Medicine and Health Sciences Commons^™

Prolonged Antibiotic Use In A Preclinical Model Of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-Like Pathology Via Increased Micro-Rna 21-Induced Pten Inhibition That Is Correlated With Low Host, Ayushi Trivedi, Dipro Bose, Punnag Saha, Subhajit Roy, Madhura More, Jonathan Skupsky, Nancy G. Klimas, Saurabh Chatterjee

HPD Articles

Gulf War (GW) veterans show gastrointestinal disturbances and gut dysbiosis. Prolonged antibiotic treatments commonly employed in veterans, especially the use of fluoroquinolones and aminoglycosides, have also been associated with dysbiosis. This study investigates the effect of prolonged antibiotic exposure on risks of adverse renal pathology and its association with gut bacterial species abundance in underlying GWI and aims to uncover the molecular mechanisms leading to possible renal dysfunction with aging. Using a GWI mouse model, administration of a prolonged antibiotic regimen involving neomycin and enrofloxacin treatment for 5 months showed an exacerbated renal inflammation with increased NF-κB activation and pro-inflammatory …

Case Report And Literature Review Of An Atypical Polymyalgia Rheumatica And Its Management, Saad Bilal Ahmed, Saara Ahmad, Hanmei Pan

Department of Biological & Biomedical Sciences

Polymyalgia rheumatica (PMR) is a systemic inflammatory disease of the elderly population that increases in incidence as age advances. It is characterised by the sudden or sub-acute onset of symptoms affecting the shoulder and pelvic girdles, often accompanied by constitutional symptoms. Due to the lack of consensual diagnostic criteria and specific laboratory or radiological investigations for PMR, its diagnosis can be very challenging, particularly because it can be mimicked or masked by other geriatric syndromes. PMR responds well to glucocorticoid treatment, but if left untreated, can lead to morbidity and poor quality of life. We present the case of an …

Thrombotic And Hemorrhagic Complications Following Left Ventricular Assist Device Placement: An Emphasis On Gastrointestinal Bleeding, Stroke, And Pump Thrombosis, Joseph Phan, Kareem Elgendi, Masi Javeed, Juan M. Aranda, Mustafa M. Ahmed, Juan Vilaro, Mohammad Al-Ani, Alex M. Parker

HPD Articles

The left ventricular assist device (LVAD) is a mechanical circulatory support device that supports the heart failure patient as a bridge to transplant (BTT) or as a destination therapy for those who have other medical comorbidities or complications that disqualify them from meeting transplant criteria. In patients with severe heart failure, LVAD use has extended survival and improved signs and symptoms of cardiac congestion and low cardiac output, such as dyspnea, fatigue, and exercise intolerance. However, these devices are associated with specific hematologic and thrombotic complications. In this manuscript, we review the common hematologic complications of LVADs.

Syndromic Antibiograms And Nursing Home Clinicians' Antibiotic Choices For Urinary Tract Infections, Brigid M. Wilson, Taissa A. Bej, Robin L.P. Jump

Faculty Scholarship

Importance: Empirical antibiotic prescribing in nursing homes (NHs) is often suboptimal. The potential for antibiograms to improve empirical antibiotic decision-making in NHs remains poorly understood. Objective: To determine whether providing NH clinicians with a urinary antibiogram improves empirical antibiotic treatment of urinary tract infections (UTIs). Design, Setting, and Participants: This was a survey study using clinical vignettes. Participants were recruited via convenience sampling of professional organization listservs of NH clinicians practicing in the US from December 2021 through April 2022. Data were analyzed from July 2022 to June 2023. Interventions: Respondents were randomized to complete vignettes using a traditional antibiogram …

Is Homoeopathy Contributing To The Universal Health Coverage Goal Of #Healthforall?, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The expansion of health service coverage, a key target of the 2015 Sustainable Development Goals, has seen limited progress in recent years, further hindered by the COVID-19 pandemic. In addition, the financial protection has witnessed a decline. Fifty percent of the global population lacks access to essential health services. An estimated 2 billion people grapple with financial hardships resulting from out-of-pocket health expenses, including 344 million individuals residing in extreme poverty.

