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Full-Text Articles in Medicine and Health Sciences

Effect On Refractive Outcomes After Cataract Surgery Of Intraocular Lens Constant Personalization Using The Haigis Formula, Sofia Charalampidou, Lorraine Cassidy, Eugene Ng, James Loughman, John Nolan, Jim Stack, Stephen Beatty Jul 2010

Effect On Refractive Outcomes After Cataract Surgery Of Intraocular Lens Constant Personalization Using The Haigis Formula, Sofia Charalampidou, Lorraine Cassidy, Eugene Ng, James Loughman, John Nolan, Jim Stack, Stephen Beatty

Articles

Methods Personalization of Haigis IOL constants was performed using a series of 248 suitable eyes after biometry by partial coherence interferometry (IOLMaster) and IOL prediction based on optimized IOL constants derived from pooled data from the User Group for Laser Interference Biometry web site. A mean error of prediction and a mean absolute error were then calculated using the personalized IOL constants and compared with those derived using optimized IOL constants, allowing evaluation and quantification of the maximum realizable refractive benefits (if any) of personalization. Results There was no statistically significant difference between personalized and optimized Haigis IOL constants in …


Surgically Induced Astigmatism After Phacoemulsification With And Without Correction For Posture-Related Ocular Cyclotorsion, I. Dooley, S. Charalampidou, A. Malik, G. Ormonde, James Loughman, Laura Molloy, Stephen Beatty Apr 2010

Surgically Induced Astigmatism After Phacoemulsification With And Without Correction For Posture-Related Ocular Cyclotorsion, I. Dooley, S. Charalampidou, A. Malik, G. Ormonde, James Loughman, Laura Molloy, Stephen Beatty

Articles

Purpose To report the impact of posture-related ocular cyclotorsion on one surgeon's surgically induced astigmatism (SIA) results and the variance in SIA. Setting Institute of Eye Surgery, Whitfield Clinic, Waterford, Ireland. Methods This prospective randomized controlled study included eyes that had phacoemulsification with intraocular lens implantation. Eyes were randomly assigned to have (intervention group) or not have (control group) correction for posture-related ocular cyclotorsion. In the intervention group, the clear corneal incision was placed precisely at the 120-degree meridian with instruments designed to correct posture-related ocular cyclotorsion. In the control group, the surgeon endeavored to place the incision at the …


Augmentation Of Macular Pigment Following Supplementation With All Three Macular Carotenoids: An Exploratory Study, Eithne Connolly, Stephen Beatty, David Thurnham, James Loughman, Alan Howard, Jim Stack, John Nolan Apr 2010

Augmentation Of Macular Pigment Following Supplementation With All Three Macular Carotenoids: An Exploratory Study, Eithne Connolly, Stephen Beatty, David Thurnham, James Loughman, Alan Howard, Jim Stack, John Nolan

Articles

Purpose:At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed to measure serum and macular responses to a macular carotenoid formulation. Materials and Methods:Ten subjects were recruited into this study (five normal and five with early age-related macular degeneration [AMD]). Subjects were instructed to consume a formulation containing 7.3mg of MZ, 3.7mg of L, and 0.8mg of Z everyday over an eight-week period. The spatial profile of MP optical density (i.e., MPOD at 0.25°, 0.5°, 1°, and 1.75°) was measured using customized heterochromatic flicker photometry, and …


The Relationship Between Macular Pigment And Visual Performance, James Loughman, Mukunda Akkali, Stephen Beatty, Grainne Scanlon, Peter Davison, Veronica O'Dwyer, Thomas Cantwell, Philip Major, Jim Stack, John Nolan Apr 2010

The Relationship Between Macular Pigment And Visual Performance, James Loughman, Mukunda Akkali, Stephen Beatty, Grainne Scanlon, Peter Davison, Veronica O'Dwyer, Thomas Cantwell, Philip Major, Jim Stack, John Nolan

Articles

This study was designed to assess whether macular pigment optical density (MPOD) is associated with visual performance. One hundred and forty-two young healthy subjects were recruited. Macular pigment optical density and visual performance were assessed by psychophysical tests including best corrected visual acuity (BCVA), mesopic and photopic contrast sensitivity, glare sensitivity, photostress recovery time (PRT). Measures of central visual function, including BCVA and contrast sensitivity, were positively associated with MPOD (p < 0.05, for all). Photostress recovery and glare sensitivity were unrelated to MPOD (p > 0.05). A longitudinal, placebo-controlled and randomized supplementation trial will be required to ascertain whether augmentation of MPOD can influence visual performance.


