivery Of Stress Management And Resiliency Training (Smart) During The Covid-19 Pandemic To Hematology/Oncology Fellows: A Pilot Study, Colt Williams, Sherry Chesak, Deirdre R. Pachman, Ross Dierkhising, Laura Rhee, Konstantinos Leventakos

Journal of Wellness

Introduction: Medical trainees experience a high degree of stress that predisposes them to burnout. This pilot study tested a scalable approach to deliver a validated resilience program (Stress Management and Resiliency Training (SMART)) among Hematology/Oncology fellows at an academic medical center.

Methods: This was a mixed-methods, prospective, single-arm clinical trial involving Hematology/Oncology fellows at Mayo Clinic in Rochester, MN, USA. Four one-hour training sessions were conducted virtually with 26 fellows. Stress, burnout, and emotional resilience were measured at baseline, three months, and six months post-intervention using the Perceived Stress Scale (PSS-10), Maslach Burnout Inventory (MBI-HSS), and Connor-Davidson Resilience …

Ethiopian Residents’ Attitudes Toward Dermatology Research: A Survey Study, Rishab R. Revankar, Heli A. Patel, Joo Yeon Shin, Alice B. Gottlieb, Loren D. Krueger, Benjamin K. Stoff

Student Papers, Posters & Projects

Dermatology programs in resource-limited settings manage high patient volumes.1 Trainees have extensive clinical responsibilities, which may preclude engaging in research. Programs in such settings may lack the infrastructure to provide adequate support. At the Department of Dermatovenereology at the University of Gondar in Ethiopia, residents anecdotally report a high caseload and lack of resources, including time, to pursue research. Members of Emory and Mount Sinai Dermatology designed and delivered a 30-minute presentation about research design and methods. Residents were surveyed pre- and postintervention about their attitudes toward pursuing dermatology research during residency

In Situ Profiling Reveals Metabolic Alterations In The Tumor Microenvironment Of Ovarian Cancer After Chemotherapy, Sara Corvigno, Premal H Thaker, Et Al.

2020-Current year OA Pubs

In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients with high-grade serous ovarian cancer (HGSC) who had poor response (PR) or excellent response (ER) to NACT were examined. Desorption electrospray ionization mass spectrometry (DESI-MS) was performed on sections of HGSC tissues collected according to a rigorous laparoscopic triage algorithm. Quantitative MS-based proteomics and phosphoproteomics were performed on a subgroup of pre-NACT samples. Highly abundant metabolites in the pre-NACT PR tumors were related to pyrimidine metabolism in the epithelial regions and oxygen-dependent proline …

Management Of Chronic Pain And Ptsd In Veterans With Tdcs+Prolonged Exposure: A Pilot Study, Melba A Hernandez-Tejada, Kathryn E Cherry, Sheila A M Rauch, Ron Acierno, Gabriel R Fries, Wendy Muzzy, Ellen J Teng, Bethany Wangelin, Hyochol Ahn

Faculty, Staff and Student Publications

Introduction: Chronic pain and posttraumatic stress disorder (PTSD) are prevalent comorbid conditions, particularly in Veterans; however, there are few integrated treatments for chronic pain and PTSD. Instead, interventions are typically implemented separately and may involve addictive opioids. Although there are highly effective, non-pharmacological treatments for PTSD, they are plagued by high dropout, which may be exacerbated by comorbid pain, as these PTSD treatments typically require increased activity. Importantly, a noninvasive pain treatment, tDCS (transcranial direct current stimulation) shows indications of effectiveness and may be integrated with psychological treatments, even when delivered via telehealth. This study examines the feasibility and initial …

Neglected Tropical Disease Vaccines: Hookworm, Leishmaniasis, And Schistosomiasis, Peter J Hotez, Maria Elena Bottazzi, Paul M Kaye, Bruce Y Lee, Karl Philipp Puchner

Faculty, Staff and Students Publications

No abstract provided.