On 12 December 2012, a historic resolution endorsing the acceleration of progress towards Universal Health Coverage (UHC) as a paramount international development priority was unanimously endorsed by the United …

Impact Of Homoeopathy Along With Yoga As An Integrated Pilot Project With The National Programme For Prevention And Control Of Cancer, Diabetes, Cardiovascular Diseases And Stroke: A Cross-Sectional Study, Roja Varanasi, Shashi Giri, Jyotika Bhatti, Khushboo Garg, Gurudev Choubey, Ramesh Supadu Bawaskar, Umakanta Prusty, Raveender Chinta, Manjula Narang, Praveen Oberai, Anil Khurana, Leimapokhpam Swasticharan, Raj K. Manchanda, Npcdcs-Ayush (Homoeopathy) Integration Project Study Group

Indian Journal of Research in Homoeopathy

Background: There is a growing concern about the increasing burden of non-communicable diseases (NCDs) and their risk factors globally.

Objectives: This study assesses the impact of the integration of Ayush (homoeopathy along with yoga) in the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases, and Stroke at the level of patients and conventional physicians.

Methods: This cross-sectional study was carried out on the participants already enrolled for the treatment of NCDs at 22 Ayush-Lifestyle Disorders clinics in four districts across India. Participants of any gender, aged 30 years or older, were included. A structured …

Chronic Alcoholic Pancreatitis With Necrotising Exacerbation And Pseudocyst Treated With Homoeopathy: A Case Report, Bipin Sohanraj Jain, Tanvir Abdul Hamid Sheikh

Indian Journal of Research in Homoeopathy

Introduction: Chronic alcoholic pancreatitis with necrotising exacerbation and pseudocyst is a condition with a poor prognosis. The disease pathology, along with a history of trauma, and alcohol dependence, adds up to the severity making it more difficult to treat. The main surgical management is cyst drainage. Individualised homoeopathic medicine can resolve this without surgical intervention.

Case Summary: In a case with a combination of pathology, trauma and addiction, arriving at a homoeopathic similimum can be challenging. The present case study demonstrates the management of a patient in a semi-comatose state with abdominal rigidity and ultrasonographic evidence of pancreatic …

Tinea Capitis Treated With Homoeopathic Medicine Pulsatilla Nigricans: A Case Report, Khushboo Garg, Divya Bansal, Aayush Mittal

Indian Journal of Research in Homoeopathy

Introduction: Tinea infection is a common complaint encountered in day-to-day practice with increasing incidence, especially in countries such as India over the past decade. Tinea capitis is predominantly a disease of prepubertal children characterised by lesions of variable morphology on the scalp associated with itching, erythema, signs of inflammation and hair loss. Prompt recognition and treatment are necessary to prevent its spread due to its contagious nature, associated hair loss and the resultant psychological impact on social life. Individualised homoeopathic treatment has a significant scope in treating and combating such conditions cost-effectively through the totality of symptoms.

Case Summary …

Bleeding Nasal Polyp In A Child, Treated With Individualised Homoeopathy: A Case Report, Ranjit Sonny

Indian Journal of Research in Homoeopathy

Introduction: A nasal polyp (NP) is a type of growth inside the nose or sinuses typically presenting with nasal congestion, nasal obstruction and anosmia or hyposmia. It is amenable to the individualised homoeopathic treatment. In this case, we present how an NP in a female child was successfully treated with individualised homoeopathy.

