Medicine and Health Sciences Commons^™

Perception Of Pre-Existing Dm2 Management Among Pregnant Asian Indian Immigrants During Covid-19, Sanya Bedi Grewal

Walden Dissertations and Doctoral Studies

Type 2 diabetes is a chronic disease that exerts a significant burden among communities by increasing healthcare costs, reducing productivity, higher rates for premature mortality, and tangible socioeconomic burden, which overall reduces the quality of life. The purpose of the study was to explore the perception of pregnant Asian Indian immigrants regarding diabetes self-management strategies during the COVID-19 pandemic. Five women were recruited via purposive sampling from Facebook groups. Data were collected via individual interviews using Facebook groups. The health belief model was used to help understand and interpret the findings. Clarke and Braun’s thematic analysis method was used to …

Understanding The Relationship Between [Atp], Growth Rate, And Inoculum Effect In Β-Lactamase Producing Bacteria, Ariane R. Kalifa

All HCAS Student Capstones, Theses, and Dissertations

2.8 million Americans are infected with antibiotic-resistant bacteria on an annual basis, leading to increased mortality and morbidity. With the incidence of infection due to antibiotic-resistant bacteria on the rise, it is critical to understand the mechanisms bacteria use to resist antibiotics. The inoculum effect (IE) is a phenomenon that has been observed for many antibiotics and bacterial species. In IE, the density of the bacterial population determines the minimum inhibitory concentration of the antibiotic (MIC) of an antibiotic; as the density of the bacterial population increases, the MIC increases. IE is highly prevalent in bacteria that express β-lactamases where …

Noninvasive Technique For Measuring Cardiac Output, Grace E. Kolar, Rachel Simonton, Eli Strohecker

Williams Honors College, Honors Research Projects

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Fine-Tuning Gene Expression: A Novel Therapeutic Approach For Rett Syndrome, Yewon Rhee

Master's Theses

Rett Syndrome (RTT) is a neurodevelopmental disorder that is characterized by a myriad of debilitating symptoms impacting nearly every aspect of life, including motor and gait impairment, social and cognitive deficits, as well as seizures and breathing abnormalities. RTT is caused by X-linked de novo loss-of-function mutations in the methyl-CpG binding protein 2 gene (MECP2), which is an essential epigenetic modulator. Any cure for RTT must directly target MECP2, a highly dosage-sensitive gene. This thesis developed a novel MECP2-targeted therapeutic approach using site-blocking antisense oligonucleotides to prevent microRNA-induced repression of MECP2, allowing fine-tuned control of gene expression. Here we report …

Building Trust: The Role Of Place-Based Consciousness In Vaccine Hesitancy, Ramsey W. Ash

Quantitative Social Science Undergraduate Senior Theses

Vaccine hesitancy poses a threat to public health initiatives of the 21st century. Following a stark divide in the rural/urban COVID-19 vaccine uptake and harsh disparities between these areas in COVID-19 moralities and morbidities, further understanding of the drivers of vaccine hesitancy are needed. This study makes use of the framework of place-based consciousness (PBC), pioneered by scholars of rural political science, such as Katherine Cramer, to explore this phenomenon as a mechanism by which to understand vaccine hesitancy. To examine this, an experimental survey was distributed to 300 Americans (150 rural and 150 urban) that inquired about their PBC, …

Transport Of The Fluorescent Substrate Asp+ By Organic Cation Transporter-3 In Human Corneal Epithelial Cells, Jeremy Laws

Theses & Dissertations

ABSTRACT

Organic cation transporter-3 (OCT3) is expressed abundantly throughout the body, but little is known about the presence of these transporters within the eye and, more specifically, the cornea epithelium. An extensive library of compounds interacts with OCT3, including the fluorescent molecule ASP⁺ and metformin. Metformin is an OCT3 substrate and antidiabetic medication that can lower the risk of eye-related diseases like keratopathy and retinopathy linked to hyperglycemia. Utilizing high throughput microplate assays in a human cornea epithelial cell line (HCE-S), the time-dependent saturation of ASP⁺ uptake and the competition of ASP⁺ uptake by corticosterone (CORT), a …

