Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Publication
- Publication Type
Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
Chronic Toxicity Study Of Kaempferia Parviflora Wall Ex. Extract, Songpol Chivapat, Pranee Chavalittumrong, Aimmanas Attawish, Anudep Rungsipipat
Chronic Toxicity Study Of Kaempferia Parviflora Wall Ex. Extract, Songpol Chivapat, Pranee Chavalittumrong, Aimmanas Attawish, Anudep Rungsipipat
The Thai Journal of Veterinary Medicine
K. parviflora is a medicinal plant possessing high potential for development of various health products. The objective of this chronic toxicity study was to investigate the safety of ethanolic extract of chronic Kaempferia parviflora Wall ex Bak in Wistar rats. The animals were randomly divided into five groups, twenty four rats each (12 males and 12 females). Three treatment groups were orally administered with K. parviflora extract at doses of 5, 50 and 500 mg/kg/day for six months respectively, which were equivalent to 1, 10 and 100 times of human use, while two control groups were orally given with distilled …
The Efficacy Of Pure Natural Repellents On Rat Responses Using Circular Open Field, Sarinee Kalandakanond-Thongsong, Suwaporn Daendee, Boonrit Thongsong, Vivat Chavananikul
The Efficacy Of Pure Natural Repellents On Rat Responses Using Circular Open Field, Sarinee Kalandakanond-Thongsong, Suwaporn Daendee, Boonrit Thongsong, Vivat Chavananikul
The Thai Journal of Veterinary Medicine
Rodent infestation is considered as one of the major pest problems since it is not only acting as a health hazard, but also causes damages to household, agricultural fields and even transportation business. The use of rodenticides is a common approach to rodent control, however, most rodenticides are poisonous to man. Therefore, using natural extracts as a rat repellent may be a better alternative. In the current study, various natural extracts were experimented whether they could repel a rat when testing in the behavioral model, a circular open field. The tested substances were wintergreen oil, chilli, peppermint oil, bergamot oil …
Evidence For A Role Of Endocannabinoids, Astrocytes And P38 Phosphorylation In The Resolution Of Postoperative Pain, Matthew S. Alkaitis, Carlos Solorzano, Russell P. Landry, Daniele Piomelli, Joyce A. Deleo, E. Alfonso Romero-Sandoval
Evidence For A Role Of Endocannabinoids, Astrocytes And P38 Phosphorylation In The Resolution Of Postoperative Pain, Matthew S. Alkaitis, Carlos Solorzano, Russell P. Landry, Daniele Piomelli, Joyce A. Deleo, E. Alfonso Romero-Sandoval
Dartmouth Scholarship
Background: An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating cannabinoid receptors type 1 (CB1) and type 2 (CB2). We have previously shown that intrathecal administration of a CB2 receptor agonist reverses both surgical incision-induced behavioral hypersensitivity and associated over-expression of spinal glial markers. We therefore hypothesized that endocannabinoid signaling promotes the resolution of acute postoperative pain by modulating pro-inflammatory signaling in spinal cord glial cells. …
Toxicity Testing Of Flowers Of Neem Tree (Azadirachta Indica A. Juss), Piengchai Kupradinun, Anong Tepsuwan, Nopsarun Tanthasri, Nuntana Meesiripan, Sirirat Tunsakul, Warayupa Tompat, Yaninee Jarratwisarutporn, Wannee R. Kusamran
