Medicine and Health Sciences Commons^™

At The Heart Of The Diagnosis: A Case Of Systemic Lupus Erythematosus Presenting As Cardiac Tamponade, Jose Gomez Casanovas, Mery Bartl, Laura Rincon-Rueda, Christine E. Loftis, Emilia Dulgheru

School of Medicine Publications

Systemic lupus erythematosus (SLE) is a heterogenous, systemic disease characterized by the production of pathogenic autoantibodies against nuclear antigens. Although the most common cardiac manifestation of SLE is pericardial effusions, their progression to cardiac tamponade is rare and has an incidence between 1-3%. We describe a case of a 42-year-old Hispanic woman who presented with severe shortness of breath, vague chest pain, and hemodynamic compromise secondary to cardiac tamponade. The patient's underlying etiology of cardiac tamponade was attributed to a new diagnosis of SLE based on the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology classification (EULAR/ACR) criteria …

Measures Of Carotid Atherosclerosis And Fall-Related Hospitalization Risk: The Perth Longitudinal Study Of Ageing Women, Abadi K. Gebre, Marc Sim, Jack Dalla Via, Alexander J. Rodríguez, Jonathan M. Hodgson, Catherine P. Bondonno, Peter L. Thompson, Richard L. Prince, Joshua R. Lewis

Research outputs 2022 to 2026

Background and aims: We and others have identified links between cardiovascular conditions and poor musculoskeletal health. However, the relationship between measures of carotid atherosclerosis such as focal carotid plaque and common carotid intima media thickness (CCA-IMT) and falls remains understudied. This study examined the association between measures of carotid atherosclerosis and fall-related hospitalization over 11.5 years in community dwelling older women. Methods and results: 1116 older women recruited in 1998 to a five-year randomized controlled trial to examine the effect of calcium supplementation in preventing fracture and who had undertaken B-mode ultrasound in 2001 (three years after the baseline clinical …

The Hepatic Mitochondrial Pyruvate Carrier As A Regulator Of Systemic Metabolism And A Therapeutic Target For Treating Metabolic Disease, Kyle S Mccommis, Brian N Finck

2020-Current year OA Pubs

Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy stored in this nutrient to be fully harnessed to generate ATP or to become the building block of new biomolecules. Given the requirement for mitochondrial import, it is not surprising that the mitochondrial pyruvate carrier (MPC) has emerged as a target for therapeutic intervention in a variety of diseases characterized by altered mitochondrial and intermediary metabolism. In this review, we focus on the role of the MPC and related metabolic pathways …

Effect Of Histology On Stereotactic Body Radiotherapy For Non-Small Cell Lung Cancer Oligometastatic Pulmonary Lesions, Alexander J. Allen, Dominic A. Labella, Roman O. Kowalchuk, Michael R. Waters, Charles R. Kersh

2020-Current year OA Pubs

BACKGROUND: Stereotactic body radiotherapy (SBRT) is commonly used to provide targeted treatment to metastatic lung disease. Investigation is needed to understand the influence of histology on treatment outcomes. We report how tumor histology affects local control (LC) in a cohort of patients with non-small cell lung cancer (NSCLC) receiving SBRT for oligometastatic and recurrent pulmonary lesions.

METHODS: Patients who received SBRT to recurrent or oligometastatic NSCLC pulmonary lesions from 2015-2019 at our institution were included in this retrospective cohort study. Minimum follow-up was 2 months. Kaplan-Meier (KM) analysis was performed to assess local progression-free survival (LPFS). Local failure cumulative incidence …

Nonhuman Primate Genetic Models For The Study Of Rare Diseases, Eric J Vallender, Charlotte E Hotchkiss, Anne D Lewis, Jeffrey Rogers, Joshua A Stern, Samuel M Peterson, Betsy Ferguson, Ken Sayers

Faculty, Staff and Students Publications

Pre-clinical research and development relies heavily upon translationally valid models of disease. A major difficulty in understanding the biology of, and developing treatments for, rare disease is the lack of animal models. It is important that these models not only recapitulate the presentation of the disease in humans, but also that they share functionally equivalent underlying genetic causes. Nonhuman primates share physiological, anatomical, and behavioral similarities with humans resulting from close evolutionary relationships and high genetic homology. As the post-genomic era develops and next generation sequencing allows for the resequencing and screening of large populations of research animals, naturally occurring …

