Medicine and Health Sciences Commons^™

Leveraging Igg N-Glycosylation To Infer The Causality Between T2d And Hypertension, Haotian Wang, Yuan Li, Weijie Cao, Jie Zhang, Mingyang Cao, Xiaoni Meng, Di Liu, Youxin Wang

Research outputs 2022 to 2026

Background: Observational studies demonstrated a bidirectional association between type 2 diabetes (T2D) and hypertension, whereas Mendelian randomization (MR) analyses supported the causality from T2D to hypertension but not causal from hypertension to T2D. We previously found that IgG N-glycosylation is associated with both T2D and hypertension, and thus IgG N-glycosylation might link the causality between them. Methods: We carried out a genome-wide association study (GWAS) to identify IgG N-glycosylation-quantitative-trait loci (QTLs) integrating GWAS for T2D and hypertension and then performed bidirectional univariable and multivariable MR analyses to infer the causal association among them. The inverse-variance-weighted (IVW) analysis was performed as …

Longitudinal Association Of Remnant Cholesterol With Joint Arteriosclerosis And Atherosclerosis Progression Beyond Ldl Cholesterol, Zhiyuan Wu, Jinqi Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Yue Liu, Xinlei Miao, Ze Han, Xiaoping Kang, Xia Li, Xiuhua Guo, Lixin Tao, Wei Wang

Research outputs 2022 to 2026

Background: Arteriosclerosis and atherosclerosis are closely related with cardiovascular disease (CVD) risk. Remnant cholesterol (RC) could predict CVD. However, its effect on joint arteriosclerosis and atherosclerosis progression remains unclear. This study aims to evaluate the association of RC with joint arteriosclerosis and atherosclerosis progression trajectories in the general population. Methods: This study collected data across five biennial surveys of the Beijing Health Management Cohort from 2010 to 2019. Multi-trajectory model was used to determine the joint arteriosclerosis and atherosclerosis progression patterns by brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI). We also performed discordance analyses for RC vs. …

Major Aviation Accident Investigation Methodologies Used By Itsa Members, Kym Bills, Leesa Costello, Marcus Cattani

Research outputs 2022 to 2026

The International Civil Aviation Organization (ICAO) Annex 13 framework for aviation investigation is longstanding and well developed but does not require or audit use of methodologies for investigation analysis, including research literature safety/accident models (SAMs). Government Safety Investigation Authority (SIA) websites rarely mention methodologies. Limited published research engages directly with SIAs. A research/practice gap has been suggested. To address ICAO, SIA and research gaps, this qualitative multi-case study examines SIA use and documentation of methodologies for accident analysis. Nine of seventeen SIA members of the International Transportation Safety Association (ITSA) that investigate aviation accidents agreed to participate and provided written …

Prevalence Of Preeclampsia And Algorithm Of Adverse Foeto-Maternal Risk Factors Among Pregnant Women In The Central Region Of Ghana: A Multicentre Prospective Cross-Sectional Study, Enoch O. Anto, Wina I. O. Boadu, Ezekiel Ansah, Augustine Tawiah, Joseph Frimpong, Valentine C. K. T. Tamakloe, Emmanuel E. Korsah, Emmanuel Acheampong, Evans A. Asamoah, Stephen Opoku, Eric Adua, Ebenezer Afrifa-Yamoah, Max E. Annani-Akollor, Agartha O. Anto, Christian Obirikorang

Research outputs 2022 to 2026

Background: Preeclampsia is a leading cause of foeto-maternal deaths especially in Sub-Saharan Africa. However, the prevalence and risk factors of preeclampsia are scarce in the Central region of Ghana with previous study assessing individual independent risk factors. This study determined the prevalence and algorithm of adverse foeto-maternal risk factors of preeclampsia. Methods: This multi-centre prospective cross-sectional study was conducted from October 2021 to October 2022 at the Mercy Women’s Catholic Hospital and Fynba Health Centre in Central region, Ghana. A total of 1,259 pregnant women were randomly sampled and their sociodemographic, clinical history, obstetrics and labour outcomes were recorded. Logistic …

