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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
Cyclin C Regulated Oxidative Stress Responsive Transcriptome In Mus Musculus Embryonic Fibroblasts, David C Stieg, Kai-Ti Chang, Katrina F Cooper, Randy Strich
Cyclin C Regulated Oxidative Stress Responsive Transcriptome In Mus Musculus Embryonic Fibroblasts, David C Stieg, Kai-Ti Chang, Katrina F Cooper, Randy Strich
Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship
The transcriptional changes that occur in response to oxidative stress help direct the decision to maintain cell viability or enter a cell death pathway. Cyclin C-Cdk8 is a conserved kinase that associates with the RNA polymerase II Mediator complex that stimulates or represses transcription depending on the locus. In response to oxidative stress, cyclin C, but not Cdk8, displays partial translocation into the cytoplasm. These findings open the possibility that cyclin C relocalization is a regulatory mechanism governing oxidative stress-induced transcriptional changes. In the present study, the cyclin C-dependent transcriptome was determined and compared to transcriptional changes occurring in oxidatively …
Regulation Of Diabetic Cardiomyopathy By Caloric Restriction Is Mediated By Intracellular Signaling Pathways Involving 'Sirt1 And Pgc-1alpha', Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Michal Laniado-Schwartzman, Nader G. Abraham, Edith Hochhauser
Regulation Of Diabetic Cardiomyopathy By Caloric Restriction Is Mediated By Intracellular Signaling Pathways Involving 'Sirt1 And Pgc-1alpha', Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Michal Laniado-Schwartzman, Nader G. Abraham, Edith Hochhauser
Nader G. Abraham
BACKGROUND: Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and fibrosis, both of which are aggravated by angiotensin. Caloric restriction (CR) is cardioprotective in animal models of heart disease through its catabolic activity and activation of the expression of adaptive genes. We hypothesized that in the diabetic heart; this effect involves antioxidant defenses and is mediated by SIRT1 and the transcriptional coactivator PGC-1alpha (Peroxisome proliferator-activated receptor-gamma coactivator). METHODS: Obese Leptin resistant (db/db) mice …
Development Of Nash In Obese Mice Is Confounded By Adipose Tissue Increase In Inflammatory Nov And Oxidative Stress, David Sacerdoti, Shailendra P. Singh, Joseph Schragenheim, Lars Bellner, Aliza Meissner, Ilana Grant, Nader G. Abraham
Development Of Nash In Obese Mice Is Confounded By Adipose Tissue Increase In Inflammatory Nov And Oxidative Stress, David Sacerdoti, Shailendra P. Singh, Joseph Schragenheim, Lars Bellner, Aliza Meissner, Ilana Grant, Nader G. Abraham
Nader G. Abraham
Aim: Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity. We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO-1) levels in adipose and hepatic tissue, resulting in the development of NASH in obese mice. Methods: Mice were fed a high fat diet (HFD) and obese animals were administered an HO-1 inducer with or without an inhibitor of HO activity to examine levels of adipose-derived NOV and possible links between increased synthesis of inflammatory adipokines and hepatic pathology. Results: NASH mice displayed decreased HO-1 levels and HO …
Similarities In Vasoconstrictor Responsiveness To Exogenous Norepinephrine In The Cutaneous Circulation Between Young Black And White Men, Rauchelle E. Richey, John Akins, Jeremiah Campbell, Guillermo Olvera, Zachary Martin, R Matthew Brothers
Similarities In Vasoconstrictor Responsiveness To Exogenous Norepinephrine In The Cutaneous Circulation Between Young Black And White Men, Rauchelle E. Richey, John Akins, Jeremiah Campbell, Guillermo Olvera, Zachary Martin, R Matthew Brothers
International Journal of Exercise Science: Conference Proceedings
Black (BL) men have an increased risk of hypertension and CVD compared to white (WH) men which is partially related to vascular dysfunction. In particular, elevated vascular resistance and increased sympathetic vascular transduction (SVT; greater constrictor and blood pressure responses for a burst of sympathetic nerve activity) may be a contributing factor. Previous reports indicate that BL men have exaggerated responses to a variety of stressors including cold pressor, orthostasis, and exercise; while also exhibiting increased SVT at rest. Additionally, rodent models indicate that oxidative stress contributes to heightened SVT. For example, hypertensive rats have elevated SVT which is attenuated …
Impact Of Time Restricted Feeding On Markers Of Cardiometabolic Health, Liliana I. Renteria, Elias Villalobos, Hunter S. Waldman, Matthew J. Mcallister
Impact Of Time Restricted Feeding On Markers Of Cardiometabolic Health, Liliana I. Renteria, Elias Villalobos, Hunter S. Waldman, Matthew J. Mcallister
International Journal of Exercise Science: Conference Proceedings
