Medicine and Health Sciences Commons^™

Adolescent Overweight And Obesity In Ireland—Trends And Sociodemographic Associations Between 1990 And 2020, Aoibhín Moore Heslin, Aisling O'Donnell, Laura Kehoe, Janette Walton, Albert Flynn, John Kearney, Breige Mcnulty

Articles

Background: Overweight and obesity in adolescence is a growing issue and can have a range of both short- and long-term consequences on health.

Objectives: To analyse trends in adolescent weight status in Ireland across a 30-year period and to examine the influence of sociodemographic factors on overweight/obesity in Irish adolescents over time.

Methods: Body composition and body mass index weight status of Irish adolescents were compared using data from three nationally representative, cross-sectional Irish national food consumption surveys from 1990, 2006 and 2020. Adjusted analysis of associations between socio-demographic factors with the risk of adolescent overweight/obesity at each time point …

Food And Nutrient Intakes And Compliance With Recommendations In School-Aged Children In Ireland: Findings From The National Children’S Food Survey Ii (2017–2018) And Changes Since 2003–2004., Laura Kehoe, Maria Breffini, Breige A. Mcnulty, John Kearney, Albert Flynn, Janet Walton

Articles

The childhood years represent a period of increased nutrient requirements during which a balanced diet is important to ensure optimal growth and development. The aim of this study was to examine food and nutrient intakes and compliance with recommendations in school-aged children in Ireland and to examine changes over time. Analyses were based on two National Children's Food Surveys; NCFS (2003-2004) (n 594) and NCFS II (2017-2018) (n 600) which estimated food and nutrient intakes in nationally representative samples of children (5-12 years) using weighed food records (NCFS: 7-d; NCFS II: 4-d). This study found that nutrient intakes among school-aged …

Energy Metabolism, Metabolite, And Inflammatory Profiles In Human Ex Vivo Adipose Tissue Are Influenced By Obesity Status, Metabolic Dysfunction, And Treatment Regimes In Patients With Oesophageal Adenocarcinoma, Fiona O'Connell, Eimear Mylod, Noel E. Donlon, Aisling B. Heeran, Christine Butler, Anshul Bhardwaj, Sinead Ramjit, Michael Durand, Gerard Lambe, Paul Tansey, Ivan Welartne, Kevin P. Sheahan, Xiaofei Yin, Claire L. Donohoe, Narayanasamy Ravi

Articles

Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current treatment modalities and has a strong link to obesity. To better elucidate the role of visceral adiposity in this disease state, a full metabolic profile combined with analysis of secreted pro-inflammatory cytokines, metabolites, and lipid profiles were assessed in human ex vivo adipose tissue explants from obese and non-obese OAC patients. These data were then related to extensive clinical data including obesity status, metabolic dysfunction, previous treatment exposure, and tumour regression grades. Real-time energy metabolism profiles were assessed using the seahorse technology. Adipose explant conditioned media …

The Relationship Between Diet And Lifestyle Behaviours In A Sample Of Higher Education Students; A Cross-Sectional Study, Stephen Doak, John Kearney, Jacqueline M. Mccormack, Laura Keaver

Articles

Transitioning into higher education (HE) impacts health behaviours. Poor dietary and lifestyle behaviours may correlate and increase risk of co-morbidities. The introduction of the Okanagan Charter detailed the important role of health promotion within a HE setting. The aim of this study was to assess the relationship between dietary quality and lifestyle behaviours of students attending HE.

An Analysis Of Jade2 In Non-Small Cell Lung Cancer (Nsclc), Ciara Murphy, Gloria Gornes Pons, Anna Keogh, Lisa Ryan, Lorraine Mccarra, Chris Maria Jose, Shagun Kesar, Siobhan Nicholson, Gerard J. Fitzmaurice, Ronan Ryan, Vincent Young, Sinead Cuffe, Stephen P. Finn, Steven Gray

Articles

The JADE family comprises three members encoded by individual genes and roles for these proteins have been identified in chromatin remodeling, cell cycle progression, cell regeneration and the DNA damage response. JADE family members, and in particular JADE2 have not been studied in any great detail in cancer. Using a series of standard biological and bioinformatics approaches we investigated JADE2 expression in surgically resected non-small cell lung cancer (NSCLC) for both mRNA and protein to examine for correlations between JADE2 expression and overall survival. Additional correlations were identified using bioinformatic analyses on multiple online datasets. Our analysis demonstrates that JADE2 …

