Exploration Of Cancer Associated Fibroblasts Phenotypes In The Tumor Microenvironment Of Classical And Pleomorphic Invasive Lobular Carcinoma, Harsh Batra, Qingqing Ding, Renganayaki Pandurengan, Heladio Ibarguen, Neus Bota Rabassedas, Aysegul Sahin, Ignacio Wistuba, Edwin Roger Parra, Maria Gabriela Raso

Faculty, Staff and Student Publications

UNLABELLED: As the second most common subtype of breast carcinoma, Invasive Lobular Carcinoma (ILC) microenvironment features have not been thoroughly explored. ILC has different histological subtypes and elucidating differences in their microenvironments could lead to a comprehensive development of cancer therapies. We designed a custom-made cancer associated fibroblast (CAFs) panel and used multiplex immunofluorescence to identify the differences in tumor microenvironment between Classic ILC and Pleomorphic ILC.

MATERIALS AND METHODS: Multiplex immunofluorescence were performed on formalin fixed paraffin embedded tissues using Opal-7 color kit. The antibodies used for phenotyping CAFs were Pan CK (AE1/AE3), CD45, A-SMA, FAP, S100, Thy-1 with …

Phantom-Based Quality Assurance Of A Clinical Dose Accumulation Technique Used In An Online Adaptive Radiation Therapy Platform, Borna Maraghechi, Thomas Mazur, Dao Lam, Alex Price, Lauren Henke, Hyun Kim, Geoffrey D Hugo, Bin Cai

2020-Current year OA Pubs

PURPOSE: This study aimed to develop a routine quality assurance method for a dose accumulation technique provided by a radiation therapy platform for online treatment adaptation.

METHODS AND MATERIALS: Two commonly used phantoms were selected for the dose accumulation QA: Electron density and anthropomorphic pelvis. On a computed tomography (CT) scan of the electron density phantom, 1 target (gross tumor volume [GTV]; insert at 6 o'clock), a subvolume within this target, and 7 organs at risk (OARs; other inserts) were contoured in the treatment planning system (TPS). Two adaptation sessions were performed in which the GTV was recontoured, first at …

Evaluation Of A Complexity-Based Morphosyntactic Treatment For Children With Language Disorders Of Mixed Etiologies, Kirsten M. Russell

Faculty Publications

Language disorder is characterized by difficulty with the comprehension and production of different aspects of language. School-aged children with developmental language disorder (DLD) and school-aged children with Down syndrome (DS) demonstrate similar deficits in the area of morphosyntax, which often creates barriers during social interactions and for academic learning. Although affected children may receive intervention, progress can be slow. Selecting appropriate treatment targets is critical for effective intervention. Traditional approaches for selecting treatment targets are based on developmental readiness (i.e., developmental) or functional need (i.e., remedial). However, intervention utilizing targets selected by these methods produce only modest results, despite a …

Diabetes-Related Major And Minor Amputation Risk Increased During The Covid-19 Pandemic., Dominick J Casciato, Sara Yancovitz, John Thompson, Steven Anderson, Alex Bischoff, Shauna Ayres, Ian Barron

Heart and Vascular Articles

BACKGROUND: Along with significant case transmission, hospitalizations, and mortality experienced during the global severe acute respiratory syndrome coronavirus 2 pandemic, there existed a disruption in the delivery of health care across multiple specialties. We studied the effect of the pandemic on inpatients with diabetic foot problems in a Level I trauma center in central Ohio.

METHODS: A retrospective chart review of patients necessitating a consultation by the foot and ankle surgery service were reviewed from the first 8 months of 2020. A total of 270 patients met the inclusion criteria and were divided into prepandemic (n = 120) and pandemic …

Case Report: It's Not Always About The Veins; Intervention Of Bilateral May-Thurner Syndrome Secondary To Iliac Aneurysm., Syed H Haq, Sidra R Shah, Jaya Chandra, Pavithra Kannan, Sandeep M Patel

Heart and Vascular Articles

May-Thurner Syndrome (MTS) remains evasive because of the insidiousness and variable etiologies by which it can manifest. In this study, we examine a unique presentation of MTS resulting from compression of both common iliac veins by a right common iliac artery aneurysm that required complex endovascular venous and arterial intervention.

