Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 30 of 38
Full-Text Articles in Medicine and Health Sciences
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
Xu-Feng Huang
Description The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain currently available. The second edition of this classic book is a complete revision, featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will again be the indispensable resource for all scientists working on the primate nervous system. Key Features * 151 coronal diagrams and 151 accompanying photographic plates spaced at 120 um intervals; diagrams completely revised * 60 photographic coronal plates of SMI immunoreactivity; delineations completely revised. New in this edition * DVD …
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
Xu-Feng Huang
Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative …
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Xu-Feng Huang
An abstract of a poster presentation that presented at Australian Neuroscience Society 32nd Annual meeting.
Metabotropic Glutamate Receptor Subtype 5 Is Reduced In Schizophrenia Subjects With Comorbid Major Depression And Unchanged Following Antipsychotic Drug Treatment, N Jimenez, Xu-Feng Huang, C Deng, K Newell
Metabotropic Glutamate Receptor Subtype 5 Is Reduced In Schizophrenia Subjects With Comorbid Major Depression And Unchanged Following Antipsychotic Drug Treatment, N Jimenez, Xu-Feng Huang, C Deng, K Newell
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
Xu-Feng Huang
From the Back Cover The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive, detailed atlas of the monkey brain ever constructed. The first chapter, "Photographic and Diagrammatic Atlas of the Rhesus Monkey Brain," presents 151 plates illustrating the subcortex and parts of the cortex in high magnification, and 151 corresponding diagrams complementing each image. The second chapter, "Delineation of the Rhesus Monkey Cortex on the Basis of the Distribution of a Neurofilament Protein," consists of 64 fully labeled plates depicting an entire hemisphere. Jointly, the two chapters constitute the most serious morphological work ever undertaken on the monkey. …
Novel Olanzapine Analogues Presenting A Reduced H1 Receptor Affinity And Retained 5ht2a/D2 Binding Affinity Ratio, Somayeh Jafari, Marc E. Bouillon, Xu-Feng Huang, Stephen G. Pyne, Francesca Fernandez-Enright
Novel Olanzapine Analogues Presenting A Reduced H1 Receptor Affinity And Retained 5ht2a/D2 Binding Affinity Ratio, Somayeh Jafari, Marc E. Bouillon, Xu-Feng Huang, Stephen G. Pyne, Francesca Fernandez-Enright
Xu-Feng Huang
Background Olanzapine is an atypical antipsychotic drug with high clinical efficacy, but which can cause severe weight gain and metabolic disorders in treated patients. Blockade of the histamine 1 (H1) receptors is believed to play a crucial role in olanzapine induced weight gain, whereas the therapeutic effects of this drug are mainly attributed to its favourable serotoninergic 2A and dopamine 2 (5HT2A/D2) receptor binding affinity ratios. Results We have synthesized novel olanzapine analogues 8a and 8b together with the already known derivative 8c and we have examined their respective in vitro affinities for the 5HT2A, D2, and H1 receptors. Conclusions …
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Xu-Feng Huang
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission, with implications for the pathophysiology of schizophrenia. Post-mortem studies have demonstrated altered NRG1-ErbB4 signalling in the brain of schizophrenia patients. Antipsychotic drugs have different effects on NRG1-ErbB4 signalling depending on treatment duration. Abnormal behaviours relevant to certain features of schizophrenia are displayed in NRG1/ErbB4 knockout mice or …
Mglur5 And Nmda Receptor Density Are Reduced In The Dorsolateral Prefrontal Cortex Of Schizoaffective But Not Schizophrenia Patients, Kelly Newell, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang
Mglur5 And Nmda Receptor Density Are Reduced In The Dorsolateral Prefrontal Cortex Of Schizoaffective But Not Schizophrenia Patients, Kelly Newell, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang
Xu-Feng Huang
Abstract of a poster that presented at the Society of Biological Psychiatry 67th Annual Meeting.