The Eccentric:Concentric Strength Ratio Of Human Skeletal Muscle In Vivo: Meta-Analysis Of The Influences Of Sex, Age, Joint Action, And Velocity, James L. Nuzzo, Matheus D. Pinto, Kazunori Nosaka, James Steele

Research outputs 2022 to 2026

For decades, researchers have observed that eccentric (ECC) muscle strength is greater than concentric (CON) muscle strength. However, knowledge of the ECC:CON strength ratio is incomplete and might inform resistance exercise prescriptions. Our purposes were to determine the magnitude of the ECC:CON ratio of human skeletal muscle in vivo and explore if sex, age, joint actions/exercises, and movement velocity impact it. A total of 340 studies were identified through searches. It was possible to analyse 1516 ECC:CON ratios, aggregated from 12,546 individuals who made up 564 groups in 335 of the identified studies. Approximately 98% of measurements occurred on isokinetic …

Getting A Grip On Safewards: The Cross Impact Of Clinical Supervision And Safewards Model On Clinical Practice, Jennifer Hamilton, Amanda Cole, Richard Bostwick, Irene Ngune

Research outputs 2022 to 2026

The Safewards model is used across various mental health settings to reduce incidents of conflict and containment and its efficacy in reducing the use of seclusion and restraint, improving patients' experiences of care, and enhancing safety within clinical settings is well documented (Bowers, Journal of Psychiatric & Mental Health Nursing, 21, 2014, 499). However, there are barriers to successful implementation, including level of staff buy-in (Baumgardt et al., Frontiers in Psychiatry, 10, 2019, 340; Price et al., Mental Health Practice, 19, 2016, 14). This mixed-method study assessed the impact of adopting a Safewards model within a clinical supervision framework in …

Distinct Hyperuricemia Trajectories Are Associated With Different Risks Of Incident Diabetes: A Prospective Cohort Study, Jia Liu, Huiying Pan, Yue Liu, Mengying Guan, Xia Li, Shuo Chen, Xingyao Tong, Yanxia Luo, Xiaonan Wang, Xinghua Yang, Xiuhua Guo, Jingbo Zhang, Lixin Tao

Research outputs 2022 to 2026

Background and aim: Conflicting results suggest a link between serum uric acid and diabetes and previous studies ignored the effect of continuous exposure of serum uric acid on diabetes risk. This study aims to characterize hyperuricemia trajectories in middle-aged adults and to examine its potential impact on diabetes risk, considering the role of obesity, dyslipidemia, and hypertension. Methods and results: The cohort included 9192 participants who were free of diabetes before 2013. The hyperuricemia trajectories during 2009–2013 were identified by latent class growth models. Incident diabetes during 2014–2018 was used as the outcome. Modified Poisson regression models were used to …

Targeted Alveo-Pleural Fistula Endobronchial Valve Treatment Using Ventilation Scintigraphy, Calvin Sidhu, Shoba Ratnagobal, Rajesh Thomas, Gary Y.C. Lee, Enya Drudy, Roslyn J. Francis

Research outputs 2022 to 2026

Persistent air-leaks can be difficult to localize in radiology. Bronchoscopic management of air-leaks requires identification of the leak's location to allow suitable targeted treatment. One-way endobronchial valves have become a suitable option for persistent air-leaks. In this report, a combination scintigraphy and one-way endobronchial valve treatment successfully resolved a persistent air-leak.