Case Summary: A case of NP in a 5-year-old female child presented to the outpatient department in November 2021. It was bleeding frequently, especially when hurt. It blocked the right nostril and was visible from the outside. Acidum nitricum (Acid-nit) was prescribed based on the totality …

Research Highlights, Shweta Singh, Gurpreet Singh

Indian Journal of Research in Homoeopathy

Research Highlights

Acknowledgement To Reviewers (2023), Ijrh Editorial Board

Indian Journal of Research in Homoeopathy

The Editorial Board gratefully acknowledges the invaluable inputs of the following experts, who reviewed manuscripts for the Indian Journal of Research in Homoeopathy in 2023. Their timely inputs enabled a fair and rigorous peer review process, and we are sincerely thankful for the same.

Review On Therapeutic Potential Of Phytochemicals From Medicinal Plants, Iqra Afzal, Ume Habiba, Humaira Yasmeen

Journal of Bioresource Management

Nature has provided plants with a vast range of phytochemicals. These phytochemicals are enriched with different pharmacological activities. These pharmacological activities have a potential to be wisely used for therapeutic purpose. It can be utilized in so many ways for the expansion of therapeutic strategies. With the advancement in the field of medicine and due to increasing side effects of synthetic medicines there emerges a need to discover novel therapeutic remedies. Medicinal plants serve as the best source for the manufacture of new remedies for many diseases. Medicinal plants bear a potential towards treating incurable chronic diseases. The aim of …

Understanding The Biering-Sørensen Test: Contributors To Extensor Endurance In Young Adults With And Without A History Of Low Back Pain, Jonathan Shaw, Jesse V. Jacobs, Linda R. Van Dillen, George J. Beneck, Jo Armour Smith

Physical Therapy Faculty Articles and Research

The Biering-Sørensen test is commonly used to assess paraspinal muscle endurance. Research using a single repetition of the test has provided conflicting evidence for the contribution of impaired paraspinal muscle endurance to low back pain (LBP). This study investigated how Sørensen test duration, muscle activation, and muscle fatigability are affected by multiple repetitions of the test and determined predictors of Sørensen test duration in young adults with and without a history of LBP. Sixty-four young individuals performed three repetitions of the Sørensen test. Amplitude of activation and median frequency slope (fatigability) were calculated for the lumbar and thoracic paraspinals and …

Antifungal Activity Of Homoeopathic Medicines Towards Alternaria Solani Of Solanum Lycopersicum Plant – An In Vitro Study And On-Farm Trial, Akkilla Suya, Vettrivel Arul, Rajamanickam Kandasamy

Indian Journal of Research in Homoeopathy

Background: The overuse of pesticides has damaged biodiversity, raising concerns about the potential for genetic mutations in humans and other organisms caused by pesticide residues in food. The recent research has demonstrated that homoeopathic medicines can act as fertilisers for plant nourishment.

Objectives: The study aimed to evaluate the antifungal activity of homoeopathic medicines in vitro and on-farm trials.

Methods: The impact of homoeopathic medicines, Sulphur 30C, Ocimum basilicum 30C and Cuprum metallicum 30C, on inhibiting the mycelial growth of Alternaria solani was studied in-vitro using Agar well-diffusion assay. In an on-farm trial using Solanum lycopersicum (PKM-1 …

Ethnobotanical Study Of Antihemorrhagic Plants In The Skikda Region (North East Of Algeria), Nabila Souilah, Hamdi Bendif, Abdelkrim Benaradj, Abdelouaheb Belaid, Scherazad Mekious

Journal of Bioresource Management

Our survey was carried out at the level of 17 Municipalities of the Province of Skikda. Questionnaire sheets were distributed to 55 herbalists and 350 locale population (informants). The processing of survey data with the local population shows us that women (52 %) have more knowledge of phytotherapy compared to men (48 %) with a fairly high level of education. For the herbalists, we found that most are men (85.45 %) aged between 31-40 years (29.09 %) and 41-50 years (25.45 %), and with level of university study (36.36 %). On the other hand, 52.73 % of herbalists said they …

Using Long-Read Cage Sequencing To Profile Cryptic-Promoter-Derived Transcripts And Their Contribution To The Immunopeptidome, Ju Heon Maeng, H Josh Jang, Alan Y Du, Shin-Cheng Tzeng, Ting Wang