Are There Different Neural Mechanisms Responsible For Three Stages Of Weight Gain Development In Anti-Psychotic Therapy: Temporally Based Hypothesis, Nagesh Pai, Chao Deng, Shae-Leigh Vella, David Castle, Xu-Feng Huang
Are There Different Neural Mechanisms Responsible For Three Stages Of Weight Gain Development In Anti-Psychotic Therapy: Temporally Based Hypothesis, Nagesh Pai, Chao Deng, Shae-Leigh Vella, David Castle, Xu-Feng Huang
Xu-Feng Huang
Weight gain as a result of atypical anti-psychotic treatment is a common issue with different atypical anti-psychotic treatments causing differing magnitudes of weight gain. Although differing amounts of weight gain result from different atypical agents little is known about the temporal course of weight gain in anti- psychotic treatment. Specifically is the time course of weight gain comparable across different agents. Therefore this article reviews the temporal course of weight gain for three common atypical anti-psychotics namely; clozapine, olanzapine and risperidone. It is evident that all three of these agents exhibit similar although at distinct magnitudes temporal courses of weight …
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Xu-Feng Huang
The serotonergic system has close interactions with the dopaminergic system and is strongly implicated in the pathophysiological mechanisms and therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate regional changes in 5-hydroxytryptamine (5-HT) 2A receptors in the rat brain 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). 5-HT 2A receptor distributions and alterations in the postmortem rat brain were detected by [3H]ketanserin-binding autoradiography. In the 6-OHDA-induced Parkinson’s rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [3H]ketanserin binding, predominantly in the agranular insular cortex (17.3%, P 5 0.03), cingulate cortex (18.2%, P < 0.001), prefrontal …
Activation Of Signal Pathways And The Resistance To Anti-Egfr Treatment In Colorectal Cancer, J-Z Chen, Xu-Feng Huang, Andrew Katsifis
Activation Of Signal Pathways And The Resistance To Anti-Egfr Treatment In Colorectal Cancer, J-Z Chen, Xu-Feng Huang, Andrew Katsifis
Xu-Feng Huang
No abstract provided.
The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang
The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang
Xu-Feng Huang
Atypical antipsychotics such as olanzapine and clozapine are effective at treating the multiple domains of schizophrenia, with a lowrisk of extra-pyramidal side-effects. However amajor downfall to their use is metabolicside-effects particularly weight gain/obesity,which occurs by unknownmechanisms. The present paper explores the potential candidature of histaminergic neurotransmission in the mechanisms of atypical antipsychoticinduced weight gain, with a focus on the histaminergic H1 and H3 receptors. Olanzapine and clozapine have a high affinity for the H1 receptor, andmeta-analyses showa strong correlation between risk ofweight gain andH1 receptor affinity. In addition, olanzapine treatment decreases H1 receptor binding and mRNA expression in the rat …
Effects Of Simvastatin And 6-Hydroxydopamine On Histaminergic H1 Receptor Binding Density In Rat Brains, Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, Cansheng Zhu, Yu Yang, Yuge Wang, J-Z Chen, Xu-Feng Huang, Qing Wang
Effects Of Simvastatin And 6-Hydroxydopamine On Histaminergic H1 Receptor Binding Density In Rat Brains, Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, Cansheng Zhu, Yu Yang, Yuge Wang, J-Z Chen, Xu-Feng Huang, Qing Wang
Xu-Feng Huang
Statins have been widely used for the treatment of a variety of medical conditions including psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play an important role in the regulation of neural activity, however, it is unknown whether statins act on histamine receptors, particularly for their neural regulatory effects. This study examined the effects of simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [3H] pyrilamine binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core …
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Xu-Feng Huang
Antipsychotic drugs have various neuropharmacological properties as a result of their structural diversity. Despite their therapeutic benefits, most of the prescribed atypical antipsychotics can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases. Among the developed atypical antipsychotic agents, tetracyclic dibenzodiazepine and thienobenzodiazepine compounds, particularly clozapine and olanzapine, are associated with the greatest weight gain and metabolic disturbances. However, the unique chemical structure of these compounds causes the low risk of side effects reported for typical antipsychotics (e.g. extrapyramidal symptoms and tardive dyskinesia). This report reviews the recent discovery of the potential role of the …
