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Articles 1 - 22 of 22
Full-Text Articles in Medicine and Health Sciences
Children’S Nonword Repetition Skills As A Function Of Their Race And Clinical Status, Hannah Smitherman
Children’S Nonword Repetition Skills As A Function Of Their Race And Clinical Status, Hannah Smitherman
Honors Theses
No abstract provided.
Development And Characterization Of A Murine Model Of Rickettsia Parkeri Rickettsiosis, Britton Grasperge
Development And Characterization Of A Murine Model Of Rickettsia Parkeri Rickettsiosis, Britton Grasperge
LSU Doctoral Dissertations
Rickettsia parkeri, a member of the spotted fever group of Rickettsia, is the agent of an emerging rickettsiosis in the southeastern United States and South America. Despite increased recognition of human cases, limited information is available regarding infection of invertebrate and vertebrate hosts for this emerging tick-borne disease. Towards development of a viable transmission model and to further characterize the pathology associated with R. parkeri infection, inbred mouse strains (A/J, Balb/C, C3H/HeJ, and C3H/HeN) were intravenously and intradermally inoculated with R. parkeri. The C3H/HeJ strain of mice were identified as the most susceptible to R. parkeri infection and were found …
Evaluation Of Plasma Sprayed Hydroxyapatite Coated Ao Cortical Screws In Equine Third Metacarpal Bone, Myra Elizabeth Durham
Evaluation Of Plasma Sprayed Hydroxyapatite Coated Ao Cortical Screws In Equine Third Metacarpal Bone, Myra Elizabeth Durham
LSU Master's Theses
ABSTRACT Objectives - To compare the osteointegration of plasma sprayed hydroxyapatite (HA) coated and uncoated 5.5 mm cortical screws in equine third metacarpal (MC3) bones in combination with a 4.5mm broad dynamic compression plate (DCP). Study design - In vivo study. Animals – 6 Adult Thoroughbred horses. Methods – For each horse, four HA coated screws were placed unicortically through a 4.5mm broad DCP in the dorsal cortex of a randomly chosen MC3 bone, with 4 uncoated screws placed in an identical manner in the contralateral MC3 bone. All screws were tightened to a torque of 5.4 N-m. Extraction torques …
Effects Of Rhyming Instruction On Learning The Alphabetic Principle, Phonemic Awareness, And Rhyming Complexity Skills With At-Risk Prekindergarten Students, Crystal Randolph
Effects Of Rhyming Instruction On Learning The Alphabetic Principle, Phonemic Awareness, And Rhyming Complexity Skills With At-Risk Prekindergarten Students, Crystal Randolph
LSU Doctoral Dissertations
At-risk prekindergarten students (i.e., low SES, speech-language impaired) typically lag behind their peers in phonological awareness and other emergent literacy skills such as letter knowledge and vocabulary (Duursma et al., 2008; Lundberg, 2009). However, there is a limited amount of research that has studied the efficacy of phonological interventions for at-risk children (Ziolkowski & Goldstein, 2008). Because of the long-lived debate concerning the role of rhyme versus the role of phoneme awareness, it is uncertain whether learning rhyming skills will provide the most facilitative context to learn other emergent literacy skills (e.g., letter knowledge, phonemic awareness). The current study investigated …
The Relationship Between Children's Nonmainstream English Dialect Density And Their Emergfent Reading Achievement, Katelyn Danielle Rodrigue
The Relationship Between Children's Nonmainstream English Dialect Density And Their Emergfent Reading Achievement, Katelyn Danielle Rodrigue
LSU Master's Theses
The purpose of this study was to examine the relation between children’s use of nonmainstream dialect and their emerging reading ability. The data were from 79 kindergarteners; 39 were AA and 40 were non-AA; 38 were male and 41 were female. All children presented with varying language abilities and dialect densities, as measured by the DELV-ST. Dialect densities ranged from Mainstream American English (MAE), some variation of MAE, and strong variations of MAE. The children’s reading abilities were measured by the DIBELS, which was administered at the beginning, middle, and end of the school year. Preliminary results showed that children’s …
