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Tlr2 (-196 To -174 Ins/Del) And Tlr3 (1377c>T) As Biomarkers For Nasopharyngeal Cancer In Tunisia, Lamia Makni, Amira Messadi, Sabrina Zidi, Ezzedine Gazouani, Amel Mezlini, Besma Yacoubi-Loueslati
Tlr2 (-196 To -174 Ins/Del) And Tlr3 (1377c>T) As Biomarkers For Nasopharyngeal Cancer In Tunisia, Lamia Makni, Amira Messadi, Sabrina Zidi, Ezzedine Gazouani, Amel Mezlini, Besma Yacoubi-Loueslati
Turkish Journal of Medical Sciences
Background/aim: We evaluated the association of TLR2 (-196 to -174 Ins/Del) and TLR3 (1377 C>T) as potential risk factors for nasopharyngeal carcinoma (NPC) in Tunisians. Material and methods: The study subjects comprised 137 NPC patients and 164 cancer-free control subjects. TLR2 genotyping was done by PCR and TLR3 genotyping was performed by PCR-RFLP. Results: Minor allele frequency (MAF) and genotypes of TLR3 (1377 C>T) were comparable between NPC patients and controls. Significantly higher MAF and TLR2-containing Del allele genotypes of TLR2 (-196 to -174 Ins/Del) were seen in NPC patients compared to controls [OR (95% CI) = 2.10 …