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Increases In Peptide Y-Y Levels Following Oat Β-Glucan Ingestion Are Dose-Dependent In Overweight Adults, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, Xu-Feng Huang
Increases In Peptide Y-Y Levels Following Oat Β-Glucan Ingestion Are Dose-Dependent In Overweight Adults, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, Xu-Feng Huang
Xu-Feng Huang
Peptide Y-Y (PYY) is an anorexigenic hormone implicated in appetite control, and β-glucan is a fiber known to affect appetite. We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses of β-glucan. The objective was to test whether the effect could be seen with β-glucan delivered through extruded cereals containing a high β-glucan oat bran with demonstrated high molecular weight and solubility. Fourteen subjects consumed a control meal and 3 cereals of varying β-glucan concentration (between 2.2 and 5.5 g), and blood samples were collected over 4 hours. Analysis of raw PYY data showed a …
Distinct Neurobehavioural Effects Of Cannabidiol In Transmembrane Domain Neuregulin 1 Mutant Mice, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S. Mcgregor, Jonathon Arnold, Tim Karl
Distinct Neurobehavioural Effects Of Cannabidiol In Transmembrane Domain Neuregulin 1 Mutant Mice, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S. Mcgregor, Jonathon Arnold, Tim Karl
Xu-Feng Huang
The cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic properties. We have previously shown that transmembrane domain neuregulin 1 mutant (Nrg1 TM HET) mice display altered neurobehavioural responses to the main psychoactive constituent of cannabis, D9-tetrahydrocannabinol. Here we investigated whether Nrg1 TM HET mice respond differently to CBD and whether CBD reverses schizophrenia-related phenotypes expressed by these mice. Adult male Nrg1 TM HET and wild type-like littermates (WT) received vehicle or CBD (1, 50 or 100 mg/kg i.p.) for 21 days. During treatment and 48 h after withdrawal we measured behaviour, whole blood CBD concentrations and autoradiographic receptor binding. Nrg1 …
Developmental Vitamin D Deficiency Alters Mk-801-Induced Behaviours In Adult Offspring, James Kesby, Jonathan O'Loan, Suzanne Alexander, Chao Deng, Xu-Feng Huang, John Mcgrath, Darryl Eyles, Thomas Burne
Developmental Vitamin D Deficiency Alters Mk-801-Induced Behaviours In Adult Offspring, James Kesby, Jonathan O'Loan, Suzanne Alexander, Chao Deng, Xu-Feng Huang, John Mcgrath, Darryl Eyles, Thomas Burne
Xu-Feng Huang
Rationale Developmental vitamin D (DVD) deficiency is a candidate risk factor for developing schizophrenia in humans. In rodents DVD deficiency induces subtle changes in the way the brain develops. This early developmental insult leads to select behavioural changes in the adult, such as an enhanced response to amphetamine-induced locomotion in female DVD-deficient rats but not in male DVDdeficient rats and an enhanced locomotor response to the Nmethyl- D-aspartate (NMDA) receptor antagonist, MK-801, in male DVD-deficient rats. However, the response to MK- 801-induced locomotion in female DVD-deficient rats is unknown. Therefore, the aim of the current study was to further examine …
Oat Β-Glucan Supplementation Does Not Enhance The Effectiveness Of An Energy-Restricted Diet In Overweight Women, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, Xu-Feng Huang
Oat Β-Glucan Supplementation Does Not Enhance The Effectiveness Of An Energy-Restricted Diet In Overweight Women, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, Xu-Feng Huang
Xu-Feng Huang
Epidemiological evidence shows an inverse relationship between dietary fibre intake and body weight gain. Oat β-glucan, a soluble fibre alters appetite hormones and subjective satiety in acute meal test studies, but its effects have not been demonstrated with chronic consumption. The present study aimed to test the effects in women of two different doses of oat β-glucan on weight loss and hormones associated with appetite regulation. In a 3-month parallel trial, sixty-six overweight females were randomised into one of three 2 MJ energy-deficit diets: a control and two interventions including 5–6 g or 8–9 g β-glucan. Anthropometric and metabolic variables …
Reciprocal Signalling Between Nr2 Subunits Of The Nmda Receptor And Neuregulin 1 And Their Role In Schizophrenia, Amy Geddes, Xu-Feng Huang, Kelly A. Newell