Nitrate: The Dr. Jekyll And Mr. Hyde Of Human Health?, Catherine P. Bondonno, Liezhou Zhong, Nicola P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Alex Liu, Anjana Rajendra, Pratik Pokharel, Dorit W. Erichsen, Oliver Neubauer, Kevin D. Croft, Jonathan M. Hodgson

Research outputs 2022 to 2026

Background: Dietary nitrate has a controversial role in human health. For over half a century, the nitrate content of the three major dietary sources – vegetables, meat, and water – has been legislated, regulated, and monitored due to public health concerns over cancer risk. In contrast, a growing and compelling body of evidence indicates that dietary nitrate, particularly from vegetables, protects against cardiovascular disease and other chronic diseases. This evidence for the protective effect of nitrate is overshadowed by the potential for nitrate to form carcinogenic N-nitrosamines. Scope and approach: The nitrate content, regulations and estimated intake from vegetables, meat …

Cardiovascular Disease, Muscle Function, And Long-Term Falls Risk: The Perth Longitudinal Study Of Ageing Women, Abadi K. Gebre, Marc Sim, Jack Dalla Via, Alexander J. Rodríguez, Kun Zhu, John T. Schousboe, Jonathan M. Hodgson, Catherine P. Bondonno, Richard L. Prince, Joshua R. Lewis

Research outputs 2022 to 2026

Background: A few cross-sectional studies have highlighted inconsistent associations between cardiovascular disease (CVD) and musculoskeletal conditions. We sought to investigate the relationship between clinical CVD including subtypes, compromised muscle function, as well as incident self-reported and injurious falls in older women. Materials and methods: 1431 community-dwelling older women (mean age ± SD; 75.2 ± 2.7 years) were included in over 14.5 years of a prospective study, the Perth Longitudinal Study of Ageing in Women. CVD (up to 18-years prior to the baseline visit) and injurious fall hospitalizations over 14.5 years were obtained from linked health records. Self-reported falls for five …

Low Pre-Season Hamstring-To-Quadriceps Strength Ratio Identified In Players Who Further Sustained In-Season Hamstring Strain Injuries: A Retrospective Study From A Brazilian Serie A Team, Filipe Veeck, Cassio V. Ruas, Matheus Daros Pinto, Rafael Grazioli, Gustavo Pacheco Cardoso, Thiago Albuquerque, Lucas Schipper, Henrique Gonçalves Valente, Victor H. Santos, Márcio Dornelles, Paulo Rabaldo, Clarice S. Rocha, Bruno Manfredini Baroni, Eduardo Lusa Cadore, Ronei Silveira Pinto

Research outputs 2022 to 2026

A common pre-season injury prevention assessment conducted by professional football clubs is the hamstring-to-quadriceps (H:Q) strength ratio calculated by peak torque (PT). However, it is debatable whether players that present low pre-season H:Q ratios are more susceptible to further sustaining in-season hamstring strain injuries (HSI). Based upon retrospective data from a Brazilian Serie A football squad, a particular season came to our attention as ten out of seventeen (~59%) professional male football players sustained HSI. Therefore, we examined the pre-season H:Q ratios of these players. H:Q conventional (CR) and functional (FR) ratios, and the respective knee extensor/flexor PT from the …

A Multi-Species Simulation Of Mosquito Disease Vector Development In Temperate Australian Tidal Wetlands Using Publicly Available Data, Kerry Staples, Steven Richardson, Peter J. Neville, Jacques Oosthuizen

Research outputs 2022 to 2026

Worldwide, mosquito monitoring and control programs consume large amounts of resources in the effort to minimise mosquito-borne disease incidence. On-site larval monitoring is highly effective but time consuming. A number of mechanistic models of mosquito development have been developed to reduce the reliance on larval monitoring, but none for Ross River virus, the most commonly occurring mosquito-borne disease in Australia. This research modifies existing mechanistic models for malaria vectors and applies it to a wetland field site in Southwest, Western Australia. Environmental monitoring data were applied to an enzyme kinetic model of larval mosquito development to simulate timing of adult …

Combined Evaluation Of Arterial Stiffness And Blood Pressure Promotes Risk Stratification Of Peripheral Arterial Disease, Zhiyuan Wu, Yue Jiang, Qian Zhu, Haiping Zhang, Zhiwei Li, Jinqi Wang, Huiying Pan, Zheng Guo, Yulu Zheng, Xia Li, Lixin Tao, Bo Gao, Xiuhua Guo