Development Of An Advanced Step Counting Algorithm With Integrated Activity Detection For Free Living Environments, Paige M. Dolan

Master's Theses

Physical activity plays a crucial role in maintaining overall health and reducing the risk of various chronic diseases. Step counting has emerged as a popular method for assessing physical activity levels, given its simplicity and ease of use. However, accurately measuring step counts in free-living environments presents significant challenges, with most activity trackers exhibiting a percent error above 20%. This study aims to address these challenges by creating a machine learning algorithm that leverages activity labels to improve step count accuracy in real-world conditions. Two approaches to balancing data were used: one employed a simpler oversampling technique, while the other …

Postural Control In Adults With Age-Related Hearing Loss, Elizabeth Tobener

Alternative Theses and Dissertations (AETDs)

The present study investigated postural control measures in adults with age-related hearing loss (ARHL). Individuals between the age of 50 and 70 were recruited (10 with normal hearing, 32 with ARHL) and evaluated using pure-tone audiometry, vestibular function assessments, and postural control measures. Results of this study revealed significant correlations between ARHL and cervical vestibular evoked myogenic potential (VEMPs) and ocular VEMPs. As ARHL increased, amplitude of cervical VEMPs and ocular VEMPs decreased. There were no significant correlations for ARHL and video head impulse test (vHIT) gain. Single leg stance with head tilt was significantly associated with ARHL. As ARHL …

Representation Of Nouns And Verbs During Play Between Caregivers And Children With Developmental Language Disorder, Alaina Grissom

Alternative Theses and Dissertations (AETDs)

Purpose. This project compared how children and caregivers use gestures and objects to contribute to the representation of nouns and verbs during play interactions between children with developmental language disorder (DLD) and their caregivers. Observations were used to determine if there was any differentiation in how children or caregivers used gestures and/or objects when nouns and verbs were presented within the play context.

Methods. Observations of parent-child dyads were recorded at a local children’s museum. All dyads included children with DLD between four and six years of age. The child and caregiver’s use of gestures and objects within the interaction …

Evaluation Of Sphingolipid Biosynthetic Inhibitor L-Cycloserine To Prevent Retinal Degeneration, Faiza Tahia

Alternative Theses and Dissertations (AETDs)

Retinal degenerative diseases, affecting millions worldwide, are caused by irreversible photoreceptor cell death. These conditions lead to irreversible vision loss or blindness, presenting significant economic challenges. Retinal degenerative diseases result from a complex interplay of genetic and environmental factors, such as light exposure and oxidative stress. Effective treatments are currently limited, which underscores the urgent need for comprehensive solutions. Ceramide, a bioactive sphingolipid, has emerged as a pivotal mediator in the apoptotic cascade associated with retinal degeneration, presenting a promising target for therapeutic intervention. This research explores the therapeutic potential of L-Cycloserine, a small molecule inhibitor of de novo ceramide …

The Role Of Skeletal Muscle Ampk/Mtorc1 Signaling In Disrupted Metabolism During Chemotherapy Treatment And Recovery, Jessica L. Halle

Alternative Theses and Dissertations (AETDs)

Colorectal cancer patient survival rate has increased over the past decade due to improved screening and treatment options. The clinically relevant FOLFOX (5-fluorouracil [5-FU], oxaliplatin, leucovorin) chemotherapy regimen is a mainstay treatment option, despite the development of severe side-effects that can occur acutely or develop as a late effect after treatment cessation. Cancer and chemotherapy can promote systemic metabolic dysfunction; consequently, patients will likely experience debilitating weakness and fatigue, and these symptoms are often accompanied by excessive fat and muscle loss. Although studies have established chemotherapy effects on the tumor, few have investigated mechanisms underlying the metabolic complications associated with …

