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Functional Characterization Of The Streptococcus Sanguinis Com Regulon, Jill Callahan
Functional Characterization Of The Streptococcus Sanguinis Com Regulon, Jill Callahan
Theses and Dissertations
Streptococcus sanguinis is an important component of the dental plaque biofilm and is believed to play a beneficial role in the oral cavity. S. sanguinis is also a leading cause of infective endocarditis (IE), a potentially lethal infection of the cardiac valves. S. sanguinis possesses genetic competence, the ability to acquire exogenous DNA into its genome. In the well characterized system of S. pneumoniae, genetic competence requires a quorum sensing system encoded by the early comCDE genes, as well as late genes controlled by the alternate sigma factor, ComX. Previous studies in other streptococcal species have suggested functions for the …
Systematic Study Of Gene Functions For Morphological Chain Formation In Streptococcus Sanguinis, Karra Evans
Systematic Study Of Gene Functions For Morphological Chain Formation In Streptococcus Sanguinis, Karra Evans
Theses and Dissertations
Streptococcus sanguinis is a gram-positive facultative anaerobe that is indigenous to the oral cavity and a primary colonizer of the oral cavity. It serves as a tether for the attachment of several oral bacteria that colonize the tooth surface, form dental plaque, and cause periodontal disease. Previous experiments with streptococcal strains have suggested that cellular chain morphology of streptococci may influence the competitiveness, susceptibility to phagocytosis, acidurance, and aggregation of the bacterium. The purpose of this study was to systematically determine gene functions that contribute to cellular chain length morphology in the SK36 strain of S. sanguinis. Gene functions for …