Medicine and Health Sciences Commons^™

Potential Of Dietary Flavonoids In The Prevention And Therapy Of Covid-19 : Focusing In Mast Cell - Calcium Ion Channel Axis, Aryo Tedjo

Indonesian Journal of Medical Chemistry and Bioinformatics

Syndrome Acute Respiratory Syndrome Corona Virus-2 (SARS COV2) is the virus that causes the COVID19 disease and has caused more than 4 million deaths worldwide. This virus infects the host cell through the interaction between the virus’s glycoprotein S molecule with the ACE2 which is the virus receptor, binding, undergoes membrane fusion and enters the cell and replicates in it. Currently, several strategies used in developing anti-viral compounds are targeting compounds that play a role in the process of entering the virus into host cells such as ACE2, S glycoprotein, and TMPRSS2, while some target main proteases such as RNA …

Inferring Gene Regulatory Networks From Rna-Seq Data Using Kernel Classification, Amira Al-Aamri, Andrzej S Kudlicki, Maher Maalouf, Kamal Taha, Dirar Homouz

Faculty, Staff and Student Publications

Gene expression profiling is one of the most recognized techniques for inferring gene regulators and their potential targets in gene regulatory networks (GRN). The purpose of this study is to build a regulatory network for the budding yeast Saccharomyces cerevisiae genome by incorporating the use of RNA-seq and microarray data represented by a wide range of experimental conditions. We introduce a pipeline for data analysis, data preparation, and training models. Several kernel classification models; including one-class, two-class, and rare event classification methods, are used to categorize genes. We test the impact of the normalization techniques on the overall performance of …

Students' Understanding Of Self-Management In Aphasia Treatment, Maryse Azer

Honors College Theses

Aphasia is a neurogenic language disorder caused by damage to the language areas of the brain in the left hemisphere, resulting in speech and language impairments. People with aphasia (PWA) often receive services from speech-language pathologists (SLPs) who provide screening, assessment, diagnosis, and treatment to address communication deficits. Aphasia is a chronic condition and PWA experience symptoms throughout their lives. Healthcare costs related to aphasia account for $46 billion annually. Provider shortages, lack of transportation, insurance constraints, and travel expenses can leave PWA without adequate care. One possible solution to the costs and access issues is the implementation of self-management …

Correction: Single-Cell Multi-Omics Integration For Unpaired Data By A Siamese Network With Graph-Based Contrastive Loss, Chaozhong Liu, Linhua Wang, Zhandong Liu

Faculty, Staff and Students Publications

No abstract provided.

Steroid Receptor Coactivator-3 Is A Key Modulator Of Regulatory T Cell-Mediated Tumor Evasion, Sang Jun Han, Prashi Jain, Yosef Gilad, Yan Xia, Nuri Sung, Mi Jin Park, Adam M Dean, Rainer B Lanz, Jianming Xu, Clifford C Dacso, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Steroid receptor coactivator 3 (SRC-3) is most strongly expressed in regulatory T cells (Tregs) and B cells, suggesting that it plays an important role in the regulation of Treg function. Using an aggressive E0771 mouse breast cell line syngeneic immune-intact murine model, we observed that breast tumors were 'permanently eradicated' in a genetically engineered tamoxifen-inducible Treg-cell specific SRC-3 knockout (KO) female mouse that does not possess a systemic autoimmune pathological phenotype. A similar eradication of tumor was noted in a syngeneic model of prostate cancer. A subsequent injection of additional E0771 cancer cells into these mice showed continued resistance to …

Hpv-Related Anal Cancer Is Associated With Changes In The Anorectal Microbiome During Cancer Development, Jacob H Elnaggar, Victoria O Huynh, Daniel Lin, R Tyler Hillman, Chike O Abana, Molly B El Alam, Katarina C Tomasic, Tatiana V Karpinets, Ramez Kouzy, Jae L Phan, Jennifer Wargo, Emma B Holliday, Prajnan Das, Melissa P Mezzari, Nadim J Ajami, Erica J Lynn, Bruce D Minsky, Van K Morris, Andrea Milbourne, Craig A Messick, Ann H Klopp, P Andrew Futreal, Cullen M Taniguchi, Kathleen M Schmeler, Lauren E Colbert

Faculty, Staff and Student Publications

BACKGROUND: Squamous cell carcinoma of the anus (SCCA) is a rare gastrointestinal cancer. Factors associated with progression of HPV infection to anal dysplasia and cancer are unclear and screening guidelines and approaches for anal dysplasia are less clear than for cervical dysplasia. One potential contributing factor is the anorectal microbiome. In this study, we aimed to identify differences in anal microbiome composition in the settings of HPV infection, anal dysplasia, and anal cancer in this rare disease.