Sensory's Role In The General Education Classroom, Grace Sievert

OT Student Capstones

Background. Sensory processing significantly impacts students’ ability to learn successfully in educational environments (Little et al., 2017). Classroom sensory strategies have been shown as an effective method to regulate student’s sensory systems, promoting academic success through improved participation and attention (Dean et al., 2018). Academic faculty are the ideal candidates to provide sensory strategies to the general student population, yet these roles typically lack sensory education (Budd & Rehling, 2014). Occupational therapists are in a prime position to provide academic faculty with sensory education due to their expertise in sensory processing, their responsibility to provide professional development to educators, and …

Leisure Education Program For Older Adults At Beatitudes Campus, Kendall Morrissey

OT Student Capstones

As individuals age they may experience a decrease in quality of life that impacts their overall health and well-being. One way to improve quality of life in older adults it through leisure activities that can provide a sense of purpose, autonomy, and roles or routines within their lives. The purpose of this doctoral capstone experience and report is to enhance older adult’s leisure competence through to improve leisure satisfaction and overall quality of life. The occupational therapy capstone student developed a five-session Leisure Education Program for residents at a continuing care retirement community, Beatitudes Campus. Using an occupational therapy point …

Low Vision And Dementia, Anna Bradner

OT Student Capstones

Low vision and dementia are highly common among older adults. Individuals with these conditions often experience decreased ability to perform daily tasks safely and independently due to the functional implications of visual and cognitive decline. This leads not only to decreased participation in meaningful activities but also to an increased dependence on a caregiver. Over time, these caregivers can experience a perceived strain, or caregiver burden, that affects not only their own health but also the health of the individual they are caring for. Occupational therapists can provide skilled services to address the needs of older adults with low vision …

Novel Occupational Therapy Treatment In The Pediatric Intensive Care Unit, Aegia Mari Baldevia

OT Student Capstones

Millions of children are hospitalized in the United States each year. Hospitalization can negatively impact the child, their family, and their education. Occupational therapy can be used to target the family unit in coping and engagement in meaningful occupations in the hospital setting. The magazine photo collage has been used in the past to target coping and social interaction, but there is limited evidence of its use in occupational therapy in the hospital setting. This project aimed to explain the experience of families in creating and using the magazine photo collage in occupational therapy in the hospital setting. In this …

Understanding The Role Of Ot In Infertility, Jordan Swarztrauber

OT Student Capstones

Infertility is prevalent in the United States, affecting approximately 16% of couples. Those affected by infertility often seek Assistive Reproductive Technology (ART) treatments to help them conceive. Past literature has found that ARTs have negative effects on those undergoing treatments in their occupations, routines, habits, and mental health. Although it is commonly known in the medical literature, there is a dearth of research and clinical support for individuals who are experiencing disturbances in the above-described areas, leaving a gap in care for individuals who are undergoing ARTs. The present research study consists of 13 in-depth qualitative interviews, which gather data …

Dance As A Sensory-Based Occupation To Improve Regulation Skills In A Pediatric Population, Anna Seedall

OT Student Capstones

Dance is integrated into every culture. There are several psychosocial, cognitive, and physical benefits to dancing. The sensory system is highly involved in dance. Further, many children have difficulties with sensory processing and regulation. There are finite programs outside of therapeutic services to address this gap in utilizing sensory strategies. Limited research has been conducted to determine if dance is an effective approach for improving sensory regulation. A 10-week program was designed for eight participants, ages 4 to 8 by an occupational therapy doctoral student. The program utilized the Alert Program®, breathing techniques, yoga positions, tactile input, proprioceptive input, and …

Maximizing Prehabilitative Care For Breast Cancer: Program Evaluation And Quality Improvement In Outpatient Therapy, Aedan Collins

OT Student Capstones

Background. Individuals with breast cancer experience side effects and impairments from the disease and treatments that impact their physical, cognitive, neurological, emotional, and social health. Breast cancer-related psychosocial issues are most prevalent right after diagnosis. Services prior to receiving breast cancer treatment or surgery are termed prehabilitation (prehab) and have been shown to improve patient outcomes. Occupational therapy (OT) practitioners play an important role in the rehabilitation of patient with cancer and can contribute to prehab services.

