Medicine and Health Sciences Commons^™

Formulation, Characterization, And In Vivo Immunogenicity Evaluation Of Heat-Stabilized Dissolvable Polymeric Microneedles, Aidan Lane Leyba

Biomedical Engineering ETDs

Since its introduction, vaccination has improved health outcomes tremendously. However, modern vaccination efforts are still difficult to implement, particularly in developing countries with warm climates. This includes complex and expensive cold-chain management of vaccines to maintain stability, a lack of medical personnel to administer parental vaccines, and needle phobia. As an alternative, dissolvable microneedles have recently been studied for their simple and painless application. In this thesis, I present a novel manufacturing process for polymer-based dissolvable microneedles, loaded with virus-like particles vaccines conjugated to TRIO or Sialokinin peptides to target malaria and arboviruses, respectively. We have performed multiple characterization studies …

Characterizing The Roles Of Bacterial And Viral Agents In House Crickets (Acheta Domesticus) At Commercial Rearing Facilities In The United States, Kimberly L. Boykin

LSU Doctoral Dissertations

Feeder insects, and in particular crickets, are becoming more popular as food for humans and domesticated animals. However, disease outbreaks continue to decimate commercial populations. The goals of this dissertation were to characterize the epidemiology of different viral and bacterial pathogens affecting the survival of European house crickets (Acheta domesticus) being raised under mass rearing conditions and identify methods to reduce the impact of these pathogens.

Crickets from nine different producers across the United States were sampled during different seasons to better estimate the prevalence of three pathogenic viruses: Acheta domesticus densovirus (AdDV), Acheta domesticus volvovirus (AdVVV), and …

Different Error Patterns Of /L/ In Children And Speech-Language Pathologists' Perception And Treatment, Grace E. Lemoine

LSU Master's Theses

Children often simplify target speech sounds using phonological processes, or common developmental error patterns. However, some children produce less common error patterns that differ from common errors. In the current study, less common errors involving /l/ sounds were studied as the phoneme /l/ is a sound that is subject to frequent misarticulations in young children and perceptual confusion among listeners. The current study focused on less common errors because studies have suggested that atypical errors can indicate weak phonological representations and poor phonological awareness skills, which can have long-term effects on children’s literacy skills. Therefore, the aim of the current …

Exploring Benefits And Barriers That Impact The Implementation Of Pediatric Facility Dogs In Child Life Clinical Programs, Brittany Dame

Graduate Theses, Dissertations, and Capstones

The utilization of facility dog interventions is a quickly growing practice among healthcare facilities across the country. Facility dogs have the ability to provide support, a calming presence, and socialization to patients. This intervention is increasingly popular within child life departments at pediatric hospitals. Child life specialists, who are healthcare professionals that provide psychosocial care to pediatric patients and their families, utilize facility dogs to help pediatric patients cope with hospitalization and medical treatments. The implementation of a child life led facility dog program can come with potential barriers and benefits.

The purpose of this study was to explore the …

Impact Of Preexisting Hypertension And Demographic Factors On Pandemic-Era Anxiety Using The Coronavirus Anxiety Scale, Chukwuemeka Ogbonnaya Okpom

Walden Dissertations and Doctoral Studies

No abstract provided.

Clinical Competence In Evaluating The Consistent Use Of The Criteria For Post-Acute Levels Of Care Guideline, Oluwademilade O. Evbuomwan

Walden Dissertations and Doctoral Studies

No abstract provided.

Neuromodulation Of Mouse Auditory Cortex Using Focused Ultrasound, Jacob Hehir

NYMC Student Theses and Dissertations

Neurological diseases impose a large health and financial burden for nations worldwide. Current treatments for many conditions are limited to pharmacological or invasive surgical approaches. Neuromodulation is an alternative therapy wherein electrical currents, magnetic fields, or electromagnetic waves are used to noninvasively modify brain function. Focused ultrasound (FUS) has been shown to alter neural activity, theoretically with much higher spatial resolution than other neuromodulation techniques. However, these predictions assume that neuromodulatory effects are constrained to the acoustic focus. Given that the architecture of neural circuitry in the cerebral cortex supports delicately balanced lateral processing on spatial scales that may exceed …

Spatial-Temporal Variation Of Diarrhea And Associated Sociobehavioral Factors Between 2010-2020 In Rwanda, Amans Ntakarutimana

Walden Dissertations and Doctoral Studies

No abstract provided.

Lived Experiences Of Nurses Caring For Persons With Mental Illnesses And Chronic Health Conditions, Luwieth Bolt

Walden Dissertations and Doctoral Studies

No abstract provided.

