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Full-Text Articles in Medicine and Health Sciences
Cyp 2d6*4 Polymorphism And Interindividual Response Variation To Metoprolol Instage 1 Hypertensive Patients: No Association In A Rural Indian Population?, Rajagopal Ayyappadhas, Unnikrishnan Dhanalekshmi, Chelliah Jestin
Cyp 2d6*4 Polymorphism And Interindividual Response Variation To Metoprolol Instage 1 Hypertensive Patients: No Association In A Rural Indian Population?, Rajagopal Ayyappadhas, Unnikrishnan Dhanalekshmi, Chelliah Jestin
Turkish Journal of Medical Sciences
Background/aim: Genetic polymorphism of CYP2D6 shows diverse pharmacokinetic and pharmacodynamic variation. Therefore, the present work was designed to study the variation in therapeutic responses to metoprolol (MP) in stage 1 hypertensive patients and also aims to verify the association of CYP2D6*4 polymorphism and response variation in an Indian population for the first time. Materials and methods: Clinically, a total of 119 hypertensive patients and 116 healthy individuals as controls were included. Patients were treated with MP extended release 25 mg tablets once daily for 2 weeks. Reduction in systolic blood pressure, diastolic blood pressure, and pulse rate were recorded before …
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population. Materials and methods: Fifty-three AD patients and 56 controls were included to examine polymorphism and allele frequency of the APOE and BIN1 …
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid β-peptide, which is derived from β-amyloid precursor protein through degradation by β-secretase and γ-secretase complexes. One of the major components of γ-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the γ-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population. Materials and methods: In this study, 49 AD patients and 45 healthy controls were included. The genetic polymorphisms and allele frequencies …
Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere
Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere
Turkish Journal of Medical Sciences
To investigate cold-induced autoinflammatory syndrome 1 (CIAS1) gene polymorphisms that cause autoinflammatory diseases in patients with nasal polyposis (NP). Materials and methods: The study included 30 patients diagnosed with NP and 30 healthy age-matched individuals as a control group. CIAS1 polymorphisms were assessed by DNA sequence analysis. Patients with nasal polyps and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the CIAS1 gene was analyzed separately in the patient group. Results: The most frequently observed polymorphisms in the patient group were c.732G > A in 83%, c.663C > T in 23%, and c.1308C > A …
Association Of Clu And Tlr2 Gene Polymorphisms With Late-Onsetalzheimer Disease In A Northwestern Iranian Population, Nasim Sohrabifar, Jalal Gharesouran, Mahnaz Talebi, Morteza Ghojazadeh, Seiied Mojtaba Mohaddes Ardebili
Association Of Clu And Tlr2 Gene Polymorphisms With Late-Onsetalzheimer Disease In A Northwestern Iranian Population, Nasim Sohrabifar, Jalal Gharesouran, Mahnaz Talebi, Morteza Ghojazadeh, Seiied Mojtaba Mohaddes Ardebili
Turkish Journal of Medical Sciences
Background/aim: A number of genetic variants from different genes have been reported to be related to late-onset Alzheimer disease (LOAD) susceptibility. From these genes, polymorphisms in CLU and TLR2 have been replicated in several studies. In this study we examined the association of rs11136000 in CLU and the TLR2 -196 to -174 del polymorphism with the risk of LOAD in a northwestern Iranian population. Materials and methods: We conducted a case-control study with a dataset of 160 LOAD patients and 163 healthy controls. To examine polymorphisms of CLU and TLR2 in LOAD we used the PCR/RFLP method and genotype frequencies …
Determination Of The Alui Polymorphism Effect Of Bovine Growth Hormone Gene On Carcass Traits In Zavot Cattle With Analysis Of Covariance, Aytaç Akçay, Bi̇lal Akyüz, Davut Bayram
Determination Of The Alui Polymorphism Effect Of Bovine Growth Hormone Gene On Carcass Traits In Zavot Cattle With Analysis Of Covariance, Aytaç Akçay, Bi̇lal Akyüz, Davut Bayram
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to determine the genotypes of bovine growth hormone and to investigate their association with daily weight gain in the Zavot cattle breed. The bovine growth hormone (GH) genotypes of 45 male Zavot cattle were identified by PCR-RFLP. The effect of the bovine growth hormone gene on daily weight gain was estimated from a dataset obtained from cattle up to the age of 9 months. The mean differences of carcass weight or carcass yield among the genotype groups were assessed by analysis of covariance (ANCOVA). Two alleles for bovine growth hormone locus, L and V, …
Polymorphisms Of Ovine Prion Protein (Prp) Gene In Pramenka Sheepbreed Population In Bosnia And Herzegovina, Ervin Zecevic, Admir Dokso, Amra Kazic, Muhamed Brka
Polymorphisms Of Ovine Prion Protein (Prp) Gene In Pramenka Sheepbreed Population In Bosnia And Herzegovina, Ervin Zecevic, Admir Dokso, Amra Kazic, Muhamed Brka
Turkish Journal of Veterinary & Animal Sciences
Transmissible spongiform encephalopathies (TSEs) are a group of diseases that affect the nervous system and lead to death. The putative infectious agent is the host-encoded prion protein (PrP) and it appears that the development of scrapie in sheep is closely related to polymorphisms in the host PrP gene. The aim of this study was to investigate three well-known polymorphisms in exon 3 of the PrP gene (at codons 136, 154, and 171) that have a clear and significant effect on scrapie in sheep. Four other polymorphisms (at codons 145, 185, 231, and 237) that are yet undefined were also investigated. …