Methods. This was a program evaluation and quality improvement project that used data collected during prehab evaluations for breast cancer to create supplemental …

The Effect Of The Safe And Sound Protocol On The Emotional Regulation Of Children: The Caregiver Experience, Brooklyn Gratzer

OT Student Capstones

Introduction: Emotional regulation is a complex process that develops throughout one's lifetime. Emotional dysregulation can be due to an individual’s unbalanced physiological state leading the vagus nerve into a “fight or flight” mode (Auditory Processing Center, 2022). The Safe and Sound Protocol (SSP) targets the autonomic nervous system through filtered music to improve social-emotional functioning by bringing safety to the nervous system.

Methods: The purpose of this project is to evaluate the effect of the SSP on emotional regulation in children through the caregivers perspective. Participants were chosen if their child had difficulties with emotional regulation. They completed a caregiver …

Discharge To Success: A Life Skills Manual Developed By Ots For Transitioning Individuals With Smi From Forensic Hospitals, Kelsie Cooper

OT Student Capstones

This research project examined the development of and staff training using a discharge manual aimed at improving transition outcomes for individuals with serious mental illness (SMI) within a forensic psychiatric setting. The manual, tailored to the needs of patients at Arizona State Hospital (ASH), addresses barriers to community reintegration through the provision of occupation-based interventions and resources. Occupational therapists (OTs) played a central role in the project, emphasizing the importance of meaningful activities in promoting independence and well-being among individuals with SMI in an effort to reduce recidivism. Interdisciplinary collaboration among healthcare professionals underscored the holistic approach to mental health …

Exploring Advanced Technology In The Outpatient Adult Neurorehabilitation Clinical Setting, Cynthia Burhop

OT Student Capstones

Background: Occupational therapists have access to many advanced technological devices that can aid in enhancing patients’ functional occupations. Such devices can be very costly and beneficial to the profession at large however they are not being used to their fullest potential. Barriers surrounding the usage of advanced technology can include a lack of therapist training, a lack of confidence in skills required to operate the devices and being uninformed on the benefit that technology can have on the client’s functionality. Purpose: The purpose of this study is to identify and reduce the barriers surrounding the usage of the neurosensorimotor integrator …

The Effects Of A Training Module On Ot's Self-Efficacy In Montessori Settings, Raquel Crowe

OT Student Capstones

Background. The Montessori method is a non-traditional education setting that uses child-directed learning with practical life materials to foster natural learning patterns in students. Montessori students have been shown to display increased cognitive, academic, and psychological skills that continue to impact an individual through their adulthood. Due to the traditional ways of the Montessori method, related services, such as occupational therapy (OT), are not always viewed as a valuable addition to a student’s learning environment. Lack of familiarity and education regarding the Montessori method may impact the self-efficacy an occupational therapist has when providing services to Montessori students. Methods. A …

A Client-Centered Life Skills Education Program For Enhancing Successful Integration Among Newly Arrived Refugee And Asylum Seeking Afghan Women, Irene Kwangaba

OT Student Capstones

Introduction. Refugees and asylum seekers are subsects of immigrants who are forcibly displaced from their home environments. They face unique challenges after immigrating that prohibit their ability to acclimate to their new environments, such as language barriers, role and identity changes, and a lack of social support. This capstone project explores the effects of a ten-week client-centered life skills education program on integration into their newfound communities for refugees and asylum seekers. Methods. Three participants who identified as refugees or asylum seekers seeking services at the community partner for this project, Matthew House, were included. All participants were from …

Canine Animal Assisted Therapy: Educating Otp And Students, Anna Medel

OT Student Capstones

Canine animal assisted therapy demonstrates health benefits throughout numerous populations and healthcare environments. Unfortunately, there is limited literature and resources available regarding how to utilize canine animal assisted therapy within the profession of occupational therapy. The capstone project proposed the following question due to the limited resources available: within the profession of occupational therapy, would an educational course on how to utilize an animal assisted therapy canine increase the knowledge, confidence, and interest of use within the profession? An educational workshop, Canines in Occupational Therapy, was developed throughout the 12-week capstone experience and administered on March 30th, 2024, at A.T. …

