Medicine and Health Sciences Commons^™

Pregnancy Outcome In Primiparae Of Advanced Maternal Age, Ilse Delbaere, Hans Verstraelen, Sylvie Goetgeluk, Guy Martens, Guy De Backer, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Objective: To investigate the impact of maternal age on singleton pregnancy outcome, taking into account intermediate and confounding factors.

Study design: In this population-based retrospective cohort study, perinatal data of primiparous women aged 35 years or more ( n = 2970), giving birth to a singleton child of at least 500 g, were compared to data of primiparous women aged 25–29 years old ( n = 23,921). Univariate analysis was used to assess the effect of maternal age on pregnancy outcomes. The effects of intermediate (hypertension, diabetes and assisted conception) and confounding factors (level of education) were assessed through multivariable …

Growth Environment And Sex Differences In Lipids, Bodyshape And Diabetes Risk, Mary Schooling, Tai Hing Lam, G. Neil Thomas, Benjamin J. Cowling, Michelle Heys, Edward D. Janus, Gabriel M. Leung

Publications and Research

Background
Sex differences in lipids and body shape, but not diabetes, increase at puberty. Hong Kong Chinese are mainly first or second generation migrants from China, who have shared an economically developed environment for years, but grew up in very different environments in Hong Kong or contemporaneously undeveloped Guangdong, China. We assessed if environment during growth had sex-specific associations with lipids and body shape, but not diabetes.

Methodology and Principal Findings
We used multivariable regression in a population-based cross-sectional study, undertaken from 1994 to 1996, of 2537 Hong Kong Chinese residents aged 25 to 74 years with clinical measurements of …

Pparα Is A Key Regulator Of Hepatic Fgf21, Thomas Lundasen, Mary Hunt, Lisa-Marie Nilsson, Sabysashi Sanyal, Bo Angelin, Stefan Alexson, Mats Rudling

Articles

The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. Using quantitative RT-PCR, we here show that the hepatic gene expression of FGF21 is regulated by the peroxisome proliferator-activated receptor alpha (PPARalpha). Fasting or treatment of mice with the PPARalpha agonist Wy-14,643 induced FGF21 mRNA by 10-fold and 8-fold, respectively. In contrast, FGF21 mRNA was low in PPARalpha deficient mice, and fasting or treatment with Wy-14,643 did not induce FGF21. Obese ob/ob mice, known to have increased PPARalpha levels, displayed 12-fold increased hepatic FGF21 mRNA levels. The potential importance of PPARalpha for …

Cost Effectiveness Of Screening Of All Newly Recruited Employees For Diabetes At A Tertiary Care Hospital, Niloufer Sultan Ali, Ali Khan Khuwaja

Department of Anaesthesia

Diabetes Mellitus is a disease which remains asymptomatic for long duration of time and usually diagnosed either when gets complicated or by routine or opportunistic screening. The practice of universal screening is not recommended, particularly in constraint resources . However, we embarked with a study to assess the yield of recommended screening for Type 2 diabetes in all the newly recruited employees at a tertiary care hospital in Karachi. Methods: All the information required for this study was collected from medical records of all newly recruited employees of nursing services department of a tertiary care hospital of Karachi, Pakistan, over …

Care Patterns And Outcomes For Hospitalized Patients With Diabetes In Nevada, Jay J. Shen

Nevada Journal of Public Health

This study demonstrates substantial differences between Nevada and the national average in patterns of hospital based care in patients with type 2 diabetes. Diabetic patients in Nevada are more likely to be hospitalized through the emergency department, and more likely to be admitted for a condition related to diabetes. Moreover, in Nevada, Medicaid and uninsured patients with diabetes are more likely to experience adverse outcomes then their privately insured counterparts. These differences may be primarily reflective of variances in access to ambulatory care, care seeking behavior, and availability of health services and facilities. Policies promoting expansion of health care benefits …

Continuing Stability Of Center Differences In Pediatric Diabetes Care: Do Advances In Diabetes Treatment Improve Outcome?, Carine E. De Beaufort, Peter G. F. Swift, Timothy C. Skinner, - Hvidoere Study Group On Childhood Diabetes

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective: To reevaluate the persistence and stability of previously observed differences between pediatric diabetes centers and to investigate the influence of demography, language communication problems, and changes in insulin regimens on metabolic outcome, hypoglycemia, and ketoacidosis.

