Medicine and Health Sciences Commons^™

Hearing Loss As A Risk Factor For Cognitive Decline In The Elderly: A Rapid Review, Natalie Large, Nannette Nicholson

Internet Journal of Allied Health Sciences and Practice

Purpose: The aim of this rapid review was to identify and evaluate evidence exploring hearing loss as a risk factor for cognitive decline in the elderly population. Methods: A literature search was performed in three databases: CINAHL, Cochrane Central, and PubMed. The PRISMA template was used to record the search and selection process. Search criteria included older adults aged 65 and up with diagnosed or self-reported hearing loss and no previous diagnosis of dementia or Alzheimer’s disease. Participants were excluded if they had been diagnosed with dementia or tested for it before the study began. Hearing loss was categorized using …

The Effects Of Non-Pharmacological Interventions For Behavior And Psychological Symptoms Of Dementia: A Benchmark Study, Rachel R. Williams

MSN Capstone Projects

The management of behavioral and psychological symptoms of dementia (BPSD) in patients who reside in nursing homes can be challenging. These neuropsychiatric behaviors can include but are not limited to aggression, agitation, delirium, depression, and psychosis (Cloak & Al Khalili, 2022). Patients with BPSD often have difficulty expressing their needs due to the disease process, resulting in further complexity when managing behaviors. There are no psychotropic medications to treat BPSD specifically, but many are often prescribed to treat the symptoms or behaviors exhibited by patients. The use of psychotropics, especially long-term can cause a myriad of adverse effects and should …

Chemical Restraint As Behavioural Euthanasia: Case Studies From The Royal Commission Into Aged Care Quality And Safety, Patricia Cain, Pelden Chejor, Davina Porock

Research outputs 2022 to 2026

Background: The prescription of psychotropic medication to older people living with dementia in residential aged care has become an increasing concern. The use of prescription medication is often prefaced as a way of preventing harm to self and others. However, the use of such medications has been considered a way of managing some of the behavioural and psychological symptoms of dementia. Using a large secondary data set, this study aimed to identify the precursors and mediating factors that influence the use of chemical restraint of older people in residential aged care. Methods: Publicly available documents from the Australian Royal Commission …

Art Of Aging – A Portraiture Study, Alaina Mann

Theses/Capstones/Creative Projects

The process of aging can be viewed through different lenses within our society. In the past, scientists and medical professionals performed various studies to better understand and analyze different facets of aging, medicine, and health in general. Historically the arts have reflected multiple aspects of medicine and treatments while more recently, the arts have been used in a research capacity to provide different ways to represent illness, suffering, and care. This study used art-based research methods and portraiture to gather qualitative observations on the older populations within our community. Data collected included drawings, a field journal, and interviews. This study …

Postmortem Brain Imaging In Alzheimer's Disease And Related Dementias: The South Texas Alzheimer's Disease Research Center Repository, Karl Li, Tanweer Rashid, Jinqi Li, Nicolas Honnorat, Anoop Benet Nirmala, Elyas Fadaee, Di Wang, Sokratis Charisis, Gladys E. Maestre, Peter T. Fox

School of Medicine Publications and Presentations

Background:

Neuroimaging bears the promise of providing new biomarkers that could refine the diagnosis of dementia. Still, obtaining the pathology data required to validate the relationship between neuroimaging markers and neurological changes is challenging. Existing data repositories are focused on a single pathology, are too small, or do not precisely match neuroimaging and pathology findings.

Objective:

The new data repository introduced in this work, the South Texas Alzheimer’s Disease research center repository, was designed to address these limitations. Our repository covers a broad diversity of dementias, spans a wide age range, and was specifically designed to draw exact correspondences between …

Depression And Anxiety Of Care Partners During The Emergency Department Visit Of Older Adults With Cognitive Impairment, Nancy Glober, Anthony Perkins, Joshua Chodosh, Karen Connor, Sujuan Gao, Frank Messina, Malaz Boustani, Soo Borson, Nicole R. Fowler

Journal of Geriatric Emergency Medicine

Background: Older adults with cognitive impairment (CI) are more likely to visit the emergency department (ED) than those without CI. They are also more likely to suffer poor outcomes after an ED visit. Family and friends who serve as care partners contribute significant time and resources to the care of these patients and may need particular attention to their emotional needs during and after the ED encounter. In this study, we examined the association between patient and care partner characteristics on care partner depression and anxiety at the time of the ED visit.

