Medicine and Health Sciences Commons^™

Maternal Separation Affects Dopamine Transporter Function In The Spontaneously Hypertensive Rat: An In Vivo Electrochemical Study, Jacqueline S. Womersley, Jennifer H. Hsieh, Lauriston A. Kellaway, Greg A. Gerhardt, Vivienne A. Russell

Neuroscience Faculty Publications

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterised by symptoms of inattention, impulsivity and hyperactivity. The spontaneously hypertensive rat (SHR) is a well-characterised model of this disorder and has been shown to exhibit dopamine dysregulation, one of the hypothesised causes of ADHD. Since stress experienced in the early stages of life can have long-lasting effects on behaviour, it was considered that early life stress may alter development of the dopaminergic system and thereby contribute to the behavioural characteristics of SHR. It was hypothesized that maternal separation would alter dopamine regulation by the transporter (DAT) in ways that distinguish SHR …

A Non-Invasive Assay For Monitoring Stress Responses: A Comparison Between Wild And Captive-Reared Rainbowfish (Melanoteania Duboulayi), Amina Zuberi, Sinan Ali, Culum Brown

Aquaculture Collection

The stress response of wild and captive reared rainbowfish (Melanoteania duboulayi) following chasing by a simulated predator was examined. Cortisol release rate was monitored using a flow through system by measuring water borne hormone levels. Tests using known cortisol concentrations revealed that the technique yielded 95% of the cortisol present in the water. Cortisol release rates increased several fold in both populations after being chased but peaked at different time periods. Wild fish showed a typical stress response with release rate rising to (2.29±0.22 ng g⁻¹ h⁻¹) 2 h after exposure followed by rapid recovery. The captive-reared …

Hospital Extra. Understanding The Sources Of Stress For Nurses, Diane Huber

Diane Huber

Can knowing the sources of our professional stress lead to significant health care reforms?

Paradoxical Reversal Learning Enhancement By Stress Or Prefrontal Cortical Damage: Rescue With Bdnf., Carolyn Graybeal, Michael Feyder, Emily Schulman, Lisa M Saksida, Timothy J Bussey, Jonathan L Brigman, Andrew Holmes

Brain and Mind Institute Researchers' Publications

Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effect of stress, whereas orbitofrontal and dorsolateral striatal lesions impaired reversal. Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems.

Geriatric Mental Health: Staff Stress On An Alzheimer's Unit, Paula Mobily, Meridean Maas, Kathleen Buckwalter, Lisa Skemp Kelley

Paula Mobily

Nurses who work with patients with Alzheimer's disease (AD) are especially vulnerable to the effects of stress and burnout. Many are poorly trained to cope with the emotional and behavioral problems of these residents and are repeatedly frustrated by their inability to manage these recurrent problems. Specialized care units (SCUs) reduced stress in the areas of staff knowledge, abilities, and resources. The SCU was designed specifically to provide the special environmental structures, support, and service systems required for the care of persons with AD that would enhance functioning and decrease associated behavioral problems. Support groups can assist nurses to recognize …

Factors Explaining Children's Responses To Intravenous Needle Insertions, Ann Mccarthy, Charmaine Kleiber, Kirsten Hanrahan, M. Zimmerman, N. Westhus, S. Allen

Ann Marie McCarthy

BACKGROUND: Previous research shows that numerous child, parent, and procedural variables affect children's distress responses to procedures. Cognitive-behavioral interventions such as distraction are effective in reducing pain and distress for many children undergoing these procedures. OBJECTIVES: The purpose of this report was to examine child, parent, and procedural variables that explain child distress during a scheduled intravenous insertion when parents are distraction coaches for their children. METHODS: A total of 542 children, between 4 and 10 years of age, and their parents participated. Child age, gender, diagnosis, and ethnicity were measured by questions developed for this study. Standardized instruments were …

Psychological Screening Of Children For Participation In Nontherapeutic Invasive Research, Ann Mccarthy, L. Richman, R. Hoffman, L. Rubenstein

Ann Marie McCarthy

BACKGROUND: The need for children to participate in research has raised concerns about ethical issues surrounding their participation. OBJECTIVES: To describe a protocol of preresearch psychological screening and postresearch outcomes and to present the results of the screening process for a nontherapeutic, invasive research study. DESIGN AND SETTING: Descriptive study carried out at The University of Iowa Hospitals and Clinics, Iowa City. PARTICIPANTS: Twenty-eight children (mean age, 10.6 years) were screened, with 4 not completing the research study and another 4 unavailable for psychological follow-up. MAIN OUTCOME MEASURES: Prescreening interviews with parent and child and screening measures of appropriate child …