Toxicity Testing Of Flowers Of Neem Tree (Azadirachta Indica A. Juss), Piengchai Kupradinun, Anong Tepsuwan, Nopsarun Tanthasri, Nuntana Meesiripan, Sirirat Tunsakul, Warayupa Tompat, Yaninee Jarratwisarutporn, Wannee R. Kusamran
The Thai Journal of Veterinary Medicine
Flowers of neem (Azadirachta indica A. Juss) possess a strong cancer chemopreventive potential in rats as well as antimicronucleus formation in mice. However, toxicity testing has never been evaluated. This study was aimed to determine its acute and subacute toxicities in Wistar rats. Acute toxicity was conducted by feeding methanol extract of neem flowers (MENF) suspending in 20% propylene glycol at 6, 9 and 12 g/kg bw. On the other hand, subacute toxicity testing was carried out by feeding MENF suspending in 0.5% tragacanth at 150, 750 and 1,500 mg/kg bw for 90 consecutive days. Hematology, blood chemistry and histopathology …
Activation Of Peroxisome Proliferator-Activated Receptor G In Brain Inhibits Inflammatory Pain, Dorsal Horn Expression Of Fos, And Local Edema, Jenny Morgenweck, Omar D. Abdel-Aleem, Katelyn C. Mcnamara, Renee R. Donahue, M Z. Badr, Bradley K. Taylor
Activation Of Peroxisome Proliferator-Activated Receptor G In Brain Inhibits Inflammatory Pain, Dorsal Horn Expression Of Fos, And Local Edema, Jenny Morgenweck, Omar D. Abdel-Aleem, Katelyn C. Mcnamara, Renee R. Donahue, M Z. Badr, Bradley K. Taylor
Renee R. Donahue
Systemic administration of thiazolidinediones reduces peripheral inflammation in vivo, presumablybyacting at peroxisome proliferator-activated receptor g (PPARg) in peripheral tissues. Based on a rapidly growing body of literature indicating the CNS as a functional target of PPARg actions, we postulated that brain PPARg modulates peripheral edema and the processing of inflammatory pain signals in the dorsal horn of the spinal cord. To test this in the plantar carrageenan model of inflammatory pain, we measured paw edema, heat hyperalgesia, and dorsal horn expression of the immediate-early gene c-fos after intracerebroventricular (ICV) administration of PPARg ligands or vehicle. We found that ICV rosiglitazone …
Dietary Fish Oil Reduces Skeletal Muscle Oxygen Consumption, Provides Fatigue Resistance And Improves Contractile Recovery In The Rat In Vivo Hindlimb, Gregory E. Peoples, Peter L. Mclennan
Dietary Fish Oil Reduces Skeletal Muscle Oxygen Consumption, Provides Fatigue Resistance And Improves Contractile Recovery In The Rat In Vivo Hindlimb, Gregory E. Peoples, Peter L. Mclennan
Faculty of Health and Behavioural Sciences - Papers (Archive)
Dietary fish oil modulates skeletal muscle membrane fatty acid composition. Similar changes in heart membrane composition modulate myocardial oxygen consumption and enhance mechanical performance. The rat in vivo autologous perfused hindlimb was used to investigate the influence of membrane composition on skeletal muscle function. Male Wistar rats were fed either saturated fat (SF), n-6 PUFA (linoleic acid rich) or n-3 PUFA (fish oil) diets for 8 weeks. Hindlimb skeletal muscle perfused using the animal’s own blood was stimulated via the sciatic nerve (1 Hz, 6-12 V, 0·05 ms) to contract in repeated 10 min bouts. The n-3 PUFA diet markedly …
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Faculty of Health and Behavioural Sciences - Papers (Archive)
No abstract provided.