Research outputs 2022 to 2026

Background: Previous studies have reported the separate association of arterial stiffness (AS) and blood pressure with peripheral arterial disease (PAD). Objectives: The aim of this study was to investigate the risk stratification capacity of AS on incident PAD beyond blood pressure status. Methods: A total of 8,960 participants from Beijing Health Management Cohort were enrolled at the first health visit between 2008 and 2018 and then followed until the incidence of PAD or 2019. Elevated AS was defined as brachial-ankle pulse-wave velocity (baPWV) > 1,400 cm/s, including moderate stiffness (1,400 ≤ baPWV < 1,800 cm/s) and severe stiffness (baPWV ≥ 1,800 cm/s). PAD was defined as ankle-brachial index < 0.9. A frailty Cox model was used to calculate the HR, integrated discrimination improvement, and net reclassification improvement. Results: During follow-up, 225 participants (2.5%) developed PAD. After adjusting for confounding factors, the highest risk for PAD was observed in the group with elevated AS and blood pressure (HR: 2.253; 95% CI: 1.472-3.448). Among participants with ideal blood pressure and those with well-controlled hypertension, PAD risk was still significant for severe AS. The results remained consistent in multiple sensitivity analyses. In addition, baPWV significantly improved the predictive capacity for PAD risk beyond systolic and diastolic blood pressures (integrated discrimination improvement 0.020 and 0.190, net reclassification improvement 0.037 and 0.303). Conclusions: This study suggests the clinical importance of combined evaluation and control of AS and blood pressure for the risk stratification and prevention of PAD.

Factors Impacting Readiness To Perform Secondary Population-Based Triage During The Second Wave Of Covid-19 In Victoria, Australia: Pilot Study, Zachary B. Horn

Research outputs 2022 to 2026

Objective: Pandemics generate such a significant demand for care that traditional triage methods can become saturated. Secondary population-based triage (S-PBT) overcomes this limitation. Although the coronavirus disease (COVID-19) pandemic forced S-PBT into operation internationally during the first year of the pandemic, Australian doctors were spared this responsibility. However, the second wave of COVID-19 provides an opportunity to explore the lived experience of preparing for S-PBT within the Australian context. The aim of this study is to explore the lived experience of preparing to operationalize S-PBT to allocate critical care resources during Australia's second wave of COVID-19 in 2020. Methods: Intensivists …

Association Of Computed Tomography Measures Of Muscle And Adipose Tissue And Progressive Changes Throughout Treatment With Clinical Endpoints In Patients With Advanced Lung Cancer Treated With Immune Checkpoint Inhibitors, Azim Khan, Christopher J. Welman, Afaf Abed, Susan O’Hanlon, Andrew Redfern, Sara Azim, Pedro Lopez, Favil Singh, Adnan Khattak

Research outputs 2022 to 2026

To investigate the association between skeletal muscle mass and adiposity measures with disease-free progression (DFS) and overall survival (OS) in patients with advanced lung cancer receiving immunotherapy, we retrospectively analysed 97 patients (age: 67.5 ± 10.2 years) with lung cancer who were treated with immunotherapy between March 2014 and June 2019. From computed tomography scans, we assessed the radiological measures of skeletal muscle mass, and intramuscular, subcutaneous and visceral adipose tissue at the third lumbar vertebra. Patients were divided into two groups based on specific or median values at baseline and changes throughout treatment. A total number of 96 patients …

Nurses' Understanding And Management Of Iron Deficiency In Australia: A Cross-Sectional, Exploratory Study, Therese A. O'Sullivan, Pradeep H. Jayasuriya, Natalie Tsalis, Nina Calogero, Ramesh Manocha

Research outputs 2022 to 2026

Objectives: To assess the experiences and knowledge of nurses in the area of iron deficiency. Design: A cross-sectional, exploratory study using online survey. Setting: Data were collected from nurses working at various primary, secondary and tertiary Australian health practices and organisations. Participants: Australian nurses currently in practice. Method: Australian nurses currently in practice were invited to complete an online survey about their work background, personal experiences with iron deficiency and iron-deficiency identification and treatment. The survey included a nine-item questionnaire to assess knowledge of iron-deficiency risk factors and biochemistry. Results: A total of 534 eligible nurses participated in the survey. …

