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Full-Text Articles in Medicine and Health Sciences

Method Of Treatment Of Conditions Associate With Oxidative Tissue Damage, John M. Carney, Robert A. Floyd Aug 2000

Method Of Treatment Of Conditions Associate With Oxidative Tissue Damage, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Compositions containing as the active ingredient a spin-trapping reagent, preferably α-phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventing symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or α-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, …


Bipolar Disorder And Locus Of Control: Implications For Treatment Compliance, Linda J. Ryan-Cox Aug 2000

Bipolar Disorder And Locus Of Control: Implications For Treatment Compliance, Linda J. Ryan-Cox

Theses

Theoretically, a paradigm shift in the 1960s made community-based care and out-patient treatment an acceptable alternative to institutionalization of the chronically mentally ill. Utilizing the Levenson Multidimensional Locus of Control Scale for Psychiatric Patients, the author conducted a causal-comparative study to determine if a link exists between having bipolar disorder, a chronic mental illness, and an external locus of control, a link which might explain the inability of this population to maintain their optimal level of mental health utilizing the out-patient treatment model. Though the study failed to demonstrate any significant differences in external measures of loci of control between …


Use Of Lobeline Compounds In The Treatment Of Central Nervous System Diseases And Pathologies, Peter A. Crooks, Linda P. Dwoskin Jul 2000

Use Of Lobeline Compounds In The Treatment Of Central Nervous System Diseases And Pathologies, Peter A. Crooks, Linda P. Dwoskin

Pharmaceutical Sciences Faculty Patents

Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine ([3H]DA). The lobeline-evoked overflow is calcium-independent and not antagonized by mecamylamine, suggesting a mechanism of action other than the stimulation of nicotinic receptors. Whereas nicotine stimulates nicotinic receptors, lobeline inhibits [3H]DA uptake into synaptic vesicles and striatal synaptosomes. The results suggest that different mechanisms are responsible for the increase in striatal DA release evoked by lobeline and nicotine. [3H]-Dihydrotetrabenazine [3H]DTBZ), used routinely to probe a high-affinity binding site-on the vesicular monoamine transporter (VMAT2) binds to vesicle …


An Identification Of The Core Variables That Assist People Diagnosed With Mental Illness In A Time Of Transition, Robyn M. Martin Jan 2000

An Identification Of The Core Variables That Assist People Diagnosed With Mental Illness In A Time Of Transition, Robyn M. Martin

Theses: Doctorates and Masters

This study has sought to identify the core variables or factors that are utilised by people with a diagnosis of mental illness in a time of transition. The specific transition involved study participants exiting a non government community mental health agency. The variables of interest are those that assist individuals to cope during this time of change and transition. The specific transition involves participants leaving or exiting from a non government mental health agency that provides community based, psychosocial support. The study topic is located in the context of a formalised mental health system in the process of changing from …


The Common Cold: What Pharmacists Need To Know, Peggy Han, Peggy Mcmillan, Jeffery A. Goad Jan 2000

The Common Cold: What Pharmacists Need To Know, Peggy Han, Peggy Mcmillan, Jeffery A. Goad

Pharmacy Faculty Articles and Research

A primer on the common cold for pharmacists, including its causes and pathophysiology and how to assess and treat patients.