Discovery, Structure-Activity Relationship And In Vitro Anticancer Activity Of Small-Molecule Inhibitors Of The Protein-Protein Interactions Between Af9/Enl And Af4 Or Dot1l, Xin Li, Xiaowei Wu, Shenyou Nie, Jidong Zhao, Yuan Yao, Fangrui Wu, Chandra Bhushan Mishra, Md Ashraf-Uz-Zaman, Bala Krishna Moku, Yongcheng Song

Faculty, Staff and Students Publications

Simple Summary

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene generate potent fusion oncogenes and cause acute myeloid leukemia or lymphocytic leukemia, which account for ~75% infant and 5–10% child/adult acute leukemia cases with a poor prognosis (5-year survival rates < 45%). Protein–protein interactions between the most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are critical to malignant gene expression and are therefore a potential drug target for cancer. Compound screening followed by medicinal chemistry studies identified several novel small-molecule inhibitors showing strong inhibition of these protein–protein interactions, significant suppression of characteristic gene expression, and robust cellular anticancer activities with negligible cytotoxicity. These compounds are useful chemical probes for biological studies of these protein–protein interactions, as well as pharmacological leads for further drug development against MLL-rearranged and other leukemias.

Abstract

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause 5–10% acute leukemias with poor clinical outcomes. Protein–protein interactions (PPI) between the most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are drug targets for MLL-rearranged (MLL-r) leukemia. Several benzothiophene-carboxamide compounds were identified as novel inhibitors of these PPIs with IC₅₀ values as …

In Situ Profiling Reveals Metabolic Alterations In The Tumor Microenvironment Of Ovarian Cancer After Chemotherapy, Sara Corvigno, Sunil Badal, Meredith L Spradlin, Michael Keating, Igor Pereira, Elaine Stur, Emine Bayraktar, Katherine I Foster, Nicholas W Bateman, Waleed Barakat, Kathleen M Darcy, Thomas P Conrads, G Larry Maxwell, Philip L Lorenzi, Susan K Lutgendorf, Yunfei Wen, Li Zhao, Premal H Thaker, Michael J Goodheart, Jinsong Liu, Nicole Fleming, Sanghoon Lee, Livia S Eberlin, Anil K Sood

Faculty, Staff and Student Publications

In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients with high-grade serous ovarian cancer (HGSC) who had poor response (PR) or excellent response (ER) to NACT were examined. Desorption electrospray ionization mass spectrometry (DESI-MS) was performed on sections of HGSC tissues collected according to a rigorous laparoscopic triage algorithm. Quantitative MS-based proteomics and phosphoproteomics were performed on a subgroup of pre-NACT samples. Highly abundant metabolites in the pre-NACT PR tumors were related to pyrimidine metabolism in the epithelial regions and oxygen-dependent proline …

Personal Factors And Baseline Function In Patients Undergoing Non-Operative Management For Chronic Hip-Related Groin Pain: A Cross-Sectional Study, Rebecca D Demargel, Karen Steger-May, Simon Haroutounian, Patricia Zorn, Abby Cheng, John C Clohisy, Marcie Harris-Hayes

2020-Current year OA Pubs

AIM: Little is known about the relationship between personal factors and perception of hip-related function among patients with chronic hip-related groin pain (HRGP) seeking non-operative management. This analysis was performed to determine if depressive symptoms, central sensitisation, movement evoked pain (MEP), pressure hypersensitivity and activity level were associated with patients' perception of hip-related function, represented by the International Hip Outcome Tool (iHOT-33).

METHODS: This cross-sectional study used baseline data from a pilot randomised clinical trial. Participants had anterior hip symptoms for at least 3 of the past 12 months reproduced on examination. Depressive symptoms, central sensitisation and activity level were …

Segregated Patterns Of Hospital Care Delivery And Health Outcomes, Sunny C Lin, J. Gmerice Hammond, Michael Esposito, Cassandra Majewski, Randi E Foraker, Karen E Joynt Maddox

2020-Current year OA Pubs

IMPORTANCE: Residential segregation has been shown to be a root cause of racial inequities in health outcomes, yet little is known about current patterns of racial segregation in where patients receive hospital care or whether hospital segregation is associated with health outcomes. Filling this knowledge gap is critical to implementing policies that improve racial equity in health care.