Time restricted feeding (TRF) is a form of intermittent fasting in which all calories are consumed within a certain amount of time (i.e. 6-8 hrs) only water is ingested for the remainder of the day. Previous research shows improvements in body composition and some markers of cardiometabolic health, but it is not clear if these results were due to the decreased eating window, or due to a decrease in caloric intake that typically occurs with fasting protocols. PURPOSE: to assess whether a caloric deficit is necessary to achieve improvements in cardiometabolic health as well as evaluate the impact TRF has …
Circulating Inflammatory And Oxidative Stress Responses To Steady-State Moderate-Intensity And High-Intensity Interval Exercise In Mid-Spectrum Chronic Kidney Disease, Matthew Peterson, Jeffrey S. Forsse, James K. Taylor, Zach Papadakis, Nick Schwedock, Burritt Hess, Jackson O. Griggs Md, Crawford Allison, Ron Wilson Md, Kathleen Adair, Mitch Cholewinski, Peter Grandjean
Circulating Inflammatory And Oxidative Stress Responses To Steady-State Moderate-Intensity And High-Intensity Interval Exercise In Mid-Spectrum Chronic Kidney Disease, Matthew Peterson, Jeffrey S. Forsse, James K. Taylor, Zach Papadakis, Nick Schwedock, Burritt Hess, Jackson O. Griggs Md, Crawford Allison, Ron Wilson Md, Kathleen Adair, Mitch Cholewinski, Peter Grandjean
International Journal of Exercise Science: Conference Proceedings
Inflammation and oxidative stress can be potent modulators of vascular function. These factors may transiently respond to moderate-intensity steady state exercise (SSE) in a manner that improves post-exercise vascular function in healthy adults. Whether exercise imparts similar effects in adults with Stage 3 or 4 chronic kidney disease (CKD) remains understudied. Moreover, a comparison of SSE and high-intensity interval exercise (HIIE) may add to clinically-relevant findings for improving vascular function in mid-spectrum CKD. PURPOSE: To determine the influence of SSE and a comparable amount of HIIE on post-exercise inflammation and oxidative stress in patients diagnosed with secondary Stage 3 or …
Green Tea Extract, Epigallocatechin Gallate, Protect Against Methamphetamine-Induced Striatal Neurotoxicity In Mice, Allen L. Pan
Green Tea Extract, Epigallocatechin Gallate, Protect Against Methamphetamine-Induced Striatal Neurotoxicity In Mice, Allen L. Pan
Dissertations, Theses, and Capstone Projects
Methamphetamine (METH) is a strong psychostimulant and its exposure can lead to serious neurological complications. METH-induced neuronal injury is the result of a complex interplay of different factors including dopamine (DA) overflow, oxidative stress and neuroinflammation. Although the mechanisms of METH-induced neurotoxicity have been extensively studied, there is still no effective therapeutic treatment. Therefore, it is essential to study potential drug candidates that can treat METH-induced neurotoxicity. Green tea extract, epigallocatechin gallate (EGCG), has emerged as a neuroprotective agent that can protect against several neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Recently, our lab has shown that EGCG prevents …
Disruption Of The Hippocampal And Hypothalamic Blood-Brain Barrier In A Diet-Induced Obese Model Of Type Ii Diabetes: Prevention And Treatment By The Mitochondrial Carbonic Anhydrase Inhibitor, Topiramate, Therese S. Salameh, William G. Mortell, Aric F. Logsdon, D. Allan Butterfield, William A. Banks
Disruption Of The Hippocampal And Hypothalamic Blood-Brain Barrier In A Diet-Induced Obese Model Of Type Ii Diabetes: Prevention And Treatment By The Mitochondrial Carbonic Anhydrase Inhibitor, Topiramate, Therese S. Salameh, William G. Mortell, Aric F. Logsdon, D. Allan Butterfield, William A. Banks
Chemistry Faculty Publications
Background: Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood–retinal barrier (BRB) and blood–brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms by which diet or metabolic syndrome induces dysfunction are not understood. A proposed mechanism is an increase in reactive oxygen species (ROS) and oxidative stress. Inhibition of mitochondrial carbonic anhydrase (mCA) decreases ROS and oxidative stress. In this study, topiramate, a mCA inhibitor, was examined for its ability to protect the BRB and BBB in diet-induced obese type II …
Mitochondrial Superoxide Disrupts The Metabolic And Epigenetic Landscape Of Cd4, Cassandra M. Moshfegh, Christopher W. Collins, Venugopal Gunda, A. Vasanthakumar, J. Z. Cao, Pankaj K. Singh, L. A. Godley, Adam J. Case
Mitochondrial Superoxide Disrupts The Metabolic And Epigenetic Landscape Of Cd4, Cassandra M. Moshfegh, Christopher W. Collins, Venugopal Gunda, A. Vasanthakumar, J. Z. Cao, Pankaj K. Singh, L. A. Godley, Adam J. Case
Journal Articles: Eppley Institute
While the role of mitochondrial metabolism in controlling T-lymphocyte activation and function is becoming more clear, the specifics of how mitochondrial redox signaling contributes to T-lymphocyte regulation remains elusive. Here, we examined the global effects of elevated mitochondrial superoxide (O2-) on T-lymphocyte activation using a novel model of inducible manganese superoxide dismutase (MnSOD) knock-out. Loss of MnSOD led to specific increases in mitochondrial O2- with no evident changes in hydrogen peroxide (H2O2), peroxynitrite (ONOO-), or copper/zinc superoxide dismutase (CuZnSOD) levels. Unexpectedly, both mitochondrial and glycolytic metabolism showed significant reductions …