The Role Of Gylcoprotein K (Gk) In The Ocular And Neuropathogenesis Of Herpes Simplex Virus-Type 1 (Hsv-1), Andrew Timothy David
The Role Of Gylcoprotein K (Gk) In The Ocular And Neuropathogenesis Of Herpes Simplex Virus-Type 1 (Hsv-1), Andrew Timothy David
LSU Doctoral Dissertations
Herpes simplex virus type 1 (HSV-1) is a DNA virus that is a ubiquitous pathogen of humans. The hallmark of the HSV-lifecycle is infection of a mucosal surface with spread to sensory neurons where the virus establishes a latent infection with periodic recurrences for the life of the host. The most common course of symptomatic disease with HSV-1 is the typical mucocutaneous lesion that is self-limiting. HSV-1 can also cause acute encephalitis and ocular pathology on reactivation. Both of these manifestations of the disease have severe consequences. Although ocular infection is less frequent, the extensive prevalence of HSV makes it …
Role Of Herpes Simplex Type I Glycoproteins In Entry And Cell-Cell Fusion, Sona Chowdhury
Role Of Herpes Simplex Type I Glycoproteins In Entry And Cell-Cell Fusion, Sona Chowdhury
LSU Doctoral Dissertations
Herpes simplex virus type I (HSV-1) is a neurotropic virus that infects primarily mucocutaneous epithelial cells and nervous tissue. Membrane fusion is an important aspect of the HSV-1 lifecycle, that occurs during viral entry (virus-cell fusion), viral spread (cell-to-cell fusion), as well as, during virion morphogenesis (assembly and egress). These membrane fusion steps involve complex interactions between multiple viral glycoproteins and cellular receptors. HSV-1 glycoprotein B (gB) is necessary but not sufficient for membrane fusion events. Despite the fact, that the majority of known hypermorphic mutations which cause extensive virus-induced cell fusion occur within glycoprotein K (gK); yet the role …
Role Of Intraocular Leptospira Infections In The Pathogenesis Of Equine Recurrent Uveitis In The Southern United States, Florence Polle
Role Of Intraocular Leptospira Infections In The Pathogenesis Of Equine Recurrent Uveitis In The Southern United States, Florence Polle
LSU Master's Theses
To investigate the role of intraocular leptospiral infections in horses with Equine Recurrent Uveitis (ERU), ocular fluid samples were collected from donated and client-owned horses with a history and ocular findings consistent with chronic ERU. Additionally, eyes were harvested from horses with normal ophthalmic examinations as a control group. Blood samples were obtained for Leptospira serology using microscopic agglutination test (MAT). Aqueous and vitreous humor samples were aseptically obtained and submitted for aerobic culture and Leptospira culture, PCR and MAT. Twenty-one control horses (40 eyes) and 31 ERU horses (46 eyes) were available for study. Serology results were available for …
A Syntax-Based Reading Intervention For English As Second-Language Learners, Christina Tausch
A Syntax-Based Reading Intervention For English As Second-Language Learners, Christina Tausch
LSU Doctoral Dissertations
Students with English as second language (ESL) are typically behind monolingual peers in reading comprehension even when phonemic awareness skills, phonics and word recognition are at grade level. The lack of syntactic awareness is one of the reasons cited in multiple studies (August & Shanahan, 2010; Da Fountoura & Siegel, 1995; Lesaux & Siegel, 2003; Lesaux et al., 2006; Chong, 2009). This study investigated the effects of a six week intervention designed to increase syntactic awareness, including meta-awareness of key structures of English for young ESL students in the upper elementary grades. Twenty typically developing ESL students in the fourth …
Ayahuasca Characterization, Metabolism In Humans, And Relevance To Endogenous N,N-Dimethyltryptamines, Ethan Hamilton Mcilhenny
Ayahuasca Characterization, Metabolism In Humans, And Relevance To Endogenous N,N-Dimethyltryptamines, Ethan Hamilton Mcilhenny
LSU Doctoral Dissertations