Human Fatalities Resulting From Wild Pig Attacks Worldwide: 2000–2019, John J. Mayer, James E. Garabedian, John C. Kilgo

Human–Wildlife Interactions

Although reported to be rare, human fatalities resulting from wild pig (Sus scrofa) attacks do occur. Toward a better understanding of patterns in fatal wild pig attacks, we synthesized worldwide reports of wild pig attacks on humans between 2000 and 2019. We documented 163 separate reports of fatal wild pig attacks that resulted in 172 human deaths. On average, 8.6 human deaths occurred annually due to wild pig attacks during those 2 decades. The majority of fatal attacks resulted in a single human death; however, there were 6 cases in which an individual fatal attack resulted in 2–4 …

The Path To U.S. National Registration Of A Toxic Bait For The Control Of The Small Indian Mongoose, Carmen C. Antaky, Steven C. Hess, Emily W. Ruell, Israel L. Leinbach, Shane R. Siers, Robert T. Sugihara

Human–Wildlife Interactions

The small Indian mongoose (Urva auropunctata [syn. Herpestes auropunctatus]; mongoose) is a highly invasive species in its introduced range that negatively impacts ecosystems. Mongooses depredate native species, serve as a vector of disease posing a risk to human health, and cause sanitation issues in food processing facilities and public areas. Introduced for biocontrol in the late 1800s in Hawaiʻi and the Caribbean, mongooses currently have well-established populations across multiple islands in both island archipelagos and have invaded numerous other locations throughout the world. The concern of accidental introduction to mongoose-free islands, the difficulty in species detection, and the …

Still, We Thrive: Understanding How Gay, Bisexual, Transgender, And Other Men Who Have Sex With Men (Gbtmsm) Experience Structural Barriers & Facilitators To Wellness, Lucas Gergyek

Theses and Dissertations (Comprehensive)

Historically and concurrently, structural violence has been a significant force influencing the sexual health and broader health of gay, bisexual, transgender and other men who have sex with men (GBTMSM). Yet to date, the majority of projects exploring the health inequities facing GBTMSM have focused on intrapsychic and behavioural factors as most related to poor health outcomes. As well, these studies are sometimes deficits focused, and fail to evaluate how GBTMSM continue to thrive, and maintain positive health. As a result, the ways in which systems and policies underlie and perpetuate health inequities facing GBTMSM have been somewhat obscured. Connectedly, …

Disrupting And Expanding The Discourse: Palliative Care Clinicians' Experiences With Patients' Non-Physical Suffering, Maxxine Rattner

Theses and Dissertations (Comprehensive)

While one of the primary aims of palliative care is to prevent and relieve suffering, both physical and non-physical, research to date has been very limited re: clinicians’ experiences with patients’ non-physical suffering (e.g., suffering that may be psychological, emotional, social, spiritual and/or existential in nature); both how clinicians work with/respond to this kind of suffering in their day-to-day work, and the effect of this aspect of their work on clinicians themselves. No research to date has considered the impact of palliative care’s dominant non-physical suffering discourse — which presents the relief of non-physical suffering as falling along a binary …

Anxiety And Uterine Artery Doppler Flow In A Population Of Pregnant Women Of High Risk Down Syndrome Fetus: A Prospective Cohort Study, Mahboobeh Shirazi, Mehnoosh Torkzaban, Margan Ghaemi, Maryam Moshfeghi, Mahmood Shirazi, Maryam Emadzadeh, Lida Ahmadi, Zahra Khazaeipoor, Sara Mirzaeian

Department of Radiology Faculty Papers

Background: Fetal exposure to maternal anxiety is associated with low birth weight and maternal stress may be led to constriction of uterine arteries. This study compared the relation of anxiety and uterine artery doppler flow indices in pregnant women with the high and low-risk of Down syndrome.