The Role Of Adaptive Goal Processes In Mental Wellbeing In Chronic Pain, Tara Swindells, Joanne Iddon, Joanne M. Dickson

Research outputs 2022 to 2026

Chronic pain, experienced as pain persisting for three months or longer, is associated with risk of poor mental health and disability. Research has implicated adaptive goal processes as important to mental wellbeing in a range of populations. However, research has rarely assessed these mechanisms in relation to pain characteristics and mental wellbeing in chronic pain populations. This study aimed to examine the potentially mediating roles of goal flexibility and goal tenacity in the relationships between pain intensity and pain interference and mental wellbeing among individuals with chronic pain. Community members who self-identified as experiencing non-cancer chronic pain (N = 315) …

Adaptive Goal Processes And Underlying Motives That Sustain Mental Wellbeing And New Year Exercise Resolutions, Joanne M. Dickson, Amelia Hart, Caitlin Fox-Harding, Christopher D. Huntley

Research outputs 2022 to 2026

Exercise resolutions are the most common goals people set each New Year. However, research has rarely examined adaptive goal processes and motives that may maintain wellbeing and resolution pursuit. We therefore investigated if (1) personal goal flexibility and tenacity maintain mental wellbeing and adherence to New Year exercise resolutions and if (2) underlying intrinsic and extrinsic motives maintain wellbeing and sustained exercise resolution adherence. A community sample (N = 297) completed an online longitudinal study. At baseline, participants listed their most important exercise-related New Year resolution. Participants then completed measures to assess goal flexibility and tenacity, resolution motives, and mental …

Canine Cognitive Dysfunction Syndrome And Pet Tourism, Jun Wen, Fangli Hu, Joshua Aston

Research outputs 2022 to 2026

Highlights:

• Introduces canine cognitive dysfunction syndrome into the tourism literature

• Describes the nexus between canine cognitive dysfunction syndrome and pet tourism

• Highlights travel-related benefits for aging pets

• Discusses the need to consider travel a non-pharmacological intervention for pets

• Presents an interdisciplinary discussion to develop this niche market

Sprint Cycling Rate Of Torque Development Associates With Strength Measurement In Trained Cyclists, Shannon Connolly, Peter Peeling, Martyn J. Binnie, Paul S. R. Goods, Christopher Latella, Janet L. Taylor, Anthony J. Blazevich, Wouter P. Timmerman, Chris R. Abbiss

Research outputs 2022 to 2026

Purpose:

A cyclist’s rate of force/torque development (RFD/RTD) and peak force/torque can be measured during single-joint or whole-body isometric tests, or during cycling. However, there is limited understanding of the relationship between these measures, and of the mechanisms that contribute to each measure. Therefore, we examined the: (i) relationship between quadriceps central and peripheral neuromuscular function with RFD/RTD in isometric knee extension, isometric mid-thigh pull (IMTP), and sprint cycling; and (ii) relationship among RFD/RTD and peak force/torque between protocols.

Methods:

Eighteen trained cyclists completed two familiarisation and two experimental sessions. Each session involved an isometric knee extension, IMTP, and sprint …

Treatment Integrity And Differentiation In The Very Early Rehabilitation In Speech (Verse) Trial, Emily Brogan, Natalie Ciccone, Erin Godecke

Research outputs 2014 to 2021

Background:

Key elements of treatment fidelity include treatment integrity (adherence to the treatment protocol) and treatment differentiation (the difference in treatment ingredients in the control and intervention groups). The Very Early Rehabilitation in SpEech (VERSE) trial established treatment fidelity at the macro level for key components of therapy.

Aims:

To complete a detailed analysis of treatment integrity and differentiation at the utterance level of a therapeutic interaction.

