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Synthesis Of 3-(Substituted-Aryl)-1,2,3,4-Oxatriazolium-5-Olates As Potential Hypotensive Agents, Mary Quinn Lund

Theses and Dissertations

Hypertension or high blood pressure is a major cause of illness and death in the United States today.^1,2 An estimated thirty-six million people suffer from this disease.³ Prolonged hypertension and its attendant strain on various organs may cause heart failure, brain stroke or kidney damage.⁴ Usually, a pressure of 140/90 mm Hg is taken to be the dividing line between normotension and hypertension.^5,6

The hypertensive condition is generally characterized as either primary (essential) hypertension or secondary hypertension.¹ A specific cause can be identified in secondary hypertensive patients, such as, pheochromocytoma or adrenal tumor. These causes …