METHODS: Patients were enrolled in two prospective studies. Patients with anal dysplasia were part of a cross-sectional cohort that enrolled women with high-grade …

Rare Variant Enrichment Analysis Supports Greb1l As A Contributory Driver Gene In The Etiology Of Mayer-Rokitansky-Küster-Hauser Syndrome, Angad Jolly, Haowei Du, Christelle Borel, Na Chen, Sen Zhao, Christopher M Grochowski, Ruizhi Duan, Jawid M Fatih, Moez Dawood, Sejal Salvi, Shalini N Jhangiani, Donna M Muzny, André Koch, Konstantinos Rouskas, Stavros Glentis, Efthymios Deligeoroglou, Flora Bacopoulou, Carol A Wise, Jennifer E Dietrich, Ignatia B Van Den Veyver, Antigone S Dimas, Sara Brucker, V Reid Sutton, Richard A Gibbs, Stylianos E Antonarakis, Nan Wu, Zeynep H Coban-Akdemir, Lan Zhu, Jennifer E Posey, James R Lupski

Faculty, Staff and Student Publications

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by aplasia of the female reproductive tract; the syndrome can include renal anomalies, absence or dysgenesis, and skeletal anomalies. While functional models have elucidated several candidate genes, only WNT4 (MIM: 603490) variants have been definitively associated with a subtype of MRKH with hyperandrogenism (MIM: 158330). DNA from 148 clinically diagnosed MRKH probands across 144 unrelated families and available family members from North America, Europe, and South America were exome sequenced (ES) and by family-based genomics analyzed for rare likely deleterious variants. A replication cohort consisting of 442 Han Chinese individuals with MRKH was …

Pre-Surgical Features Of Intrinsic Brain Networks Predict Single And Joint Epilepsy Surgery Outcomes, Walter Hinds, Shilpi Modi, Ankeeta Ankeeta, Michael R Sperling, Dorian Pustina, Joseph I Tracy

Department of Neurology Faculty Papers

Despite the effectiveness of surgical interventions for the treatment of intractable focal temporal lobe epilepsy (TLE), the substrates that support good outcomes are poorly understood. While algorithms have been developed for the prediction of either seizure or cognitive/psychiatric outcomes alone, no study has reported on the functional and structural architecture that supports joint outcomes. We measured key aspects of pre-surgical whole brain functional/structural network architecture and evaluated their ability to predict post-operative seizure control in combination with cognitive/psychiatric outcomes. Pre-surgically, we identified the intrinsic connectivity networks (ICNs) unique to each person through independent component analysis (ICA), and computed: (1) the …

Virtual And In Vitro Screening Of Natural Products Identifies Indole And Benzene Derivatives As Inhibitors Of Sars-Cov-2 Main Protease (MPro), Dony Ang, Riley Kendall, Hagop S. Atamian

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The rapid spread of the coronavirus disease 2019 (COVID-19) resulted in serious health, social, and economic consequences. While the development of effective vaccines substantially reduced the severity of symptoms and the associated deaths, we still urgently need effective drugs to further reduce the number of casualties associated with SARS-CoV-2 infections. Machine learning methods both improved and sped up all the different stages of the drug discovery processes by performing complex analyses with enormous datasets. Natural products (NPs) have been used for treating diseases and infections for thousands of years and represent a valuable resource for drug discovery when combined with …

Xylazine In The Opioid Epidemic: A Systematic Review Of Case Reports And Clinical Implications, Shahana Ayub, Shanli Parnia, Karuna Poddar, Anil K. Bachu, Amanda Sullivan, Ali M. Khan, Saeed Ahmed, Lakshit Jain

School of Medicine Publications

Introduction and objectives: The opioid overdose epidemic is exacerbated by the emergence of Xylazine as an illicit drug adulterant. Xylazine, a veterinary sedative, can potentiate opioid effects while also causing toxic and potentially fatal side effects. This systematic review aims to assess the impact of Xylazine use and overdoses within the opioid epidemic context.

Method: A systematic search was conducted following PRISMA guidelines to identify relevant case reports, and case series related to Xylazine use. A comprehensive literature search included databases like Web of Science, PubMed, Embase, and Google Scholar, utilizing keywords and Medical Subject Headings (MeSH) terms related to …

The Midwest Sarcoma Trials Partnership: Bridging Academic And Community Networks In A Collaborative Approach To Sarcoma, Natalie K Heater, Angela C Hirbe, Mia C Weiss, Brian Van Tine, Et Al.