Methods:

This was an observational study of therapy videos collected as part of the VERSE trial. Participants were people with aphasia in the very early phase of recovery post stroke (n = 44) …

Development Of A Tool To Identify Barriers And Enablers To Practice Innovation In Midwifery: A Participatory Action Research Study, Sara D. Davis, Sara Bayes, Sadie Geraghty

Research outputs 2022 to 2026

Introduction: Transferring research evidence into midwifery practice is fraught with challenges and obstacles. Implementation tools can streamline the process and are most effective when they are discipline-specific; however, there are currently no midwifery specific implementation tools. The aim of this study was to develop a midwifery specific tool to identify barriers and enablers to evidence-informed practice change within the clinical setting. Methods: Participatory action research methodology was employed to ensure potential end-users contributed to content and format of the tool. Purposeful sampling ensured participants were selected from a range of midwifery practice settings in Western Australia and the United Kingdom. …

Overview Of Muscle Fatigue Differences Between Maximal Eccentric And Concentric Resistance Exercise, James L. Nuzzo, Matheus D. Pinto, Kazunori Nosaka

Research outputs 2022 to 2026

Since the 1970s, researchers have studied a potential difference in muscle fatigue (acute strength loss) between maximal eccentric (ECCmax) and concentric (CONmax) resistance exercise. However, a clear answer to whether such a difference exists has not been established. Therefore, the aim of our paper was to overview methods and results of studies that compared acute changes in muscle strength after bouts of ECCmax and CONmax resistance exercise. We identified 30 relevant studies. Participants were typically healthy men aged 20–40 years. Exercise usually consisted of 40–100 isokinetic ECCmax and CONmax repetitions of the knee extensors or elbow flexors. Both ECCmax and …

Barry Turner: The Under-Acknowledged Safety Pioneer, Kym Bills, Leesa N. Costello, Marcus Cattani

Research outputs 2022 to 2026

Barry Turner’s 1978 Man-made Disasters and Charles Perrow’s 1984 Normal Accidents were seminal books but a detailed comparison has yet to be undertaken. Doing so is important to establish content and priority of key ideas underpinning contemporary safety science. Turner’s research found socio-technical and systemic patterns that meant that major organisational disasters could be foreseen and were preventable. Perrow’s macro-structuralist industry focus was on technologically deterministic but unpredictable and unpreventable “system” accidents, particularly rare catastrophes. Andrew Hopkins and Nick Pidgeon respectively suggested that some prominent writers who wrote after Turner may not have been aware of, or did not properly …

Changes In Deadlift Six Repetition Maximum, Countermovement Jump Performance, Barbell Velocity, And Perceived Exertion Over The Duration Of A Microcycle, Stuart N. Guppy, Tsuyoshi Nagatani, Wayne C. K. Poon, Kristina L. Kendall, Jason P. Lake, G. Gregory Haff

Research outputs 2022 to 2026

The primary aim of this study was to investigate the stability of the six-repetition maximum (6RM) deadlift over the length of a five-day microcycle and whether the fatigue induced by maximal effort testing detrimentally impacted preparedness. Twelve participants performed four testing sessions, comprising a one-repetition maximum test and three 6RM tests separated by 48 hours. Countermovement jumps were performed before each testing session, and barbell velocity was measured during each warm-up set to assess changes in preparedness. The 6RM deadlift was not statistically different between any of the testing sessions (p  =  .056; η_p²  =  0.251). Similarly, …

Investigating The Perspectives Of Older Adults In Residential Aged Care On Oral Health-Related Quality Of Life, Parisa Malekpour, Amanda Devine, Julie Dare, Leesa Costello

Research outputs 2022 to 2026

Objective

The objective of the study was to explore how older people living in a residential aged care facility perceived that their oral health influenced their food preferences and attitudes towards food, their social interactions and their self-esteem.

Background

Poor oral health can have biological, behavioural and social impacts on quality of life among older adults (aged 65+ years). In terms of biological impacts, oral health impairments may cause older adults to avoid many types of foods. This shift in dietary pattern can lead to malnutrition among older people, undermine general health and negatively impact quality of life (QOL).