The Effects Of Adding Methylprednisolone To Low-Potassium Dextran Solution On Preserved Ischemic Lungs, Ali̇ Yegi̇nsu, Makbule Ergi̇n, Hüseyi̇n Özyurt, Çi̇ğdem Elmas, Güleser Çağlar Göktaş
The Effects Of Adding Methylprednisolone To Low-Potassium Dextran Solution On Preserved Ischemic Lungs, Ali̇ Yegi̇nsu, Makbule Ergi̇n, Hüseyi̇n Özyurt, Çi̇ğdem Elmas, Güleser Çağlar Göktaş
Turkish Journal of Medical Sciences
To investigate the effects of adding methylprednisolone to low-potassium dextran solution on cold-preserved ischemic lungs. Materials and methods: The study included 42 rat lung blocks that were divided into 7 groups (n = 6). Lung blocks were preserved in 40 mL of cold Perfadex solution, to which 5, 15, 30, 60, and 120 mg kg-1 (approximately 40, 120, 240, 480, and 960 mg L-1) of methylprednisolone were added. After a 24-h preservation period, the lungs were removed from the solution and examined. Results: As compared to the Perfadex only group, cell death and degeneration were significantly higher in the Perfadex …
Morphine Modulates Microvascular Leakage Dose-Dependently In The Airway Of Ovalbumin-Sensitized Rats, Seyfullah Oktay Arslan
Morphine Modulates Microvascular Leakage Dose-Dependently In The Airway Of Ovalbumin-Sensitized Rats, Seyfullah Oktay Arslan
Turkish Journal of Medical Sciences
To investigate the effect of morphine on ovalbumin-evoked airway microvascular leakage in sensitized rats. Materials and methods: Rats were sensitized on days 0, 14, and 21 with ovalbumin. Intravenous ovalbumin (2 mg/kg) or capsaicin (50 µg/kg) increased the extravasation of Evans blue dye in trachea, bronchi, and intra-pulmonary tissues of sensitized rats. Results: Morphine (1-10 mg/kg) inhibited ovalbumin-evoked increase in microvascular plasma leakage in a dose-dependent manner; however, it had no significant effect at the doses of 0.1 or 30 mg/kg. In addition, morphine, at the doses of 1-30 mg/kg, abolished microvascular leakage increased by capsaicin. The inhibition caused by …
Protective Effect Of Selenium On Intussusception-Induced Ischemia/Reperfusion Intestinal Oxidative Injury In Rats*, Hülya Akman, Sali̇h Somuncu, Günnur Di̇kmen, Şebnem Ayva, Tutku Soyer, Paki̇ze Doğan, Murat Çakmak
Protective Effect Of Selenium On Intussusception-Induced Ischemia/Reperfusion Intestinal Oxidative Injury In Rats*, Hülya Akman, Sali̇h Somuncu, Günnur Di̇kmen, Şebnem Ayva, Tutku Soyer, Paki̇ze Doğan, Murat Çakmak
Turkish Journal of Medical Sciences
To evaluate the protective effect of selenium on intestinal ischemia-reperfusion injury due to intussusception. Materials and methods: Forty Wistar albino rats were allocated to 4 equal groups (n = 10). After anesthetization, 2 cm of intestinal segment, 20 cm proximal to the ileocecal valve, was removed in the control group (CG). In the intussusception group (ING), intussusception was performed 20 cm proximal to the ileocecal valve by pushing the proximal intestinal segment distally with a stylet, and 2 cm of intestinal segment was removed 4 h later. Intussusception was reduced and a 2 cm segment was removed after another 4 …
Effect Of Viscum Album On Acute Hepatic Damage Caused By Carbon Tetrachloride In Rats, Omar Mohamed Abdel-Salam, Amany Ameen Sleem, Nermeen M. Shaffie
Effect Of Viscum Album On Acute Hepatic Damage Caused By Carbon Tetrachloride In Rats, Omar Mohamed Abdel-Salam, Amany Ameen Sleem, Nermeen M. Shaffie
Turkish Journal of Medical Sciences
To investigate the effect of Viscum album, a plant used for the treatment of hepatocellular carcinoma that has immune-modulating properties, on acute hepatic injury in rats. Materials and methods: Hepatotoxicity was induced by CCl_4 orally (0.28 mL/kg). Rats received either Viscum album at 1 of 2 dose levels (0.1 or 0.2 mL/kg) once weekly subcutaneously alone or with silymarin (25 mg/kg, orally), or silymarin (25 mg/kg) once daily orally for 1 month, starting at the time of administration of CCl_4. Liver damage was assessed by determining liver serum enzyme activities and by hepatic histopathology. Results: Viscum album administration decreased the …