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The Effect Of Andrographolide On The Metabolism Of Carbamazepine In Rats, Elizabeth Aziz, Samuel Franklin, Ankit Pandav, Abigail Savino, Caleb Thompson, Caleb Vandyke, Ruth Choi, Elisha R. Injeti
The Effect Of Andrographolide On The Metabolism Of Carbamazepine In Rats, Elizabeth Aziz, Samuel Franklin, Ankit Pandav, Abigail Savino, Caleb Thompson, Caleb Vandyke, Ruth Choi, Elisha R. Injeti
The Research and Scholarship Symposium (2013-2019)
Objective: To determine if andrographolide (AND) impacts the pharmacokinetics of carbamazepine (CBZ).
Background: CBZ is an anticonvulsant medication that is metabolized in the liver by cytochrome P450 (CYP) enzymes. AND is an over-the-counter medication that is common in Eastern cultures to treat inflammation and is a CYP enzyme inhibitor. Because CBZ is metabolized in the liver by these specific CYP enzymes, coadministration of andrographolide and CBZ could result in a herb-drug interaction. Methods: Sprague-Dawley rats (N=12) aged between 3 months and 6 months (250-350 g) will be split into control (N=6) and treatment (N=6) groups. The treatment group will receive …