Conceptualised Psycho-Medical Footprint For Health Status Outcomes And The Potential Impacts For Early Detection And Prevention Of Chronic Diseases In The Context Of 3p Medicine, Ebenezer Afrifa-Yamoah, Eric Adua, Enoch O. Anto, Emmanuel Peprah-Yamoah, Victor Opoku-Yamoah, Emmanuel Aboagye, Rashid Hashmi

Research outputs 2022 to 2026

Background: The Suboptimal Health Status Questionnaire-25 (SHSQ-25) is a distinctive medical psychometric diagnostic tool designed for the early detection of chronic diseases. However, the synaptic connections between the 25 symptomatic items and their relevance in supporting the monitoring of suboptimal health outcomes, which are precursors for chronic diseases, have not been thoroughly evaluated within the framework of predictive, preventive, and personalised medicine (PPPM/3PM). This baseline study explores the internal structure of the SHSQ-25 and demonstrates its discriminatory power to predict optimal and suboptimal health status (SHS) and develop photogenic representations of their distinct relationship patterns. Methods: The cross-sectional study involved …

Musculoskeletal Complaint Epidemiology In Australian Special Operation Forces Trainees, Lisa Wolski, Joanne Stannard, Liam Toohey, Alison Fogarty, Michael Drew

Research outputs 2022 to 2026

Intorduction: Elite military trainees are burdened by high numbers of musculoskeletal (MSK) injuries and are a priority military population for injury prevention. This research aims to describe the MSK complaint epidemiology of trainees undertaking special forces (SF) training in the Australian Defence Force (ADF). One barrier to accurate injury surveillance in military populations is that traditional surveillance methods rely on personnel engaging with the military healthcare system to collect injury data. This approach is likely to underestimate the injury burden as it is known that many military personnel, particularly trainees, avoid reporting their injuries because of various motives. Subsequently, the …

Genetic And Immunological Insights Into Covid-19 With Acute Myocardial Infarction: Integrated Analysis Of Mendelian Randomization, Transcriptomics, And Clinical Samples, Zequn Zheng, Yueran Zhou, Yongfei Song, Pengxiang Ying, Xuerui Tan

Research outputs 2022 to 2026

Background: Globally, most deaths result from cardiovascular diseases, particularly ischemic heart disease. COVID-19 affects the heart, worsening existing heart conditions and causing myocardial injury. The mechanistic link between COVID-19 and acute myocardial infarction (AMI) is still being investigated to elucidate the underlying molecular perspectives. Methods: Genetic risk assessment was conducted using two-sample Mendelian randomization (TSMR) to determine the causality between COVID-19 and AMI. Weighted gene co-expression network analysis (WGCNA) and machine learning were used to discover and validate shared hub genes for the two diseases using bulk RNA sequencing (RNA-seq) datasets. Additionally, gene set enrichment analysis (GSEA) and single-cell RNA-seq …

Palliative And End-Of-Life Care Access For Immigrants Living In High-Income Countries: A Scoping Review, Gertrude G. Phiri, Joyce Muge-Sugutt, Davina Porock

Research outputs 2022 to 2026

This scoping review aimed to explore what is known about palliative and End-of-Life (EOL) care access by immigrants with culturally and linguistically diverse (CALD) background living in high-income Organization for Economic Co-operation and Development (OECD) countries. CaLD immigrants have low utilization of palliative care services with patients’ family members taking up the role of caring, leading to immigrants not fully benefiting from the specialized services that are offered to alleviate suffering and promote quality of life. While there is some research in this area mainly in Europe, it cannot be said about all high-income OECD countries. Achieving person-centered care in …

Corticosteroid-Laba Inhalers Increase Phonation Threshold Pressure (Ptp) And Flow (Ptf) In Rabbits, Christopher Dromey, Kristine Tanner, Heidi J. Robison, Maya Elena Stevens, Ray M. Merrill, Julie Barkmeier-Kraemer, Ben Christensen

