Medicine and Health Sciences Commons^™

Pain In Parkinson’S Disease: Characteristics And Responses In Ambulatory Care Patients, Lisette Bunting-Perry

Lisette K Bunting-Perry

Pain is often a disabling symptom in Parkinson’s disease (PD), and is currently underassessed, underdiagnosed, and undertreated in this population of primarily older adults. Guided by the Rugh Model of Psychological Components of Pain, an exploration of the characteristics of pain experienced by individuals with PD, and the relationships among the emotional, cognitive, perceptual, and behavioral aspects of pain was undertaken. A convenience sample of 125 patients with PD reporting average daily pain as 2 or greater on the Brief Pain Inventory-Short Form, were recruited for a cross-sectional descriptive survey from two large urban movement disorder centers. Multiple measures were …

Detecting Structure In Glass Patterns: An Interocular Transfer Study, Dawn Vreven, Jarrod Berge

Dawn L Vreven

Glass patterns are visual stimuli used here to study how local orientation signals are spatially integrated into global pattern perception. We measured a form aftereffect from adaptation to both static and dynamic Glass patterns and calculated the amount of interocular transfer to determine the binocularity of the detectors responsible for the perception of global structure. Both static and dynamic adaptation produced significant form aftereffects and showed a very high degree of interocular transfer, suggesting that Glass-pattern perception involves cortical processing beyond primary visual cortex. Surprisingly, dynamic adaptation produced significantly greater interocular transfer than static adaptation. Our results suggest a functional …

Effects Of Red Raspberry On Doxorubicin Chemotherapy Induced Neurotoxicity, Ran He

All Dissertations

Chemotherapy is a widely used treatment for cancer, with significant side effects including cognitive impairments that affect patients' quality of life. Red raspberries are known to inhibit growth of cancer cells with recent research suggesting the ability to also protect neurons. If this protective ability can be confirmed, red raspberry may emerge as a promising natural intervention for cognitive impairments associated with chemotherapy. In addition, many studies have linked cognitive functions to epigenetic mechanisms postulating that transient reprogramming of epigenetic mechanisms, such as DNA methylation, is required for some basic neuronal/cognitive functions.
The objective of this dissertation is to study …

Practice Effects In A Longitudinal, Multi-Center Alzheimer's Disease Prevention Clinical Trial, Erin L. Abner, Brandon C. Dennis, Melissa J. Mathews, Marta S. Mendiondo, Allison Caban-Holt, Richard J. Kryscio, Frederick A. Schmitt, John J. Crowley

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Practice effects are a known threat to reliability and validity in clinical trials. Few studies have investigated the potential influence of practice on repeated screening measures in longitudinal clinical trials with a focus on dementia prevention. The current study investigates whether practice effects exist on a screening measure commonly used in aging research, the Memory Impairment Screen (MIS).

METHODS: The PREADViSE trial is a clinical intervention study evaluating the efficacy of vitamin E and selenium for Alzheimer's disease prevention. Participants are screened annually for incident dementia with the MIS. Participants with baseline and three consecutive follow-ups who made less …

Protocol For A Randomized Controlled Trial Evaluating The Effect Of Physical Activity On Delaying The Progression Of White Matter Changes On Mri In Older Adults With Memory Complaints And Mild Cognitive Impairment: The Aibl Active Trial, E V Cyarto, N T Lautenschlager, P M Desmond, D Ames, C Szoeke, O Salvado, Matthew Sharman, Kathryn A Ellis, P M Phal, C L Masters, C C Rowe, Ralph Martins, Kay L Cox

Research outputs 2012

Background: Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter hyperintensities (WMH) are associated with VRF, SMC and cognitive impairment. Findings from a growing number of clinical trials with older adults are providing strong evidence for the benefits of physical activity for maintaining cognitive function, but few studies are investigating these benefits in high-risk populations. …

The Effect Of Concurrent Cognitive, Linguistic And Motor Tasks On Speech Intensity In Parkinson’S Disease, Teresa J. Valenzano

Electronic Thesis and Dissertation Repository

This study investigated the effect of concurrent tasks on speech intensity in Parkinson’s disease (PD). Thirteen PD participants and twenty-two controls performed three tasks concurrent with a speech task. The speech task involved a repeated carrier phrase and a target word. The concurrent tasks involved math addition (cognitive), verb generation (linguistic), and manual visuomotor tracking (motor) at three levels of difficulty. All three concurrent tasks were associated with reduced speech intensity relative to the isolated speech task. The concurrent motor task was generally associated with the greatest reduction in speech intensity. Task performance measures were not significantly different for the …

