Medicine and Health Sciences Commons^™

Implementation Of Psychiatric Collaborative Care Management In Rural Primary Care Practices, Ryan Dean Kruis

MUSC Theses and Dissertations

Behavioral health (BH) disorders are highly prevalent in the United States and especially concerning in rural communities which disproportionately lack access to BH services. While models for integrating BH into primary care, such as psychiatric collaborative care management (CoCM), have shown promise in mitigating the BH crisis, implementation in rural communities has proved challenging.
This dissertation examines implementation of CoCM nationally and in rural settings through three distinct aims. First, a claims-based retrospective cohort study was used to determine whether commercially insured patients receiving CoCM had lower acute BH care utilization and cost as compared to similar patients not receiving …

Identification And Characterization Of Novel, Small Molecule Inhibitors Of Spermine Oxidase, Amelia Bryn Furbish

MUSC Theses and Dissertations

The major intracellular polyamines spermine and spermidine are abundant endogenous compounds that are essential for cellular growth and development. Dysregulation of polyamine metabolism has been implicated as a key mechanism of injury across multiple forms of clinically challenging pathologies. Of the enzymes within the polyamine pathway, the catabolic enzyme spermine oxidase (SMOX) is of particular interest as it is subject to induction in response to infection, neuronal excitotoxicity, ischemia, and oxidative stress. In addition to the loss of radical scavenging capabilities associated with spermine depletion, catabolism of spermine by SMOX results in the production of toxic byproducts, including H_{2 …}

Respite Care And Relief For Brain Injury Survivors And Their Caregivers, Sydney Bradley

OTD Capstone Projects

This doctoral capstone was completed through a partnership with Neuro Therapy Nashville. Neuro Therapy Nashville (NTN) is an outpatient interdisciplinary clinic that provides services to brain injury survivors including stroke, traumatic brain injury, Parkinson’s, etc. Their mission is work in collaboration with patients to regain as much normal function as possible and return to better, more productive lives through a positive, hopeful and expectant environment. The primary purpose of this project was to create and develop three different programs to provide respite and relief for the brain injury survivors and their caregivers. The process of the project involved collaboration with …

Modeling The Human Learning Process Using An Industrial Steam Boiler Analogy To Design A Psychophysiological-Based Hypermedia Adaptive Automation System, Liliana María Villavicencio López

USF Tampa Graduate Theses and Dissertations

This dissertation aims to address the existing gap in the integration of various dimensions within the student learning system, encompassing cognitive, emotional, and physical variables. The primary objective is to construct a Personalized Learning Adaptive Automation model using Electroencephalography (EEG) technology.

To provide deeper insight into the intricate nature of the Human Learning Process, this study introduces a novel analogy with an Industrial Steam Boiler. This analogy serves as a distinctive contribution to research in the field.

The research methodology involved the collection of brainwaves data from engineering students while they undertook educational tasks of varying levels of difficulty, categorized …

To Decipher Genomic Evolution Of Dengue Virus And To Probe The Activation Mechanism Of A Her2 Directed Chimeric Antigen Receptor Toward Computer Aided Drug Design (Cadd), Mariya Hryb

Theses and Dissertations

This study encompasses three significant chapters focusing on diverse yet interconnected aspects of pharmaceutical research. Chapter 1 delves into the complexities of drug development, emphasizing the challenges and the pressing need for advanced technologies to streamline the process. Computational methods like Computer-Aided Drug Design (CADD) extend their scope beyond small molecules, aiding in the design of intricate biomolecules vital for biomedical advancements, especially in immunotherapy. Chapter 2 introduces the Near-Neutral Balanced Selectionist Theory (NNBST) validated through analysis of Dengue virus evolution. The unique features observed align with NNBST, surpassing existing theories. This approach offers a deeper understanding of viral evolution …

Quality Of Life And Well-Being Of Breast Cancer Patients While Following A Breast Cancer-Related Lymphedema Surveillance Protocol, Madisen L. Prasek

Occupational Therapy Capstone Presentations

With breast cancer being one of the most common cancers in women globally and treatments being one of the greatest risk factors for secondary lymphedema (Eaton et al., 2020; He et al., 2023; Jørgensen et al., 2021), it is essential to understand how a breast cancer diagnosis and treatments affect an individual’s quality of life (QoL) and well-being. This capstone project aimed to gain in-depth clinical skills in lymphedema care, specifically in breast-care related lymphedema (BCRL), and educate on the psychosocial needs of the breast cancer population, with an emphasis on how being at risk for or diagnosed with BCRL …