Reciprocal Signalling Between Nr2 Subunits Of The Nmda Receptor And Neuregulin 1 And Their Role In Schizophrenia, Amy Geddes, Xu-Feng Huang, Kelly A. Newell
Xu-Feng Huang
Schizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the N-methyl-D-aspartate receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and functional subunits of the NMDAR and are developmentally and spatially regulated. Altered NR2 gene and protein expression has been found in human post-mortem schizophrenia brain tissue together with changes in NRG1 and its receptor ErbB4. The NR2 subunits and ErbB4 share a common anchoring domain on the postsynaptic density and therefore a disruption to either of these molecules may influence the …
The Effects Of Antipsychotic Drugs Administration On 5-Ht1a Receptor Expression In The Limbic System Of The Rat Brain, Mei Han, Xu-Feng Huang, Teresa Du Bois, Chao Deng
The Effects Of Antipsychotic Drugs Administration On 5-Ht1a Receptor Expression In The Limbic System Of The Rat Brain, Mei Han, Xu-Feng Huang, Teresa Du Bois, Chao Deng
Xu-Feng Huang
Increasing evidence suggests that 5-HT1A receptors are involved in the pathophysiology and treatment of schizophrenia. This paper investigated 5-HT1A receptor mRNA expression and binding density in female rats treated with aripiprazole (2.25 mg/kg/day), olanzapine (1.5 mg/kg/day), haloperidol (0.3 mg/kg/day) or vehicle (control) orally three times/day for 1 or 12 weeks. Animals were sacrificed 48 h after the last administration. Aripiprazole significantly increased 5-HT1A receptor binding density by 33% in the CA1 region of the hippocampus and by 21% in the medial posterodorsal nuclei of posterior amygdala (MeP) compared to the control group after 1 week of treatment. Olanzapine significantly decreased …
Insulin Decreases Therapeutic Efficacy In Colon Cancer Cell Line Ht29 Via The Activation Of The Pi3k/Akt Pathway, J-Z Chen, Andrew Katsifis, Changhua Hu, Xu-Feng Huang
Insulin Decreases Therapeutic Efficacy In Colon Cancer Cell Line Ht29 Via The Activation Of The Pi3k/Akt Pathway, J-Z Chen, Andrew Katsifis, Changhua Hu, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Acute Sleep Restriction Alters Neuroendocrine Hormones And Appetite In Healthy Male Adults, Christopher Magee, Xu-Feng Huang, Don Iverson, Peter Caputi
Acute Sleep Restriction Alters Neuroendocrine Hormones And Appetite In Healthy Male Adults, Christopher Magee, Xu-Feng Huang, Don Iverson, Peter Caputi
Xu-Feng Huang
No abstract provided.
Reducing Olanzapine-Induced Weight Gain Side-Effect By Using Betahistine: A Study In The Rat Model, Chao Deng, Jiamei Lian, Nagesh Brahmavar Pai, Xu-Feng Huang
Reducing Olanzapine-Induced Weight Gain Side-Effect By Using Betahistine: A Study In The Rat Model, Chao Deng, Jiamei Lian, Nagesh Brahmavar Pai, Xu-Feng Huang
Xu-Feng Huang
Olanzapine is effective at treating multiple domains of schizophrenia symptoms. However, it induces serious metabolic side effects. Antipsychotic drug’s antagonistic affinity to histamine H1 receptors has been identified as a main contributor for weight gain/obesity side effects. This study therefore investigated whether a combined treatment of betahistine (a H1 receptor agonist and H3 receptor antagonist) could reduce the body weight/obesity induced by olanzapine. Female Sprague Dawley rats were treated orally with olanzapine (1 mg/kg, t.i.d.) and/or betahistine (2.67 mg/kg, t.i.d.), or vehicle for two weeks. Rats treated with olanzapine exhibited significant body weight gain and increased food intake. Co-treatment of …
Density Of Metabotropic Glutamate Receptors 2 And 3 (Mglur2/3) In The Dorsolateral Prefrontal Cortex Does Not Differ With Schizophrenia Diagnosis But Decreases With Age, Elisabeth Frank, Kelly Newell, Xu-Feng Huang
Density Of Metabotropic Glutamate Receptors 2 And 3 (Mglur2/3) In The Dorsolateral Prefrontal Cortex Does Not Differ With Schizophrenia Diagnosis But Decreases With Age, Elisabeth Frank, Kelly Newell, Xu-Feng Huang
Xu-Feng Huang
Metabotropic glutamate receptors 2 and 3 (mGluR2/3) have been shown as efficient targets for antipsychotic intervention. We therefore investigated the receptor density of mGluR2/3 in the dorsolateral prefrontal cortex (dlPFC; Brodman area 46) of schizophrenia/schizoaffective patients (n=37) and matched controls (n=37) using receptor autoradiography. No difference in mGluR2/3 density was identified in relation to schizophrenia diagnosis. Overall and in individual groups, a negative correlation of mGluR2/3 density and age at death has been found. These and previous results suggest that density of mGluR2/3 in the dlPFC is less likely to impact on the efficiency of the mGluR2/3 agonist in treating …