Research Design and Methods: This was an observational cross-sectional international study in 21 centers, with clinical data obtained from all participants and A1C levels assayed in one central laboratory. All individuals with diabetes aged 11–18 years (49.4% female), with duration of diabetes of at least 1 year, were invited to participate. Fourteen of the centers participated in previous Hvidoere Studies, allowing direct …

Qualitative Study Into Quality Of Life Issues Surrounding Insulin Pump Use In Type 1 Diabetes, Katharine D. Barnard, Timothy Chas Skinner

Faculty of Health and Behavioural Sciences - Papers (Archive)

Currently, there is a need for qualitative research about how insulin pump therapy changes quality of life, which is significant to people with type 1 diabetes. This study aimed to elicit the experiences of current insulin pump users in order to discover the therapy's benefits, downsides and effect on their quality of life. A qualitative approach was taken in order to reveal subjective experiences. This research will inform future research and assist with policy and guideline development by health care providers about pump therapy.

Participants were briefly interviewed by telephone about their experiences of living with an insulin pump. Four …

One-Year Changes In Glucose And Heart Disease Risk Factors Among Participants In The Wisewoman Programme, Jc Will, O Khavjou, Ea Finkelstein, Rk Loo, Ky Gregory-Mercado

Public Health Resources

Background: WISEWOMAN provides chronic disease risk factor screening, referrals and lifestyle interventions to low-income, uninsured women, to reduce their heart disease and stroke risk. Participants learn behaviour-changing skills tailored to low-income populations, such as collaborative goal setting, the need to take small steps and other empowerment techniques.

Aim: To quantify the baseline prevalence of pre-diabetes (fasting blood glucose 5.5–6.9 mmol/l) and diabetes among WISEWOMAN participants and assess one year changes in glucose levels and other diabetes risk factors.

Methods: We used 1998–2005 baseline and one-year follow-up data from WISEWOMAN participants. Using a multilevel regression model, we assessed …

Diabetes Self-Management In The Migrant Latino Population, Dawn Weiler, Janice D. Crist

Nursing Faculty Publications and Presentations

This article will present an in-depth exploration and synthesis of current literature that informs nursing knowledge of diabetes self-management for the migrant Latino population. Extensive research in diabetes care has been conducted, however, there is a significant knowledge gap related to the factors that influence the achievement of glycemic control and self-management practices of the Latino population. Based on well-documented disparities in complications and health outcomes among Latinos when compared with White Americans, there is sufficient evidence to question whether traditional White beliefs about self-management are successful or appropriate for the Latino population in general and migrants specifically. Traditional models …

Review Of Diabetes Among Indigenous Peoples, Australian Indigenous Healthinfonet

Research outputs pre 2011

This review provides detailed information on the extent of diabetes, and its complications and comorbidities among Aboriginal and Torres Strait Islander people, including: incidence and prevalence data; hospitalisations; mortality and burden of disease. This review discusses the issues of prevention and management of diabetes, and provides information on relevant programs, services, policies and strategies that address the health issue of diabetes among Aboriginal and Torres Strait Islander people.

This review concludes by discussing possible future directions for combatting the growing epidemic of diabetes in Australia.

The review focuses primarily on type 2 diabetes among Aboriginal and Torres Strait Islander people …

Office Nurse Educators: Improving Diabetes Self-Management For The Latino Population In The Clinic Setting, Dawn Weiler, Laura Tirrell

Nursing Faculty Publications and Presentations

Diabetes patients who understand their disease and how to manage it can achieve a lower complication rate. The American Diabetes Association recommends that patients receive self-management education and that patients' skills and knowledge be reassessed annually. The Healthy People 2010 objectives include a goal of at least 60% of diabetes patients receiving diabetes education. However, to date overall, far fewer (20%–50%) obtain comprehensive diabetes education and skills development to effectively implement self-management techniques. Low-income Latino patients generally fare even worse. This article describes a successful method to address this problem: the development and evaluation of an in-house diabetes education program, …