Playing It Sun Safe: A Quality Improvement Project, Sarah P. Tarr, Kathryn K. Dambrino, R. David Phillippi, Ashley Karpinos

DNP Projects

Background: Athletes who play outdoor sports have multiple risk factors for the development of skin cancer. Literature highlights the need for the use of evidence-based strategies to improve the knowledge and utilization of sun protection practices in this high-risk population. Methods: Playing it Sun Safe was a multifaceted skin cancer prevention initiative implemented in a population of collegiate soccer athletes in collaboration with a university athletic department and campus health clinic. Evidence-based interventions were designed through application of the Health Belief Model (HBM) and were implemented using the Institute for Healthcare Improvement (IHI) quality improvement framework. Purpose: The two-fold aim …

Type 2 Diabetes Health Beliefs Of College Students, Emily Spindler

Honors College Theses

College students of health-related majors are sometimes assumed to have greater health literacy. The belief can be attributed to the students taking classes discussing health problems, diseases, risk factors, medical management, nutrition, and exercise. How often the health classes discuss type 2 diabetes (T2D) remains undetermined; therefore, the amount of knowledge and beliefs health students have of T2D is unknown. The objective of the study was to examine the relationship between students' majors, health beliefs about T2D, and engagement in behavioral risk factors at a mid-size regional public university. A quantitative, non-experimental, survey design was chosen, and responses were obtained …

Tunable Dual-Phase Dual-Drug Delivery System Using A Plga Microparticle/Pva Hydrogel Composite, Timothy John Eck

Theses and Dissertations

Current drug-eluting coatings have demonstrated controlled long-term, sustained release but have only tried to mitigate short-term burst release as a negative side effect. For applications like wound healing, there is a need for a drug-eluting coating which is adjustable in both short- and long-term release, independent of each other. We present a tunable dual-phase dual-drug delivery coating composed of drug-loaded polymer microparticles and drug-loaded hydrogel which can control short term and long term release individually in this study. This coating was created using lidocaine and dexamethasone encapsulated in poly(D,L-lactide-co-glycolide) particles combined with lidocaine- and dexamethasone-loaded poly(vinyl alcohol) hydrogel. Hydrogel drug …

Veterinarian Perception Of The Impact Of Covid-19 On The Mortality Of Pets, Jason Bainbridge

Honors Theses

The pandemic led to many changes in society, changes that may have affected pets either directly or indirectly from the new way people had to live life. The primary variable of investigation is if the changes were significant enough to affect pets enough to see a trend in mortality. This thesis used a survey, sent out to veterinarians for their perspective, to see the effects the pandemic had on the mortality of pets, as well as any secondary variables. This survey had 38 responses, with 34 being eligible to complete the survey. The survey did not obtain the information of …

Effects Of Three Different Loading Models On Strength And Body Composition In Resistance Trained Persons, Orlando Rivera

Seton Hall University Dissertations and Theses (ETDs)

Background: Periodization of the annual training plan is a commonly utilized tool within the strength and conditioning community. Within the periodized plan, load is a key variable that is often manipulated to optimize strength development. At the present moment, a common model for load prescription involves the use of a percentage-based training (PBT) plan. However, inherent problems within a PBT loading model may reduce the accuracy of the training stimulus due to various reasons including atypical one repetition maximum (1RM) performance, strength improvements, or an acute decrease in an individual’s ability to perform. Thus, autoregulatory loading models may be a …

Current Awareness And Tools Available For Stress-Induced Ibs In Children, Tripta Rughwani

Harrisburg University Dissertations and Theses

Introduction: Irritable Bowel Syndrome (IBS) is a gastrointestinal (GI) disorder that affects 13-38% of children (4-17 years) worldwide. Early life stresses like trauma, family pressure, abuse, and parenting factors may alter the HPA axis leading to GI sensitivity. IBS symptoms can impact an individual’s quality of life, affect school attendance, and can be emotionally and financially stressful for the caregivers. To date, there is no known cure for IBS. While antidepressants have shown some efficacy in treating moderate to severe IBS in adults, prescribing a universal antidepressant drug, especially to the pediatric population is challenging due to the variability …