Ayahuasca denotes an Amazonian psychotropic plant tea obtained from Banisteriopsis caapi, which contains beta-carboline (b-carboline) alkaloids, chiefly harmine, harmaline and tetrahydroharmine. The tea usually incorporates the leaves of Psychotria viridis, which are rich in N,N-dimethyltryptamine (DMT), a psychoactive 5-HT2A agonist. The beta-carbolines reversibly inhibit monoamine-oxidase (MAO), effectively preventing oxidative deamination of the orally inactive DMT and allowing its absorption and access to the central nervous system. Despite increased use of the tea worldwide, easy to perform and validated methods for its characterization do not exist and the metabolism and excretion of DMT and the b-carbolines has not been studied systematically …
Mechanisms By Which Exercise Training Attenuates Blood Pressure In Animals: Roles Of Cytokines, Oxidative Stress, And Glycogen Synthase Kinase-3Â, Deepmala Agarwal
Mechanisms By Which Exercise Training Attenuates Blood Pressure In Animals: Roles Of Cytokines, Oxidative Stress, And Glycogen Synthase Kinase-3Â, Deepmala Agarwal
LSU Doctoral Dissertations
Hypertension is a chronic multifactorial condition with high morbidity and mortality rates, currently affecting about one billion people worldwide. Currently available anti-hypertensive medications are found to be effective in reducing blood pressure (BP), but still more than 50% of those diagnosed with hypertension fail to respond to these anti-hypertensive regimens. Although hypertension has multiple etiologies, physical inactivity has been found to have strong correlation with the disease, so exercise has recently been recommended as a part of lifestyle modifications for all hypertensive patients. Therefore, the present series of in vivo and in vitro studies were undertaken to gain more insight …
Anatomical Studies Of Canine Vascular And Ligamentous Ear Structures With Revelance To Acute-Onset Deafness, Cathryn Kay Stevens-Sparks
Anatomical Studies Of Canine Vascular And Ligamentous Ear Structures With Revelance To Acute-Onset Deafness, Cathryn Kay Stevens-Sparks
LSU Doctoral Dissertations
Hearing loss in dogs and cats following dental or ear procedures performed under anesthesia has recently been reported. The most likely causes for this acute-onset deafness were considered to be mechanical or vascular. Jaw manipulation as a possible cause of acute-onset deafness in the dog was investigated in the current study. Structures adjacent to the temporomandibular joint were of interest because changes in jaw orientation could disrupt vessels and nerves in this area. Current descriptions of the anatomy of the vasculature supplying the canine ear are either incomplete or inconsistent. Another considered cause was a jaw-ear connection via a ligamentous …
Essential Role Of Monocyte Chemoattractant Protein-1 In Gram-Negative Bacterial Pneumonia, Gayathriy Balamayooran
Essential Role Of Monocyte Chemoattractant Protein-1 In Gram-Negative Bacterial Pneumonia, Gayathriy Balamayooran
LSU Doctoral Dissertations
Acute gram-negative bacterial infections are a leading cause of mortality among the nosocomial infections. Increasing numbers of immunosuppressed individuals and growing numbers of antibiotic resistant strains make antibiotic treatment difficult. Neutrophils are the first cells recruited to the site of infection and are critical players in the host defense against gram-negative bacterial pneumonia. Therefore, identification of targets that boost neutrophil-associated host defense in the lung is essential in designing better therapies to control pulmonary infections. Production of chemokines is an important step for neutrophil recruitment. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that is important for monocyte and T-lymphocyte influx. …
The Effects Of Iodixanol Present During Equine Semen Cryopreservation, David Paul Beehan
The Effects Of Iodixanol Present During Equine Semen Cryopreservation, David Paul Beehan
LSU Master's Theses
