Medicine and Health Sciences Commons^™

Telehealth Benefits In Rural Areas: Occupational Therapy, Grant E. Tolkkinen, Grace K. Torgerson, Kaitlyn J. Wanner

Critically Appraised Topics

This paper focuses on the efficacy of occupational-based interventions administered via telehealth within a rural-dwelling adult (18 years and older) population with mental health conditions. The main factors to consider in this scenario are the mental health services in rural areas, the features of the rural population, and the role of occupational therapy (OT) and telehealth in rural mental health. The Occupational Therapy Practice Framework defined health management as “activities related to developing, managing, and maintaining health and wellness routines, including self-management, with the goal of improving or maintaining health to support participation and other occupation” (AOTA, 2020, p.32).

Advanced Microstructural Characterization Of Functionally Graded Dental Ceramic Material For Materials-Informed Finishing, Angani Vigneswaran

Theses and Dissertations--Manufacturing Systems Engineering

Yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) has gained popularity as the choice of material for dental prosthetics. Ivoclar Vivadent’s IPS e.max ZirCAD Prime dental ceramic incorporates a unique gradient technology that varies the yttria content over the thickness of the material. The top layer is composed of 5Y-TZP which is desired for its optical properties while the bottom layer is composed of a much stronger 3Y-TZP. In between the two layers, 5Y-TZP and 3Y-TZP are mixed to form a transition layer. Varying the amount of yttria allows for more esthetically pleasing translucency in the visible areas of the restoration without compromising …

Heightened Technology In The Care Of Type 1 Diabetes: An Ethical Symbiosis?, Susanna Larsen

OUR Journal: ODU Undergraduate Research Journal

This paper explores the common negative consequences and ethical issues associated with the evolving medical technology used in the care of Type 1 diabetes. In this paper, I will discuss the ethical impacts of technology on diabetic youth: their view of self, their mechanical requirements, and their health priorities. In order to define the scope of the issues, I will use the following intellectual tools: feminist theory, care ethics, and philosophical discussions of control. This paper will also outline some possible solutions to these ethical issues.

University Of South Alabama College Of Medicine Annual Report For 2022-2023, College Of Medicine

COM Annual Reports

What a historic year it has been for the Frederick P. Whiddon College of Medicine. We celebrated the 50th anniversary of the admission of the College’s charter class. We also started the construction of a breathtaking new facility that will offer future medical students and researchers the most advanced learning and research opportunities. This 2022-2023 annual report catalogs the accomplishments of our faculty, staff and students related to teaching, research, scholarship, and community service.

Gamelan Gong Directivity Dataset, Samuel D. Bellows, Dallin T. Harwood, Kent L. Gee, Micah R. Shepherd

Directivity

No abstract provided.

How Is The Human Pangenome Project Like A Whole Person Psychology? (Editor’S Introduction), Glenn Hartelius

International Journal of Transpersonal Studies

N/A

Comments On “Is Biological Death Final? Recomputing The Drake-S Equation For Postmortem Survival Of Consciousness”, Christine Simmonds-Moore

International Journal of Transpersonal Studies

The application of the Drake-S equation to the aggregated data suggestive of survival found 30.3% of unexplained variance in the data when other factors were applied to the dataset (including living agent psi, LAP). A number of points are raised in this commentary. These include 1. the aggregated estimate for LAP should factor in implicit psi studies (among others); 2. it is difficult to ascertain the source of psi if psi is not a signal that is caused, but rather an emergent property of a connected system; 3. there may be shared variance between sources that are attributed differently in …

Forecasting Covid-19 Cases Using Dynamic Time Warping And Incremental Machine Learning Methods, Luis Miralles-Pechuán, Ankit Kumar, Andres L. Suarez-Cetrulo

Articles

The investment of time and resources for developing better strategies is key to dealing with future pandemics. In this work, we recreated the situation of COVID-19 across the year 2020, when the pandemic started spreading worldwide. We conducted experiments to predict the coronavirus cases for the 50 countries with the most cases during 2020. We compared the performance of state-of-the-art machine learning algorithms, such as long-short-term memory networks, against that of online incremental machine learning algorithms. To find the best strategy, we performed experiments to test three different approaches. In the first approach (single-country), we trained each model using data …