Materials and methods: This prospective cohort study was conducted among pregnant women in the second trimester that were classified as having a high or low risk according to their prenatal aneuploidy screening outcome. The high risk group underwent amniocentesis. Anxiety was initially assessed using the Spielberger State-Anxiety Inventory (STAI) and uterine artery blood …

Contrast-Enhanced Ultrasound Li-Rads: A Pictorial Review, Osama Mahmoud, Ajay Makkena, Corinne E. Wessner, Ji-Bin Liu, John Eisenbrey, Andrej Lyshchik

Department of Radiology Faculty Papers

The American College of Radiology has implemented the Liver Imaging Reporting and Data System (LI-RADS) to help detect, interpret, and guide the management of suspected lesions on surveillance imaging for hepatocellular carcinoma (HCC) in patients with cirrhosis. The classification of indeterminate nodules with a grading algorithm can be used for multiple imaging modalities (US, CT, and MRI) and incorporates multiple imaging features to appropriately classify observations with different likelihood of being HCC. Contrast-enhanced ultrasound (CEUS) LI-RADS has been fully implemented since 2017. The aim of this pictorial article is to provide a comprehensive review of CEUS LI-RADS utilization, discuss its …

Parental Misattunement And The Production Of Shame Of Existing: How To Address The Shame Of Existing Through An Intersubjective Systems Approach, Tal Ginsburg

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Shame is at the root of many commonly encountered psychopathologies. Its development has often been attributed to early childhood emotional misattunement. In severe cases, individuals can develop an extreme form of shame called the “shame-of-existing”. This paper primarily intends to contribute to the limited research about the shame-of-existing, which includes psychoanalytic perspectives from 1950-1990s, and theoretical analysis in 2014. The concept of shame of existence will be explored through an in-depth case study analysis of a 31-year-old, heterosexual, cisgender, white male who presented to psychotherapy with low-self-worth, and shame in acknowledging his own emotions and needs. This client was treated …

Circulating Tumor Dna Sequencing Of Pediatric Solid And Brain Tumor Patients: An Institutional Feasibility Study, Ross Mangum, Jacquelyn Reuther, Koel Sen Baksi, Ilavarasi Gandhi, Ryan C Zabriskie, Alva Recinos, Robin Raesz-Martinez, Frank Y Lin, Samara L Potter, Andrew C Sher, Stephen F Kralik, Carrie A Mohila, Murali M Chintagumpala, Donna Muzny, Jianhong Hu, Richard A Gibbs, Kevin E Fisher, Juan Carlos Bernini, Jonathan Gill, Timothy C Griffin, Gail E Tomlinson, Kelly L Vallance, Sharon E Plon, Angshumoy Roy, D Williams Parsons

Faculty, Staff and Students Publications

The potential of circulating tumor DNA (ctDNA) analysis to serve as a real-time "liquid biopsy" for children with central nervous system (CNS) and non-CNS solid tumors remains to be fully elucidated. We conducted a study to investigate the feasibility and potential clinical utility of ctDNA sequencing in pediatric patients enrolled on an institutional clinical genomics trial. A total of 240 patients had tumor DNA profiling performed during the study period. Plasma samples were collected at study enrollment from 217 patients and then longitudinally from a subset of patients. Successful cell-free DNA extraction and quantification occurred in 216 of 217 (99.5%) …

A Systematic Review Of Treatments For Misophonia, Seth A Mattson, Johann D'Souza, Katharine D Wojcik, Andrew G Guzick, Wayne K Goodman, Eric A Storch