Mutations In The Transcriptional Regulator Mecp2 Severely Impact Key Cellular And Molecular Signatures Of Human Astrocytes During Maturation, Jialin Sun, Sivan Osenberg, Austin Irwin, Li-Hua Ma, Nigel Lee, Yangfei Xiang, Feng Li, Ying-Wooi Wan, In-Hyun Park, Mirjana Maletic-Savatic, Nurit Ballas

Faculty, Staff and Students Publications

Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human astrocyte developmental maturation, thereby affecting their ability to support neurons. Using human-based models, we show that RTT-causing MECP2 mutations greatly impact the key role of astrocytes in regulating overall brain bioenergetics and that these metabolic aberrations are likely mediated by dysfunctional mitochondria. During post-natal maturation, astrocytes rely on neurons to induce their complex stellate morphology and transcriptional changes. While MECP2 mutations cause cell-intrinsic aberrations in the astrocyte transcriptional landscape, surprisingly, they do not affect the neuron-induced …

Effects Of A Race Timer On The 3-Minute All-Out Test For Critical Power, Paul Mandell, Boe Burrus, Taylor Bloedon

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 2, 2023. The 3-min all-out cycling test (3MT) elicits valuable fitness metrics including V̇O_2peak, HR_max, Critical Power (CP), and Work Above End Power (WEP; equivalent to work prime; W’). Twelve (n = 12) healthy active males were recruited to participate in the current study on the effects of the implementation of a race timer on the 3MT. Participants completed a V̇O_2peak test and one 3MT familiarization trial before completing one standard 3MT and one 3MT with the presence of a countdown race timer in …

What Did We Learn About Vads In 2022?, Maya Guglin

The VAD Journal

This is our 9^th annual literature review on mechanical circulatory support devices. Our previous reports were well received by the readers.

In this paper, we summarized the most interesting and important, from our standpoint, publications from 2022. There may be some slight overlap with the end of 2021 because some papers were published online first, and the year of the publication changed when they became available in print.

For the sixth time, we wrote a section on extracorporeal membrane oxygenation (ECMO) which primarily addresses new developments in veno-arterial ECMO.

Readers who wish to supplement this review, argue with the …

A Brief Overview Of Triple A Syndrome, Jamaal Khan

Mako: NSU Undergraduate Student Journal

Triple A Syndrome, also known as AAA Syndrome, is a rare autosomal recessive disorder caused by any mutation in the AAAS gene on chromosome 12q13, whose main function is to code for the WD-repeat family regulatory protein, ALADIN. It typically occurs as a group of diseases that are characterized by alacrima, Addison's disease, and achalasia. Alacrima can be defined by a decrease in the amount of tears produced while achalasia is nerve damage in the esophagus that can cause difficulty swallowing. Lastly, Addison's disease is the insufficient production of cortisol and aldosterone produced by the adrenal cortex. There is no …

Genetic Enhancement Of The Inevitable, Varun Kota

Mako: NSU Undergraduate Student Journal

The invention of CRISPR-CAS9 allows one to edit the genome easily. As a result, many are excited by the potential breakthroughs in medical applications. Others worry that the development of this technology will lead to genetic enhancement, the modification of a set of genes toward a non-therapeutic end goal. After reviewing the philosophical and ethical literature regarding genetic enhancement it became apparent that there was a lack of specificity. Often, the arguments portrayed genetic enhancement as an unbelievable process. In reality, the effects of genetic enhancement are far tamer. The folly in these discussions lies in the notion that traits …

Honors Thesis – Awareness Of Autism In Black And Brown Communities, Varun Kota

Mako: NSU Undergraduate Student Journal

Autism Spectrum Disorder (ASD) affects a multitude of races and ethnicities as its impact varies from person to person. ASD is typically diagnosed around the age of two to three years old since signs and symptoms of Autism become clinically apparent at that time. Increased reporting of Autism in local communities has surged from diagnostic tools and criteria. However, even with these advancements, the African American community suffers a delayed diagnosis of ASD. This issue poses problems for both the parents and children with Autism and has broader implications for the South Florida community; opportunities are limited for developmental services …

Effect Of Chlorhexidine On Nanoleakage And Bond Durability Of Two Adhesives To Dentin: An In Vitro Study, Rowayda Anwar Eltarawy, Essam Naguib, Ahmed Z. Elhoshy, Sara H. Younis

Future Dental Journal

Abstract

Aim: This study aimed to investigate the effect of chlorhexidine (CHX) on nanoleakage (NL) and dentin bond durability of two adhesives after water storage.