Successfully Transitioning Executives During Times Of Multidimensional Change: A Delphi Study Examining Organizational Practices In Large Hospital Systems, Lilicia Bailey

Theses and Dissertations

Healthcare is the fastest growing industry in the United States and globally. Economists forecast that as the population grows and life expectancy increases, the healthcare sector will continue expanding to meet consumer needs domestically and globally. Population aging and the emergence of global pandemics has substantially increased the demand for healthcare services and has created volatile, complex, uncertain, and ambiguous conditions that ignite social, economic, and workforce shifts within and outside the organization. While these factors require growth and agility within healthcare organizations, high turnover in the healthcare workforce threatens these organizations’ ability to effectively fulfill their mission. The high …

Age‑Related Differences In Lower Limb Muscle Activation Patterns And Balance Control Strategies While Walking Over A Compliant Surface, Woohyoung Jeon, Ahmed Ramadan, Jill Whitall, Nesreen Alissa, Kelly Westlake

Health & Kinesiology Faculty Publications and Presentations

Substantial evidence demonstrates that falls in older adults are leading causes of fatal and nonfatal injuries and lead to negative impacts on the quality of life in the aging population. Most falls in older fallers result from unrecoverable limb collapse during falling momentum control in the single limb support (SLS) phase. To understand why older adults are more likely to fall than younger adults, we investigated age-related differences in knee extensor eccentric control, lower limb muscle activation patterns, and their relation to balance control. Ten older and ten younger healthy adults were compared during balance control while walking on a …

The Anti-Leishmania Amazonensis And Anti-Leishmania Chagasi Action Of Copper(Ii) And Silver(I) 1,10-Phenanthroline-5,6-Dione Coordination Compounds, Simone S. C. Oliveira, Vanessa S. Santos, Michael Devereux, Malachy Mccann, Andre L.S. Santos, Marta H. Branquinha

Articles

Leishmaniasis is a neglected disease caused by protozoa belonging to the Leishmania genus. Notably, the search for new, promising and potent anti-Leishmania compounds remains a major goal due to the inefficacy of the available drugs used nowadays. In the present work, we evaluated the effects of 1,10-phenanthroline-5,6-dione (phendione) coordinated to silver(I), [Ag(phendione)2]ClO4 (Ag-phendione), and copper(II), [Cu(phendione)3](ClO4)2·4H2O (Cu-phendione), as potential drugs to be used in the chemotherapy against Leishmania amazonensis and Leishmania chagasi. The results showed that promastigotes treated with Ag-phendione and Cu-phendione presented a significant reduction in the proliferation rate. The IC50 values calculated to Ag-phendione and Cu-phendione, respectively, were …

Covidanno, Covid-19 Annotation In Human, Yuzhou Feng, Mengyuan Yang, Zhiwei Fan, Weiling Zhao, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 19 (COVID-19), has caused a global health crisis. Despite ongoing efforts to treat patients, there is no universal prevention or cure available. One of the feasible approaches will be identifying the key genes from SARS-CoV-2-infected cells. SARS-CoV-2-infected in vitro model, allows easy control of the experimental conditions, obtaining reproducible results, and monitoring of infection progression. Currently, accumulating RNA-seq data from SARS-CoV-2 in vitro models urgently needs systematic translation and interpretation. To fill this gap, we built COVIDanno, COVID-19 annotation in humans, available at http://biomedbdc.wchscu.cn/COVIDanno/. The aim …

Syllable-Pbwt For Space-Efficient Haplotype Long-Match Query, Victor Wang, Ardalan Naseri, Shaojie Zhang, Degui Zhi

Faculty, Staff and Student Publications

MOTIVATION: The positional Burrows-Wheeler transform (PBWT) has led to tremendous strides in haplotype matching on biobank-scale data. For genetic genealogical search, PBWT-based methods have optimized the asymptotic runtime of finding long matches between a query haplotype and a predefined panel of haplotypes. However, to enable fast query searches, the full-sized panel and PBWT data structures must be kept in memory, preventing existing algorithms from scaling up to modern biobank panels consisting of millions of haplotypes. In this work, we propose a space-efficient variation of PBWT named Syllable-PBWT, which divides every haplotype into syllables, builds the PBWT positional prefix arrays on …