2020-Current year OA Pubs

Recent studies have shown that the noncoding genome can produce unannotated proteins as antigens that induce immune response. One major source of this activity is the aberrant epigenetic reactivation of transposable elements (TEs). In tumors, TEs often provide cryptic or alternate promoters, which can generate transcripts that encode tumor-specific unannotated proteins. Thus, TE-derived transcripts (TE transcripts) have the potential to produce tumor-specific, but recurrent, antigens shared among many tumors. Identification of TE-derived tumor antigens holds the promise to improve cancer immunotherapy approaches; however, current genomics and computational tools are not optimized for their detection. Here we combined CAGE technology with …

Single-Pulse Electrical Stimulation Artifact Removal Using The Novel Matching Pursuit-Based Artifact Reconstruction And Removal Method (Mparrm), Tao Xie, Thomas J Foutz, Markus Adamek, James R Swift, Cory S Inman, Joseph R Manns, Eric C Leuthardt, Jon T Willie, Peter Brunner

2020-Current year OA Pubs

No abstract provided.

Campus Ornament, Arianne Marcoux

Graduate Medical Education Research Journal

NA

With Great Power Comes Great Responsibility: Ai And Its Future In Medical Education, Faruq Pradhan, Prasanth Ravipati, Zachary P. Slocum

Graduate Medical Education Research Journal

NA

Massive Upper Gi Bleeding From Duodenal Invasion Of Hepatocellular Carcinoma Successfully Treated With Embolization And Hemospray®, Patrick Twohig, Erin Walsh, Amy Calderon

Graduate Medical Education Research Journal

Direct invasion of hepatocellular carcinoma (HCC) into the duodenum is a unique and life-threatening complication of HCC that has been rarely reported. A 60-year-old male with known HCC and cirrhosis presented with melena. Computed tomography of the abdomen and pelvis showed a 7cm hepatic mass abutting the duodenum. Esophagogastroduodenoscopy demonstrated a large, actively oozing mass in the duodenum treated with Hemospray® followed by transarterial embolization (TAE). Active upper gastrointestinal bleeding due to duodenal invasion of HCC can be successfully treated with Hemospray® Endoscopic Hemostat and TAE.

Enhancing Dissemination At Medical Conferences: A Cross-Disciplinary Approach For Learners, Raquel Lamarche, Jasmine R. Marcelin

Graduate Medical Education Research Journal

Empowering novice authors, particularly trainees and learners, this perspective piece integrates a cross-disciplinary approach to bolster scholarly dissemination at medical conferences. Through a tripartite methodology — Innovate, Implement, and Influence — the article first delves into innovation, offering four essential heuristics sourced from diverse fields, guiding the germination of ideas. Next, it demystifies the transformation of these ideas into research abstracts through a structured blueprint. The finale encompasses strategies to create compelling presentations that resonate with audiences. Woven throughout is an emphasis on craftsman-like precision in idea execution, fostering relationships, and engaging genuinely with content while maintaining audience-centricity. This blueprint …

Prostatic Utricle Presenting As A Midline Scrotal Mass, Kaitlyn E. Schultis, Bryant Van Leeuwen, John Makari

Graduate Medical Education Research Journal

The prostatic utricle is a remnant of the Müllerian duct located within the verumontanum. An enlarged, clinically significant prostatic utricle has classically been associated with hypospadias. Prostatic utricles often present with persistent lower urinary tract symptoms, recurrent infections, and urinary incontinence. We present a prostatic utricle that presented as a scrotal mass concerning for rhabdomyosarcoma in a male with normal external genitalia.

Perceptions Of Medical Students By Using Internal Medicine Educational Environment Measure (Imeem) In A Rural Affiliated Teaching Hospital, Sirayut Waramit

Graduate Medical Education Research Journal

Background and Objectives: Students’ perception of the educational setting is an important source for improving and applying changes to the medical educational environment. This study aimed to determine how medical students perceive the important factors of the learning environment in Internal Medicine at a rural affiliated teaching hospital.