The Relationship Between Insufficient Sleep And Mental Health Distress In Ohio Compared To West Virginia And New Jersey, Audrey Nourse, Alexander Winkle

Scholarship in Medicine - All Papers

Objective: To compare and establish the importance of the relationship between insufficient sleep and the frequency of mental health distress in Ohio in contrast to that in West Virginia and New Jersey in 2022. Methods: The data used included information on insufficient sleep, frequency of mental health distress, and premature death per each state studied and was collected from County Health Rankings and then analyzed using a Pearson’s correlation, one way analysis of variance, and multiple linear regression. Ohio was chosen as the reference state with New Jersey and West Virginia as comparisons based on their equivalent population s ize …

Comparing The Impact Of Food Insecurity, Access To Exercise Opportunities, And County Classification On Obesity Rates In Ohio, Ankur Parekh, Deborah Lee

Scholarship in Medicine - All Papers

Objective: We completed a study to determine how food insecurity, access to exercise opportunities, and county classification (rural or urban) impacted obesity rates in Ohio. We hypothesized that the county classification impacted obesity the most followed by food insecurity and access to exercise opportunities.

Methods: We obtained data on food insecurity, access to exercise opportunities, and obesity from County Health Rankings and county classification data from the United States Department of Agriculture Census. We analyzed correlations between obesity and food insecurity and obesity and access to exercise opportunities in both county types. We also analyzed changes in obesity rates in …

Utilizing The Zebrafish Species, Danio Rerio, To Assess The Effect Of Acute Treatment With St. John’S Wort Supplements On Anxiety As Measured By The Novel Dive Tank Test, Sebastian Woodson, Lori Mcgrew Dr.

Research Projects

Background: The zebrafish species, Danio rerio, is a widely utilized model organism with well-characterized behaviors including anxiety-like behavior when placed into a novel environment. In addition, the fish can be treated with substances by immersion.

St. John’s Wort has been suggested as a plant-based treatment for depression and anxiety because it contains compounds that inhibit the serotonin transporter (SERT) among other effects. A number of St. John’s Wort supplements are commercially available.

The National Institute of Mental Health (NIMH) estimates that about 19% of US adults suffer an anxiety disorder each year and about 31% will experience an anxiety disorder …

Early Assessment Of Extremity Compartment Syndrome By Biochemical Markers In A Rat Model, Ahmet Yildirim, İbrahi̇m Özkan Önal, Zeli̇ha Esi̇n Çeli̇k, Hüsametti̇n Vatansev, Esra Paydaş Hataysal

Turkish Journal of Medical Sciences

Background/aim: This experimental study aimed to define a biochemical marker that will enable early diagnosis of acute compartment syndrome (ACS) of extremities, a mortal condition that occurs due to trauma. Materials and methods: A total of 15 Wistar rats were included in the study in which saline infusion technique, a clinically compatible ACS model, was applied. After the rats were anesthetized with ketamine-xylazine, the in-compartment pressure of the hind limb was slowly increased with saline delivered through the angiocatheter, and after reaching the target compartment pressure, the pressure level was kept with a rubber tourniquet. The in-compartment pressure level was …

Effect Of Crocin And Losartan On Biochemical Parameters And Genes Expression Of Frmd3 And Bmp7 In Diabetic Rats, Yaser Mohammadi, Mohammad Zangooei, Fatemeh Salmani, Azam Rezaei Farimani

Turkish Journal of Medical Sciences

Background/aim: Diabetes is a multifactorial and growing disease, one of the severe complications of which is diabetic nephropathy (DN), which is the most common cause of chronic renal failure. FERM domain containing 3 (FRMD3) is responsible for maintaining the shape and integrity of nephron cells, and bone morphogenetic protein 7 (BMP7) helps maintain function and reduce kidney damage. This study aimed to evaluate the effect of crocin and losartan on biochemical parameters and the expression of FRMD3 and BMP7 genes in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Forty male Wistar rats were randomly divided into five experimental groups as …