2020-Current year OA Pubs

The treatment of sarcoma necessitates a collaborative approach, given its rarity and complex management. At a single institution, multidisciplinary teams of specialists determine and execute treatment plans involving surgical, radiation, and medical management. Treatment guidelines for systemic therapies in advanced or nonresectable soft tissue sarcoma have advanced in recent years as new immunotherapies and targeted therapies become available. Collaboration between institutions is necessary to facilitate accrual to clinical trials. Here, we describe the success of the Midwest Sarcoma Trials Partnership (MWSTP) in creating a network encompassing large academic centers and local community sites. We propose a new model utilizing online …

Meeting Patients Where They Are: A Nurse-Driven Quality Improvement Project To Provide Influenza Vaccinations In The Emergency Department, Stacie Hunsaker, Larry Garrett, Katreena Merrill, Rachelle Rhodes

Faculty Publications

Introduction: Influenza is highly contagious, vaccine-preventable, and may result in significant morbidity and mortality. While vaccination is the primary protection against influenza, vaccination rates remain low. Traditionally, primary care clinics, retail pharmacies, and public health departments offer influenza vaccines. However, offering influenza vaccines in new settings may increase their availability to the public and increase community uptake. This project aimed to add emergency departments as a new influenza vaccine location to increase the number of vaccines distributed during the 2020 to 2021 influenza season.

Methods: Adult patients discharged from 24 emergency departments were included in this pre- post-intervention project. A …

Implementation Of A Nurse-Driven Clinical Frailty Scale For Geriatric Trauma Patients, Lauren Curcio Bsn, Rn, Gero-Bc, Chelsy Bechtold Adn, Rn

Patient Care Services / Nursing

No abstract provided.

Ultralow-Dose Binary Oncolytic/Helper-Dependent Adenovirus Promotes Antitumor Activity In Preclinical And Clinical Studies, Daniel Wang, Caroline E Porter, Bora Lim, Amanda Rosewell Shaw, Catherine S Robertson, Mae L Woods, Ya Xu, Greyson G W Biegert, Daisuke Morita, Tao Wang, Bambi J Grilley, Helen Heslop, Malcolm K Brenner, Masataka Suzuki

Faculty, Staff and Students Publications

We show that a binary oncolytic/helper-dependent adenovirus (CAdVEC) that both lyses tumor cells and locally expresses the proinflammatory cytokine IL-12 and PD-L1 blocking antibody has potent antitumor activity in humanized mouse models. On the basis of these preclinical studies, we treated four patients with a single intratumoral injection of an ultralow dose of CAdVEC (NCT03740256), representing a dose of oncolytic adenovirus more than 100-fold lower than used in previous trials. While CAdVEC caused no significant toxicities, it repolarized the tumor microenvironment with increased infiltration of CD8 T cells. A single administration of CAdVEC was associated with both locoregional and abscopal …

Impact Of Virtual Patient Education On Medication Adherence Among Geriatric Patients, Thomas Anmaria, Steby Mol Stephen, Sandy Crasta D, Mohamed Dharvees T, Pereira Prathibha, Madhan Ramesh, Sri Harsha Chalasani, Syed Jehath

International Journal of Health and Allied Sciences

Context: Virtual patient education for medication adherence can improve the health outcomes and reduce the hospital readmission. Aims: The study aim was to at assess the impact of virtual patient education on medication adherence. Settings and Design: A longitudinal interventional study was conducted in tertiary care hospital over a period of 6 months to assess the medication adherence amongst elderly using the medication adherence rating scale questionnaire.

Methods and Material: The impact of pharmacist-assisted patient counseling on medication adherence was assessed by reassessing the medication adherence with medication adherence rating scale questionnaire after educational intervention performed at selected time-intervals. Data …

Effects Of Equine Interaction On Mutual Autonomic Nervous System Responses And Interoception In A Learning Program For Older Adults, Ann L. Baldwin, Lisa Walters, Barbara K. Rector, Ann C. Alden

People and Animals: The International Journal of Research and Practice

Equine-assisted learning (EAL) may improve the health of older adults, but scientific data are sparse. This study investigated whether people aged 55 and older show increased heart rate variability (HRV) during EAL and awareness of bodily sensations that are overall pleasant. Subjects (n = 24) participated in mindful grooming during which they slowed their breathing and brushed a horse while noticing sensations in their body and watching the horse’s reactions. The subject’s and horse’s HRV were recorded simultaneously before, during, and after mindful grooming. For control, the same subjects performed mindful grooming with a plush simulation horse. During exit …