Faculty Publications

Objectives: This study examined the effects of a combination corticosteroid plus long-acting beta2-adrenergic agonist inhaler (IC) on rabbit phonation. Methods: White New Zealand male rabbits were assigned randomly to experimental and control groups (n = 11 per group). The experimental group received twice-daily doses of Advair HFA™ (fluticasone propionate 45 mcg and salmeterol 21 mcg) via a veterinary facemask with 1-way valve and spacer; the control group received aerosolized saline. After 8 weeks, animals were euthanized, larynges excised, frozen, and subsequently thawed and mounted on a standard bench apparatus. Phonation was elicited during 15 successive trials, and phonation threshold pressure …

Imputation Of Missing Values For Cochlear Implant Candidate Audiometric Data And Potential Applications, Cole Pavelchek, Andrew P. Michelson, Amit Walia, Amanda Ortmann, Jacques Herzog, Craig A. Buchman, Matthew A. Shew

2020-Current year OA Pubs

OBJECTIVE: Assess the real-world performance of popular imputation algorithms on cochlear implant (CI) candidate audiometric data.

METHODS: 7,451 audiograms from patients undergoing CI candidacy evaluation were pooled from 32 institutions with complete case analysis yielding 1,304 audiograms. Imputation model performance was assessed with nested cross-validation on randomly generated sparse datasets with various amounts of missing data, distributions of sparsity, and dataset sizes. A threshold for safe imputation was defined as root mean square error (RMSE) <10dB. Models included univariate imputation, interpolation, multiple imputation by chained equations (MICE), k-nearest neighbors, gradient boosted trees, and neural networks.

RESULTS: Greater quantities of missing data were associated with worse performance. Sparsity in audiometric data is not uniformly distributed, as inter-octave frequencies are less commonly …

Allele-Specific Quantification Of Human Leukocyte Antigen Transcript Isoforms By Nanopore Sequencing, Andrew E O Hughes, Maureen C Montgomery, Chang Liu, Eric T Weimer

2020-Current year OA Pubs

INTRODUCTION: While tens of thousands of HLA alleles have been identified by DNA sequencing, the contribution of alternative splicing to HLA diversity is not well characterized. In this study, we sought to determine if long-read sequencing could be used to accurately quantify allele-specific HLA transcripts in primary human lymphocytes.

METHODS: cDNA libraries were prepared from peripheral blood lymphocytes from 12 donors and sequenced by nanopore long-read sequencing. HLA reads were aligned to donor-specific reference sequences based on the known type of each donor. Allele-specific exon utilization was calculated as the proportion of reads aligning to each allele containing known exons, …

Updates In The Chronic Kidney Disease-Mineral Bone Disorder Show The Role Of Osteocytic Proteins, A Potential Mechanism Of The Bone-Vascular Paradox, A Therapeutic Target, And A Biomarker, Matthew J Williams, Sarah C White, Zachary Joseph, Keith A Hruska

2020-Current year OA Pubs

The chronic kidney disease-mineral bone disorder (CKD-MBD) is a complex multi-component syndrome occurring during kidney disease and its progression. Here, we update progress in the components of the syndrome, and synthesize recent investigations, which suggest a potential mechanism of the bone-vascular paradox. The discovery that calcified arteries in chronic kidney disease inhibit bone remodeling lead to the identification of factors produced by the vasculature that inhibit the skeleton, thus providing a potential explanation for the bone-vascular paradox. Among the factors produced by calcifying arteries, sclerostin secretion is especially enlightening. Sclerostin is a potent inhibitor of bone remodeling and an osteocyte …

Factors Associated With Patient Portal Utilization, Preventive Services Utilization, And Health Promoting Behaviors Among Adults In The United States, Elizabeth Ayangunna