The Dark Triad, Creativity And Morality, Erin Beers

Honors Theses

The Dark Triad of personality is the combination of narcissism, Machiavellianism, and psychopathy. The associative theory of creativity involves the default mode network of the brain, which is responsible for memory tasks, imagination, and thoughts of self. Since the Dark Triad traits involve inhibitory control and imagination, there is a high likelihood that observed alterations in these processes may be used to predict dark creativity patterns. Malevolent creativity involves using new ideas to complete tasks that will harm others. With creativity not being limited to positive outcomes, aspects of morality are also part of the creative decision-making processes. Morality is …

Development Of Novel Analytical Methods For The Investigation Of Mammalian Tissues And Cells, Grace A. Binder

USF Tampa Graduate Theses and Dissertations

This dissertation endeavors to advance the frontiers of analytical chemistry by addressing critical challenges across three distinct chapters. In the first chapter, the focus is on the evaluation of digestion methods for the analysis of trace metals in mammalian tissues and the Standard Reference Material NIST 1577c. The primary goal is to optimize methodologies, laying the groundwork for reliable trace metal analysis and furthering our understanding of their roles in biological systems.

Transitioning into the realm of immunomodulation, the second chapter elucidates immune response, disease and treatment through the optimization and discovery of STING modulators, utilizing the luciferase assay for …

Capstone Curriculum For University Students With Intellectual Disabilities At Lipscomb University’S Ideal Program, Aubrey J. Barcelo

OTD Capstone Projects

The IDEAL program at Lipscomb University is an inclusive postsecondary education program for young adults with intellectual disabilities. This project was centered around creating a curriculum for the capstone course for fourth year students in the IDEAL program. The capstone course is two semesters of 14-week curriculum aimed at completing an independent/semi-structured needs-based project and experiential learning. The deliverables of the advanced program capstone include a culminating project based on the five components of Person-Centered Planning. The curriculum includes templates and task lists incorporating principles of universal design to facilitate students’ ability to complete the project independently.

Development Of Teacher Training Program, Manual, & Curriculum Guide For Inclusive Dance Studio, From An Occupational Therapy Perspective, Susanna C. Dunn

OTD Capstone Projects

This capstone project was completed in collaboration with MOVE Inclusive Dance, a nonprofit, inclusive dance studio specifically serving individuals of all ages with various disabilities. A needs assessment conducted with the staff at MOVE necessitated a cohesive teacher manual, including teacher training protocol, disability index, safety precautions, sample class activities, curriculum guide, and more. The focus of this capstone was to create and distribute a teacher training manual to dance teachers at MOVE Inclusive Dance. The teacher training manual was created using anonymous pre and post test qualitative and quantitative surveys to assess teacher perceptions regarding feelings of confidence and …

Healthcare Key Performance Indicators; A Dha Study In Perception And Importance By Clinical And Non-Clinical Healthcare Professionals At A Large Healthcare System, Jennifer Burchill

MUSC Theses and Dissertations

Healthcare systems in the United States are unique structures where compassion for the care of others meets the science of medicine. It is a business, but it is a business with passionate professionals who care about the health of its customers, or patients. While most businesses have one structured financial system, health care contains finance for both the business and the patient.

KPIs or Key Performance Indicators, reported by finance are usually created for revenue driven initiatives with little contact and communication with the clinical teams. KPIs are a prominent driver utilized by health systems and reimbursement agencies to measure …

African American Women’S Perceptions Of A Group Based, Diabetic Medical Nutritional Therapy Intervention: A Qualitative Study, Megan Mcmahon, Laura Gray

DNP Projects

Background: African American women exhibit lower rates of attaining recommended diabetes management goals such as optimal blood sugar, cholesterol, and blood pressure numbers compared to other racial and gender groups. As a result, they bear a disproportionate burden of the adverse outcomes associated with poorly managed type 2 diabetes, including increased complications and mortality rates compared to other demographic groups. Despite favorable qualitative findings regarding group-based interventions for African American women with other chronic diseases, a notable gap in the literature exists regarding the women’s perceptions of a group-based medical nutritional therapy tailored to type 2 diabetes. Purpose: This scholarly …

Synthesis And Characterization Of Polymeric Nanoparticles To Enhance Celleullar Drug Delivery, Rahma Aly

