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Full-Text Articles in Medicine and Health Sciences

Selective Parp-1 Targeting For Designing Chemo/Radio Sensitizing Agents, Marcos Oliveira Jun 2006

Selective Parp-1 Targeting For Designing Chemo/Radio Sensitizing Agents, Marcos Oliveira

Pharmaceutical Sciences Faculty Patents

Poly(ADP-ribose) polymerase-1 (PARP-1) is a central signaling enzyme in a cell nucleus. PARP-1 is a target for the development of radio and chemo sensitizing agents in cancer treatment as well as providing protection from stroke. An SH3 domain and an SH3 ligand domain have now been discovered on the PARP-1 protein. These domains are involved in PARP-1 activation. This discovery makes possible the use of bioinformatics tools for the design of new drugs and strategies for drug target selection, specifically targeting the PARP-1 enzyme.


Fahasalamana Sy Ny Tontolo Iainana (Health & Environment), Nat Quansah May 2006

Fahasalamana Sy Ny Tontolo Iainana (Health & Environment), Nat Quansah

Nat Quansah

No abstract provided.


Les Plantes Médicinales Et L’Homme, Nat Quansah Apr 2006

Les Plantes Médicinales Et L’Homme, Nat Quansah

Nat Quansah

No abstract provided.