Effects Of Recurrent Ketamine Exposure On Brain Histopathology In Juvenile Rats, Ayşe Hande Arpaci, Süheyla Esra Özkoçer, Emel Güneş, Çi̇ğdem Elmas, Berri̇n Işik

Turkish Journal of Medical Sciences

Background/aim: Ketamine (KET) is a commonly used anesthetic agent. However, several previous studies reported that KET leads to neuronal damage in neurodevelopmental stages and has neuroprotective effects. The present experimental study aimed to determine the undesirable histopathological effects of KET in the cerebral cortex, striatum, and hippocampus after recurrent KET administration in juvenile rats. Materials and methods: After ethical approval was obtained, 32 juvenile male Wistar Albino rats were randomized into four groups: 1 mg/kg serum saline intraperitoneally (i.p.), 5 mg/kg KET i.p., 20 mg/kg KET i.p., and 50 mg/kg KET i.p. KET was administered for three consecutive days at …

Investigation Of Taurine And Aqueous Garlic Extract Diet Supplementation Effect On The Healing Of Rat Osteoporotic Fractures, Mesut Misirlioğlu, İzzet Bi̇ngöl, Coşkun Genç, Ayli̇n Akbulut, Mert Ocak, Nezi̇ha Yağmur Di̇ker, Ahmet Özmeri̇ç, Gökhan Koca, Meli̇ke Bahçeci̇tapar, Mehmet Şeneş, Ayşegül Firat, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k, İffet İrem Çankaya, Meli̇ha Korkmaz

Turkish Journal of Medical Sciences

Background/aim: We have evaluated the effects of taurine and aqueous garlic extract (AGE) as a dietary supplement on osteoporotic fracture (OPF) healing in the ovariectomized rat femur fracture model. Materials and methods: In this experimental animal study,twenty-four osteoporosis-remodeled female Wistar albino rats were randomly divided into 3 groups (n: 8) according to their supplemented diet; control, taurine, and AGE groups. Unilateral femur middiaphysis mini-open osteotomy was stabilized with Kirschner wires. Six weeks after osteotomy, the rats were sacrificed before the femurs were harvested and OPF healing was evaluated with biochemical, histologic, microcomputed-tomography, and scintigraphic methods. Results: As an indicator of …

The Role Of Curcumin Against Paclitaxel-Induced Oxidative Stress And Dna Damage In Testes Of Adult Male Rats, Esra Balcioğlu, Özge Göktepe, Fazi̇le Cantürk Tan, Pinar Bi̇lgi̇ci̇, Bi̇rkan Yakan, Sai̇m Özdamar

Turkish Journal of Medical Sciences

Background/aim: Paclitaxel is a widely used drug for the treatment of cancer, but it possesses toxic effects on male reproductive system. Administering paclitaxel with an antioxidant has become a strategy for preventing the side effects of paclitaxel. Although curcumin is an antioxidant, data concerning the effect of curcumin on paclitaxel-induced testis tissue are lacking. The present study was established to examine the protective impact of curcumin against testicular damage induced by paclitaxel. Materials and methods: In the study, 40 Wistar albino male rats were used and randomly divided into 4 groups (n:10). The control group received only saline solution; the …

An Experimental Study: The Effect Of S. Boulardii On Abemaciclib-Induced Diarrhea, İbrahi̇m Ethem Cakcak, Yusuf Emre Ayti̇n, Sezi̇n Sayin, Ahmet Küçükarda, Ali̇ Gökyer, İvo Gökmen, Erkan Özcan, Selçuk Korkmaz, Ebru Taşteki̇n, İrfan Çi̇çi̇n

Turkish Journal of Medical Sciences

Background/aim: In our study, we aimed to investigate the protective effects of Saccharomyces boulardii on abemaciclib-induced diarrhea model, which is a commonly used drug in breast cancer. Materials and methods: Thirty rats were divided into 3 groups as control (Group 1), abemaciclib (Group 2), and abemaciclib + Saccharomyces boulardii (Group 3) groups. The clinical status, body weight, and defecation status were monitored daily. At the end of the 15-day experiment period, the rats were killed with high-dose anesthesia and the resected small intestine segments were evaluated histopathologically. Lesions were classified according to thickening of the villus, inflammation and edema of …