OBJECTIVE: To characterize contemporary patterns of racial segregation in hospital care delivery, identify market-level correlates, and determine the association between hospital segregation and health outcomes.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study of US hospital referral regions (HRRs) used 2018 Medicare claims, …

Diagnostic And Commensal Staphylococcus Pseudintermedius Genomes Reveal Niche Adaptation Through Parallel Selection Of Defense Mechanisms, Sanjam S Sawhney, Rhiannon C Vargas, Meghan A Wallace, Carol E Muenks, Brian V Lubbers, Stephanie A Fritz, Carey-Ann D Burnham, Gautam Dantas

2020-Current year OA Pubs

Staphylococcus pseudintermedius is historically understood as a prevalent commensal and pathogen of dogs, though modern clinical diagnostics reveal an expanded host-range that includes humans. It remains unclear whether differentiation across S. pseudintermedius populations is driven primarily by niche-type or host-species. We sequenced 501 diagnostic and commensal isolates from a hospital, veterinary diagnostic laboratory, and within households in the American Midwest, and performed a comparative genomics investigation contrasting human diagnostic, animal diagnostic, human colonizing, pet colonizing, and household-surface S. pseudintermedius isolates. Though indistinguishable by core and accessory gene architecture, diagnostic isolates harbor more encoded and phenotypic resistance, whereas colonizing and surface …

Effects Of Running On Femoral Articular Cartilage Thickness For Anterior Cruciate Ligament Reconstruction Patients And Non-Aclr Control Subjects, Aubree L. Remmel, Hyunwook Lee, Minsub Oh, Seunguk Han, Steven P. Allen, Garritt L. Page, Dustin A. Bruening, Robert D. Hyldahl, J. Ty Hopkins, Matthew K. Seeley

International Journal of Exercise Science: Conference Proceedings

Anterior cruciate ligament reconstruction (ACLR) patients are more likely to develop posttraumatic knee osteoarthritis than non-ACLR counterparts. The effect of running on femoral articular cartilage thickness is unclear. PURPOSE: The purpose of this study was to compare how 30 minutes of running influences femoral articular cartilage thickness for ACLR patients and non-ACLR control subjects. We hypothesized that running would deform the femoral articular cartilage more for the ACLR patients than for the control subjects. METHODS: We recruited 20 individuals with primary unilateral ACLR and 20 matched non-ACLR controls. ACLR patients and control subjects were matched based upon age, gender, BMI, …

Influence Of Air Resistance On Ground Reaction Forces During Treadmill Running, Jared Steele, Iain Hunter

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Running is fundamentally driven by forces applied to the ground, eliciting ground reaction forces (GRFs) which accelerate the runner. These GRFs are divided into vertical, anteroposterior, and mediolateral components. As running speed alters, so do the patterns of these forces. By juxtaposing these GRF patterns with metabolic data, we can discern how movement patterns adapt across different running conditions. One of the key distinctions between treadmill and overground running is the influence of air resistance. METHODS: The study involved twenty-four active male runners experienced in achieving a sub-17-minute-5km or equivalent performance. The main objective was to examine the influence …

Environmental Heat Stress And Physiological Heat Strain In Construction Workers During Work In The Summer, Jonathan Specht, Erica Tourula, M. Jo Hite, Serena Garcia, Charlie Walker, Hillary Yoder, Zachary Schlader, Fabiano Amorim

International Journal of Exercise Science: Conference Proceedings

Construction workers are thirteen times more likely to die from heat-related illnesses compared to the general population. This elevaled risk results from both metabolic heat production due to the physical demands of construction work associated with high environmental heat stress. However, it is important to recognize that the magnitude of heat stress experienced varies across job types withing the construction industry reflecting the diversity of tasks performed. In addition, environmental heat stress can significantly vary for workers based on whether they operate in covered or uncovered work areas, creating varying levels of heat sttres, particularly during during summer months. Notably, …

Physical Function In Young And Older Adult Active Pickleball Players, Leighanne T. Paulson, Eric Martin, Kent J. Adams Facsm, Marcus M. Lawrence