The Effect Of Ad Libitum Hydration On Cognitive Function Following Exercise In The Heat, Matthew Wittbrodt

Masters Theses

The purpose of this study was to quantify the effect of different hydration strategies on physiological and cognitive variables after an exercise bout in the heat. On three occasions, twelve males performed three heat stress tests of 50min at 60%VO_2peak in a hot environment (32°C; 65%RH). The heat stress tests differed in hydration strategy to be implemented during exercise (NF: no fluid, AL: ad libitum, FR: full fluid replacement). A cognitive battery was administered pre-­ and post-­exercise to examine alterations in cognition. Fluid loss during NF was greater than the AL and FR (NF: 1.54 %; AL: 0.29 …

Neurological Soft Signs In Persons With Amnestic Mild Cognitive Impairment And The Relationships To Neuropsychological Functions, Hui-Jie Li, Peng-Yun Wang, Yang Jiang, Raymond C.K. Chan, Hua-Li Wang, Juan Li

Behavioral Science Faculty Publications

BACKGROUND: Neurological abnormalities have been reported in people with amnestic mild cognitive impairment (aMCI). The current study aimed to examine the prevalence of neurological soft signs (NSS) in this clinical group and to examine the relationship of NSS to other neuropsychological performances.

METHODS: Twenty-nine people with aMCI and 28 cognitively healthy elderly people were recruited for the present study. The NSS subscales (motor coordination, sensory integration, and disinhibition) of the Cambridge Neurological Inventory and a set of neuropsychological tests were administered to all the participants.

RESULTS: People with aMCI exhibited significantly more motor coordination signs, disinhibition signs, and total NSS …

The Six Dimensions Of Wellness And Cognition In Aging Adults, Kelley A. Strout, Elizabeth P. Howard

Nursing Faculty Scholarship

Objective: Examine how wellness in six dimensions (occupational, social, intellectual, physical, emotional, and spiritual) protects cognition in aging adults. Background: cognitive impairment increases with age. Baby boomers represent a significant percent of the population at risk for cognitive impairment. Cognitive impairment has a negative impact on nursing resources, health care finances, patient mortality, and quality of life. Wellness and prevention is one focus of Institute of Medicine’s vision for the future of nursing. Method: Literature was retrieved from Cumulative Index to Nursing and Allied Health Literature and MEDLINE. Research that examined the affect of wellness in each of the six …

Cybercycling For Cognitive Health: Comparing Physical Mental And Combined Exercise, Anna Scribner

Honors Theses

Several meta-analyses of randomized controlled trials (RCT) have shown exercise to improve cognitive function in normal aging, mild cognitive impairment (MCI) and dementia (Colcombe & Kramer, 2003, O’ Leary et al., 2011). Cognitive benefit from mental exercise alone is less definitive. A recent RCT (Anderson-Hanley et al., 2012) found greater benefit from three months of virtual-reality enhanced exercise than physical exercise alone among 79 independent living older adults. The current study aimed to replicate this work. In this study, six seniors that either lived or worked at Schaffer Heights were enrolled in the study. Participants were randomized into one of …

Self-Harm And Suicidal Behaviors In Hong Kong Adolescents: Prevalence And Psychosocial Correlates, Daniel T. L. Shek, Lu Yu

Pediatrics Faculty Publications

The present paper examined the prevalence and psychosocial correlates of adolescent deliberate self-harm (DSH) and suicidal behavior in a representative sample of 3,328 secondary school students in Hong Kong. With reference to the previous year, 32.7% of the students reported at least one form of DSH, 13.7% of the respondents had suicide thoughts, 4.9% devised specific suicidal plans, and 4.7% had actually attempted suicide. Adolescent girls had significantly higher rates of DSH and suicidal behavior than did adolescent boys. Having remarried parents was related to an increased likelihood of DSH and suicide. While high levels of family functioning, overall positive …

Vitamin D And Brain Imaging In The Elderly: Should We Expect Some Lesions Specifically Related To Hypovitaminosis D?, Cédric Annweiler, Manuel Montero-Odasso, Susan W Muir, Olivier Beauchet