Materials and Methods: Thirty-six extracted molars were divided into three groups and their buccal surfaces were reduced to expose flat dentin surfaces. In group 1 Single Bond Universal Adhesive (SBU) was used, in group 2 Peak universal Bond (PUB) was applied while in group 3 Chlorhexidine Gluconate Disinfecting Solution followed by Single Bond Universal Adhesive (CHX+SBU) was used. Application of resin composite restorations was performed in all three groups. For each bonding procedure, …

Effect Of External Bleaching On Color Change Of Single Shade Resin Composite Versus Nano-Filled Resin Composite In Class V (In Vitro Study), Akram Gamal Diab, Essam Naguib, Ahmed Zoheir Elhoshy, Ahmed Mohamed Fouad

Future Dental Journal

This study investigated the effect of bleaching on color change of the single shade universal composite (Omnichroma) versus nano-filled resin composite (Z350 XT).

Methods: Twenty premolars of shade A3 were used for the study. Standardized class V cavities were prepared on the cervical third of the buccal surface of all teeth. After that, teeth were randomly divided into two groups of 10 teeth each according to the type of resin composite used. After composite application, all teeth were stored individually in distilled water for 24 hours. Evaluation of the restoration color was done using VITA Easyshade. The teeth were bleached …

Evaluation Of Color Difference And Translucency Of Modified Peek Restorations Veneered With Different Veneering Materials Before And After Thermal Cycling, Mohamed Hamdy Abdulmaguied, Tarek Salah Morsi, Mennatallah M. Wahba, Hesham Katamish

Future Dental Journal

Objective: The aim of this study was to investigate the effect of different PEEK veneering materials, as well as thermocycling on the color difference (ΔE) and the translucency parameter (TP) of modified PEEK veneered restorations.

Materials and Methods: Thirty disc shaped specimens of veneered BioHPP (1.5 mm X 12 mm) were randomly divided into three groups (n=10) based on the type of the veneering material. Group (A): Discs veneered with CAD milled Lithium Disilicate, group (B): Discs veneered with pre-cured milled composite, and group (C): Discs veneered with conventional light cured composite. CIELab values were calculated for all specimens over …

Correlating Parenting Style With Their Children’S Behavior, Dental Anxiety And Dental Caries During The First Dental Visit, Esraa Abdelfattah Khattab, Norhan Abd El-Wahab El-Dokky Professor Of Pediatric Dentistry & Dental Public Health, Randa Youssef Abd Al Gawad Professor Of Pediatric Dentistry & Dental Public Health

Future Dental Journal

Aim: Correlating parenting style with their children’s behavior, dental anxiety and dental caries during the first dental visit.

Methodology: A cross sectional study was conducted. Self-administered structured questionnaire ( PSDQ) contains 32 statements regarding different parent reactions to child behavior, and participants rated responses to each item using a five-point likert scale from “never” to “always” (coded 1 to 5).The target population consisted of 105 children with their parents in Faculty of Dentistry, Future University aged 3-6 years old. The highest mean score placed the parent in the proper parenting category. The child behavior was assessed using the Frankl scale …

Simultaneous 3d Reconstruction And Implant Placement Using Allogenic Laminar Bone Membranes In Atrophic Mandible. A Comparative Clinical Study, Sara T. Elshayat, Mohamed Diaa Zein El-Abdein, Waleed Ragab El Beialy, Waleed F. Esmael

Future Dental Journal

Objective: to compare the outcome of allogenic bone sheets clinically and radiographically in posterior mandibular vertical augmentation in Luhr class III cases with simultaneous implant placement using autogenous versus xenografts.

Patients and methods: this study was based on a total of 12 implants placed in 4 patients, 2 of which were males and 2 females. Patients were divided into 2 groups, both treated with implants placed with exposed threads 3 mm crestally and covered buccolingually with the laminar bone membrane; group 1 received autogenous bone obtained from the same surgical site using 4.5 diameter ACM bur mixed with PRP and …

Clinical And Radiographic Assessment Of Xenogenic Bone Graft With Or Without Hyaluronic Acid For Post Extraction Socket Preservation (Randomized Clinical Trial), Khaled Mohie Aldeen Abdelzaher, Lobna Abdel Aziz Aly Prof, Mostafa Ezz Prof., Mahmoud Mohsen Elsayed Hassan Elarini Dr.

Future Dental Journal

hyaluronic acid shows osteogenic potentials which considered important property during bone regeneration. So, we aim to assess the efficiency of hyaluronic acid with xenograft mixture in post extraction alveolar sockets to decelerate resorption of dental alveolar ridge.

