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Muscarinic Receptor Antagonists, The Overactive Bladder And Efficacy Against Urinary Urgency, Kylie J. Mansfield

Graduate School of Medicine - Papers (Archive)

The overactive bladder (OAB) is a debilitating condition in which patients suffer from urinary urgency, frequency and nocturiawith or without urge urinary incontinence. The mainstay of pharmacotherapy for OAB is muscarinic receptor antagonists, which havebeen shown to be effective treatments for the symptoms of OAB. The mechanism underlying the efficacy of antimuscarinic agentsagainst the symptoms of OAB is not completely understood. This review explores the role of bladder mucosal muscarinic receptors in the signaling pathways that are activated in response to bladder filling. The cholinergic system is seen to be involved in bladder afferent signaling at many levels and as …