Development Of The Distraction Coaching Index, Charmaine Kleiber, Ann Mccarthy, Kirsten Hanrahan, L. Myers, N. Weathers

Ann Marie McCarthy

Children's distress during medical procedures can be decreased when professionals or parents provide distraction coaching, but the quality of distraction may contribute to the variation in the results. This article describes the development of the Distraction Coaching Index (DCI), a tool for measuring the quality and frequency of distraction coaching. Nominal group technique and consensus agreement were used for concept clarification and development of behavioral indicators and descriptors. Videotapes of untrained parents, trained parents, and expert professional coaches, who provided distraction to children (4-10 years old) undergoing peripheral intravenous catheter insertion, were used to assess interrater reliability and construct validity. …

Children's Responses To Sequential Versus Simultaneous Immunization Injections, M. Horn, Ann Mccarthy

Ann Marie McCarthy

INTRODUCTION: The purpose of this study was to compare distress behaviors and perceptions of distress in 4- to 6-year-old children who received two immunization injections simultaneously with those in children who received their immunizations sequentially. METHOD: This experimental study used a convenience sample of 46 children scheduled for pre-kindergarten examinations. The children were randomly assigned to either a sequential injection or a simultaneous injection group. Direct observation and videotapes were made of the children's behaviors before and after injection. Distress behaviors were analyzed with the Observation Scale of Behavioral Distress-Revised, and perceptions of distress were obtained from both children (with …

Strategies For Salivary Cortisol Collection And Analysis In Research With Children, Kirsten Hanrahan, Ann Mccarthy, Charmaine Kleiber, S. Lutgendorf, E. Tsalikian

Ann Marie McCarthy

Salivary cortisol has emerged in pediatric research as an easy-to-collect, relatively inexpensive, biologic marker of stress. Cortisol is highly variable and is responsive to a wide range of factors that should be considered when incorporating this measure into research with children. Strategies for sample collection include: (1) standardizing the time for sample collection, including baseline samples; (2) using consistent collection materials and methods; (3) controlling for certain drinks, foods, medications, and diagnoses; and (4) establishing procedures and protocols. Other strategies for laboratory analyses include: (1) selecting the appropriate assay and laboratory; (2) identifying units of measure and norms; and (3) …

Parent Behavior And Child Distress During Urethral Catheterization, Charmaine Kleiber, Ann Marie Mccarthy

Charmaine Kleiber

ISSUES AND PURPOSE: Researchers need a clear understanding of the natural behaviors parents use to help their children cope. This study describes the relationships between naturally occurring parent behaviors and child distress behaviors during urethral catheterization. DESIGN AND METHODS: In this descriptive study, researchers videotaped the behaviors of parent-child interactions during urethral catheterization. RESULTS: Parents used distraction to maintain calm behavior during the first part of the procedure and used more reassurance when the children started to become distressed. Seven of the nine children displayed calm behavior at least half the time following distraction. Parental reassurance did not decrease distress …

Narratives Of Family Caregiving: Four Story Types, Lioness Ayres

Lioness Ayres

RESULTS/CONCLUSIONS: This study used a combination of across-case, thematic analysis and within-case, narrative analysis to develop a typology of stories for family caregivers. Both researchers and clinicians can benefit from interpretive methods that offer access s into the processes and products of making meaning though stories. It is often easier to see the possibilities for reinterpretation from outside a story than from within it. It may be that nurses will also be uniquely able to help clients who are in the process of "getting the story straight" to find new, more sustaining meanings and even to live more happily ever …

Preferential Quadriceps Activation In Female Athletes With Incremental Increases In Landing Intensity, Kevin R. Ford, Gregory D. Myer, Laura C. Schmitt, Timothy L. Uhl, Timothy E. Hewett

Physical Therapy Faculty Publications

The purpose of this study was to identify alterations in preparatory muscle activation patterns across different drop heights in female athletes. Sixteen female high school volleyball players performed the drop vertical jump from three different drop heights. Surface electromyography of the quadriceps and hamstrings were collected during the movement trials. As the drop height increased, muscle activation of the quadriceps during preparatory phase also increased (p < .05). However, the hamstrings activation showed no similar increases relative to drop height. Female athletes appear to preferentially rely on increased quadriceps activation, without an increase in hamstrings activation, with increased plyometric intensity. The resultant decreased activation ratio of the hamstrings relative to quadriceps before landing may represent altered dynamic knee stability and may contribute to the increased risk of ACL injury in female athletes.