Chemistry Theses

Medicines in the form of nanoparticles called nanomedicines, stand at the forefront of revolutionary advancements in healthcare, offering precise drug delivery and diagnostic capabilities. A recent example of nanomedicine in the clinic is the COVID-19 vaccine, which helped prevent death during the pandemic. While the potential benefits are immense, a myriad of challenges complicate their seamless integration into clinical practice. The design and fabrication of nanoparticles demand meticulous attention to biocompatibility and toxicity. Interactions with biological systems are complex, requiring a delicate balance between therapeutic efficacy and safety. The reticuloendothelial system's rapid clearance of nanoparticles, their instability in physiological environments, …

An Exploration Of The Effectiveness Of Xanthorrhiza Simplicissima And Its Secondary Alkaloids As Antibiotics Against Staphylococcus Aureus With The Use Of Reserpine, Donald Bothe, Savita Chaurasia

Undergraduate Theses

Xanthorhiza simplicissima is a plant that is steeped in medical history. It has been used for hundreds of years by the Native Americans, and later by the Europeans, of Appalachia for its medicinal properties. One of the most useful medical applications of this plant are its antibiotic properties, as typified by its use as a tea that was consumed to treat mouth sores. These antibiotic properties can be attributed to some of its secondary alkaloids such as berberine, liriodenine, oxyacanthine, and magnoflorine. These compounds have been studied in other systems; however, oxyacanthine and magnoflorine have not been researched in tandem …

The Experiences Of Staff Nurses Who Remained In Their Permanent Positions During The Covid-19 Pandemic, Huifang Cheng

Seton Hall University Dissertations and Theses (ETDs)

Amidst the persistent shortage of practicing nurses in the nursing profession, exacerbated by the unprecedented challenges of the COVID-19 pandemic, this study investigates the experiences of permanent staff nurses during the pandemic, with a specific focus on the factors influencing their decision to remain in their roles despite the adversities. Employing a phenomenological approach, in-depth interviews were conducted with thirteen permanent staff nurses to explore the intricacies of their experiences. Throughout the pandemic, the participants encountered profound ethical dilemmas. However, their determination to persist was fueled by a sense of professional duty, solidarity within their professional community, and deep camaraderie …

Relationship Between Knowledge, Years Of Licensure, And Attitudes Of Midwives About Female Genital Mutilation And Its Prevalence Among Their Patients In Bawku, Ghana, Frank Debrah

Walden Dissertations and Doctoral Studies

Female genital mutilation (FGM) is one of the hindrances to girls' development. FGM is often a rite of passage between childhood and adulthood. This cross-sectional study examined the relationship between the knowledge, years of licensure, and attitudes of midwives regarding FGM and the prevalence of FGM among their patients in Bawku, Ghana. Bronfenbrenner's social ecological model served as the theoretical framework to describe the link between midwives' knowledge, attitude, years of licensure, and FGM prevalence. The knowledge and attitude of midwives were classified as exosystem factors. Hence, their direct interaction with patients is likely to affect the patient's practice of …

Implementation Of A Standardized Suicide Screening Process In A University Student Health Clinic: A Quality Improvement Project, Addie Grace Strong, Kathryn Dambrino, R. David Phillippi, Linda Wofford

DNP Projects

Background: Suicide is a leading cause of death among college age students, prompting the need for evidence-based screening tools like the Columbia Suicide Severity Rating Scale (C-SSRS) to enable early detection and timely intervention. Inconsistencies in suicide screening may pose a risk of missed intervention opportunities. This Doctor of Nursing Practice project specifically aimed to improve the quality and consistency of suicide screening in a university student health clinic by implementing the C-SSRS tool into the clinic workflow during mental health appointments. Methods: Employing a quality improvement framework, this scholarly project followed the Institute for Healthcare Improvement Model for Improvement …

Dental Therapists: Arizona Dentists’ Perceptions And Attitudes Towards The Workforce Model, Autumn Butler

Dental Hygiene ETDs

Dental therapists have emerged as a solution to improve access to dental care. Understanding Arizona dentists' attitudes towards dental therapists is crucial in the successful integration into the dental workforce and its potential to be a viable solution. Licensed dentists in Arizona were invited to participate in an anonymous study. Participants were asked questions regarding the scope of practice, current educational standards, and quality of treatment to determine the attitudes of dentists towards dental therapists. Eight dentists licensed in Arizona participated in the survey (N=8). The study found concerns among Arizona dentists regarding the treatment quality and educational standards (N=3; …