Physical Therapy Publications

Hypovitaminosis D is associated with cognitive decline in the elderly, but the issue of causality remains unresolved. Definitive evidence would include the visualization of brain lesions resulting from hypovitaminosis D. The aim of the present article is to determine, through a literature review, the location and nature of possible brain disorders in hypovitaminosis D. We found limited brain-imaging data, which reported ischemic infarcts and white matter hyperintensities in hypovitaminosis D, though did not provide their specific location or report any focal atrophy. Based on the finding of executive dysfunctions (i.e., mental shifting and information updating impairments) in the presence of …

The Effects Of Phosphatidylserine On Reaction Time And Cognitive Function Following An Exercise Stress, Adam John Wells

Electronic Theses and Dissertations

Phosphatidylserine (PS) is an endogenously occurring phospholipid that has been shown to have cognition and mood enhancing properties in humans, possibly through its role as an enzyme co-factor in cellular signal transduction. Specifically, PS has been identified as activator of classical isoforms of protein kinase C, an enzyme known to be involved in the growth and differentiation of neural cells, and is therefore thought to play a role in the protection of neurons. The purpose of this study was to examine the effects of supplementation with PS and caffeine on measures of cognition, reaction time and mood prior to and …

Comparison Of Performance Between Elderly Individuals And Collegiate Athletes On The Immediate Post-Assessment And Cognitive Test, Kevin Van Den Bogaard

Open Access Theses & Dissertations

Preventing falls in the elderly population requires a collaborative effort that includes medical treatment, rehabilitation, and environmental modification. Medical assessment of the elderly after a fall is designed to treat the potential conditions associated with the fall, such as broken limbs and trauma to the head resulting in a mild traumatic brain injury (mTBI). Currently, there is no standardized test or protocol accepted across health care facilities to track the cognitive-communicative recovery of elderly patients. A group of elderly individuals deemed healthy and capable of independent living were administered the baseline Immediate Post Assessment and Cognitive Test (ImPACT). This study …

Predictors Of Rapid Cognitive Decline In Alzheimer's Disease: Results From The Australian Imaging, Biomarkers And Lifestyle (Aibl) Study Of Ageing, A Sona, P Zhang, D Ames, A I Bush, N T Lautenschlager, Ralph Martins, C L Masters, C C Rowe, C Szoeke, Kevin Taddei, Kathryn A Ellis

Research outputs 2012

Background: The AIBL study, which commenced in November 2006, is a two-center prospective study of a cohort of 1112 volunteers aged 60+. The cohort includes 211 patients meeting NINCDS-ADRDA criteria for Alzheimer's disease (AD) (180 probable and 31 possible). We aimed to identify factors associated with rapid cognitive decline over 18 months in this cohort of AD patients. Methods: We defined rapid cognitive decline as a drop of 6 points or more on the Mini-Mental State Examination (MMSE) between baseline and 18-month follow-up. Analyses were also conducted with a threshold of 4, 5, 7 and 8 points, as well as …

Altered Expression Of Alzheimer's Disease-Related Proteins In Male Hypogonadal Mice, Eleanor S. Drummond, Ralph Martins, D J Handelsman, A R Harvey

Research outputs 2012

Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal (hpg) male and female mice. hpg Mice have a spontaneous, inactivating genetic mutation in the GnRH gene resulting in lifelong deficiency of gonadotropins and gonadal sex hormones. Western blot analysis revealed low levels of amyloid precursor protein and high levels of presenilin 1, amyloid precursor protein C-terminal fragment, and β-amyloid 42 in brains of aged male, but not female, hpg mice. Changes were confined to the …

Lifestyle And Late Life Cognitive Health: Sufficient Evidence To Act Now?, Bruce Barber, D Ames, Kathryn Ellis, Ralph Martins, C Masters, C Szoeke

Research outputs 2012

Not available

Intense Physical Activity Is Associated With Cognitive Performance In The Elderly, Belinda Brown, Jeremiah Peiffer, Hamid Sohrabi, Alinda Mondal, Veer Bala Gupta, Stephanie Rainey-Smith, Kevin Taddei, S Burnham, K Ellis, C Szoeke, C L Masters, D Ames, C Rowe, Ralph Martins