Faculty, Staff and Students Publications

Research into misophonia treatments has been limited and it is unclear what treatment approaches may be effective. This systematic review extracted and synthesized relevant treatment research on misophonia to examine the efficacy of various intervention modalities and identify current trends in order to guide future treatment research. PubMed, PsycINFO, Google Scholar, and Cochrane Central were searched 4using the keywords "misophonia," "decreased sound tolerance," "selective sound sensitivity," or "decreased sound sensitivity." Of the 169 records available for initial screening, 33 studied misophonia treatment specifically. Data were available for one randomized controlled trial, one open label trial, and 31 case studies. Treatments …

Corticosteroid-Laba Inhalers Increase Phonation Threshold Pressure (Ptp) And Flow (Ptf) In Rabbits, Christopher Dromey, Kristine Tanner, Heidi J. Robison, Maya Elena Stevens, Ray M. Merrill, Julie Barkmeier-Kraemer, Ben Christensen

Faculty Publications

Objectives: This study examined the effects of a combination corticosteroid plus long-acting beta2-adrenergic agonist inhaler (IC) on rabbit phonation. Methods: White New Zealand male rabbits were assigned randomly to experimental and control groups (n = 11 per group). The experimental group received twice-daily doses of Advair HFA™ (fluticasone propionate 45 mcg and salmeterol 21 mcg) via a veterinary facemask with 1-way valve and spacer; the control group received aerosolized saline. After 8 weeks, animals were euthanized, larynges excised, frozen, and subsequently thawed and mounted on a standard bench apparatus. Phonation was elicited during 15 successive trials, and phonation threshold pressure …

Teaching Non-Native Sound Contrasts Using Visual Biofeedback, Shawn L. Nissen

Faculty Publications

This demonstration will explain how non-native sound contrasts can be taught to second language (L2) learners using real-time visual biofeedback through an electropalatographic (EPG) sensor. How the EPG sensor is created from a dental mold and is subsequently produced will be shown during the presentation. An explanation of how a student can visualize the contact patterns of their speech and how a tutor might use the various features of the associated software to customize the instruction to an individual speaker will be illustrated during the presentation. Possible limitations, costs, and drawbacks to using the technology will also be discussed.

Similar Overall Expression, But Different Profiles, Of Autistic Traits, Sensory Processing, And Mental Health Between Young Adult Males And Females, Garrett Cardon

Faculty Publications

Recent trends suggest that autism is more common in females than traditionally held. Additionally, some argue that females express autistic traits differently than males. Dimensional views of autism could shed light on these issues, especially with regards to understudied behavioral areas, such as sensory processing. We examined autistic traits, sensory processing, anxiety, and related behaviors in a large sample of neurotypical young adult males and females (n = 1122; 556 female; ages 19–26). Participants completed an online survey containing questionnaires related to the above. Between groups statistical analyses, as well as within groups correlations and mediation analyses containing these constructs …

Uncertainty, Sensory Processing, And Stress In Autistic Children During The Covid-19 Pandemic, Garrett Cardon, Mollie Bradley

Faculty Publications

Background: COVID-19 increased uncertainty for most and was especially disruptive to autistic people and their families, due in part to tendencies toward intolerance for uncertainty across this population. As such, COVID presented a natural experiment of uncertainty and its correlates in autism. Previous reports have shown associations between intolerance of uncertainty, sensory difficulty, and stress. Aims: We investigated changes in sensory difficulties and stress associated with COVID-related increases in uncertainty. Methods and procedures: Primary caregivers of 47 autistic children (ages 6–15) completed online surveys containing questions about demographics, experiences, and supports received during the pandemic. Additionally, caregivers filled out measures …

Daily Rehabilitative Therapy For High-Risk Patients Leads To A Decrease In Post-Acute Rehab Discharges, Kelsey Bacon Pt, Dpt, Carlene Mull Ms, Otr/L, Daniel Sawyer Pt, Dpt, Michael Pechulis Pt, Dpt

Department of Medicine

No abstract provided.

Prosthetic Training For A Patient With Bilateral Lower Limb Amputation: Can Therapy Frequency Impact Functional Outcomes?, Rebecca Kleintop Pt, Dpt, Helen Yiu Pt, Dpt, Ocs

Department of Medicine

No abstract provided.