Evaluation Of The Effects Of Three Natural Products And A Hemostatic Agent On Wound Healing: An Experimental Study, Ayşe Çeli̇k Yilmaz, Di̇lek Aygi̇n

Turkish Journal of Medical Sciences

Background/aim: People have used many natural materials such as plant leaves, roots, liquids derived from plants, and animal products to treat wounds throughout history. It can be said that the research on wound care in recent years have focused on traditional and natural products again. This study aimed to investigate the effects of sweetgum oil, propolis, silk protein, and Ankaferd Blood Stopper (ABS) on wound healing in an experimental excisional wound model. Materials and methods: Including 36 Balb/c inbreed mice in the study were divided equally into four groups. Two circular excisional wounds were created on the dorsal skin of …

Is Advanced Bipolar Vessel Sealing Device Really Effective In Decreasing The Pelvic Lymphocele Ratio In Open Surgery For Endometrial Cancer?, Mehmet Ali̇ Nari̇n, Sevda Baş, Sevtap Seyfetti̇noğlu, Tuba Yar, Razi̇ye Nari̇n

Turkish Journal of Medical Sciences

Background/aim: We aim to show pelvic lymphocele (PL) rates in patients who were operated for endometrial cancer (EC) and underwent systematic paraaortic bilateral pelvic lymph node dissection (PABPLND) with advanced bipolar vessel sealing device (ABVSD) Materials and methods: The medical files of all patients who underwent open surgery for EC between January 2017 and December 2021 were retrospectively analyzed. One hundred three patients who operated with the diagnosis of high-intermediate and high-risk endometrial cancer were included. Systematic PABPLND was performed with total abdominal hysterectomy with or without bilateral salpingo-oophorectomy during surgery to all patients. All operations were performed by same …

Primary Versus Secondary Intraocular Lens Implantation Following Removal Of Congenital/Developmental Cataracts: Outcomes After At Least 4 Years, Ayşi̇n Tuba Kaplan, Si̇bel Öskan Yalçin, Ayşe Yeşi̇m Oral

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to evaluate the long-term outcomes of primary and secondary intraocular lens (IOL) implantation following removal of congenital/developmental cataracts. Materials and methods: One hundred and forty-four patients aged under 16 years who were followed up between 2003 and 2021 were analyzed retrospectively. The long-term results of children who underwent surgery before 2 years of age for congenital or developmental cataracts and underwent secondary IOL implantation after 2 years of age and those who underwent cataract surgery with primary IOL implantation after 2 years of age were compared. Patients with traumatic, secondary cataracts and cataracts …

Postnatal Surgery For Myelomeningocele In Neonates: Neurodevelopmental Outcomes, Melek Akar, Gülşah Çeti̇n, Mi̇ne İnal, Mehmet Helvaci, Ni̇hal Olgaç Dündar, Firat Ergi̇n, Özgün Uygur, Si̇nem Akbay, Nai̇l Özdemi̇r, Meltem Koyuncu Arslan, Mehmet Yekta Öncel

Turkish Journal of Medical Sciences

Background/aim: The study aims to evaluate the neurodevelopmental outcomes of neonates with myelomeningocele (MMC) operated in the postnatal period. Materials and methods: This is a prospective follow-up study in a tertiary neonatal intensive care unit. Neurodevelopmental outcomes of term neonates operated for MMC and healthy term newborns were compared with the Bayley Scales of Infant and Toddler Development -Third Edition (BSID III) at 12-18 months. Results: A total of 57 cases were included in the study (patient group = 27; control group = 30). Demographic data between the groups were similar. Cognitive, linguistic, and motor composite scores of the patient …