College of Graduate Studies: Theses & Dissertations

Background: Nearly 60% of adults in the United States are estimated to have one or more chronic conditions, necessitating strategies to improve the health status of persons with chronic disease. Given that health information technology (HIT) is considered highly valuable for superior disease management, it is imperative to examine how HIT use can improve health behaviors, which can in turn improve health status. This study aimed to examine if there was an association between patient portal utilization and the use of preventive services & health-promoting behaviors. Also, this study examined the influence of self-efficacy on preventive health behaviors among adults …

Acute Effects Of Trunk Stretching On Aortic Arterial Stiffness And Central And Peripheral Blood Pressure In Middle-Aged Older Adults, Kylee West

College of Graduate Studies: Theses & Dissertations

BACKGROUND: Physical activity may alter the trajectory of age-related arterial stiffening, which is associated with cardiovascular morbidity and mortality. Trunk stretching has reduced arterial stiffness (AS) in young males, but its effect in middle-aged to older adults is unclear. This study examined the effects of passively assisted trunk stretching (PATS) on aortic arterial stiffness and central and peripheral blood pressure in middle-aged to older adults. METHODS: Carotid-femoral pulse wave velocity (cf-PWV) and Augmentation Index normalized to a heart rate of 75 beats per minute (AIx75) were measured in 28 middle-aged to older adults (14M/14F; 72 ± 7 years; 28.5 …

Racial Differences In Depression Indicators Before And After 2008 Financial Crisis In A Sample Of Older Adults, Angelina E. Jackson

College of Graduate Studies: Theses & Dissertations

The present study was designed to examine patterns of mental health outcomes in older Black and White adults after the national 2008 financial crisis. The data was acquired from the University of Michigan Health and Retirement Study, a publicly available dataset. This longitudinal study has obtained data from a representative sample of approximately 20,000 older adults in America, aged 55 and older. The hypotheses were (1) rates of mental health indicators related to symptoms of depression will increase after the 2008 financial crisis and (2) that increase will be significantly higher in Black respondents compared to White respondents. The analysis …

Factors Associated With Physical Activity Intent Among Adults With Multiple Sclerosis, Biebele Okpeahior

College of Graduate Studies: Theses & Dissertations

Introduction. Although research has highlighted the benefits of physical activity in people with Multiple Sclerosis (MS), they are still more likely to live an inactive lifestyle. There are limited studies that examine the relationship between physical activity and the Theory of Planned Behavior (TPB) among the MS population. This study aimed to explore the factors that associate with physical activity intent of adults with MS utilizing the constructs of the TPB. Methods. This study utilized a cross-sectional online survey done via a social media platform. There were 326 respondents to the survey and ultimately 249 surveys that met the criteria …

Mental Health Help-Seeking Behaviors Of First-Year University Students, Kylie A. Roberts

College of Graduate Studies: Theses & Dissertations

The early college years represent a specific period in a student’s life that is crucial for their development. Approximately one in three college students meet the criteria for a mental health problem (Eisenberg et al., 2013). Universities have unique opportunities for identifying risk and delivering prevention or intervention strategies to students in need. The purpose of this study was to investigate factors associated with First-Year University students’ help-seeking behaviors for university-based mental health services. H₁: There will be group differences between gender and race/ethnicity on help-seeking behaviors, knowledge barriers of services or providers and perceived stigma. H_{2 …}

Evaluation Of The Loving Support Peer Counseling Program On Breastfeeding Duration Rates Among African American Women Enrolled In The Program (2017-2018), Nancy S. Jeffery

College of Graduate Studies: Theses & Dissertations

Mothers and babies form an inseparable biological and social unit; the health and nutrition of one group cannot be divorced from the health and nutrition of the other.”-World Health Organization. The aim of this study was to evaluate the effectiveness of the Loving Support Peer Counseling (LSPC) program, under the WIC program in the state of Georgia, on breastfeeding duration rates among African American postpartum primiparas women. This observational study analyzed state-level data from January 2017 through December 2018. A cross-sectional design was used to evaluate the effectiveness of the Loving Support Peer Counseling Program (LSPC) in six of the …

