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Full-Text Articles in Medicine and Health Sciences
Acid, But Not Capsaicin, Is An Effective Stimulus For Atp Release In The Porcine Bladder Mucosa, Prajni Sandananda, Kylie J. Mansfield, Elizabeth Burcher
Acid, But Not Capsaicin, Is An Effective Stimulus For Atp Release In The Porcine Bladder Mucosa, Prajni Sandananda, Kylie J. Mansfield, Elizabeth Burcher
Graduate School of Medicine - Papers (Archive)
Hypothesis / aims of study: Urothelial ATP release is thought to play an important role in bladder afferent signaling via activation of purinergic receptors on suburothelial afferent nerves. Stretch of the bladder mucosa is a well documented stimulus for ATP release in several species, including the pig [1]. In addition, in mouse bladder, capsaicin is also an effective stimulus for ATP release, acting via stimulation of vanilloid (TRPV1) receptors [2]. While acid is an agonist at the TRPV1 receptor, specialized acid sensing ion channels (ASICs) are also present in several organ systems [3]. Our aim was to characterize the ATP …
Atp Release During Cystometry In Women With Detrusor Overactivity And Painful Bladder Syndrome: Contribution To 'Urgency'?, Elizabeth Burcher, Kylie J. Mansfield, W Allan, C Walsh, Kate H. Moore, Ying Cheng
Atp Release During Cystometry In Women With Detrusor Overactivity And Painful Bladder Syndrome: Contribution To 'Urgency'?, Elizabeth Burcher, Kylie J. Mansfield, W Allan, C Walsh, Kate H. Moore, Ying Cheng
Graduate School of Medicine - Papers (Archive)
ATP is an important signalling molecule whose release from the bladder urothelium in response to stretch is thought to stimulate afferent nerves and thus convey information about bladder fullness (and the sensation of urgency). Our aim was to measure the release of ATP during urodynamic filling of bladders of women with idiopathic detrusor overactivity (DO), painful bladder syndrome (PBS) and stress incontinence (controls), in order to test the hypothesis that ATP release might play a role in bladder function and/or dysfunction.