Materials …

North-Central Nigerian Women’S Experiences Of Obstetric Fistula Risk Factors And Their Perceived Treatment Services: An Interpretive Description, Lydia Babatunde Bulndi, Sara J. Bayes, Esther A. Adama, Deborah M. Ireson

Research outputs 2022 to 2026

Background

An obstetric fistula also known as vesico vaginal fistula (VVF), or recto-vaginal fistula (RVF) is an abnormal opening between the urogenital tract and intestinal tract caused by prolonged obstructed labour; when the head of the baby presses on the soft tissues in the pelvis leading to loss of blood flow to the women’s bladder, vagina, and rectum. This can cause necrosis of the soft tissues resulting in debilitating fistula formations.

Aim

This study aimed to uncover North-central Nigerian women’s experiences of obstetric fistula and their perceived treatment services.

Design

Qualitative, interpretive descriptive methodology underpinned by symbolic interactionism involving face-to-face …

The Stability Of The Deadlift Three Repetition Maximum, Stuart N. Guppy, Tsuyoshi Nagatani, Wayne C. K. Poon, Kristina L. Kendall, Jason P. Lake, G. Gregory Haff

Research outputs 2022 to 2026

This study investigated the stability of three repetition maximum (3RM) strength during the deadlift. Eleven participants performed four testing sessions comprising a one repetition maximum test and 3RM tests separated by 48 h. Preparedness was assessed before each testing session using countermovement jumps and by measuring barbell velocity during each set of deadlifts. Trivial statistically significant differences were determined for the 3RM between T1 and both T2 (p = 0.012; ES [95% CI] = −0.1 [−0.58, 0.41]) and T3 (p = 0.027; ES [95% CI] = −0.09 [−0.57, −0.43]). No significant differences were noted between T2 and T3 …

Impact Of Vascular Screening Interventions On Perceived Threat, Efficacy Beliefs And Behavioural Intentions: A Systematic Narrative Review, Reindolf Anokye, Ben Jackson, James Dimmock, Joanne M. Dickson, Mary A. Kennedy, Carl J. Schultz, Lauren C. Blekkenhorst, Jonathan M. Hodgson, Mandy Stanley, Joshua Lewis

Research outputs 2022 to 2026

Health-related behaviours contribute to the global burden of cardiovascular disease (CVD). Cardiovascular imaging can be used to screen asymptomatic individuals for increased risk of CVD to enable earlier interventions to promote health-related behaviours to prevent or reduce CVD risk. Some theories of behaviour and behaviour change assume that engagement in a given behaviour is a function of individual threat appraisals, beliefs regarding the performance of behaviour, self-efficacy for performing the desired behaviour and/or dispositions to act (e.g. behavioural intentions). To date, little is known about the impact of cardiovascular imaging interventions on these constructs. This article summarises evidence related to …

Feasibility Of Supervised Telehealth Exercise For Patients With Advanced Melanoma Receiving Checkpoint Inhibitor Therapy, Brendan J. Crosby, Robert U. Newton, Daniel A. Galvão, Dennis R. Taaffe, Pedro Lopez Da Cruz, Tarek M. Meniawy, Muhammad A. Khattak, Wei-Sen Lam, Elin S. Gray, Favil Singh

Research outputs 2022 to 2026

Purpose: To determine the feasibility, safety and preliminary efficacy of a telehealth supervised exercise programme in patients with advanced melanoma receiving checkpoint inhibitor therapy. Methods: A 8-week non-randomised feasibility pilot trial utilising a telehealth delivered multimodal exercise programme undertaken thrice weekly with assessments at baseline and post-intervention. The study was considered feasible if there were no severe or life-threatening adverse events as a result of exercise, and three or more of the following criteria were met: the recruitment rate was > 50%, completion rate was > 80%, median programme attendance was > 75%, median exercise compliance > 75%, and average tolerance was > 70%. Preliminary …