Transbronchial Lung Cryobiopsy For The Diagnosis Of Diffuse Parenchymal Lung Disease: Pitfalls And Challenges, A Single Center Experience, Kemal Can Tertemi̇z, Ayli̇n Özgen Alpaydin, Nurcan Güler, Volkan Karaçam, Duygu Gürel, Naci̇ye Si̇nem Gezer

Turkish Journal of Medical Sciences

Background/aim: Transbronchial lung cryobiopsy (TBLC) is a minimally invasive technique of the diagnosis of diffuse parenchymal lung diseases (DPLD). The aim of this study is to determine the clinical-radiological and histopathological characteristics of patients in whom cryobiopsy contributes to the diagnosis. Materials and methods: In this retrospective study, we searched for the medical records of patients who underwent TBLC from July 2015 to March 2020 at the pulmonology department of our university hospital clinic. Radiological images were evaluated by a chest radiologist experienced in DPLD. Prediagnosis was indicated by clinical-radiological findings. The final diagnosis was determined by the contribution of …

Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ

Turkish Journal of Medical Sciences

Background/aim: Preterm births cause fetuses to be born without completing the development of their organs. Due to this undesirable situation, it is the pulmonary tissue which has to be most exposed to harmful effects of extrauterine environment. Early disappearance of the prophylactic and constructive effects of amniotic fluid (AF) on developing tissues, such as pulmonary tissue, facilitates the formation of pulmonary morbidities resulting from oxygen. Setting out from this knowledge, we wanted, in addition to assessing the beneficent effects of AF on pulmonary tissue, to study the importance of AF in morbidities of this tissue thought to originate from oxygen. …

A New Method For Second Toe Flap Revascularization In Plantar Dominant Artery Pattern - Dorsal Metatarsal Artery Interpositional Graf, Erhan Sönmez, Ersi̇n Akşam, İlker Uyar

Turkish Journal of Medical Sciences

Background/aim: Toe transfer to hand is a viable option for patients, which can provide functionally useful digits. Harvesting of the second toe is still accepted as a demanding surgical procedure. The major questions before this transfer are the location and the dominance of the arterial anatomy of the second toe. The authors present the incidence of patients with a dominant plantar artery system and a description of a versatile technique that can be used for toe transfers in these patients. Materials and methods: The study was designed retrospectively. Toe to hand transfers performed between 2010 and 2018 were reviewed. The …

Effects Of Breast Milk On Behçet's Disease Clinical Features, Hati̇ce Ecem Konak, Abdulsamet Erden, Berkan Armağan, Serdar Can Güven, Hakan Apaydin, Pinar Akyüz Dağli, Yağnur Uzun, Merve Kaygisiz, Orhan Küçükşahi̇n, Ahmet Omma

Turkish Journal of Medical Sciences

Background/aim: The etiology of Behçet's disease (BD) is not clearly known, however, abnormal activity in T helper (Th) 1, Th 17, and regulatory T cells (Treg) has critical importance in pathogenesis. It has been shown that the intestinal microbiome can be effective in the modulation of these immune abnormalities in BD patients. Breastfeeding increases the maturation of the infant's intestinal permeability by affecting the newborn's immature intestinal microbiome and metagenome. We aimed to examine the effects of breastfeeding on disease related symptoms, organ involvements and course of the disease in BD patients. Materials and methods: This study was designed as …

Decreased Circulating Microrna-21 And Microrna-143 Are Associated To Pulmonary Hypertension, Zekeri̇ya Düzgün, Lati̇fe Meral Kayikçioğlu, Çağdaş Aktan, Buşra Bara, Fatma Zuhal Eroğlu, Burcu Yağmur, Vi̇ldan Bozok Çeti̇ntaş, Meli̇ke Bayindir, Sanem Nalbantgi̇l, Asli Teti̇k Vardarli

Turkish Journal of Medical Sciences

Background/aim: Pulmonary arterial hypertension (PAH) is characterized by maladaptation of pulmonary vasculature which is leading to right ventricular hypertrophy and heart failure. miRNAs play a crucial role in the regulation of many diseases such as viral infection, cancer, cardiovascular diseases, and pulmonary hypertension (PH). In this study, we aimed to investigate the expression pattern of eight human plasma miRNAs (hsa-miR-21-3p, hsa-miR-143- 3p, hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-190a, hsa-miR-204-3p, hsamiR-206, hsa-miR-210-3p) in mild-to-severe PH patients and healthy controls. Materials and methods: miRNAs were extracted from the peripheral plasma of the PH patients (n: 44) and healthy individuals (n: 30) by using the miRNA …