The objectives of this study were to determine what effects iodixanol would have on total and progressive motility, plasma membrane integrity (viability), acrosome integrity and DNA structure when present during cryopreservation of equine spermatozoa,. We hypothesized that the addition of iodixanol would improve post-thaw values for measured parameters. Ejaculates from six stallions were collected, centrifuged at 900 x g for ten minutes to remove supernatant, and suspended to 200 x 106 cells/ml with 0%, 2.5% and 5% iodixanol in an egg-yolk based extender and cryopreserved. Before and after cryopreservation sperm motility was assessed by computer assisted semen analysis, and samples …
Spectral Analysis Of Stop Consonants In Individuals With Dysarthria Secondary To Stroke, Trescha S. Kay
Spectral Analysis Of Stop Consonants In Individuals With Dysarthria Secondary To Stroke, Trescha S. Kay
LSU Master's Theses
Dysarthria refers to a group of neurogenic speech disorders which result in abnormal strength, speed, range, steadiness, tone, or accuracy of movements required for speech production. Although speech deficits of dysarthria are heterogeneous according to lesion sites and/or etiologies such as stroke, traumatic brain injury, cerebral palsy, Parkinson’s disease (PD), “imprecise consonants” has been known as one of the most prominent and frequently occurring features of dysarthria, which subsequently contributes to decreased speech intelligibility. The present study points out the paucity of acoustic data on consonants produced by speakers with dysarthria, especially by spectral analysis, and reports four spectral moment …
A Single-Subject Study Examining The Effects Of A Behavioral Intervention For Verbal Recurrent Perserveration, Jenifer Juengling-Sudkamp
A Single-Subject Study Examining The Effects Of A Behavioral Intervention For Verbal Recurrent Perserveration, Jenifer Juengling-Sudkamp
LSU Doctoral Dissertations
BACKGROUND: Approximately 1 million people in the United States suffer from aphasia and > 50% of those people may demonstrate recurrent perseverations. No consensus has been forthcoming on whether (1) a therapy that directly confronts clients with imminent pre-articulatory automatisms (the perseverations) or (2) a more typical neuropsychological therapy that eschews any direct confrontation with automatic behaviors works best. PURPOSE: The purpose of this study was to determine the treatment efficacy of a non-confrontational picture naming intervention on naming ability in individuals with aphasia and recurrent perseverations. METHODS: This is a prospective single-subject ABAB multiple baseline design replicated across 3 right-handed …
Comparing The Treatment Effect Of Conversational And Traditional Aphasia Treatments Based On Conversational Outcome Measures, Meghan Collins
Comparing The Treatment Effect Of Conversational And Traditional Aphasia Treatments Based On Conversational Outcome Measures, Meghan Collins
LSU Doctoral Dissertations
This prospective Phase I single-subject (ABABA) study repeated across 4 participants with quasi-randomized treatment order investigated the treatment effects of conversation and traditional stimulation treatments on conversational outcomes. Treatment was administered for 10 sessions (2 one-hour weekly sessions) per treatment type. Primary conversational outcomes included 6-minute conversations coded for pragmatic behaviors and percent Correct Information Units (CIUs). Traditional stimulation probes included auditory comprehension, lexical retrieval, and syntax probe performance. Secondary outcome measures represented the domains of the ICF (WHO, 2001) model with the addition of quality of life. These included the Western Aphasia Battery (Kertesz, 2007), the American Speech Language …
Structural And Molecular Pathology Of The Atrium In Boxer Arrhythmogenic Cardiomyopathy, Jorge Luis Vila
Structural And Molecular Pathology Of The Atrium In Boxer Arrhythmogenic Cardiomyopathy, Jorge Luis Vila
LSU Master's Theses
Arrhythmogenic cardiomyopathy (AC), also known as arrhythmogenic right ventricular cardiomyopathy (ARVC), is a disease characterized by fatty or fibro-fatty myocardial replacement, predominantly in the right ventricle and to a lower extent the left ventricle. It is recognized as a disease affecting the cardiac intercalated disc. Clinically, it is associated with ventricular arrhythmias, although atrial arrhythmias and atrial histopathological changes characteristic of AC have occasionally been reported. The full extent of atrial involvement in AC has not been investigated. Therefore, we aimed to apply histopathology, immunochemical detection, immunolocalization and transmission electron microscopy (TEM) techniques to characterize the distribution of desmosomal and …
