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Full-Text Articles in Medicine and Health Sciences
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia. Some factors in the development of AD, age being the best-known one, have been suggested; however, no causes have been found yet. The pathophysiology of the disease is highly complex, current therapies are palliative, and a cure is still lacking. Adverse effects of anesthetics in the elderly have been reported since the 1950s; however, awareness of this old problem has recently gained importance again. Whether exposure to surgery and general anesthesia (GA) is associated with the development of AD has been questioned. …
Comparison Of Sevoflurane And Isoflurane Effects On Cardiovascular Andrespiratory System During Spontaneous Ventilation In Angora Goats, Ali̇ Kumandaş, Ertuğrul Elma
Comparison Of Sevoflurane And Isoflurane Effects On Cardiovascular Andrespiratory System During Spontaneous Ventilation In Angora Goats, Ali̇ Kumandaş, Ertuğrul Elma
Turkish Journal of Veterinary & Animal Sciences
Seven healthy Angora goats were used to compare the effects of isoflurane and sevoflurane on the cardiovascular and respiratory systems during anesthesia periods. Once anesthesia was induced with propofol at 5.1 ± 0.9 mg/kg, it was maintained with isoflurane at 1%-3% in the first treatment period and sevoflurane at 2%-4% in the second treatment period after a 15-day interval. Heart rates measured immediately after anesthesia induction and 5 min later were found to be statistically significant between anesthetic groups (P < 0.05). Mean blood pressure in the isoflurane group decreased (75.7 ± 7.2 to 59.8 ± 9.8 mmHg) (P < 0.05) throughout the anesthesia period. It was determined that respiratory rate in sevoflurane treatment was lower than that in isoflurane treatment. In terms of time to stand up, sevoflurane-administered animals recovered significantly faster than animals intubated with isoflurane anesthesia (13.1 ± 4.4 and 25.0 ± 8.6 min) (P < 0.05). According to cardiopulmonary values, the respiratory rate was lower in the sevoflurane-applied animals compared to that of those receiving isoflurane anesthesia, although the difference was not statistically significant, and hypercapnia were not observed in either group. Consequently, it was determined that in the Angora goat, propofol-sevoflurane anesthesia exerts lower pressure on the cardiovascular system than isoflurane anesthesia. At the same time, recovery from sevoflurane anesthesia was shorter, and therefore it can be preferred to other anesthesia agents for routine anesthesia.
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β …
Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör
Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common cause of dementia. The cardinal manifestation of AD is progressive loss of memory. However, there are some nonamnestic presentations of AD, also called atypical AD. Symptoms of AD can sometimes start suddenly. In the presence of atypical symptoms or sudden onset, it may be difficult to distinguish AD from other dementias. We would like to discuss the confusing features of atypical AD that mimic other dementias. In this review, the literature associated with confusing features of AD, suggesting other dementia syndromes, is reviewed. In addition, a case of semantic dementia (SD) with the …