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Full-Text Articles in Medicine and Health Sciences
Involvement Of Akt In Er-To-Golgi Transport Of Scap/Srebp: A Link Between A Key Cell Proliferative Pathway And Membrane Synthesis, X Du, Ika Kristiana, Jenny Wong, A Brown
Involvement Of Akt In Er-To-Golgi Transport Of Scap/Srebp: A Link Between A Key Cell Proliferative Pathway And Membrane Synthesis, X Du, Ika Kristiana, Jenny Wong, A Brown
Illawarra Health and Medical Research Institute
Akt is a critical regulator of cell growth, proliferation, and survival that is activated by phosphatidylinositol 3-kinase (PI3K). We investigated the effect of PI3K inhibition on activation of sterol regulatory element binding protein-2 (SREBP-2), a master regulator of cholesterol homeostasis. SREBP-2 processing increased in response to various cholesterol depletion approaches (including statin treatment) and this increase was blunted by treatment with a potent and specific inhibitor of PI3K, LY294002, or when a plasmid encoding a dominant-negative form of Akt (DN-Akt) was expressed. LY294002 also suppressed SREBP-2 processing induced by insulin-like growth factor-1. Furthermore, LY294002 treatment down-regulated SREBP-2 or -1c gene …
The Legitimacy Of My Ethnographic Gaze: Context, Methodology And Insights From In The Field, Lao Pdr, K Alexander, D H R Spennemann
The Legitimacy Of My Ethnographic Gaze: Context, Methodology And Insights From In The Field, Lao Pdr, K Alexander, D H R Spennemann
Illawarra Health and Medical Research Institute
Rural development in the uplands of Lao Peoples' Democratic Republic (Lao PDR) presents many challenges for farmers and their communities. Swidden cultivation has long been the traditional farming system providing subsistence livelihoods for generations. The Lao government has based development policy on the reduction in swidden cultivation of upland rice and this is having a profound effect on food security, biodiversity, land degradation, and productivity. The research gives voice to community opinions and concerns about the impact of government policy and the influence of the emerging market economy on their capacity to modify their farming practices. The practical implications of …
Education And Disadvantaged Children, Judy Cashmore, Michelle Townsend
Education And Disadvantaged Children, Judy Cashmore, Michelle Townsend
Illawarra Health and Medical Research Institute
The difficulties faced with specific reference to meeting the special needs of Aboriginal children, children with disabilities, children from non-English speaking backgrounds, and children in rural and particularly small and isolated communities are discussed. The efforts by schools concerning children's access to computers and participation in school activities including sports, excursions, social events including fun days which should not be limited by their families' financial situation, is highlighted.