International Journal of Exercise Science: Conference Proceedings

Limited information exists on pickleball’s impact on physical function in adults, especially older adults (65+ years), despite reported health benefits. PURPOSE: This study evaluated the physical function of active older adult (OA) female and male recreational pickleball players via handgrip strength and fatigue, 6-minute walk distance (6MWD) test, as well as the short physical performance battery (SPPB) compared to sex-matched young adult (YA) controls. METHODS: Thirty YA (18-26 years; n=15 female/male) participants and 27 OA (65-89 years; n=13 female, n=15 male) participants who played pickleball at least three times per week were assessed for physical function outcomes of …

Effects Of Aerobic Exercise On Individulas With Down Syndrome Via Telerehabilitation, Zeel K. Patel Miss, Isha Gautami, Namrata Jain, Jacob Hinkel-Lipsker Professor

International Journal of Exercise Science: Conference Proceedings

BACKGROUND: Most of the children and adolescents with Down’s syndrome (DS) have poor aerobic capacity, physical fitness and demonstrate diminished cognitive abilities. Recent studies suggest that increased physical activity may prove to be important for maintaining components of cognition, including memory along with physical fitness.

In addition, there is interest among practitioners in determining the efficacy of virtual exercise classes, which can be more convenient for clients. However, it is unknown whether group exercise classes delivered over videoconferencing achieve desired outcomes—particularly in special populations such as those with DS.

PURPOSE: The purpose of this study is to evaluate the effect …

The Risk Of Bias In Validity And Reliability Studies Testing Physiological Variables Using Consumer-Grade Wearable Technology: A Systematic Review And Wear-Bot Analysis, Bryson Carrier, Jennifer Bunn, Joel D. Reece, Charli D. Aguilar, Chris Eschbach, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

INTRODUCTION: Wearable technology is a quickly evolving field, and new devices with new features to measure/estimate physiological variables are being released constantly. Despite their use, the validity of the devices are largely unknown to the users or researchers, and the quality of the studies that do test validity and reliability vary widely. PURPOSE: Therefore, the purpose of this systematic review was to review the current validity and reliability literature concerning consumer-grade wearable technology measurements/estimates of physiological variables during exercise. Additionally, we sought to perform risk of bias assessments utilizing the novel WEArable technology Risk of Bias and Objectivity Tool (WEAR-BOT). …

The Effect Of Ibuprofen On Thermoregulatory Responses And Gastrointestinal Distress To Exercise In Hot Environments, Alyssa Bailly, Jonathan Specht, Serena Garcia, Steven Klepacz, Suzana Andrade De Oliveira, David Lucero, Fabiano Amorim

International Journal of Exercise Science: Conference Proceedings

Ibuprofen, a commonly used nonsteroidal anti-inflammatory drug (NSAID) among athletes to alleviate pain and inflammation during exercise, is hypothesized to mitigate exercise-induced increases core temperature (Tc) and improve heat tolerance during exercise in hot environments. However, its prophylactic use specially during exercise associated with heat stress may lead to harmful effects specifically inducing gastrointestinal complications such upper-GI bleeding. PURPOSE: To investigate the effect of ibuprofen on thermoregulatory responses and the occurrence of gastrointestinal symptoms to exercise in a hot environment. METHODS: In a double-blind, randomized, counterbalanced cross-over design, 6 endurance trained males and females (n=12) completed 60-minutes of treadmill running …

Heat Strain In Road Construction Workers During The Summer, An Observational Study, Serena Garcia

International Journal of Exercise Science: Conference Proceedings

Road construction workers perform physically demanding, typically including building frames, laying concrete and asphalt, and operating heavy machinery. These activities result in high metabolic demands, leading to significant internal heat production. When combined with environmental heat stress during warmer periods of the year, road construction workers may experience substantial heat strain, making them susceptible to heat-related illnesses and ultimately heat-related deaths. In fact, construction workers are 13 times more likely to die from heat related illness compared to other occupations. Despite these statistics, no studies have assessed heat strain in road construction workers during the summer. PURPOSE: To quantify …