Analysis Of Smile Characteristics Of Adult Female Subjects With Skeletal Class Ii Division 2 Malocclusion, Ahmed Ibrahim Nabawi, Fouad A. El Sharaby

Future Dental Journal

Aim: The objective of this study was to evaluate the smile characteristics of adult females with Angle Class II division 2 malocclusion compared to Angle Class I malocclusion. Materials and Methods: Two frontal photographs were taken for 30 orthodontically untreated female adult subjects with age range (18-30) years, at rest and posed smile from a fixed (1.5m) distance between the camera and the subjects. The 30 subjects were divided into 2 groups, 15 for Class II div 2 subjects and 15 for Class I subjects. The camera was focused only on the mouth, showing from the nose to the chin. …

Effect Of Low-Level Diode Laser Bio-Stimulation On Implant Stability Before, During And After Immediate Implants In Mandibular Molars. (A Randomized Clinical Study), Ahmed Elsayed Fahim A.Faim, Ahmed Farid Shehab, Waleed Ragab El-Beialy, Ahmed Abozekry

Future Dental Journal

Introduction: Tooth loss can affect the person’s life dramatically. Tooth loss is accompanied by bone loss in all dimensions, so preservation of the bone is mandatory for placement of dental implant.

Immediate implant can preserve alveolar bone. Due to difference in shape between the implants and extracted roots a gap appears between the immediately placed implant and the extraction socket resulting in jumping distance, Bone grafts are commonly used to fill this gap, recent studies suggest that jumping gaps shouldn’t always be grafted.

Low level bio stimulation has stimulatory effect on bone cells so it can be used in immediate …

Evaluation Of Apoptotic Effect Of Betanin Nanoparticles Against Squamous Cell Carcinoma Cell Line Compared To Doxorubicin, Noha Hassanine [email protected], Future University In Egypt, Amany M. Taha Lecturer, Al Azhar University, Egypt, Eman A. Abohager Professor, Al Azhar University

Future Dental Journal

Objective : to evaluate the anticancer effect of nano sized betanine particles (betanine NP) on squamous cell carcinoma cell line compared to doxorubicin (DOX) by measuring apoptosis through caspase 3. Methods: Three groups of the human tongue squamous cell carcinoma cell line (SCC 25) were created, and two of them were treated with DOX and betanine NP. The third group served as a negative control and was not given any treatment. To evaluate the concentration of caspase 3 using the ElISA technology, different quantities of betanin NP and DOX were administered to SCC25 at 48- and 72-hour intervals.Results: …

The Effect Of Different Irrigant Activation Methods On Postoperative Pain After Endodontic Retreatment, Reem B. Habib, Wael H. Kamel, Nehal N. Roshdy, Marwa M. Aboushadi

Future Dental Journal

Objective: This study was designed to evaluate the effect of different irrigant activation methods on post operative pain after endodontic retreatment. Materials and Methods : Seventy eight patients need non surgical retreatment in mandibular first molar were involved in the study. The retreatment was performed in two visits ,at first visit cases were randomly divided into three groups according to methods of irrigant activation after root canal retreatment with protaper next rotary Ni-TI system. Group A (n=26) Root canals were irrigated using 2.6% sodium hypochlorite (NaOCl) with manual dynamic agitation using master cone Group B (n=26) Root canals were irrigated …

Evaluation Of Postoperative Pain Following Sonic And Ultrasonic Root Canal Irrigation Activation Protocols In Patients With Non-Vital Teeth Associated With Apical Periodontitis (Randomized Clinical Trial), Esraa Ashraf Ibrahim, Wael Ahmed Hessein, Nehal Nabil Roshdy, Adel Abdelwahed

Future Dental Journal

Objectives Evaluate the degree of postoperative pain in patients with necrotic teeth with symptomatic apical periodontitis in mandibular first molar teeth at 6, 12, 24, 48 and 72 hrs time interval after using different irrigation activation techniques in single-visit endodontic treatment.