Methods: This was a descriptive study carried out in the Department of Medicine, Sakon Nakhon Hospital, Thailand, from May 2021 to April 2023. Sixth-year medical students completed a validated Internal Medicine Education Environment Measure (IMEEM) questionnaire at the end of four weeks of learning the Clerkship Internal Medicine course.

Results: A …

Recurrent Polymicrobial Bloodstream Infections As Harbingers Of A Duodenal-Inferior Vena Cava Fistula, Gregory E. Koval, Richard J. Hankins, Jasmine R. Marcelin

Graduate Medical Education Research Journal

This is a case of an 82-year-old patient who presented with recurrent polymicrobial bloodstream infections and no obvious undrained source of infection. She had prior double barrel iliocaval stenting for post thrombotic syndrome. The patient underwent exploratory laparotomy and primary repair of a duodenal-caval fistula with a fascia lata patch and an omental pedicle flap. No further bloodstream infections were documented after the repair. This discussion highlights an uncommon complication of IVC stenting, its presentation as well as the operative approach used to repair the fistula.

Vocal Fold Paresis And Bilateral Anterior Laryngeal Saccular Cysts In A Singer., Ryan Witcher, Lauren E Melley, Omar Ramadan, Robert T Sataloff

Otolaryngology (ENT) Resident Research

No abstract available

A Novel Multimodal Postoperative Pain Protocol For 1- To 2-Level Open Lumbar Fusions: A Retrospective Cohort Study, Michael Markowitz, Barrett I. Woods, Gregory D. Schroeder, Christopher K Kepler, David Kaye, Mark Kurd, Joshua Armstrong, Alex R. Vaccaro, Kris Radcliff

Rothman Institute Papers

BACKGROUND: There has been increased interest in exploring methods to reduce postoperative pain without opioid medications. In 2015, a multimodal analgesia protocol was used involving the perioperative use of celecoxib, gabapentin, intravenous acetaminophen, lidocaine, and liposomal bupivacaine. Overall, the goal was to reduce the utilization of scheduled opioids in favor of nonopioid pain management.

METHODS: The results of a consecutive series of 1- to 2-level open primary lumbar fusions were compared to a cohort of patients after the implementation the perioperative multimodal pain management protocol. Primary endpoints included patient-reported pain scores and secondary endpoints included length of stay.

RESULTS: There …

A Distinct Human Cell Type Expressing Mhcii And Rorγt With Dual Characteristics Of Dendritic Cells And Type 3 Innate Lymphoid Cells, Alina Ulezko Antonova, Silvia Lonardi, Matilde Monti, Francesco Missale, Changxu Fan, Matthew L Coates, Mattia Bugatti, Natalia Jaeger, Patrick Fernandes Rodrigues, Simone Brioschi, Tihana Trsan, José L Fachi, Khai M Nguyen, Ryan M Nunley, Daniele Moratto, Stefania Zini, Lingjia Kong, Jacques Deguine, Mark E Peeples, Ramnik J Xavier, Menna R Clatworthy, Ting Wang, Marina Cella, William Vermi, Marco Colonna

The Brown Foundation: Institute of Molecular Medicine

Recent studies have characterized various mouse antigen-presenting cells (APCs) expressing the lymphoid-lineage transcription factor RORγt (Retinoid-related orphan receptor gamma t), which exhibit distinct phenotypic features and are implicated in the induction of peripheral regulatory T cells (Tregs) and immune tolerance to microbiota and self-antigens. These APCs encompass Janus cells and Thetis cell subsets, some of which express the AutoImmune REgulator (AIRE). RORγt+ MHCII+ type 3 innate lymphoid cells (ILC3) have also been implicated in the instruction of microbiota-specific Tregs. While RORγt+ APCs have been actively investigated in mice, the identity and function of these cell subsets in humans remain elusive. …