Methods: Baseline data from 640 patient-care partner …

Interventions For Care Partners Of Adults With Dementia: A Systematic Review, Makenzie Kay Homan, Azia Marie Ourada, Reannon Taylor Rieber, Grace Delaney Tynan

Student Systematic Reviews: Occupational Therapy

Interventions for Care Partners of Adults with Dementia: A Systematic Review

PURPOSE: It is estimated that 8.5 million people are informal care partners for people with dementia (Friedman et al., 2015), which is a challenging role associated with emotional strain, anxiety and depression, increased care partner burden, poorer quality of life (QoL), financial strain, and lack of support (Hellis & Mukaetova-Ladinska, 2023). It is important for occupational therapy practitioners (OTPs) to use the most effective interventions that can be implemented to preserve informal care partners’ health, wellbeing, and quality of life (QoL) (Hellis & Mukaetova-Ladinska, 2023). The purpose of this …

Gender Differences In Episodic Memory In Later Life: The Mediating Role Of Education, Sara Robinson

USF Tampa Graduate Theses and Dissertations

In the United States (U.S.), 14 million individuals aged 65+ are expected to be diagnosed with dementia by 2060, and women are nearly twice as likely to be diagnosed. Low education is a well-established risk factor for dementia and is hypothesized to partly explain the gender differences in late-life cognition. However, few studies have investigated education as a mediator of these gender differences. This study aims to investigate education as a mediator of gender differences in episodic memory using longitudinal data from the U.S. Health and Retirement Study (HRS). I used a sample of 35,721 respondents (20,190 women and 15,531 …

A Multi-Modal Imaging Analysis Of Inter-Community Hub Nodes In Subjective Cognitive Decline Linking Longitudinal Hub Function Disruption To White Matter Integrity Kurtosis, Duncan Nowling

MUSC Theses and Dissertations

Subjective Cognitive Decline (SCD) has garnered much interest as a potential identifiable preclinical stage and indicator of risk for cognitive decline in Alzheimer’s Disease and related dementias (ADRD). Identification of individuals in this stage though is difficult, as they present with objectively normal cognitive evaluation scores, relying instead upon self-report of concern about decline in cognitive abilities. The use of non-invasive in-vivo imaging methods like BOLD functional imaging and diffusion tensor have allowed for complex mapping of both the functional and structural network features unique to this condition. This study furthers this network biomarker map of SCD by investigating the …

The Association Of Long-Term Exposure To Criteria Air Pollutants, Fine Particulate Matter Components, And Airborne Trace Metals With Late-Life Brain Amyloid Burden In The Atherosclerosis Risk In Communities (Aric) Study, Erin E Bennett, Dean F Wong, Et Al.

2020-Current year OA Pubs

BACKGROUND: Studies suggest associations between long-term ambient air pollution exposure and outcomes related to Alzheimer's disease (AD). Whether a link exists between pollutants and brain amyloid accumulation, a biomarker of AD, is unclear. We assessed whether long-term air pollutant exposures are associated with late-life brain amyloid deposition in Atherosclerosis Risk in Communities (ARIC) study participants.

METHODS: We used a chemical transport model with data fusion to estimate ambient concentrations of PM

RESULTS: At PET imaging, eligible participants (N = 318) had a mean age of 78 years, 56% were female, 43% were Black, and 27% had mild cognitive impairment. We …

Hearing Health And Dementia - Authors' Reply, Dongshan Zhu, Shiva Raj Mishra, Salim S. Virani, Nipun Shrestha, Fan Jiang

Office of the Provost

No abstract provided.

Apoe Polymorphism And Its Association With Dementia, Neuropsychiatric Disorders, And Demographic Factors In U.S Hispanic Population, Victoria I. Padilla

Research Symposium

In 2019, the United States Census revealed that Hispanics are the greatest minority group in the U.S, 18% of the population; in 2060, it is expected to increase by 28%. Hispanics ages 65 have one of the highest rates of Alzheimer’s disease (AD) in the U.S. Studies have linked AD and other cognitive impairments, MCI, with apolipoprotein or APOE gene. APOE has also shown to increase the risk of neuropsychiatric disorders in individuals. However, there are limited studies in U.S Hispanics. This study examines the APOE gene and its associations with dementiarelated phenotypes, neuropsychiatric disorders, and demographic factors in U.S …

Years Of Education And Total Intracranial Volume: A Longitudinal Study, Okechukwu C. Erinne

Research Symposium

Background: Education is one of the factors that contribute to a higher brain reserve. Based on the brain reserve hypothesis, the greater the brain reserve, the less likely it is to develop a neurocognitive disorder, such as dementia.