Methods Seventy-eight patients diagnosed with necrotic mandibular first molar with symptomatic apical periodontitis were randomly allocated into 1 of 3 separate groups (n=26); Navitip group (control), EndoUltra group, or Eddy group. After a single visit root canal treatment and a specific method of agitation, depending on each group, the patients were given a questionnaire on which the patient would …

International Multicenter Study Comparing Covid-19 In Patients With Cancer To Patients Without Cancer: Impact Of Risk Factors And Treatment Modalities On Survivorship., Issam I Raad, Ray Hachem, Nigo Masayuki, Tarcila Datoguia, Hiba Dagher, Ying Jiang, Vivek Subbiah, Bilal Siddiqui, Arnaud Bayle, Robert Somer, Ana Fernández Cruz, Edward Gorak, Arvinder Bhinder, Nobuyoshi Mori, Nelson Hamerschlak, Samuel Shelanski, Tomislav Dragovich, Yee Elise Vong Kiat, Suha Fakhreddine, Abi Hanna Pierre, Roy F Chemaly, Victor Mulanovich, Javier Adachi, Jovan Borjan, Fareed Khawaja, Bruno Granwehr, Teny John, Eduardo Yepez Yepez, Harrys A Torres, Natraj Reddy Ammakkanavar, Marcel Yibirin, Cielito C Reyes-Gibby, Mala Pande, Noman Ali, Raniv Dawey Rojo, Shahnoor M Ali, Rita E Deeba, Patrick Chaftari, Takahiro Matsuo, Kazuhiro Ishikawa, Ryo Hasegawa, Ramón Aguado-Noya, Alvaro Garcia García, Cristina Traseira Puchol, Dong Gun Lee, Monica Slavin, Benjamin Teh, Cesar A Arias, Dimitrios P Kontoyiannis, Alexandre E Malek, Anne-Marie Chaftari

Oncology Articles

BACKGROUND: In this international multicenter study, we aimed to determine the independent risk factors associated with increased 30 day mortality and the impact of cancer and novel treatment modalities in a large group of patients with and without cancer with COVID-19 from multiple countries.

METHODS: We retrospectively collected de-identified data on a cohort of patients with and without cancer diagnosed with COVID-19 between January and November 2020 from 16 international centers.

RESULTS: We analyzed 3966 COVID-19 confirmed patients, 1115 with cancer and 2851 without cancer patients. Patients with cancer were more likely to be pancytopenic and have a smoking history, …

Dynamic Fecal Microbiota Transfer From Mice With Western Diet-Induced Severe Colitis And Colon Tumorigenesis Did Not Exacerbate Colitis Symptoms Or Colon Tumorigenesis In Recipient Mice Fed Either The Ain93g Diet Or The Total Western Diet, Abby D. Benninghoff

Browse all Datasets

Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter the fecal microbiome composition in mice as com-pared to mice fed a healthy diet, AIN93G (AIN). However, it is unclear whether the gut micro-biome contributes directly to colitis-associated CRC in this model. The objective of this study was to determine whether dynamic fecal microbiota transfer (FMT) from host mice fed either AIN or TWD basal diets would alter colitis symptoms or colitis-associated CRC in recipient mice, which were fed either AIN or TWD directly using a 2x2 factorial experiment …

2023-01-30_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

How Covid Changed School, Anonymous

Community Reflections

I would have told you that this is a science-fiction story but it actually happened to me while I was in high school. My experience in high school was just like everyone else’s that I knew. There were good days and bad days. It was a lot like my older sister’s experience in high school until it wasn't due to COVID-19.

Learning During Covid, Anonymous

Community Reflections

This shows how covid effected my education as well as my mental health.

2023-01-30 Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Homeschool Educators’ Perspectives About Student Needs Within Occupational Therapy Scope Of Practice: A Pilot Study, Susan L. Iliff, Mary T. Hill, Rose White, Aubrey Alexander

Pediatrics Research and Scholarship

Homeschool educators (n = 31) were recruited to complete an electronic survey describing their perspectives. Findings indicated that many students had medical/academic needs, and accessed additional services such as occupational therapy (OT). Data analysis of open-ended questions revealed common categories: (a) curricula met or did not meet student needs (b) participants had experience-based, general or no knowledge of OT and (c) most felt homeschooling was a positive experience and expressed that limited resources were available. Further research is warranted to investigate available resources, specific needs, and how to best support students who homeschool.

Sight The Mite: A Meta-Analysis On The Diagnosis Of Scabies, Qaas Shoukat, Ahraz Rizvi, Waseem Wahood, Skyler Coetzee, Algevis Wrench

HPD Articles

This meta-analysis was performed to assess the efficacy of the diagnostic tests for scabies infections that are currently in wide use. Scabies is most commonly diagnosed through clinical presentations; however, due to the wide array of symptoms, diagnosis is difficult. The most commonly used diagnostic test is skin scraping. However, this test relies on correctly selecting the site of mite infection for sampling. Due to the mobile nature of a live parasitic infection, the mite can often be missed based on its current location within the skin. The goal of this paper is to determine if a gold standard confirmatory …