Historic Redlining And Health Outcomes: A Systematic Review, Noa T. Kraus, Sarah Connor, Krista Shoda, Scott Emory Moore, Elliane Irani

Faculty Scholarship

Objective: The purpose of this systematic review was to synthesize the existing literature on the associations between historic redlining and modern-day health outcomes across the lifespan. Method: This review searched PubMed and CINAHL for peer-reviewed, data-based articles examining the relationship between historic redlining and any health outcome. Articles were appraised using the JBI critical appraisal checklist. The results were synthesized using a narrative summary approach. Results: Thirty-six articles were included and focused on various health outcomes, including cardiovascular outcomes, breast cancer incidence and mortality, firearm injury or death, birth-related outcomes, and asthma outcomes. Most of the included articles (n = …

Stabilizing Vimentin Phosphorylation Inhibits Stem-Like Cell Properties And Metastasis Of Hybrid Epithelial/Mesenchymal Carcinomas, Nick A Kuburich, Petra Den Hollander, Maria Castaneda, Mika Pietilä, Ximing Tang, Harsh Batra, Francisco Martínez-Peña, Tanvi H Visal, Tieling Zhou, Breanna R Demestichas, Ritesh V Dontula, Jojo Y Liu, Joanna Joyce Maddela, Reethi S Padmanabhan, Lan Thi Hanh Phi, Matthew J Rosolen, Thiru Sabapathy, Dhiraj Kumar, Filippo G Giancotti, Luke L Lairson, Maria Gabriela Raso, Rama Soundararajan, Sendurai A Mani

Faculty, Staff and Student Publications

Epithelial-mesenchymal transition (EMT) empowers epithelial cells with mesenchymal and stem-like attributes, facilitating metastasis, a leading cause of cancer-related mortality. Hybrid epithelial-mesenchymal (E/M) cells, retaining both epithelial and mesenchymal traits, exhibit heightened metastatic potential and stemness. The mesenchymal intermediate filament, vimentin, is upregulated during EMT, enhancing the resilience and invasiveness of carcinoma cells. The phosphorylation of vimentin is critical to its structure and function. Here, we identify that stabilizing vimentin phosphorylation at serine 56 induces multinucleation, specifically in hybrid E/M cells with stemness properties but not epithelial or mesenchymal cells. Cancer stem-like cells are especially susceptible to vimentin-induced multinucleation relative to …

Impact Of Cumulative Dose Of Brentuximab Vedotin On Outcomes Of Frontline Therapy For Advanced-Stage Hodgkin Lymphoma, Raphael E Steiner, Steven R Hwang, Arushi Khurana, Thomas M Habermann, Narendranath Epperla, Kaitlin Annunzio, Pamela Blair Allen, Katelin Baird, Darina Paulino, Juan Pablo Alderuccio, Izidore S Lossos, Kevin David, Andrew M Evens, Karan Pandya, Steven M Bair, Manali Kamdar, Sheeba Ba Aqeel, Pallawi Torka, Ryan Lynch, Stephen Smith, Lei Feng, Mansoor Noorani, Sairah Ahmed, Ranjit Nair, Francisco Vega, Susan Wu, Penny Fang, Chelsea C Pinnix, Jillian R Gunther, Bouthaina S Dabaja, Hun J Lee

Faculty, Staff and Student Publications

In the pivotal study ECHELON-1, brentuximab vedotin (BV), doxorubicin, vinblastine, and dacarbazine (A + AVD) demonstrated superior efficacy compared with bleomycin + AVD for the treatment of advanced-stage classic Hodgkin lymphoma (cHL). However, there are minimal available data regarding the frequency of dose reductions or omission of BV during curative therapy and the potential impact on patient outcomes. In a real-world analysis, we retrospectively reviewed the characteristics and outcomes of 179 patients with stage III or IV cHL treated with frontline A + AVD from January 2010 to April 2022. Treatment consisted of up to 1.2 mg/kg of BV and …