Association Between Stress And Decisional Procrastination In Parents Of Children With Down Syndrome During Their Developmental Transitions, Laurel Zeisler

Seton Hall University Dissertations and Theses (ETDs)

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Endothelial Differentiation Of Adipose-Derived Stem Cells From Elderly Patients With Cardiovascular Disease., Ping Zhang, Neil Moudgill, Eric Hager, Nicolas Tarola, Christopher Dimatteo, Stephen Mcilhenny, Thomas Tulenko, Paul J Dimuzio

Department of Surgery Faculty Papers

Adipose-derived stem cells (ASCs) possess significant therapeutic potential for tissue engineering and regeneration. This study investigates the endothelial differentiation and functional capacity of ASCs isolated from elderly patients. Isolation of ASCs from 53 patients (50-89 years) revealed that advanced age or comorbidity did not negatively impact stem cell harvest; rather, higher numbers were observed in older donors (>70 years) than in younger. ASCs cultured in endothelial growth medium-2 for up to 3 weeks formed cords upon Matrigel and demonstrated acetylated-low-density lipoprotein and lectin uptake. Further stimulation with vascular endothelial growth factor and shear stress upregulated endothelial cell-specific markers (CD31, …

Stress And Associated Factors Among Ruamkatanyu Rescue Workers In Bangkok Mmetropolis, P Somboon, C. Roomruangwong

Chulalongkorn Medical Journal

Background : Ruamkatanyu rescue workers is a special properties and especial individual occupation. They are working with injured and emergency patients which may have additional work danger that have effect on physical, emotional and any pressure. However, the prevalence and predictors of stress in this group of subject have not been studied. This aim of study was to assess the prevalence and risk factors of stress among Ruamkatanyu rescue workers in Bangkok Metropolis. Objective : To study stress and associated factors among Ruamkatanyu rescue workers in Bangkok Metropolis. Design : A cross – sectional descriptive study. Setting : Ruamkatanyu rescue …

Type, Content, And Source Of Social Support Perceived By Women During Pregnancy: Evidence From Matlab, Bangladesh, Joyce K. Edmonds, Moni Paul, Lynn M. Sibley

Joyce K. Edmonds

Specific and contextualized data on social support during distinct health events are needed to improve social support interventions. This study identified the type, content, and source of social support perceived by women during pregnancy. In-depth interviews with 25 women, aged 18-49 years, living in Matlab, Bangladesh, were conducted. The findings demonstrated that women perceived, the receipt of eight distinct types of support. The four most frequently-mentioned types included: practical help with routine activities, information/advice, emotional support and assurance, as well as the provision of resources and material goods. Sources varied by type of support and most frequently included--mothers, mothers-in-law, sisters-in-law, …

The Constant Threat Of Terrorism: Stress Levels And Coping Strategies Amongst University Students Of Karachi, Ayesha Ejaz Ahmed, Komal Masood, Sohni Vicky Dean, Tanzila Shakir, Ahmed Abdul Hafeez Kardar, Usman Barlass, Syed Haider Imam, Mohammad Ghawar Khan Mohmand, Hussain Ibrahim, Imad Saeed Khan, Usman Akram, Farid Hasnain

Department of Psychiatry

OBJECTIVES: To assess the levels of stress in the face of terrorism and the adopted coping strategies, amongst the student population of universities in Karachi

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METHODS: A descriptive, cross sectional study was conducted on undergraduate students from four universities of Karachi. Self-administered questionnaires were filled out by 291 students. Pearson Chi-Square test was used to assess associations between stress levels and different variables at a level of significance of 0.05%

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RESULTS: A total of 65.8% of the students had mild stress levels, 91.5% of university students were exposed to terrorism through television, while only 26.5% students reported personal …

Healthy In Mind, Body, And Spirit, Milton E. Becknell

Psychology Faculty Publications

The stress of modern life can manifest itself in our physical, mental, and spiritual health. Rest is crucial for optimal health across all dimensions.

