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Predicting The Effects Of Supplemental Epa And Dha On The Omega-3 Index, Rachel E. Walker, Kristina Harris Jackson, Nathan L. Tintle, Gregory C. Shearer, Aldo Bernasconi, Serge Masson, Roberto Latini, Bobak Heydari, Raymond Y. Kwong, Michael Flock, Penny M. Kris-Etherton, Anne Hedengran, Robert M. Carney, Ann Skulas-Ray, Samuel S. Gidding, Antonella Dewell, Christopher D. Gardner, Marlene Grenon, Barbara Sarter, John W. Newman, Theresa L. Pedersen, Mark K. Larson, William S. Harris Aug 2019

Predicting The Effects Of Supplemental Epa And Dha On The Omega-3 Index, Rachel E. Walker, Kristina Harris Jackson, Nathan L. Tintle, Gregory C. Shearer, Aldo Bernasconi, Serge Masson, Roberto Latini, Bobak Heydari, Raymond Y. Kwong, Michael Flock, Penny M. Kris-Etherton, Anne Hedengran, Robert M. Carney, Ann Skulas-Ray, Samuel S. Gidding, Antonella Dewell, Christopher D. Gardner, Marlene Grenon, Barbara Sarter, John W. Newman, Theresa L. Pedersen, Mark K. Larson, William S. Harris

Faculty Work Comprehensive List

Background: Supplemental long-chain omega-3 (n–3) fatty acids (EPA and DHA) raise erythrocyte EPA + DHA [omega-3 index (O3I)] concentrations, but the magnitude or variability of this effect is unclear.

Objective: The purpose of this study was to model the effects of supplemental EPA + DHA on the O3I.

Methods: Deidentified data from 1422 individuals from 14 published n–3 intervention trials were included. Variables considered included dose, baseline O3I, sex, age, weight, height, chemical form [ethyl ester (EE) compared with triglyceride (TG)], and duration of treatment. The O3I was measured by the same method in all included studies. Variables were selected …


Association Of Reported Fish Intake And Supplementation Status With The Omega-3 Index, Kristina H. Jackson, Jason M. Polreis, Nathan L. Tintle, Penny M. Kris-Etherton, William S. Harris Mar 2019

Association Of Reported Fish Intake And Supplementation Status With The Omega-3 Index, Kristina H. Jackson, Jason M. Polreis, Nathan L. Tintle, Penny M. Kris-Etherton, William S. Harris

Faculty Work Comprehensive List

Background: An Omega-3 Index (O3I; EPA+DHA as a % of erythrocyte total fatty acids) in the desirable range (8%-12%) has been associated with improved heart and brain health.

Objective: To determine the combination of fish intake and supplement use that is associated with an O3I of >8%.

Design: Two cross-sectional studies comparing the O3I to EPA+DHA/fish intake.

Participants/setting: The first study included 28 individuals and assessed their fish and EPA+DHA intake using both a validated triple-pass 24-hr recall dietary survey and a single fish-intake question. The second study used de-identified data from 3,458 adults (84% from US) who self-tested their …