Importance Of Complete Assessment In The Work-Up Of Late Onset Mania, Sarah Mullen, William Lyons

EMET Projects

A female, age 78, with generalized anxiety disorder (GAD), history of major depression, and hypothyroidism presents for mood and anxiety concerns. Her mood is depressed, and sleep, appetite, energy, and concentration are poor. She recently saw a geriatric psychiatrist and described no past manic episodes, psychotic symptoms, or family history for bipolar disorder. No one has concerns about her cognition. She began levothyroxine 150 mcg 3 weeks ago for newly diagnosed hypothyroidism. On exam, she is talkative, overinclusive, has almost pressured speech, labile mood, and lid lag. Neuropsychology testing, CBC, and CMP are normal. TSH is 0.173. She is diagnosed …

Immunohistochemical Markers Of Temporomandibular Disorders: A Review Of The Literature, Luis Eduardo Almeida, Andrea Doetzer, Matthew L. Beck

School of Dentistry Faculty Research and Publications

Temporomandibular disorders (TMD) are a group of internal derangements encompassing dysfunction, displacement, degeneration of the temporomandibular joints and surroundings muscles of mastication, often accompanied by pain. Relationships between TMD and various chemical biomarkers have been examined throughout the years. This paper aims to gather evidence from the literature regarding other biomarkers and presenting them as one systematic review to investigate the potential links between TMD and different biochemical activity. To identify relevant papers, a comprehensive literature search was carried out in MEDLINE/PubMED, EMBASE, Web of Science and a manual search was performed in the International Journal of Oral and Maxillofacial …

Optimization Of The Modular Reinforced Bone Scaffold For Customized Alveolar Bone Defects, Meisam Omidi, Luis Eduardo Almeida, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A modular reinforced bone scaffold with enhanced mechanical properties has recently been developed by our group. It includes: 1) A load-bearing module: a skeleton which is made of a slowly degradable material, undertaking mechanical necessities of the scaffold, and 2) A bio-reactive module: a porous and biodegradable component undertaking biological necessities of the scaffold. The load-bearing module is placed into the bio-reactive module to reinforce it. This paper is dedicated to optimizing the load-bearing module for a certain customized alveolar bone defect. More specifically, a 3D-printed skeleton, made of polycaprolactone (PCL), is optimized based on the boundary conditions of the …

The Influence Of Decorin, A Potential Pro-Inflammatory Stimulant, On The Mechanical Properties Of The Annulus Fibrosus, Sabrina Sinopoli

Theses and Dissertations (Comprehensive)

Previous literature has investigated the biomechanical properties of various animal models, but few have studied an isolated and intact rat tail annulus fibrosus. Decorin, a class 1 small leucine-rich protein (SLRP) has the potential to trigger an inflammatory environment as previous research has shown that it may stimulate inflammation via the toll-like receptor (TLR) pathway. An increased inflammatory environment can have biomechanical implications for the disc, and so the ability of decorin to stimulate an environment that alters the mechanical properties of the disc was investigated.

The purpose of this study was to investigate the potential of decorin, a proteoglycan …

Ethical Dilemmas And Moral Distress In Companion Animal Veterinary Medicine: Mental Health Implications, Bronwyn Dickson

Theses and Dissertations (Comprehensive)

Mental health concerns are a significant problem in the veterinary community, and studies suggest that veterinarians working in Western countries are at higher risk of suicide compared to the general population and other healthcare professionals (Bartram et al., 2009; Bartram & Baldwin, 2010; Platt et al., 2012). Additionally, veterinary medicine is an occupation inundated with complex ethical and moral dilemmas. However, current studies are limited in their ability to contextualize the risk and contributing factors fully; therefore, they offer limited insight into effective preventative and support strategies. Using Interpretive Phenomenological Analysis (IPA), eight companion animal veterinarians were interviewed about their …