Macular Pigment Optical Density In An Aging Irish Population: The Irish Longitudinal Study On Ageing, John Nolan, Roseanne Kenny, Claire O'Regan, Hilary Cronin, James Loughman, Eithne Connolly, Patricia Kearney, Stephen Beatty Jan 2010

Macular Pigment Optical Density In An Aging Irish Population: The Irish Longitudinal Study On Ageing, John Nolan, Roseanne Kenny, Claire O'Regan, Hilary Cronin, James Loughman, Eithne Connolly, Patricia Kearney, Stephen Beatty

Articles

Purpose: The 3 carotenoids lutein, zeaxanthin, and meso-zeaxanthin, which account for the ‘yellow spot’ at the macula and which are referred to as macular pigment (MP), are believed to play a role in visual function and protect against age-related macular degeneration (AMD) via their optical and antioxidant properties. This study was undertaken to compare MP optical density (MPOD) in a population aged ≧50 years with MPOD values from a normative database of subjects aged 18–60 years. Methods: Seventy-nine subjects were recruited into this pilot study (The Irish Longitudinal Study on Ageing-TILDA). MPOD was measured using heterochromatic flicker photometry. Retinal fundus …


Macular Pigment And Its Contribution To Visual Performance And Experience [El Pigmento Macular Y Su Contribución Al Rendimiento Y Experiencia Visuals], James Loughman, Peter Davison, John M. Nolan, Mukunda C. Akkali, Stephen Beatty Jan 2010

Macular Pigment And Its Contribution To Visual Performance And Experience [El Pigmento Macular Y Su Contribución Al Rendimiento Y Experiencia Visuals], James Loughman, Peter Davison, John M. Nolan, Mukunda C. Akkali, Stephen Beatty

Articles

There is now a consensus, based on histological, biochemical and spectral absorption data, that the yellow colour observed at the macula lutea is a consequence of the selective accumulation of dietary xanthophylls in the central retina of the living eye. Scientific research continues to explore the function(s) of MP in the human retina, with two main hypotheses premised on its putative capacity to (1) protect the retina from (photo)-oxidative damage by means of its optical filtration and/or antioxidant properties, the so-called protective hypothesis and (2) influence the quality of visual performance by means of selective short wavelength light absorption prior …


Changes In Intraocular Pressure And Anterior Segment Morphometry After Uneventful Phacoemulsification Cataract Surgery, J. Dooley, S. Charalampidou, A. Malik, James Loughman, L. Molloy, S. Beatty Jan 2010

Changes In Intraocular Pressure And Anterior Segment Morphometry After Uneventful Phacoemulsification Cataract Surgery, J. Dooley, S. Charalampidou, A. Malik, James Loughman, L. Molloy, S. Beatty

Articles

Purpose To study changes in anterior segment morphometry after uneventful phacoemulsification cataract surgery, and to investigate whether there is a relationship between any observed changes and intraocular pressure (IOP) reduction after the procedure. Methods The anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), central corneal thickness (CCT), and IOP were measured in 101 non-glaucomatous eyes before and after uneventful phacoemulsification cataract surgery. Results After cataract surgery, the mean ACD, ACV, and ACA values increased by 1.08mm, 54.4mm3, and 13.11, respectively, and the mean IOP (corrected for CCT) decreased by 3.2mmHg. The predictive value of a previously …


Macular Pigment And Its Contribution To Visual Performance And Experience, James Loughman, Peter Davison, John Nolan, Mukunda Akkali, Stephen Beatty Jan 2010

Macular Pigment And Its Contribution To Visual Performance And Experience, James Loughman, Peter Davison, John Nolan, Mukunda Akkali, Stephen Beatty

Articles

There is now a consensus, based on histological, biochemical and spectral absorption data, that the yellow colour observed at the macula lutea is a consequence of the selective accumulation of dietary xanthophylls in the central retina of the living eye. Scientifi c research continues to explore the function(s) of MP in the human retina, with two main hypotheses premised on its putative capacity to (1) protect the retina from (photo)-oxidative damage by means of its optical fi ltration and/or antioxidant properties, the so-called protective hypothesis and (2) infl uence the quality of visual performance by means of selective short wavelength …