Methods: Data for this study were obtained from the Open Access Series of Imaging Studies (OASIS) longitudinal magnetic resonance imaging (MRI) data in nondemented and demented adults. There was a total of 150 right-handed participants and 373 imaging sessions, with an average duration of 719 days between visits. The primary outcome was estimated total intracranial volume (eTIV). Multivariable longitudinal regression was used …

Critical Reflection In Practice: Generating Knowledge From The Interactions With Promotores For Engagement In Neurocognitive Disorders, Noe Garza, Ney Alliey-Rodriguez, Rosa V. Pirela, Gladys E. Maestre

Research Symposium

Background: Colonias are underserved areas along the Texas-Mexico border, with high incidences of neurocognitive disorders, dementia, and Alzheimer's disease (AD). Our goal is to build capacity to reduce risk, facilitate treatment for affected individuals, and provide caregiver support. Our aim was to construct an approach that was reflective and would reveal the rich and diverse ways in which people make meaning of their experiences and interactions with scientists, faculty, staff and students.

Methods: We examined our work with local community health workers. (CHWs), promotores in Spanish, to establish contact with, engage, mobilize, and educate the Hispanic communities of the Lower …

Understanding The Resources, Barriers, Facilitators And Interests About Aging And Dementia Research Of Community Members From The Rio Grande Valley, Karla Daniela Lopez Lorenzo, Rosa V. Pirela Mavarez, Gabriela Osuna, Kendra Stine, Nahalie Chacon De Alvarez, Noe Garza, Gladys E. Maestre

Research Symposium

Background: One of ten people aged 65 develops Alzheimer’s Disease and it is one of the sixth-leading cause of death in the United States. The Rio Grande Valley (RGV) is mostly constituted by Hispanic/Latinos (93%), a population that has a 1.5X increased risk of AD onset. Nevertheless, there are not enough resources to support people living with dementia and their care partners. This study will leverage research efforts deployed by the RGV Alzheimer’s Disease Resource Center for Minority Aging Research to understand the social representations about the resources, barriers, facilitators, and interests of the RGV community about dementia and Alzheimer’s …

The Mex-Cog Cognitive Assessment Battery: Discriminant Analysis Of The Cognitive Performance Profile In Older Adults, Silvia Mejía-Arango, Sara Aguilar-Navarro, Alberto José Mimenza-Alvarado

School of Medicine Publications and Presentations

Objective. To analyze the cognitive profile of a clinical sample using the Mex-Cog cognitive battery and establish which cognitive measures and domains contribute most to group separation.

Materials and methods. A group of 145 older adults previously diagnosed with dementia (n= 47), mild cognitive impairment MCI (n= 47), or as cognitively normal (n= 51) were assessed with the Mex-Cog cognitive battery. Six linear discriminant analyses (LDA) were estimated to compare dementia vs. cognitively normal, MCI vs. cognitively normal, and MCI vs. dementia, using ten individual measures and six cognitive domains. We used a leave-one-out cross-validation procedure to evaluate the predictive …

Using Co-Creation Focus Groups To Customise A Remote Multidomain Programme Designed To Increase Dementia Literacy, Walter Wittich, Edeltraut Kröger, Gabrielle Aubin, Asma Fadhlaoui, Nicole D Anderson, Nouha Ben Gaied, Inbal Itzhak, Sylvie Belleville

Journal Articles

Objectives

To adapt the content and functionalities of Brain Health PRO, a web-based multidomain program designed to increase dementia literacy, to the context and needs of users, providers and community organisations across Québec, Canada.

Design

Five consecutive qualitative co-creation focus group sessions 30–90 min in duration each, exploring potential barriers and facilitators to usability, accessibility, comprehensibility, participant recruitment and retention.

Setting

Virtual meetings.

Participants

A 15-member team based in Québec and Ontario, Canada, consisting of 9 researchers (including a graduate student and the project coordinator), representing occupational therapy, sensory rehabilitation, neuropsychology, psychology, health science and research methods, 3 informal caregivers …

The Effects Of Inhaled Anesthetic Agents On Long-Term Cognitive Decline, Viktor Kunder, Matthew Tayem, Sneh Parekh

HPD Articles

Background: Anesthesia is generally considered safe, but studies have shown the potential relationship between anesthetic agents and dementia after surgery. Several studies have pointed out how the commonly used anesthetic drugs induce cytotoxicity, ultimately leading to neurodegeneration and even Alzheimer's Disease (AD). Specifically, inhaled anesthetics such as isoflurane, sevoflurane, and desflurane have been shown to impact the neurophysiology of the brain. However, there is no established relationship between aesthetics and long-term postoperative cognitive decline.