Effects Of Two Different Behavioral Swallowing Exercise Protocols Performed During Radiation Therapy On Swallowing Physiology, Function, Quality-Of-Life And Weight Outcomes Following Organ-Preservation Treatments For Head And Neck Cancers, Aneesha Virani
LSU Doctoral Dissertations
Objective: The purpose of this study was to investigate the effects of two different prophylactic behavioral swallowing exercise regimens performed by head and neck cancer/s (HNC) patients during radiation therapy with/without chemotherapy (RT/C) on swallowing physiology, function, quality-of-life (QOL) and weight outcomes at the completion of RT/C. Feeding tube (PEG) status at 3 months post-treatment was also compared. Methods: This study was conducted via a prospective design. 50 patients diagnosed with HNC who were to undergo RT/C were recruited at pre-treatment based on the inclusion criteria: functional swallowing abilities; without prophylactic PEG tubes; ability to comprehend and perform therapy tasks …
Koutango: Under Reported Arboviral Disease In West Africa, Jaime Matias De Araujo Lobo
Koutango: Under Reported Arboviral Disease In West Africa, Jaime Matias De Araujo Lobo
LSU Doctoral Dissertations
Arthropod-borne viruses (arboviruses) are among the most common agents of human febrile illnesses worldwide. As crucially important emerging pathogens, they have caused multiple, notable epidemics of human disease and unnoticed epizootics over recent decades. Despite the public health relevance, very little is known about the geographic distribution of the agents and vectors, relative impact, and risk factors associated to the arboviral infection in many regions of the world and in the tropics in particular. Presented in this dissertation is an experimental study that explores the serology screening of serum samples from 151 patients whom were diagnosed with undifferentiated febrile illness …
Immunization Of West Nile Recombinant Envelope Domain Iii With Equine Cd40 Ligand Protein Vaccine Induced Specific Immune Response In Rabbits And Horses, Shiliang Anthony Liu
Immunization Of West Nile Recombinant Envelope Domain Iii With Equine Cd40 Ligand Protein Vaccine Induced Specific Immune Response In Rabbits And Horses, Shiliang Anthony Liu
LSU Master's Theses
West Nile virus (WNV) is one of several flaviruses known to infect mammalian species, including humans. There were 15,257 horse cases reported in 2002 and 1,086 in 2006 in United States. Recently, significant increases in equine and human cases have been reported in United States. Domain III of the WNV envelope protein binds to cellular receptors, and induces a significant portion of the neutralizing antibody response against the virus. CD40 Ligand (CD40L, CD154) enhances productive interactions between T cells and APC and has been shown to function as a potential adjuvant. In this study, we constructed and expressed a fusion …
Isolation And Characterization Of Adult Progenitor Cells From Healthy And Laminitic Hoof Tissue, Vanessa Pinto
Isolation And Characterization Of Adult Progenitor Cells From Healthy And Laminitic Hoof Tissue, Vanessa Pinto
LSU Master's Theses
Laminitis is an often fatal condition in horses with few available and only moderately effective treatment options. Separation of laminar dermis and epidermis lead to rotation or ventral deviation of the third phalanx inside the hoof capsule. Despite being a modified skin, equine laminar tissue does not completely return to normal after laminitis. The hypothesis tested was that adult progenitor cells in the equine laminar tissue are irreversibly damaged by laminitis. A method to harvest and culture cells in vitro from the equine lamina was established; and progenitor cells from unaffected and laminitic hooves were characterized and compared. Laminar tissue …