Healthy Living After Cancer: A Community-Based Program To Improve Exercise And Nutrition In Cancer Survivors, Czarina Banzon

OT Student Capstones

Persevering through cancer treatment is an uphill battle, but continuing survivorship for the rest of their lives becomes the biggest challenge for cancer survivors. Concerns in survivorship include side effects from cancer treatment, fear of recurrence, and returning to previous roles and routines. Additionally, survivors must maintain their health and well-being through exercise and nutrition. Occupational therapists possess the necessary skill set to create programming for cancer survivors that is relevant and realistic. They can take side effects from treatment into consideration and offer personalization of goals and maintenance strategies. Furthermore, occupational therapists can offer simple alternatives to maintaining a …

The Impact Of Individualized Exercise Programs On Athlete's Perception Of Performance In Winter Adaptive Sports, Kiley Foster

OT Student Capstones

Background: Historically, people with disabilities have faced barriers to participating in meaningful occupations like adaptive sports. Despite the positive effects of adaptive sports, sport-induced injury can impede an individual’s functional independence. This capstone project aimed to evaluate the impact of individualized exercise programs on athletes’ perception of performance in winter adaptive sports, with a focus on injury prevention.

Methods: Two recurring High Country Adaptive Sports athletes participated. They provided consent to engage in a 10-week individualized home exercise program (HEP) prior to the 2024 ski season. They completed a pre-survey at the initial meeting and a post-survey upon completion of …

Entrepreneurial Self-Efficacy In Occupational Therapy Graduate Students, Marisa Lamb

OT Student Capstones

This capstone aims to measure entrepreneurial self-efficacy in students enrolled in occupational therapy (OT) programs across the nation by sending an online survey. Occupational therapy’s profession has expressed a need for more entrepreneurs within its field. Further research into the factors that contribute to the lack of entrepreneurship in OT was performed and are described. The factor in which this capstone focuses is the first of its kind as there were no studies that have directly targeted OT graduate students as a population to measure entrepreneurial self-efficacy (ESE). By reporting on data representative of national demographics, this capstone seeks to …

The Impact Of Vision Training On Visual Perceptual Skills In Male Soccer Players, Mackenzie Watterson

OT Student Capstones

Background. Athletic performance is one of the most visually demanding activities an individual can participate in. Due to the physically and cognitively demanding nature of soccer, it is imperative to take a deeper look into how visual-perceptual skills impact overall athletic performance. If an athlete’s visual system does not correctly receive messages from environmental stimuli, overall athletic performance may suffer. For an athlete to function at their highest performance possible, it is essential to focus on improving visual-perceptual skills.

Methods. A mixed methods approach was used to determine the impact of vision training on visual perceptual skills in male soccer …

Community Education To Postpartum Parent About Pelvic Health, Rebecca Downs

OT Student Capstones

There is a lack of literature about whether pregnant and postpartum parents receive enough support and education about common pelvic floor conditions and treatment options. This lack of support can delay or stop them from knowing they have pelvic floor dysfunction, as well as seeking services to treat their pelvic floor dysfunction. This project provided pelvic floor education focused on bladder health, bowel health, and sexual health to pregnant and postpartum parents. The objective of this pelvic health education program was to increase pelvic floor knowledge in pregnant and postpartum parents, which would empower them to seek pelvic floor therapy …

Nourish To Flourish: An Educational Program For Caregiver Involvement With Children Who Have Developmental Delay, Rhea Florez

OT Student Capstones

Caregivers of children with additional needs often experience high rates of burnout, stemming from limited time, lack of knowledge about child development and/or diagnoses, and elevated stress levels. This burnout can result in decreased caregiver follow-through on addressing a child’s needs or interventions in the home environment. This project aimed to bridge the gap between parents and increase their follow-through in the outpatient setting for children diagnosed with developmental delay and/or additional needs by providing a 10-week educational program. A mixed-methods approach was used with a pre-intervention and post-intervention using the Parenting Sense of Competence Scale (PSOC) to measure parental …