Athletic Identity And Intention To Report Concussions In Collegiate Club Recreational Athletes, Kiersten D. Kuhlman

College of Graduate Studies: Theses & Dissertations

Background: Athletic identity is the extent to which one identifies with the athlete role, but we do not know what that looks like in club sports and its effect on concussion reporting intention. The athletic identity of club sport athletes and their intention to report concussive injuries is limited and needs further research. Purpose: Describe athletic identity in club sport athletes and determine its influence on concussion reporting in club sport participants. Methods: A convenience sample of 149 (age 18-28 (M= 19.95±1.81) years old) club sport athletes at Georgia Southern University completed the Athletic Identity Measurement Scale (AIMS) and …

Acceleration Patterns During Standing And Running Tumbling Passes In Collegiate Cheerleading, Benjamin L. Paquette

College of Graduate Studies: Theses & Dissertations

Tumbling requirements and expectations of heightened difficulty of tumbling skills has grown to become a vital component in competitive collegiate cheerleading. Acceleration patterns during tumbling skills has been previously explored in gymnastics, with a floor routine being the most similar in nature, but not completely transferable considering differences in tumbling surface, execution strategy, and setting. Therefore, the purpose of this study was to investigate acceleration patterns during different tumbling passes in collegiate cheerleading athletes. Fifteen female collegiate cheerleaders (age = 19.6 + 1.50) participated in the study. Each participant completed a max of seven different tumbling passes (two standing, 5 …

Implicit Beliefs About Anxiety And The Relationship With Competitive Anxiety Intensity And Direction, Luca M. Ziegler

College of Graduate Studies: Theses & Dissertations

During the Fall of 2021, 45% of male and 72% of female student-athletes reported overwhelming anxiety at least once a month (NCAA, 2021). In addition to affecting an individual’s well-being, anxiety may negatively impact athletic performance (Edwards & Hardy, 1996). To better understand the impact of anxiety on athletic performance and develop effective interventions, both the intensity and direction of symptoms experienced must be considered. Incremental beliefs have been shown to be related to desirable performance outcomes and increased well-being in various populations (Danthony et al., 2020; Dweck, 2008), and may provide an effective intervention to interpret anxiety as more …

Development And Praxis Of Ph Drug Delivery System Contra Zika, Julissa Rodriguez

College of Graduate Studies: Theses & Dissertations

As the effects of global warming continue to spread throughout the world, another critical issue is slowly gaining attention in many urban tropical countries. The Emerging Infectious Diseases/ Pathogens list from the National Institutes of Health (NIH) listed the Zika virus as a potential pandemic threat. In 2015, an outbreak of Zika was noted in several South American countries until the spread reached an all-time high of 87 countries in 2017. During the outbreaks, adults affected were noted to have joint and muscle pains, fevers, and rashes. The worst cases reported would ultimately lead to Guillain-Barre symptoms. Still, pregnant women …

Demographic And Clinical Characteristics Predicting Missed Clinic Visits Among Patients Living With Hiv On Antiretroviral Treatment., Osaremhen Ikhile

College of Graduate Studies: Theses & Dissertations

Background: Patients living with HIV (PLHIV) often face challenges that contribute to missed clinical care which can impact their health outcomes.

Purpose: The primary objective of this study was to examine associations of clinical and sociodemographic factors such as age at the entrance into antiretroviral treatment (ART), rurality-urbanicity, biological sex, province of residence, and viral load with PLHIV’s tendency to miss scheduled visits for ART among persons living with HIV (PLHIV) in the Kinshasa and Haut-Katanga provinces of the Democratic Republic of Congo (DRC) between 2018 and 2019.