Use Gpt-J Prompt Generation With Roberta For Ner Models On Diagnosis Extraction Of Periodontal Diagnosis From Electronic Dental Records, Yao-Shun Chuang, Xiaoqian Jiang, Chun-Teh Lee, Ryan Brandon, Duong Tran, Oluwabunmi Tokede, Muhammad F Walji

Faculty, Staff and Student Publications

This study explored the usability of prompt generation on named entity recognition (NER) tasks and the performance in different settings of the prompt. The prompt generation by GPT-J models was utilized to directly test the gold standard as well as to generate the seed and further fed to the RoBERTa model with the spaCy package. In the direct test, a lower ratio of negative examples with higher numbers of examples in prompt achieved the best results with a F1 score of 0.72. The performance revealed consistency, 0.92-0.97 in the F1 score, in all settings after training with the RoBERTa model. …

Towards Fair Patient-Trial Matching Via Patient-Criterion Level Fairness Constraint, Chia-Yuan Chang, Jiayi Yuan, Sirui Ding, Qiaoyu Tan, Kai Zhang, Xiaoqian Jiang, Xia Hu, Na Zou

Faculty, Staff and Student Publications

Clinical trials are indispensable in developing new treatments, but they face obstacles in patient recruitment and retention, hindering the enrollment of necessary participants. To tackle these challenges, deep learning frameworks have been created to match patients to trials. These frameworks calculate the similarity between patients and clinical trial eligibility criteria, considering the discrepancy between inclusion and exclusion criteria. Recent studies have shown that these frameworks outperform earlier approaches. However, deep learning models may raise fairness issues in patient-trial matching when certain sensitive groups of individuals are underrepresented in clinical trials, leading to incomplete or inaccurate data and potential harm. To …

The Kynurenine Pathway In Alzheimer’S Disease: A Meta-Analysis Of Central And Peripheral Levels, Brisa S Fernandes, Mehmet Enes Inam, Nitesh Enduru, Joao Quevedo, Zhongming Zhao

Faculty, Staff and Student Publications

OBJECTIVE: Changes in the kynurenine pathway are recognized in psychiatric disorders, but their role in Alzheimer's disease (AD) is less clear. We aimed to conduct a systematic review and meta-analysis to determine whether tryptophan and kynurenine pathway metabolites are altered in AD.

METHODS: We performed a systematic review and random-effects meta-analyses. Inclusion criteria were studies that compared AD and cognitively normal (CN) groups and assessed tryptophan or kynurenine pathway metabolites in cerebrospinal fluid or peripheral blood.

RESULTS: Twenty-two studies with a total of 1,356 participants (664 with AD and 692 CN individuals) were included. Tryptophan was decreased only in peripheral …

Automated Detection Of Hippocampal Sclerosis Using Real-World Clinical Mri Images, Jingwen Jiang, Jiajun Qiu, Jin Yin, Junren Wang, Xinyue Jiang, Zuo Yi, Yang Chen, Xiaobo Zhou, Xiutian Sima

Faculty, Staff and Student Publications

BACKGROUND: Hippocampal sclerosis (HS) is the most common pathological type of temporal lobe epilepsy (TLE) and one of the important surgical markers. Currently, HS is mainly diagnosed manually by radiologists based on visual inspection of MRI, which greatly relies on MRI quality and physician experience. In clinical practice, non-thin MRI scans are often used due to the time and efficiency needed for the acquisition. However, these scans can be difficult for junior physicians to interpret accurately. Thus, the rapid and accurate diagnosis of HS using real-world MRI images in clinical settings is a challenging task.

