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Full-Text Articles in Medicine and Health Sciences

Exercise − A Unique Endogenous Regulator Of Irisin, Bdnf, Leptin And Cortisol Against Depression, Gilmara Gomes De Assis, Pawel Cieszczyk Mar 2022

Exercise − A Unique Endogenous Regulator Of Irisin, Bdnf, Leptin And Cortisol Against Depression, Gilmara Gomes De Assis, Pawel Cieszczyk

Baltic Journal of Health and Physical Activity

Depression is the most prevalent stress-related disorder affecting the population world-wide with potential for an eminent increase after the 2020 pandemic. The mechanisms through which metabolism is involved in depression and stress disorders have been extensively investigated. However, their assessment using exogenous measures is a current limitation. Exercise, as is well reported in animal studies, exerts a critical regulatory influence on the main factors known to participate in these mechanisms. This overview describes the role of cortisol, leptin, irisin and BDNF in the exercise physiology and the known mechanism through which these factors act in anti-depressant mechanisms. Furthermore, the exercise …


The Benefit Of Bdnf Modification In The Treatment Of Post-Stroke Depression, Christine Gordynskiy-Ageyev Jan 2022

The Benefit Of Bdnf Modification In The Treatment Of Post-Stroke Depression, Christine Gordynskiy-Ageyev

Capstone Showcase

Neuroplasticity has been a rapidly expanding area of research, and its findings have elucidated the potential of taking advantage of some of its components for the treatment of various neural pathologies. Stroke is the most common cause of long-term disability, and it is a disease process that affects many people. There are many rehabilitation programs that seek to restore a patient’s motor and cognitive functions after stroke; if not fully, then at least partially. Unfortunately, mental health changes contribute in large part to the overall disability of a patient, but these changes are not always targeted in these programs. In …


Theta Burst Brain Stimulation In Painful Diabetic Neuropathy Patients: Investigating Neural Mechanisms, Bhushan Thakkar Jan 2022

Theta Burst Brain Stimulation In Painful Diabetic Neuropathy Patients: Investigating Neural Mechanisms, Bhushan Thakkar

Theses and Dissertations

Chronic pain (CP) is a significant contributor to disability and disease burden globally. In 2019, approximately 50.2 million adults (20.4% of the US population) experienced chronic pain, contributing to $560-635 billion in direct medical costs. In addition, the worldwide prevalence of diabetes mellitus has reached epidemic proportions and is set to increase to 629 million by 2045. Almost 50% of patients with diabetes present with diabetic neuropathy (DN), and one in five patients with diabetes presents with painful DN (pDN) which is the most common cause of neuropathic pain (NP) in the US. Symptomatic treatment is the mainstay of management …