P53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism For Chemotherapy-Induced Cardiac Injury, Joyce M. Velez, Sumitra Miriyala, Ramaneeya Nithipongvanitch, Teresa Noel, Chotiros D. Plabplueng, Terry Oberley, Paiboon Jungsuwadee, Holly Van Remmen, Mary Vore, Daret K. St Clair

Toxicology and Cancer Biology Faculty Publications

The side effects of cancer therapy on normal tissues limit the success of therapy. Generation of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic agents including doxorubicin (DOX), a potent cancer chemotherapeutic drug. The production of ROS by DOX has been linked to DNA damage, nuclear translocation of p53, and mitochondrial injury; however, the causal relationship and molecular mechanisms underlying these events are unknown. The present study used wild-type (WT) and p53 homozygous knock-out (p53(-/-)) mice to investigate the role of p53 in the crosstalk between mitochondria and nucleus. Injecting mice with DOX (20 mg/kg) causes oxidative stress …

Tai Chi For Stress Management And Well-Being In Medical Students, Susan J. Thomas, Teresa M. Treweek, Elizabeth Farmer, John A. Bushnell

Graduate School of Medicine - Papers (Archive)

No abstract provided.

Multiple “Hits” During Postnatal And Early Adulthood Periods Disrupt The Normal Development Of Sensorimotor Gating Ability In Rats, Jing Chen, Zucheng Wang, Ming Li

Department of Psychology: Faculty Publications

In the present study, we evaluated a multiple-hit animal model of schizophrenia in an attempt to capture the complex interactions among various adverse developmental factors in schizophrenia. Sprague–Dawley rats were assigned to receive either repeated daily 3-h maternal separation for eight days (first “hit”) on postnatal days (PND) 3 to 10, and/or avoidance conditioning for six days (second “hit”) on PND 49–56, and/or repeated phencyclidine treatment (third “hit”, 3.0 mg/kg, sc) immediately after each daily avoidance conditioning. Prepulse inhibition (PPI) of acoustic startle reflex was assessed at late adolescence (PND 41–43) and early adulthood (PND 62–63). The change in %PPI …

Study Of Stress, Housing Program Use, And Nursing Usage Among Homeless In Chicago, Henry Christian Cheung

Dissertations

Homelessness places people at risk of stressors that translate into stress and subsequently affect their health. Using Neuman Systems Model as a framework to identify modalities for nursing intervention among stressors and health problems of homeless people, this study compared stress levels among homeless people from three different homeless housing program types, investigated variables that predict the presence of stress among homeless, identified the degree of self-reported contact homeless people had with nurses, and measured to what extent nurses are preferred as health care providers by homeless people. This was accomplished through a cross-sectional, secondary data analysis of data from …

Pre-Nursing Club: Alleviating Secondary Admission Stress Amongst Pre-Nursing Students, Jenna Martens, Katherine Borum

Honors Projects

No abstract provided.

Reduction Of Stress, Depression And Overweight By Awareness Of Problems In Thai Medical Students, Srinakharinwirot University, K Kongsomboon, D. Pattarathitinan

Chulalongkorn Medical Journal

Objective : To determine the effect of awareness in reducing the stress, depression and overweight in medical students of Srinakharinwirot University. Design : Cohort study. Materials and Methods : All 646 medical students of Srinakharinwirot University were recruited, and the response rate was 86%. The study was done from September 2007 to March 2008. Each participant was evaluated at twice; at the end of the first and second semester. The diagnostic screening test for depression was from the Department of Mental Health, Ministry of Public Health, Thailand and the stress test of Suanprung Hospital, Thailand. After evaluation at the end …

Prenatal Maternal Stress Programs Infant Stress Regulation, Elyssia Poggi Davis, Laura M. Glynn, Feizal Waffarn, Curt A. Sandman

Psychology Faculty Articles and Research

Objective: Prenatal exposure to inappropriate levels of glucocorticoids (GCs) and maternal stress are putative mechanisms for the fetal programming of later health outcomes. The current investigation examined the influence of prenatal maternal cortisol and maternal psychosocial stress on infant physiological and behavioral responses to stress.

Methods: The study sample comprised 116 women and their full term infants. Maternal plasma cortisol and report of stress, anxiety and depression were assessed at 15, 19, 25, 31 and 36 + weeks' gestational age. Infant cortisol and behavioral responses to the painful stress of a heel-stick blood draw were evaluated at 24 hours after …

Parental And Carer Responses To Angelman Syndrome And Prader-Willi Syndrome, Allyson K. Thomson

Theses: Doctorates and Masters

The research project undertaken as part of this thesis was designed to assess family stress levels and the use of coping strategies among the carers of people with an intellectual disability caused by Angelman syndrome (AS) or Prader-Willi syndrome (PWS). Both syndromes are genomic imprinting disorders that arise from disruptions in genes located within human chromosome 15q11-q13. Although the disease phenotypes are quite distinct, the genetic mechanisms involved are common to both syndromes but involve paternally-derived mutations in PWS as opposed to maternal mutations in AS. Previous investigations in Western Australia (WA) indicated that people with AS and PWS experience …