OBJECTIVE: Our aim was to …

Individual And Combined Antioxidant Activity Of Spices And Spice Phenolics, Mohammad Hossain, Lubna Ahmed, Anna Belen Martin-Diana, Nigel P. Bruton, Catherine Barry-Ryan

Articles

The present study investigated the interaction effects (additive, synergistic, and antagonistic) of different groups of spices, their constituent phenolic compounds, and synthetic antioxidants on the total phenol (TP) content and antioxidant activity, as measured by the ferric-reducing antioxidant power (FRAP) of the mixtures. The results showed that there was an additive effect in all the groups studied, except for the group containing turmeric or curcumin. The groups containing turmeric or curcumin showed a moderate synergistic effect. Among the groups of spices, the highest summated TP (50.6 mg GAE/mL) and FRAP (106.2 mg Trolox/mL) values were observed in the group containing …

Protective Effect Of Memantine And Bacopa Monnieri On Lps-Induced Shsy5y Cells Via Amyloidosis, Anti-Inflammatory And Intrinsic Apoptotic Pathways, Archi Anupam Thakor

Selected Full-Text Master Theses 2021-

Background:

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of Amyloid-β (Aβ) plaques, causing neurotoxicity and leading to neurodegeneration. Amyloid precursor protein (APP) is processed into various Aβ isoforms. It has been shown to contribute to mitochondrial dysfunction and oxidative stress, activating mitochondrial apoptotic pathways and pro-inflammatory factors and leading to neuronal cell death. Memantine (MN) and Bacopa Monnieri (BM) are postulated to have neuroprotective effects, most likely via anti-amyloidogenic and anti-apoptotic mechanisms. The in vitro models suggest a potential for further development of biologically based adjuvant therapeutics for neurodegenerative diseases. However, more precise identification …

The Combination Of Cucurbitacin B And Evodiamine Induces Apoptosis And Inhibits Cell Propagation In Glioma Cells, Vrutti Vikasbhai Mehta

Selected Full-Text Master Theses 2021-

Background

Glioblastoma Multiform (GBM) is a lethal brain tumor. Despite aggressive treatment, the median survival time is 6 to 18 months. These malignant astrocytic tumors exhibit a high proliferation rate and acquire resistance against many existing therapeutic regimens. Temozolomide is a first line chemotherapeutic treatment prescribed along with surgery and radiation but due to the high resistance to the drug and a low patient survival rate, new drugs and drug combinations must continue to be investigated and developed. GBM cells like any cancer cells avoid differentiation and apoptosis. Thus, the induction of differentiation and apoptosis in glioblastoma cells may be …

Working Conditions, Type 2 Diabetes Mellitus, And Health Behaviors In Latino And Other Minoritized Groups Living In The United States, Tailisha M. Gonzalez

Dissertations and Theses

Background: Type 2 Diabetes Mellitus (T2DM or ‘diabetes’) poses a significant public health challenge to the healthcare system, economy, and well-being of communities in the United States (U.S.). There are also substantial racial/ethnic and social disparities in diabetes incidence and control that have persisted for decades. For Latinos and other minoritized groups in the U.S., diabetes disparities may be linked to working conditions. Globally, work is considered a major determinant of health and yet studies in the U.S. tend to focus on legacy hazards, such as chemical, biological, and environmental factors. In recent years, occupational health scholars have argued …

Pharmacy Students’ Perceptions And Attitudes Toward Face-To-Face Vs. Virtual Team-Based Learning (Tbl) In The Didactic Curriculum: A Mixed-Methods Study, Osama A. Shoair, Winter J. Smith, May H. Abdelaziz, Michael A. Veronin, Joseph S. Glavy, Shelby J. Pirtle

Pharmacy Faculty Publications and Presentations

Introduction

Virtual TBL is an online adaptation of the team-based learning (TBL) instructional strategy, emphasizing collaborative learning and problem-solving. The emergency shift to virtual TBL during the COVID-19 pandemic presented unique challenges. This study aims to 1) compare overall pharmacy students’ perceptions and attitudes toward face-to-face (FTF) TBL vs. virtual TBL in the didactic curriculum and stratify their perceptions and attitudes by various students’ characteristics; 2) evaluate students’ perceptions of the strengths and weaknesses of virtual TBL.