Maldi-Msi Identification Of Tissue-Level N-Glycomic And Proteomic Molecular Biomarkers Of Aggressive Prostate Cancer, Jordan Paige Hartig

MUSC Theses and Dissertations

Prostate Cancer (PCa) poses a significant clinical challenge, characterized by debates on screening efficacy and continuous issues with distinguishing aggressive from non-aggressive tumors. Despite treatment advancements, poor patient outcome at late stages and clinical overtreatment of indolent disease emphasizes the urgent need for markers of PCa aggression. Aberrant glycosylation and extracellular matrix (ECM) remodeling are two complex molecular processes necessary for PCa progression, highlighting a novel area for biomarker discovery. Leveraging formalin-fixed paraffin-embedded tissues, tissue microarrays (TMAs), and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), distinct N-glycan and ECM profiles are identified. Elevated bisecting, multi-antennary, and fucosylated N-glycans indicate early …

Strategies Over Knowledge: Training Gaps Present In Caring For Patients With Autism Spectrum Disorder For Pediatric And Student Nurses, Jasmine E. Johnson

Honors Thesis

With Autism Spectrum Disorder (ASD) prevalence ever increasing among the pediatric population, nurses can expect to see an increase in the number of autistic patients within their clinical practice settings. Previous researchers have shown that pediatric nurses are required to overcome many barriers when working with autistic patients, and adequate training is necessary to achieve genuine patient-centered care. However, parents have reported less than optimal care received by their children with ASD within the healthcare system. Therefore, research is needed to determine where training could be improved for this patient population. This study aimed to identify where training deficits are …

Respiratory Therapists' Attitudes On Patient Safety And The Use Of Workarounds: A Phenomenological Study, Lee Wisdom

Graduate Theses, Dissertations, and Capstones

Respiratory therapists (RTs) provide cardiopulmonary care and share the essential responsibility of keeping patients safe throughout their healthcare journey. RTs care for patients in various settings and manage mechanical ventilation (life-support), artificial airways, and attend emergencies such as cardiac arrests and other urgent clinical care matters (American Association for Respiratory Care [AARC], n.d.-b). As such, RTs may be exposed to opportunities in their day-to-day routines that influence patient safety. Currently, the literature is limited regarding RTs’ safety attitudes and the use of workarounds in respiratory care in the United States (U.S.). Both safety attitudes and the use of workarounds have …

Evidence-Based Strategy To Improve Delirium Detection In Elderly Postsurgical Patients, Aimee Baker

Doctor of Nursing Practice Scholarly Projects

Postoperative delirium (POD) is a serious adverse outcome that frequently affects older adults. Patients experiencing POD are at greater risk for postoperative mortality, increased length of hospital stay, functional decline, and increased cost of care. Current global population trends indicate that the population of adults over the age of 60 years old will double over the next thirty years. Recent guidelines call for hospitals to implement routine delirium assessment to improve early intervention. Nursing delirium assessment tools are a critical resource for early delirium identification. Nursing delirium assessment tools are often highly sensitive and specific for delirium when used in …

Implementation And Evaluation Of A Structured Mentorship Program, Cary Bedinghaus, Caroline Hillman

Doctor of Nursing Practice Scholarly Projects

The project addresses mentorship in a graduate nursing anesthesia program. The goal is to improve the existing mentorship program and to implement a durable and consistent system that gathers and responds to feedback from the students. Two literature reviews form the underpinnings of the structure and evaluation components of the project. Three structural components were identified in the review as highly effective in multiple studies of diverse mentorship programs. The first component is establishing an effective dyad matching scheme. The second component is establishing clear goals. The third component is maintaining the relationship and achieving goals through frequent and consistent …

Malaria, A Burden For Sub-Saharan Africa, Alpha Mamadou Hady Barry

Health and Kinesiology Theses

Malaria has been a worldwide health problem for centuries causing between 1.5 to 2.7 million deaths annually, and mostly affecting children aged 5 and under and pregnant women in Sub-Saharan Africa (SSA) (Phillips, 2001). The discovery of malaria parasites by Laveran in 1880 as well as the finding of mosquitoes as vectors for avian malaria by Ross in 1897, made scientific studies about malaria possible. Between 1898 and 1900, the Italian scientists Grassi, Bignami, Bastianelli, Celli, Golgi and Marchiafava discovered human malaria (Cox, 2010). Malaria has been eradicated from developed countries such as the United Staes and most European countries …

Hooked On A Feeling: The Importance Of Fostering Emotional Intelligence In Adolescents, Annika Wirkkala

Classical Conversations

In the summer of 2023, CNN reported on a 14-year old girl who claimed to have several mental health issues. These included ADHD, depression, autism, and various phobias. After a specialist examined her, however, she was officially diagnosed not with her extensive list of illnesses but with severe anxiety. How did this 14-year old girl become so convinced that she suffered from all of these problems? Social media. Sadly, this girl is not the only victim of social media self-diagnosis. According to the CNN report, “A growing number of teens are turning to social platforms such as Instagram and TikTok …