Research outputs 2012

Numerous studies have reported positive impacts of physical activity on cognitive function. However, the majority of these studies have utilised physical activity questionnaires or surveys, thus results may have been influenced by reporting biases. Through the objective measurement of routine levels of physical activity via actigraphy, we report a significant association between intensity, but not volume, of physical activity and cognitive functioning. A cohort of 217 participants (aged 60-89 years) wore an actigraphy unit for 7 consecutive days and underwent comprehensive neuropsychological assessment. The cohort was stratified into tertiles based on physical activity intensity. Compared with individuals in the lowest …

Olfactory Discrimination Predicts Cognitive Decline Among Community-Dwelling Older Adults, Hamid Sohrabi, Kristyn Bates, Mg Weinborn, A N Johnston, A Bahramian, Kevin Taddei, Simon Laws, Mark Rodrigues, Michael Morici, Matthew Howard, Georgia Martins, A Mackay-Sim, Se Gandy, Ralph Martins

Research outputs 2012

The presence of olfactory dysfunction in individuals at higher risk of Alzheimer's disease has significant diagnostic and screening implications for preventive and ameliorative drug trials. Olfactory threshold, discrimination and identification can be reliably recorded in the early stages of neurodegenerative diseases. The current study has examined the ability of various olfactory functions in predicting cognitive decline in a community-dwelling sample. A group of 308 participants, aged 46-86 years old, were recruited for this study. After 3 years of follow-up, participants were divided into cognitively declined and non-declined groups based on their performance on a neuropsychological battery. Assessment of olfactory functions …

The Impact Of Attention Training On Children With Low Vision: A Randomized Trial, Bi̇lge Başakci Çalik, Ali̇ Ki̇ti̇ş, Uğur Cavlak, Atti̇la Oğuzhanoğlu

Turkish Journal of Medical Sciences

The purpose of this study was to show the effectiveness of a 6-week attention training program on the cognition, quality of life (QOL), and activities of daily living in children with low vision. Materials and methods: Included in this study were 20 children with low vision, aged 7-12 years. The children were divided into 2 groups. While the first group (n = 10) participated in a 6-week Pay Attention© training program 3 times a week for 30 min, the second group (n = 10) was the control. Before and after the program, all of the participants were evaluated using a …

The Effects Of Dehydration On Cognitive Functioning, Mood, And Physical Performance, Molly Hodges

The Corinthian

It is no surprise to most everyone that the human life depends tremendously on a compound composed of two Hydrogen atoms and an Oxygen atom: water. Water is such a huge component of the human life; it comprises 75% of the body weight in infants, 55% in the elderly and is crucial for cellular homeostasis. In fact without water humans can only survive two to four days. In a moderately brief period of time, failure to consume enough water will lead to deteriorating neurologic function, organ failure, and ultimately death. Failure to consume a proper amount of fluid has always …

Influence Of Stress And Cytokinic Profiles On Cognitive Performance In Older Adults, Kerri S. Rawson

USF Tampa Graduate Theses and Dissertations

ABSTRACT

With aging, changes in the immune system, makes cognitive performance, and the prevalence of stressors can lead to poorer overall functioning. Within the immune system, a balance should exist between cytokines regulating Th1 and Th2 immune responses; however, age-related declines in the endocrine and immune systems can disrupt this equilibrium. Several studies report higher levels of Th1 associated cytokines in inflammatory conditions of the brain, whereas fewer studies remark on Th2 associated cytokines and cognitive functioning. Declining cognitive abilities are a common concern that accompanies advancing age and some research has suggested the prevalence and impact of stressors lead …

The Effects Of Word Length, Articulation, Oral-Motor Movement, And Lexicality On Gait: A Pilot Study, K. Davie, Janis Cardy, J. Holmes, M. Gagnon, A. Hyde, M. Jenkins, Andrew Johnson

Andrew M. Johnson

Previous research has suggested that articulatory demands are important predictors of the impact of dual-task interference on spatial-temporal parameters of gait. In this study, we evaluated the effects of word length, oral-motor movement, articulation, and lexicality, within a verbal task, on a continuous gait task. Fifteen healthy young women participated in a study in which two word lengths (monosyllabic and bisyllabic) were crossed with four levels of secondary task complexity (no dual-task, non-speech movement, spoken non-word, and spoken word). Spatial and temporal parameters of gait were measured using a 23' instrumented carpet. Results indicated a significant multivariate main effect for …