Methods

This mixed-methods, pre-post, cross-sectional study utilized an anonymous survey to collect the data. Pharmacy students completed a survey to compare their perceptions …

Modifiable Health Disparities And Cardiovascular Disease Risk Factors In Latino Migrant Seasonal Farmworkers: A Meta-Analysis, Cindy Mendez

Nursing Theses and Dissertations

BACKGROUND: Cardiovascular disease is the leading cause of death in the United States (U.S.). Existing literature concluded that Latino migrant seasonal farmworkers endure higher rates of adverse health disparities and chronic diseases than the general U.S. population. However, research on the Latino migrant seasonal farmworkers’ modifiable health disparities (i.e., alcohol use and smoking) and cardiovascular disease risk factors (i.e., high cholesterol, diabetes mellitus, hypertension, and overweight/obesity) is scarce, particularly studies comparing male and female Latino migrant seasonal farmworkers. PURPOSE: This meta-analysis had two aims. First, examine whether male or female Latino migrant seasonal farmworkers in the U.S. have …

The Perceptions Of People With Dementia, Care Partners, Cnas/Sitters, And Providers During The Covid-19 Pandemic Up To Now: A Multiple Case Study, Gaudensia Awuor

Nursing Theses and Dissertations

The perceptions of people with dementia, care partners, CNAs/sitters, and providers during the COVID-19 pandemic until now can be useful in formulating better ways to care for people with dementia in future disasters or pandemics. The study explored the perceptions of people with dementia, care partners, CNAs/sitters, and providers during the COVID-19 pandemic, from onset until now, to help formulate better ways to care for people with dementia during a pandemic or disaster. Algase’s Need-driven Dementia-compromised Behavior Model guided this comparative, multiple-case study. Six people with dementia, six care partners, five CNAs and one sitter, and six providers were interviewed …

The Impact Of Race/Ethnicity On Occupational Stress In East Texas Certified Nursing Assistants, Jackie Schniederjan Mcdonald

Nursing Theses and Dissertations

Significance: Certified nursing assistants (CNAs) provide direct care to those who live in long-term care facilities. As the population ages, the need for CNAs has grown. Nurse researchers have studied turnover and occupational stress, but no studies have examined racial/ethnic differences in CNA stress in East Texas.

Design / Purpose Statement: A convergent parallel mixed methods study was planned to address occupational stress experienced by CNAs in East Texas long-term care facilities. The Work Stress Scale and demographic questions were used to compare levels of reported occupational stress between racially diverse CNAs. However, lack of response to interview invitations necessitated …

Dataset For Effects Of Single-Session Practice Structure On Motor Skill Acquisition And Alpha And Beta Eeg Oscillations, Audrey Porter, Ronald V. Croce, Wayne Smith

Faculty Publications

Although it is known that practicing a motor skill updates the associated internal model, it is still unclear as to how cortical oscillations linked with the motor skill change under differing practice schedules. The current study investigated α- and β-power changes associated with motor skill acquisition. Firstly, we investigated the behavioral effects of practice on motor learning and retention during repetitive (RP) and variable (VP) practice schedules on an anticipation timing task. Secondly, we investigated changes in cortical α (10-13 HZ) and β (15-30 Hz) event-related synchronization and dyssynchronization (ERS/ERD) under RP and VP during early (EP) and late …

Analysis Of D- And L- Isomers Of (Meth)Amphetamine In Human K2edta Plasma, Brian Robbins, Jacob Perry, Mary Long, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Methamphetamine and its metabolite amphetamine are frequently abused drugs. Whether obtained legally or from clandestine laboratories it is of relevance to determine the chiral makeup of these drugs for investigative purpose. Although urine and oral fluid matrices are commonly offered, less available to independent laboratories are techniques to verify dextro (D-) or levo (L-) (meth)amphetamine from human K2EDTA plasma. This paper outlines the development and validation of a method that includes the addition of internal standard and a two-step liquid-liquid extraction to remove the analytes from human K2EDTA plasma by triple quadrupole mass spectrometry (LC-MS/MS). The assay was validated according …

Financial Strain Of Covid-19 And Its Impact On Willingness-To-Pay For Equine Care, Jada M. Thompson, Michelle Kibler, Jennie L.Z. Ivey

Agricultural Economics and Agribusiness Faculty Publications and Presentations

The novel COVID-19 virus caused a global pandemic disrupting lives, industries, and economies. The result was an impact on prices due to challenges with production and supply chain distribution. This study investigates the financial strain COVID-19 had on equine owners and leasers, what the market for equine care would bear if costs for care increased, and what factors contribute to their willingness to pay (WTP) for increasing cost of equine care. An online survey was distributed for 4 weeks to adult U.S. residents. Respondents reported their involvement in the equine industry, financial response to COVID-19, and responses to …