Perceptions Of Patient-Healthcare Provider Relationships In The Management Of Type 2 Diabetes, Desiree D. Lacey

Walden Dissertations and Doctoral Studies

The patient-healthcare provider relationship (PPR) is the foundation of clinical care: it is established as a human relationship and has a profound effect on health outcomes. Though PPR has been studied in multiple health domains, there is very little on its role in managing Type 2 diabetes mellitus (T2DM). The purpose of this phenomenological qualitative research study was to better understand the challenges faced by healthcare providers (HCP) and T2DM patients within the clinical PPR for diabetes selfmanagement. The health belief model served as the theoretical framework and the diabetes self-management education program as the conceptual framework. Participants were recruited …

Music For Anxiolysis In Primigravida Undergoing Cesarean Delivery Under Neuraxial Anesthesia, Jonathan Garcia

Doctor of Nursing Practice Scholarly Projects

Primigravida women undergoing cesarean section under neuraxial anesthesia frequently suffer from anxiety in the perioperative period. Literature suggests this population suffers disproportionately due to gender, surgical naiveness, lack of birthing experience, fear of complications, and exposure to the operating theatre’s noxious environment. Despite the high anxiety prevalence and numerous negative consequences, safe treatment options are lacking. Unfortunately, contemporary pharmacologic therapy to treat anxiety threatens the parturient and the fetus. However, the field of medicine has long appreciated music’s physiologically calming effects on the body. This project details a literature search, review, synthesis, and analysis of the available literature supporting and …

Hear All About It: Health Literacy And Pediatric Ototoxic Chemotherapy, Sarah Belton, Abigail Jones

Theses & Honors Papers

This study examined the accessibility of informational health documents about ototoxic chemotherapy provided to caregivers of pediatric cancer patients. Hearing loss as a result of chemotherapy can result in financial, social, and developmental consequences for these patients. Caregivers are an integral part of the medical team, and their knowledge of procedures and treatments directly impacts their ability to make informed decisions for the patient.

This study qualitatively analyzed informational health documents about chemotherapy, acquired from the websites of National Cancer Institute (NCI) designated cancer centers using federal guidelines put into place by the Plain Writing Act of 2010 and the …

Marshall Co. Parks Department: Miracle League Of Western Ky, Ragan Harris Winters

OTD Capstone Projects

This doctoral capstone project was completed by Ragan Harris Winters through a partnership with the Miracle League of Western Kentucky at Mike Miller Park to develop a training video for volunteers participating in future baseball seasons. The focus of this project was to develop a brief volunteer training video with beneficial information to prepare volunteers to assist players before, during, and after the games. The training video aimed to educate volunteers of the Miracle League to assist players with varying disabilities and what to expect when volunteering at the CFSB Field of Dreams. The project also included administrative tasks related …

Development Of Evidence-Based Clinical Practice Guidelines For Pediatric Patients At Risk Of Emergence Delirium, Christina Bensley

Doctor of Nursing Practice Scholarly Projects

Postoperative emergence agitation or emergence delirium (ED) is a phenomenon that can occur in patients who have undergone surgery requiring the administration of inhaled anesthetics. ED is a postoperative side effect of general anesthesia commonly experienced by pediatric patients that negatively impacts a patient’s overall postoperative experience. There is a lack of consistent standardized clinical practice guidelines for general anesthesia in pediatric or adult populations. The primary goal of this scholarly project is to develop and implement clinical practice guidelines focusing on the occurrence of postoperative ED and select adverse clinical outcomes in pediatric patients undergoing general anesthesia. The project …

Final Scholarly Project: Clinical Guidelines For The Perioperative Management Of Patients With Opioid Use Disorder Requiring Anesthesia, Jessica Kayla Joos

Doctor of Nursing Practice Scholarly Projects

Opioids have highly addictive properties that allow for high levels of misuse. Since the early 1990s, the misuse and deaths rates related to narcotics have steadily risen in the United States. Efforts to identify individuals using opioids prior to surgery have proven difficult. The number of patients misusing opioids and reporting for surgery can only be estimated due to under-reporting related to fear and self-stigma. With 50 million surgeries in the U.S. annually and 3.32 million people misusing opioids monthly, the chances of a patient with Opioid Use Disorder (OUD) presenting for anesthesia are exceptionally high. Moreover, patients who rate …