Influence Of Mastication And Its Relationship With Body Mass Index Before And After Prosthetic Rehabilitation In Partially Edentulous Patients, Naga Usha, Raghavendra Swamy K N, Meenakshi S, Ganesh S, Ramith Ramu

International Journal of Health and Allied Sciences

BACKGROUND: The main purpose of prosthetic rehabilitation is to enhance the masticatory function by replacing the missing teeth with an artificial substitute, which improves nutrient-rich food intake. There are recent studies which indicate the influence of chewing behavior and energy intake, but little is known about the relationship between chewing on nutritional status. OBJECTIVE: This study intended to assess the changes in masticatory efficiency before and after prosthetic rehabilitation and its influence on nutritional status and body weight. METHODS: A total of 40 partially edentulous subjects aged between 45- 65 years were recruited. Body Mass Index was determined by measuring …

Perceptual And Acoustical Assessment Of Voice In Children With Cleft Lip And Palate, Indu Thammaiah, Meenakshi S, Raghunath N, Ramith Ramu

International Journal of Health and Allied Sciences

BACKGROUND: The speech of individuals with cleft lip and palate is primarily characterized by nasality of oral speech because of cleft and or velopharyngeal dysfunction. OBJECTIVES: The aim of the present study is to investigate the acoustical assessment and perceptual rating measurements in cleft lip and palate children. METHODS: The study participants included 30 children with cleft lip and palate in the age range of 4 to 12 years. Prior parental consent was obtained for the inclusion of their children in the study. Speech samples of all the l the participants were recorded. Prerecorded speech samples of the individuals of …

Graduate Student Transcription Of Accented Speech, Emily Covington

Theses & Honors Papers

There are many speech sound differences between Standard American English and English spoken by an individual from a different language background, who speaks with an accent. The purpose of this study is to research graduate students' preparedness and ability to transcribe speech from varying cultural backgrounds. A transcription assessment was administered to current speech-language pathology graduate students with results compared to professionals in the field who completed the transcription based on both listening and spectrogram images. Graduate students were also surveyed regarding their phonetics education experiences. Overall, students were able to transcribe accented speech with 64.2% accuracy. Participants’ transcription of …

2023-03-28_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

2023-03-28_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

2023-03-28_Michiganoverview_Isdreporting, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The K-12 Aged ISD Reporting page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/k-to-12-aged-isd-reporting.

This report is created from data reported by the Michigan Disease Surveillance System (MDSS) the Michigan Department of Health and Human Services' web-based communicable disease reporting system. Data is updated every week.

The purpose of the dashboard is to report the 7 day average of COVID-19 cases in Michigan school students aged 5 through 18 at the intermediate school district and school district levels, as well as display trends over time to better illustrate the changing nature of the COVID-19 pandemic. Cases are attributed to …

Blood Pressure In Normotensive Young Adults Is Not Influenced By Resistance Training Rest Interval Duration, Jason Coles, G. Monique Mokha, W. Alex Edmonds, Lia Jiannine

HPD Articles

Introduction: We aimed to examine the effect of resistance training rest interval length on chronic changes of systolic (SBP) and diastolic blood pressure (DBP). Methods: 27 normotensive young adults were randomly assigned to one of three rest interval length groups: 30-sec, 90-sec, or 150-sec. Baseline and post-training SBP and DBP measurements were obtained. Participants trained and logged their sessions in a smartphone application three times per week for 8 weeks. They also measured their blood pressure weekly with a home kit. Changes in SBP and DBP between the three groups were tested using a mixed model 3 x 2 ANOVA …

2023-03-28_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/stats.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

Crosstalk Between The Extracellular Matrix And The Cell- Cell Junction - Associated Rnai Machinery Regulates Colon Cancer Cell Behavior, Amanda Daulagala

MUSC Theses and Dissertations

Colon cancer is the third most common and second deadliest type of cancer. Colon cancer is broadly characterized by compromised epithelial integrity and by aberrant extracellular matrix (ECM) remodeling. However, a potential mechanistic connection between epithelial integrity and ECM remodeling that could be contributing to the disease progression, has not been explored yet. The Adherens Junction (AJ) is a cell-cell adhesion complex composed of cadherin and catenin family proteins and essential for establishing and maintaining epithelial tissue integrity. Our previous work revealed that PLEKHA7, an E-cadherin-p120 catenin partner, recruits the microprocessor and the RNA-induced silencing complex (RISC), key components of …