Storytelling Heals The Wounded Mind, Liliana Whitaker

Classical Conversations

Humans are storytelling creatures. We use stories to communicate ideas in a memorable and engaging way, inspire people to believe in the best version of themselves, find truth in our legal system, empathize with experiences different than our own, and entertain ourselves for hours on end. Recent neuroscience proposes that the human mind thinks through stories. Narrative is the technical and broad term for story, defined as a series of actions and events that unfold over time according to proper cause and effect. Narrative practice is an emerging field comprising of storytelling treatments in therapy and medicine, usually focusing on …

Investing In Health, Not Speed: Alternatives To Medication For Managing Adhd Symptoms In Children And Adolescents, Hananiah A. Blomberg

Classical Conversations

The American culture values speed. While this is often beneficial, making it the chief value is dangerous. In that position, it drives people to pursue instant gratification with minimal effort or risk other values of greater importance. This is evident in America’s medical field, where the rapid results of ADHD medication are embraced at the expense of children’s health. ADHD stands for attention-deficit/hyperactivity disorder, “one of the most common neurodevelopmental disorders of childhood” (“What is ADHD?”, “Symptoms and Diagnosis of ADHD”). Once it is diagnosed by a clinician, treatment options are evaluated. Medication, both stimulant and non-stimulant, is a primary …

Integrating Sport’S Vision Training Into Vision Therapy: The Role Of Occupational Therapy, Emily M. Beaird

Capstone Projects

Sports vision training (SVT) is a specialized area of vision therapy focused on enhancing an athlete's visual skills for peak athletic performance. Vision training is vital for athletes because “athletic performance can be one of the most rigorous activities for the visual system” (Khanal, 2015) and is responsible for upward of 80% of the sensory input received during an athletic performance. However, it is often overlooked in traditional training regimens. Focusing on advanced clinical practice and program development, an unmet need for SVT at Origami Rehabilitation was achieved. The main goal was to create an SVT program that catered to …

Mindful Teaching In Adolescent Dance Educaton: Prioritizing Mental Health, Camille Chimner

Capstone Projects

Mental health continues to be a concern for all ages, especially those within the period of adolescence. Adolescence is a time of great physical, cognitive, social, and emotional change that can be positively facilitated with support and strong coping skills. Adolescent dancers have additional demands placed upon them within the dance space. Adults can play a large role in this support, especially adults who serve as educators and coaches. Dance educators have the opportunity to work closely with dancers and can have great influence on both their physical and emotional health, but are not often trained to be mindful of …

Evaluating Sensory Processing And Functional Outcomes Of Children Participating In A Therapeutic Horseback Riding Read And Ride Program: A Single-Subject Research Study, Samantha Dunleavy-Shotsberger

Capstone Projects

Therapeutic horseback riding (TR) can be beneficial to various populations, such as individuals with disabilities, trauma, behavioral problems, anxiety, developmental delay, depression, and learning challenges. However, individuals come with a variety of complex needs and diagnoses, therefore more research is needed to determine how TR impacts the individual. Specifically, there is a lack of understanding of how the individual’s behavior, learning, and sensory processing is affected by TR intervention. Therefore, this study examined the effects of TR on childhood sensory processing and at-risk academic occupational performance in reading as it relates to behavior and attention. A single subject ABA design …

Promoting And Sustaining An Adaptive Sports Program On A College Campus Through Outreach And Resource Developmen, Morgan E. Otero

Capstone Projects

Participation in physical activity is essential for an individual’s health and well-being. However, persons with disabilities have limited access to physical activity due to personal, environmental, institutional, and/or social barriers. This limited access increases a disabled individual’s likelihood of developing secondary health conditions, decreased mental health outcomes, and feelings of social isolation. To combat this, it is important that these individuals have equitable access to and knowledge of adaptive physical activity opportunities such as adaptive sport, recreation, and fitness. To address this need, this capstone project focused on promoting and sustaining an existing adaptive sports and recreation program through the …

Pediatric Developmental Milestones And Surveillance; Understanding Pediatrician, Ot, Slp, Bcba, And Respective Pre-Professionals’ Current Knowledge, Roles, And Confidence, Gabrielle A. Jones

Capstone Projects

Limited literature exists on developmental surveillance, particularly occupational therapist’s role, and clinicians’ current knowledge and understanding of the CDC milestones. A pilot study was conducted to better understand the current knowledge, role, and confidence of primary care pediatricians, Speech and Language Pathologists, Board Certified Behavior Analysts, Occupational Therapists and respective pre-professionals regarding utilization of updated CDC developmental milestones and developmental surveillance. My objectives involved gaining knowledge and collaborating to create, administer, collect data, and analyze data using an anonymous survey. This also included collaborating to create, edit, and submit an HSIRB application. Results of this study provide supporting evidence that …