Lag-3 Expression In Tumor Microenvironment Of Triple-Negative Breast Cancer, Gözde Tahtaci, Nazan Günel, Aysu Sadi̇oğlu, Nalan Akyürek, Oğulcan Boz, Aytuğ Üner

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the expression of lymphocyte activation gene-3 (LAG-3) and its relationship with programmed cell death ligand-1 (PD-L1) in triple-negative breast cancer (TNBC). Materials and methods: LAG-3 and PD-L1 was evaluated in tumor-infiltrating lymphocytes (TILs) using immunohistochemistry (IHC). The chi-square test was used to estimate the associations between LAG-3, PD-L1 and clinicopathological characteristics. Correlation between LAG-3 stromal TIL (sTIL), LAG-3 intraepitelial TIL (iTIL) and PD-L1 was assessed with using the Spearman's correlation coefficient. Survival analysis was performed using the Kaplan-Meier method. Results: The percentages of LAG-3 sTIL+, LAG-3 iTIL+, PD-L1+ tumor cells and PD-L1+ inflammatory cells …

Expression Of Laminin-1 And Matrix Metalloproteinase-9 In Benign And Malignant Endometrium, Zehra Küçükaydin, Mustafa Başaran, Yaşar Ünlü, Ahmet Başaran, Merti̇han Kurdoğlu

Turkish Journal of Medical Sciences

Background/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression from benign to malignant endometrium, so we aimed to investigate their levels of expression in these tissues. Materials and methods: This case-control study was conducted at a tertiary care center between January 2014 and December 2016. Paraffin blocks of 50 specimens of benign endometrium with proliferative (n = 20), secretory (n = 11), and atrophic (n = 5) endometrium; simple endometrial hyperplasia without atypia (n = 12); and endometrial polyp (n = 2) histology and 49 specimens of malignant endometrium with endometrioid (n = 40), serous (n = …

Serum Vitamin D Levels Are Associated With Acute Postoperative Pain And Opioid Analgesic Consumption After Laparoscopic Cholecystectomy: A Strobe Compliant Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Ahmet Yüksek, Ayşe Yeşi̇m Göçmen, Mehmet Kağan Katar, Mahmut Kiliç, Mehtap Honca

Turkish Journal of Medical Sciences

Background/aim: In this prospective observational study, we aimed to evaluate the relationship between serum levels of vitamin D and acute postoperative pain scores, as well as opioid analgesic consumption in patients undergoing laparoscopic cholecystectomy. Materials and methods: The study was performed in the Medical Faculty Hospital, from April 2020 to April 2021. Postoperative visual analog scale (VAS) pain scores, total tramadol consumption, number of requests on patient-controlled analgesia (PCA) were compared between the vitamin D deficient (≤20 ng/mL; n = 25) and vitamin D nondeficient (>20 ng/mL; n = 55) groups at five time points (T0: in the recovery …

Significance Of The Immunofluorescence Staining Patterns And Titres Of The Antinuclear Antibody Test In Paediatric Rheumatology Setting, Özge Baba, Hakan Kisaoğlu, Mukaddes Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: Antinuclear antibody (ANA) is among the most frequently ordered tests in paediatric rheumatology setting. Diseases like systemic lupus erythematosus and Sjögren syndrome is closely related with a positive ANA and classified as ANA associated diseases. Besides, ANA test is ordered in patients with juvenile idiopathic arthritis (JIA) to assess the risk for uveitis and a positive ANA could be detected in children with nonrheumaticrheumatic conditions. In this study, we aimed to investigate frequency of positive ANA in paediatric rheumatology setting and the association of immunofluorescence staining patterns and titres of ANA with rheumatic diseases. Materials and methods: Immunofluorescence staining …