Objective: The objective of this study is to explore the available research on anesthetic agents and the potential role that they have played in postoperative cognitive …

A Narrative Review Of The Many Psychiatric Manifestations Of Neurosyphilis: The Great Imitator, Baneet Kaur, Deepesh Khanna

HPD Articles

Neurosyphilis is an infection of the central nervous system caused by the spirochete, Treponema pallidum. New syphilis infections have been increasing around the world each year. This disease was much of a concern in the pre-penicillin era, where when left untreated many cases progressed to tertiary syphilis which can commonly manifest as neurosyphilis. Of particular interest, neurosyphilis has been linked to masquerading itself as various psychiatric conditions. This narrative review focuses on exploring psychiatric manifestations of neurosyphilis as well as the importance of screening in psychiatric settings and clinicians maintaining high clinical suspicion of the disease. A systematic search …

Geriatric Interest Plan For Individuals With Dementia: Improved Quality Of Life, Alexis T. Francois

Department of Occupational Therapy Entry-Level Capstone Projects

The purpose of this Capstone experience was to identify the specific needs to improve the quality of life for individuals with Dementia and Alzheimer’s. According to the Alzheimer’s Association (2022a), 1 in 9 people aged 65 and older have dementia. It is imperative for people living with this disease to be actively involved in meaningful activities that can reduce their negative symptoms. People with dementia constitute 40% of patients with significant depression (Alzheimer’s Association, 2022a). The common risk factors that increase the likelihood of depression in these adults include social isolation and loneliness, lack of exercise, and functional limitations that …

Ot's Role In Facilitating Successful Role Transition For Informal Caregivers Of People Living With Dementia, Kiyatta Freeman, Monica Watford, Evyline Chioma

Summer 2023 Virtual OTD Capstone Symposium

The aim of this capstone project was to identify education and training needs for family caregivers of individuals living with dementia and create an educational workshop based on these identified needs. This workshop is a dementia training course focused on education on the dementia diagnosis and effective care strategies to promote occupational participation and safety for the care recipient and the caregiver. The aim is to improve care competency, reduce stress, and facilitate role transition.

Apoe Gene Associated With Dementia-Related Traits, Depression, And Anxiety In The Hispanic Population, Chun Xu, Victoria Padilla, Stephanie Lozano, Daniela Gamez, Brenda Bin Su, Xuan Wang, Gladys Maestre, Kesheng Wang

Health & Biomedical Sciences Faculty Publications and Presentations

Alzheimer's disease (AD), a main cause of dementia, is commonly seen in aging populations with a strong genetic component. AD is one of the most common neurodegenerative disorders; it is a genetically and clinically heterogeneous disease. Specific demographic factors and genetic variants have been identified in non-Hispanic populations; however, limited studies have observed the Hispanic population. Therefore, we focused on investigating a known gene, APOE, associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population in our current study. A total of 1382 subjects were studied based on data collected from the Texas Alzheimer's …

Shared Disposition Decision Making In The Emergency Department For Persons Living With Dementia, Justine Seidenfeld, Fernanda Bellolio, Anita Vashi, Courtney Van Houtven, Susan Hastings

Journal of Geriatric Emergency Medicine

N/A

Shared Care Networks Assisting Older Adults: New Insights From The National Health And Aging Trends Study, Mengyao Hu, Vicki A Freedman, Sarah E Patterson, Nora Lewis

Journal Articles

BACKGROUND AND OBJECTIVES: Caregiving research often assumes older adults receiving care have a primary caregiver who provides the bulk of care. Consequently, little is known about the extent to which care responsibilities are shared more evenly within a care network, the characteristics associated with sharing, or the consequences for meeting older adults' care needs.