Utilizing The Functional Mobility Assessment/Uniform Data Set (Fma/Uds) Registry To Conduct Research Related To Wheelchair Repair Frequency, Brooke Wilson

Capstone Projects

Issues with wheelchair equipment is a common experience for users, but access to repairs and maintenance isn’t always the most efficient process. A large portion of occupational therapy’s (OT) patient population includes wheelchair users, so it’s important to consider the impact of wheelchair breakdown on a patient’s daily function. There has been a lack of research on wheelchair repair frequency during the first year of ownership, so this capstone project focused on developing a manuscript for journal submission on this topic. This was achieved utilizing data from the Functional Mobility Assessment/Uniform Data Set (FMA/UDS) Registry. Client characteristics were extracted from …

Wild Wheels: Meaningful Art Program Designed For Adults With Intellectual And Developmental Disabilities, Alexis Bailey-Lauchie

Capstone Projects

The Wild Wheels program was designed to offer adults with intellectual and developmental disabilities (IDD) an opportunity to engage in meaningful and purposeful art-based activities. The aim supports the distinctive value of occupational therapy (OT) defined as enhancing the health and quality of life (QOL) of individuals by promoting participation and engagement in meaningful daily activities. Typically, for individuals with IDD options for meaningful engagement are limited due to various physical/mental limitations and increased need for assistance. The Center for Disability Services (CDS) at Western Michigan University (WMU) introduced the Wild Wheels program to enable participants to create unique artwork …

Combating Social Isolation Among Older Adults Through Intergenerational Relationships With Children; Facilitating Meaningful Connection During Intergenerational Interactions By Improving Sensory Environment And Increasing Engagement During Group Activities, Lillian John

Capstone Projects

The following capstone project focused on the enhancement of meaningful engagement among all participants of an intergenerational care center. The interventions implemented within the intergenerational program were put in place to facilitate communication, improve behavioral regulation, modify sensory environment, create the just right challenge for group activities, and increase independence to promote meaningful engagement and social connection. The implementation of the interventions was completed through on-site education to the employees, the creation of various educational binders to support the participants individually, and adjustments to the environment and group activities. This capstones projects’ primary goal was to improve the efficacy of …

Development Of Carf Accreditation Requirements For A Vocational Rehabilitation Program For Individuals Independently Living With Post-Traumatic Brain Injury, Samantha Kowalczyk

Capstone Projects

The purpose of this capstone project was to assist a vocational rehabilitation program at Community Connections in Sterling Heights, Michigan with developing requirements for CARF Accreditation for individuals independently living with post-traumatic brain injury. This work program site is unique in the fact it is primarily run by Occupational Therapists and Certified Occupational Therapy Assistants. Achieving CARF Accreditation, which stands for Commission on Accreditation of Rehabilitation Facilities, demonstrates that standards are being met and provides greater satisfaction and the possibility for reimbursement and funding for a program. The overall aim was to assist in the development of the primary materials …

Speech Language Pathologists’ Confidence And Preparedness Working With Clients With Hearing Loss, Katherine Rosa Giustino

Masters Theses

Speech language pathologists (SLP) are professionals who may work with clients with hearing loss. With hearing loss, there are many devices, such as hearing aids, that must be functioning to provide effective speech and language therapy. Therefore, SLPs must be familiar with how to check and maintain these devices to provide optimal therapy. However, it is unknown how confident SLPs are with working with such devices. Data from a Qualtrics survey with questions that assess SLPs’ confidence in working with hearing assistive devices and communicating effectively with individuals with hearing loss was analyzed.

Overall, this study found confidence across all …

The Effect Of Dental Insurance Coverage And Economic Fluctuations On Oral Health Outcomes In The United States, Laura Singletary

Senior Theses

Proper oral health is imperative to overall health, but obstacles often persist in

receiving proper oral health care. Lack of dental insurance coverage and economic recessions are two main factors contributing to oral health outcomes. Extended time without cleanings or addressing current oral health concerns exacerbates oral health problems into more costly procedures for the patient that are conveniently not covered by many insurance plans. This thesis investigates the oral health outcomes associated with periods following economic downturns, specifically citing the time of the Great Recession from 2007-2009.

The Health Effects Of Chocolate: A Literature Review, Erika A. Pierce

Senior Theses

Chocolate has been a part of the human diet for centuries, but while it was once considered a healthy food, it is now seen as a dessert and unhealthy treat. It is known that chocolate contains polyphenols, flavonoids, and minerals that can affect body functioning. To determine the extent to which chocolate plays a role in health, a literature review was performed by searching the PubMed, CINAHL, and Web of Science databases for peer-reviewed articles published between 2004 and 2024. Of the 14 included studies, the health effects of chocolate fell into three overarching categories: neurological effects, including mental health, …