Hsc-Independent Definitive Hematopoiesis Persists Into Adult Life, Michihiro Kobayashi, Haichao Wei, Takashi Yamanashi, Nathalia Azevedo Portilho, Samuel Cornelius, Noemi Valiente, Chika Nishida, Haizi Cheng, Augusto Latorre, W Jim Zheng, Joonsoo Kang, Jun Seita, David J Shih, Jia Qian Wu, Momoko Yoshimoto

Faculty, Staff and Student Publications

It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. Here, surprisingly, we find that significant percentages of lymphocytes are not derived from HSCs, even in 1-year-old mice. Instead, multiple waves of hematopoiesis occur from embryonic day 7.5 (E7.5) to E11.5 endothelial cells, which simultaneously produce HSCs and lymphoid progenitors that constitute many layers of adaptive T and B lymphocytes in adult mice. Additionally, HSC lineage tracing reveals that the contribution …

What To Look For In Relationships: Development, Inter-Rater Reliability, And Initial Validity Estimates For A Young Child-Caregiver Relationship Assessment, Joy D. Osofsky, Margaret A. Fields-Olivieri, Andrew L. Frazer, Rebecca A. Graham, Bethany H. Mccurdy, Carl F. Weems

School of Medicine Faculty Publications

Introduction: Observational assessments are important for understanding a range of behaviors and emotions in the young child-caregiver relationship. This paper provides initial data on a multidimensional assessment for professionals who work with young children and their caregivers, the What to Look for in Relationships (WLR). The WLR was designed to assist providers in evaluating strengths and areas for improvement in five areas of young child-caregiver relationship dimensions. This paper reports on the development, interrater reliability, initial convergent and discriminant validity, and incremental utility of the scales. Methods: Data were collected from caregiver-child dyads, who participated in a semi-structured observational caregiver-child …

Evaluation And Treatment Of Postoperative Periprosthetic Humeral Fragility Fractures, Evangeline F. Kobayashi, Surena Namdari, Mara Schenker, George S. Athwal, Jaimo Ahn

Rothman Institute Papers

Postoperative periprosthetic humeral shaft fractures represent a growing and difficult complication to treat given the aging patient population and associated bone loss. Determining the best treatment option is multifactorial, including patient characteristics, fracture pattern, remaining bone stock, and implant stability. Possible treatment options include nonoperative management with bracing or surgical intervention. Nonoperative treatment has been shown to have higher nonunion rates, thus should only be selected for a specific patient population with minimally displaced fractures or those that are unfit for surgery. Surgical management is recommended with prosthetic loosening, fracture nonunion, or failure of nonoperative treatment. Surgical options include open …

School Parent Attitudes And Perceptions Relating To Animals, Animal-Assisted Interventions, And The Support Of Children's Mental Health, Rhoda A Leos, Paula M Cuccaro, John R Herbold, Belinda F Hernandez

Faculty, Staff and Student Publications

Growing awareness of the negative effects of trauma has led San Antonio, TX, school districts to expand efforts that can help mitigate these effects and support mental health. Given the literature around the psychological benefits of human-animal interactions, the concept of incorporating animals in treatments or interventions is not a new one. While schools have begun considering or utilizing animal-assisted interventions (AAIs), there have been limited efforts to understand existing perceptions relating to animals and AAIs among school parents in this Hispanic community. to address this gap, a cross-sectional study consisting of a 34-item survey was conducted to explore attitudes, …

Under Pressure: What Individual Characteristics Lead To Performance Of High-Quality Chest Compressions During Cpr Practice Sessions?, Steven Marks, Lynn Shaffer, David Zehnder, David Aeh, Dawn Prall

All Faculty and Staff Scholarship

Aim: Despite well-established protocols for cardiopulmonary resuscitation training, performance during real-life cardiac arrests can be suboptimal. Understanding personal characteristics which could influence performance of high-quality chest compressions could provide insight into the practice-performance gap. This study examined chest compression performance, while employing feedback and introducing code team sounds as an anxiety-inducing factor in registered nurses using a cardiopulmonary resuscitation training manikin.

Methods: Participants included 120 registered nurses with basic life support certification randomized to one of the following groups: no feedback and no code team sounds, feedback without code team sounds, or feedback with code team sounds. Chest compression sessions …