RESEARCH DESIGN AND METHODS: We analyze a sample of U.S. older adults receiving care from the 2011 National Health and Aging Trends Study (n = 2,398). Based on variables reflecting differences in care hours, activities, and care provided by the whole network, we create network typologies …

Establishment Of A Consensus Protocol To Explore The Brain Pathobiome In Patients With Mild Cognitive Impairment And Alzheimer's Disease: Research Outline And Call For Collaboration., Richard Lathe, Nikki M Schultek, Brian J. Balin, Garth D Ehrlich, Lavinia Alberi Auber, George Perry, Edward B Breitschwerdt, David B Corry, Richard L Doty, Robert A Rissman, Peter L Nara, Ruth Itzhaki, William A Eimer, Rudolph E Tanzi

PCOM Scholarly Papers

Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD brains. There is a need for a consensus methodology; the Alzheimer's Pathobiome Initiative aims to perform comparative molecular analyses of microbes in post mortem brains versus cerebrospinal fluid, blood, olfactory neuroepithelium, oral/nasopharyngeal tissue, bronchoalveolar, urinary, and gut/stool samples. Diverse extraction methodologies, polymerase chain reaction and sequencing techniques, and bioinformatic tools will …

The Effects Of Music Therapy On Elderly Adults With Dementia, Jeante J. Jackson

Dissertations, Theses, and Capstone Projects

As people age, the brain is more susceptible to changes that diminish cognitive function. In recent years neuroscience has found convergent evidence between music therapy and brain architecture, as it has shown the generation of new connections in the brain or a reorganization and possible strengthening of existing connections already in the brain. However, the literature regarding music training’s effects on executive control, selective attention, and speech processing is lacking particularly when it comes to older populations.

This study investigated Verbal Working Memory, Visuospatial Attention and Task Initiation, and Auditory Selective Attention in a 91-year-old adult (B.P.) diagnosed with dementia. …

Exploring The Hinterland: The Development Of A Person-Centered Music Therapy Method For A Hospice Patient With Lewy Body Dementia, Paige Chaplin

Expressive Therapies Capstone Theses

This thesis explores the development and implementation of a music therapy method with an individual diagnosed with dementia with Lewy Bodies (DLB) receiving home hospice services. There is very little known about the effect of music therapy on patients diagnosed with DLB. Informed by Tom Kitwood’s Person-Centered Care (PCC) philosophy for dementia care, Yumiko Sato’s Musical Life Review (MLR) model, and Lisa Kelly and Bill Ahessy’s Reminiscence-Focused Music Therapy (RFMT) model, a clinical method was developed to explore the effects of person-centered music therapy on reminiscence, caregiver connection, and identity. I drew inspiration from music therapy concepts by Tony Wigram …

Hearing, Cognitive Decline, And The Value Of Hearing Interventions, Lisa M. Price, Jennifer Ren, Victoria Wong Murray, Dylan Trawinski, Ethan Zerpa-Blanco, Sheam Jahan

Rowan-Virtua Research Day

The term “dementia” includes a wide array of diseases. Millions of Americans are affected by these diseases, especially with aging. Its prevalence makes dementia a candidate for exploratory research in understanding its various etiologies and cause-effect relationships in hopes of developing treatment. Numerous studies have been conducted in an attempt to discern whether a causal relationship exists between hearing loss and dementia, as hearing loss frequently precedes dementia. Some publications have reported a correlation between hearing loss treatment and a decreased dementia incidence rate. This review seeks to investigate the associations between hearing loss and dementia, the efficacy of hearing …

Training Program For Occupational Therapists Working With Skilled Caregivers In Skilled Nursing Facilities, Lovegifty Dudero, Mai Huynh, Ridhee Patel

Occupational Therapy | Graduate Capstone Projects

Dementia impairs one’s ability to live independently and participate in everyday activities (CDC, 2019). Individuals with dementia (IwD) are often referred to skilled nursing facilities (SNFs) for around-the-clock care to receive support for their everyday challenges brought on by dementia symptoms. Although certified nursing assistants (CNAs) help IwD with everyday self-care tasks, they frequently lack specialized dementia care training. Consequently, CNAs experience low self-efficacy when providing care and managing challenging behaviors IwD may have. OTs have expertise and understanding regarding the stages of dementia and how the symptoms of dementia impact participation in daily occupations. OTs working in SNFs are …

Treating Cognition Through Occupational Performance In Individuals With Neurological Disorders In Home Health, Alcina J. Park

Occupational Therapy Capstone Presentations

Neurological Disorders (ND) like Alzheimer’s Disease, is one of the leading chronic diseases in older adults (National Council on Aging, 2023). One of the most common symptoms of ND is cognitive dysfunction, which prevent individuals with NDs from pursuing their daily occupations (Liu et al., 2019). This makes the exploration of treatment that delays functional decline in NDs imperative. Occupational therapy is valued and recognized in literature, but limited research is specific to cognition in occupational performance in home health. This capstone project used cognitive therapy approaches Cognitive Stimulation Therapy, Cognitive Rehabilitation Therapy, and Cognitive Training, to combat cognitive decline …