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In Vitro Percutaneous Penetration Of Methotrexate, Rajaram Vaidyanathan
In Vitro Percutaneous Penetration Of Methotrexate, Rajaram Vaidyanathan
University of the Pacific Theses and Dissertations
This research project was designed to investigate the effects of various physical and chemical parameters on percutaneous penetration of methotrexate. The potential of propylene glycol in water as a vehicle for topical delivery of methotrexate has been examined. A detailed examination of solubility, partition coefficient and pH parameters in the range of 2 to 6 pH units has been conducted with the goal of correlating their effects on skin penetration of methotrexate. The importance of physiochemical parameters such as solubility and partition coefficient and their aid in the development of a suitable delivery system for topical application has been explained. …