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Differential Requirement For The Cd45 Splicing Regulator Hnrnpll For Accumulation Of Nkt And Conventional T Cells, Mehmet Yabas, Dale I. Godfrey, Christopher C. Goodnow, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

Natural killer T (NKT) cells represent an important regulatory T cell subset that develops in the thymus and contains immature (NK1.1^lo) and mature (NK1.1^hi) cell subsets. Here we show in mice that an inherited mutation in heterogeneous ribonucleoprotein L-like protein (hnRNPLL^thunder), that shortens the survival of conventional T cells, has no discernible effect on NKT cell development, homeostasis or effector function. Thus, Hnrpll deficiency effectively increases the NKTT cell ratio in the periphery. However, Hnrpll mutation disrupts CD45RA, RB and RC exon silencing of the Ptprc mRNA in both NKT and conventional T cells, …