The Immediate Effects Of The Nunee Patellar Support On Individuals With Patellofemoral Pain Syndrome, Nick Linn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Patellofemoral pain syndrome (PFPS) is a common form of anterior knee pain caused by general overuse, muscular weakness or strength imbalances, and poor movement coordination leading to abnormal alignment or mal-tracking of the patella. Recent guidelines do not recommend the use of a knee orthosis due to a lack of evidence supporting their effectiveness. A new patellar support (NuNee, K-Neesio LLC.) which uses distraction force to relieve pressure placed on the patella, has been proposed. The purpose of this study was to examine the immediate effects of the NuNee patellar support on perceived pain, biomechanics, and function in individuals with …

Energy Content Of Grasshoppers (Orthoptera: Acrididae) In The Diet Of Scaled Quail (Callipepla Squamata) In Southeastern New Mexico, J.L. Hunt, M.E. Grilliot, T.L. Best, C.M. Wilkerson, A.F. Huitt

Journal of the Arkansas Academy of Science

Grasshoppers (Orthoptera: Acrididae) are common insects that are important food items for many kinds of wildlife, including many species of upland game birds such as scaled quail (Callipepla squamata). We analyzed the energy content of grasshoppers obtained from the crops of scaled quail collected from plainsmesa sand-scrub in Lea and Eddy counties, New Mexico. Grasshoppers were removed from crops and dried for 48 hours at 60°C to remove moisture and standardize masses. Grasshoppers were then pulverized and analyzed for gross caloric value (i.e., energy content) in an oxygen bomb calorimeter. Energy content of grasshoppers from New Mexico averaged 19.2 J/kg …

Strabismus And Amblyopia In Africa – A Systematic Review And Meta-Analysis, Prince Kwaku Akowuah, Samuel Adade, Andrews Nartey, Ebenezer Owusu, Richard Donkor, Stephen Ankamah-Lomotey

Articles

The objective of this review was to estimate the prevalence of strabismus and amblyopia in Africa. A systematic online literature search was conducted for articles on strabismus and amblyopia in Africa. Meta-analysis was performed, using the Freeman-Tukey double arcsine transformation, to estimate the prevalence of strabismus and amblyopia in Africa. Subgroup analyses were conducted according to age, gender, study year, and type of amblyopia. Meta-regression was used to evaluate the influence of predetermined factors on the prevalence of amblyopia. 8 (1 population-based & 7 school-based) and 21 (3 population-based & 18 school-based) studies on strabismus and amblyopia with sample sizes …

Exploring The Impact Of Noise And Degradations On Heart Sound Classification Models, Davoud Shariat Panah, Andrew Hines, Susan Mckeever

Articles

The development of data-driven heart sound classification models has been an active area of research in recent years. To develop such data-driven models in the first place, heart sound signals need to be captured using a signal acquisition device. However, it is almost impossible to capture noise-free heart sound signals due to the presence of internal and external noises in most situations. Such noises and degradations in heart sound signals can potentially reduce the accuracy of data-driven classification models. Although different techniques have been proposed in the literature to address the noise issue, how and to what extent different noise …

Understanding And Predicting Cognitive Improvement Of Young Adults In Ischemic Stroke Rehabilitation Therapy, Helard Becerra Martinez, Katryna Cisek, Alejandro Garcia-Rudolph, John Kelleher, Andrew Hines

Articles

Accurate early predictions of a patient's likely cognitive improvement as a result of a stroke rehabilitation programme can assist clinicians in assembling more effective therapeutic programs. In addition, sufficient levels of explainability, which can justify these predictions, are a crucial requirement, as reported by clinicians. This article presents a machine learning (ML) prediction model targeting cognitive improvement after therapy for stroke surviving patients. The prediction model relies on electronic health records from 201 ischemic stroke surviving patients containing demographic information, cognitive assessments at admission from 24 different standardized neuropsychology tests (e.g., TMT, WAIS-III, Stroop, RAVLT, etc.), and therapy information collected …