Methods: The study participants for this quantitative study were 5338 adults …

Comparison Marker-Based And Markerless Motion Capture Systems In Gait Biomechanics During Running, Hui Tang

College of Graduate Studies: Theses & Dissertations

Background: Markerless (ML) motion capture systems have recently become available for biomechanics applications. Evidence has indicated the potential feasibility of using an ML system to analyze lower extremity kinematics. However, no research examined ML systems’ estimation of the lower extremity joint moments and powers. Objectives: This study primarily aimed to compare lower extremity joint moments and powers estimated by marker-based (MB) and ML motion capture systems during treadmill running. The secondary purpose was to investigate if movement’s speed would affect the ML’s performance. Methods: Sixteen volunteers ran on a treadmill for 120 s for each trial at the speed of …

The Impact Of Controlling Language And Source Similarity On Psychological Reactance, Caroline Yarbrough

College of Graduate Studies: Theses & Dissertations

Persuasive health messages are frequently advertised throughout the pandemic to decrease the spread of COVID-19 while increasing the likelihood of immunity. However, research demonstrates that persuasive health messages may be ineffective because they have the potential to elicit psychological reactance. Reactance is characterized by a state of unpleasant motivational arousal and often occurs when individuals experience or perceive threats to their freedom, and it can be evoked through controlling language (Frey et al., 2021; Grandpre et al., 2003). Additionally, research has shown that similarity is associated with liking (Cialdini & Trost 1998) and people are often more inclined to comply …

Assessment Of The Utilization Of Healthcare Services Specific To Pregnancy-Related Complications In Rural And Medically Underserved Georgia, Diana L. Aguirre

College of Graduate Studies: Theses & Dissertations

Maternal mortality is a continuing issue, with rates for the state of Georgia (3.7 per 100,000 live births) are higher than that of the US rates (2.9 per 100,000 per live births) (Centers for Disease Control and Prevention, National Center for Health Statistics, n.d., 2023). However, maternal mortality may not account for health disparity factors, apart from access to quality care and physiological issues, which is a factor in pregnancy-related deaths, Pregnancy-related death, as defined by the US Centers for Disease and Control (CDC), is a death of a woman that occurs during or within one year of pregnancy that …

Supports And Services To Improve Academic Success Of High School Student Athletes, Samuel G. Nichols

College of Graduate Studies: Theses & Dissertations

The purpose of this study was to determine whether supports and services offered in various study hall programs (Traditional, Objective Based, and/or Objective Based +) at the high school level to help student athletes be academically successful in terms of achieving a minimum GPA of 2.0 or above. Basketball programs were used for this study because it is a major sport in the school district in which the data were collected. Data were sought via questionnaires of chosen participants via convenience sampling from eight eligible high school athletic directors in one school district in Georgia. This study called for the …

Medical Providers' Use Of Maternal Mental Health Screening Tools During Prenatal Appointments In Southeast Georgia, Andreka Ewing

College of Graduate Studies: Theses & Dissertations

In the United States, maternal mental health disorders are the most common comorbidities experienced during pregnancy and after childbirth. In particular, the state of Georgia reports that 1 in 7 Georgian mothers experience depression, anxiety, obsessive-compulsive disorders, or psychosis related to these disorders. Research suggests that untreated maternal mental health can have adverse effects on the mother and unborn child. Conditions such as autism, mixed handedness, reduced cognitive ability, and affective disorders can develop while the child is in the womb of a depressed mother. Routine maternal mental health screening using a validated screening tool has been recommended to help …

The Relationship Between Age, Sport, And Years Coaching On Knowledge, Confidence, Preparedness, And Intention To Intervene With Youth Athletes Experiencing Mental Health Challenges, Allyson P. Looby

College of Graduate Studies: Theses & Dissertations

Introduction: Mental disorders can affect all ages and populations, but there is an increasingly high prevalence in the pediatric population. It is estimated that 1 in 5 youth between the ages of 9-17 experiences some degree of impairment from a diagnosable mental health disorder (Merikangas et al., 2010). Youth are often not equipped to seek professional support; making parents, teachers, and coaches key to detection and referral to professional help (Ng et al., 2021). The environment youth sports creates gives coaches the opportunity to have a greater impact on youth mental health (Das et al., 2016). Purpose: Determine if age, …