Association Between Objectively-Measured Sedentary Time And Self-Reported Prescription Medication Use Among Adults: A Pilot Study, Ciarra Ashley Boyne

UNF Graduate Theses and Dissertations

BACKGROUND: Prescription medication use and extended sedentary time are independently related to poor health outcomes (e.g., diabetes, metabolic syndrome, mortality). Historically, survey methods have been used to obtain estimates of total sedentary time (ST), however, recent use of accelerometers avoids self-report bias and affords more characteristics of ST that may be factors in health outcomes (e.g., frequency and duration of sedentary bouts). The aims of this pilot study were to 1) examine the association between objectively measured ST via accelerometers and self-reported prescription medication use in adults and 2) examine the independent association of sedentary bout length and frequency with …

Challenges Patients Face When Transitioning From The Hospital Into The Home Setting With An Enteral Feeding Tube & The Impact Of Staffing A Home Enteral Nutrition Registered Dietitian Case Manager, Najwa N. Worthen

UNF Graduate Theses and Dissertations

A Home Enteral Nutrition (HEN) case manager position was implemented within the Tampa Veteran’s Health System (VHS) to coordinate and ensure that the transition process from the hospital into the home setting with a new feeding tube transpires smoothly. The Knowledgeto-Action (KTA) theoretical framework was used in this quality improvement project to incorporate a systematic step-by-step process to transition evidence into practice, and assess the effectiveness as well as the sustainability of maintaining a HEN case manager position within the Tampa VHS. 1 In a repeated cross-sectional study design, HEN case management data Pre-Case Management, Post-Case Management with 1-RD case …

Nutrition Care For The Transgender Population: A Retrospective Study To Investigate Relationships Between The Nutrition Care Process Model And Patient Outcomes, Alana Minnee Marrero Gonzalez

UNF Graduate Theses and Dissertations

One of the most important roles of the registered dietitian nutritionist is to provide medical nutrition therapy that is fitting to an individual’s culture, reality, ethnicity, and dietary preferences. A review of existing literature exposes the lack of information available on LGBTQ (lesbian, gay, bisexual, transgender, queer) health, for transgender communities. The purpose of this research was to generate knowledge of the nutrition-related problems and barriers to adequate nutrition and health, and their impact in nutrition assessment in a sample of Hispanic transgender adult patients living in San Juan, Puerto Rico. A retrospective observational study was conducted, data from 114 …

The Experiences Of Transgender And Gender Diverse Individuals Seeking Mental Health Treatment, Brice T. Marks

UNF Graduate Theses and Dissertations

Transgender and Gender Diverse (TGD) individuals are underserved in communities despite experiencing disproportionately higher rates of mental health distress. The cisheteronomativity of society creates chronic stressors that impact the mental health outcomes of TGD individuals. TGD individuals face the highest rates of discrimination in healthcare settings. Yet, little is known about the population's specific experiences seeking mental health care. Using a phenomenological approach, this study interviewed eight TGD individuals to understand the experience of seeking mental health care. There were six themes: facilitation of seeking behaviors, barriers, type of care, characteristics of providers, identity disclosure, and burden of advocacy and …

Walking The Talk: A Qualitative Exploration Of Gatekeeping Staff Perceptions Surrounding Implementation Of Nutrition Policy In Florida Food Banks, Rachel Lynn Mccandless

UNF Graduate Theses and Dissertations

Food insecurity is an independent risk factor for adverse health outcomes; providing nutrient-dense food through the emergency food system to individuals who regularly seek assistance can impact population-level health disparities. This research explored the extrinsic and intrinsic barriers and facilitators surrounding formal nutrition policy implementation as seen by the logistical gatekeepers in a sample of Feeding Florida food banks. A secondary aim of this research was to explore the change readiness of these same logistical decision-makers in nutrition policy implementation. Research Questions included the following: What are the critical gatekeeping staff perceptions of the barriers and facilitators to implementing formal …