Effects Of Biodensity Training On Bone Adaptations In Young Women: A Pilot Study, Carolina M. Garcia, Auguste Torres, Braulio Cazarez, Rosalinda Escobar-Prado, Maurice Cruz, Zhaojing Chen

International Journal of Exercise Science: Conference Proceedings

Osteopenia and osteoporosis are a major public health issue in the United States, and current research suggests that moderate to high intensity resistance training is the most effective type of exercise for maintaining bone mineral density (BMD). Sclerostin is a protein secreted by osteocytes which potently inhibits bone formation by binding to the LRP4 in Wnt/β-catenin signaling. BioDensity is a novel resistance training machine that consists of four exercises performed for five seconds each, which applies mechanical loading to the bone and provides a quicker alternative to traditional resistance training. PURPOSE: To examine the effects of 12 weeks of …

Repeated, Short Cold-Water Immersions Are Sufficient To Habituate To The Cold, But Do Not Lead To Adaptations During Exercise In Normobaric Hypoxia, Geoffrey T. Dorsett, Trevor L. Gillum

International Journal of Exercise Science: Conference Proceedings

Cold and hypoxia naturally exist together, yet it is unknown if habituation to the cold can lead to improved exercise in hypoxia. PURPOSE: To assess the effects of repeated cold-water immersions (CWI) on pulmonary, metabolic, and sympathoadrenal responses to graded exercise in hypoxia. METHODS: 16 (2 female) participants (age: 21.2 ± 1.3 years; body fat: 12.3 ± 7.7 %; body surface area 1.87 ± 0.16 m², VO_2peak: 48.7 ± 7.9 mL/kg/min) underwent 6 CWI in 12.0 ± 1.2° C. Each CWI was 5 minutes, twice daily, separated by ≥4 hours, for 3 consecutive days, …

Femoral Articular Cartilage Quality, But Not Thickness, Is Decreased For Anterior Cruciate Ligament Reconstruction Patients Relative To Control, Dallin Clinger, Hyunwook Lee, Seunguk Han, Minsub Oh, Steven P. Allen, Garritt L. Page, Dustin A. Bruening, Robert D. Hyldahl, J. Ty Hopkins Facsm, Matthew K. Seeley Facsm

International Journal of Exercise Science: Conference Proceedings

Anterior cruciate ligament reconstruction (ACLR) patients are at risk of developing posttraumatic knee osteoarthritis (OA). The etiology of posttraumatic knee OA is complex, potentially involving biomechanical and biochemical factors. Changes in femoral cartilage thickness and composition are associated with knee OA, while current research is ambiguous on cartilage in ACLR patients. PURPOSE: This study aimed to compare femoral cartilage thickness and T2 relaxation time (a compositional measure) between ACLR patients and healthy controls in a resting state. We hypothesized that ACLR patients would exhibit thinner femoral cartilage and increased T2 relaxation times. METHODS: Twenty ACLR patients (6-24 months post-surgery) and …

Trauma, Identity, And Vietnamese Diaspora: Using The Medicine Wheel As A Healing-Focused Conflict Analysis Framework, Ha B. Dong

Peace and Conflict Studies Journal Conference

No abstract provided.

10 Minute Presentations Agenda (Pdf), Graduate Studies

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

The 2nd Annual Dr. Joseph Moerschbaecher, III Graduate Research Day 10 Minute Presentation Competition agenda and participants slideshow.

Urobiome Screening For Antimicrobial Peptides Against Uropathogenic Escherichia Coli, Jennifer Jones

ORBioM (Open Research BioSciences Meeting)

BACKGROUND: Urinary tract infections (UTIs) are one of the most common bacterial infections worldwide. As global incidences of UTIs caused by multidrug resistant bacteria continue to increase, so too does the demand for novel antimicrobial therapies.

Due to its relatively understudied nature, the urinary microbiome represents a niche with an untapped source of potentially novel antimicrobials (e.g., bacteriocins). Improvements to bacterial culturing and sequencing techniques have highlighted these potential alternative treatments and control strategies to target antibiotic resistant uropathogenic E. coli (UPEC).

METHODS: Expanded quantitative urine culture (EQUC) was used to culture bacterial isolates from mid-stream urine samples. Urinary isolates …