Addressing Breast Health Disparities Among Recent, Established African-Born Immigrant Women And Second-Generation Americans In Prince George County, Maryland, Omolola Okunromade

College of Graduate Studies: Theses & Dissertations

Background: Breast health disparities and underutilization of screening methods are major concerns in the United States (US), particularly affecting Black women who experience lower survival rates and advanced diagnoses. Despite the rapid growth of the African-born immigrant population, breast health among this group in the US is notably under-examined. This study aims to investigate the breast health knowledge and practices of first-generation African-born immigrants and second-generation immigrant women of African descent, aiming to understand the distinctive attributes of this group and the impact of acculturation on this public health issue.

Methods: Interviews were conducted among First Generation African immigrants and …

Emergency Preparedness And Response: Examining Rural Hospitals (Rhs) Communication Systems Before, During, And After A Natural Disaster, Geremy D. Lloyd

College of Graduate Studies: Theses & Dissertations

Introduction: Rural Hospitals (RHs) have distinctive characteristics that constitute unparalleled challenges. One of those challenges is the ability to communicate effectively in a disaster, impacting the various effects on the affected society. Research has shown that effective emergency preparedness and response (EPR) communication is paramount when communicating informed details about emergent events. Despite the evolving complexities of communication and the technology associated with disaster communication, very few studies have successfully investigated RHs communication systems before, during, and after a natural disaster. The purpose of this study was to examine and assess RHs communication systems and to highlight the strengths, identify …

Sheprep: Examining The Influence Of The Messaging And The Messenger Associated With Prep Uptake Among African American Women, Christian C. Spears

College of Graduate Studies: Theses & Dissertations

African American Women (AAW) make up less than 15% of the female population in the United States but account for over 50% of new HIV diagnoses among females. This largely preventable health disparity can be mitigated by advocating and prescribing Pre-exposure Prophylaxis (PrEP), a preventive HIV medication, to persons at risk. Despite advances in medication options, there are less than 13% of Black people who could benefit from having been prescribed PrEP, and limited research and promotion on the effectiveness of PrEP for AAW. The “ShePrEP Study” aimed to assess awareness, perceptions, and receptivity toward PrEP among AAW. This study …

What Could Go Wrong? Patient And Hospital Characteristics Associated With Pediatric Quality Of Inpatient Care And Pediatric Adverse Events, Michael H. Samawi

College of Graduate Studies: Theses & Dissertations

This study aims to analyze associations between hospital and patient characteristics with pediatric adverse events (PAE) in the inpatient hospital setting, utilizing the framework of pediatric quality indicators (PDIs) from the Agency for Healthcare Research and Quality (AHRQ) indicators. Three PDIs were identified and utilized for this purpose: NQI 03 Neonatal Blood Stream Infection, PDI 09 Postoperative Respiratory Failure, and PDI 10 Postoperative Sepsis. The data used for the study is based on an analysis of discharge data from the Healthcare Cost and Utilization Project (HCUP) Kid’s Inpatient Databases (KID) for the year 2019. The findings contribute to the growing …

Exploring Relationship Among Programmatic Expertise, Work Engagement, And Turnover Intentions Across Different Generation Cohorts In State And Local Governmental Public Health Agencies, Stephanie L. Irvin

College of Graduate Studies: Theses & Dissertations

This study examined the relationship among public health programmatic competencies, work engagement, and turnover intentions among state and local public health workers. It also explored the moderating role of generational cohorts in these relationships. It employed a quantitative secondary data analysis using the 2021 PHWINS survey, a collaboration between the de Beaumont Foundation and The Association of State and Territorial Health Officials. The study's principal findings shed light on critical relationships within the public health workforce: Firstly, an increase in programmatic expertise among public health professionals is linked to increased work engagement, particularly notable within the Millennial cohort. Secondly, a …