Medicine and Health Sciences Commons^™

An Examination Of Traumatic Brain Injury And Genes For Neurotrophins And Apolipoprotein E In Predicting Cognitive Function In Older Adults: The Cache County Study, Mikaela A. Drewel

All Graduate Theses and Dissertations, Fall 2023 to Present

Recovery from a traumatic brain injury (TBI) is influenced by a wide array of factors including age at incidence, number, and severity as well as genetic factors, some of which exhibit sex-dependent effects. This study examines how TBI history influences rate of cognitive decline in older adults, exploring the characteristics of TBI (e.g., number, severity, and timing) as predictors and interactions of TBI history with genetic variants suspected to play a role in brain health and late-life cognitive functioning. These genes include the Apolipoprotein E (APOE) as well as brain derived neurotrophic factor (BDNF) and its receptors. This study analyzed …

Exploring Complete Mental Health Screening Using Adolescent Self-Reports, Stephanie A. Vinal

All Graduate Theses and Dissertations, Fall 2023 to Present

This study comprises two separate papers that ultimately aim to create and support the use of a new school screening tool to identify student risk for a variety of school-based problems as well as identify their individual strengths. Complete mental health screening refers to a process by which the entire student body of a school is administered a screening tool in order to cast a wide net and increase the likelihood of identifying any student at risk for behavioral, social, emotional, or academic difficulties. By identifying student strengths as well as their risk for problems, schools are better aimed at …

Acute Changes In Inflammatory Biomarkers Expression Following Cosmetic Surgery With Use Of Compression Garment, Michael James Sanchez

Open Access Theses & Dissertations

BACKGROUND: Inflammation is an acute phase response to physiological conditions such as infection, tissue injury, and tissue stress and malfunction (Medzhitov, 2008). Inflammation caused by surgical trauma (tissue injury) elicits a myriad of responses by the patient that is experienced far past the operation. It is estimated that American individuals will undergo nine surgeries throughout an 85 year lifespan (Lee & Gawande, 2008). Focus on surgical recovery modalities has grown over the past few decades. The use of compression garments (CG+) following surgery has been shown to be successful in preventing deep vein thrombosis, pulmonary embolisms, as well as aiding …

Integrating Machine Learning And Simulation For Resource Planning Of Hospital Systems Based On Predicted Length Of Stay, S M Atikur Rahman

Open Access Theses & Dissertations

Recently Hospital Systems faced a high invasion of patients generated by several events such as health crisis related epidemic (COVID, FLU) or seasonal flows. Hence, managing hospital bed availability and efficiency with proper care is obligatory for addressing the challenges associated with the overburden of patients. However, the Length of stay (LOS) is often increased due to the high patient influx and overcrowding problem occurs within the Hospital. It resolves these issues, it is essential for hospital authority to predict the Patients LOS which is the crucial indicator for the use of medical resources (allocation, utilization of providers and resource) …

A Retrospective Quantitative Investigation Into Prostate Radiation Treatment Among Patients With Rectal Gas At Simulation, And How It Affects Planning: A South Florida Context., Soufiane Mansouri

Masters Projects

This study examines the effect of Hounsfield Unit (HU) correction of air in rectal tissue on dose distribution during prostate cancer radiation therapy planning. Ten patients treated between 2023 and 2024, of which received 70 Gray (Gy) in 28 fractions, were retrospectively analyzed. Inclusion criteria included the presence of rectal gas during simulation and noncompliance with pre-simulation preparation instructions. Statistical tests, including a standard t-test and a sign test, were used to compare dose planning without HU correction to planning with HU-corrected rectal gas to tissue, focusing on differences in rectal doses and planned target volume doses. Radiation therapy plans …

The Effects Of Non-Invasive Brain Stimulation On Excitability Of The Primary Motor Cortices And Complex Motor Task Learning, Erik Woodruff Wilkins

UNLV Theses, Dissertations, Professional Papers, and Capstones

Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are promising non-invasive brain stimulation techniques, particularly for clinical applications involving altered or impaired motor function, such as in stroke and Parkinson’s disease. Although tDCS and tACS are different modalities, both forms of stimulation operate on the same principle - weak electrical currents are delivered through electrodes placed on the scalp in specific configurations known as “montages”. The most commonly used montage for targeting the primary motor cortex (M1) is the M1-SO configuration. This montage leverages the established observation that cortical regions directly beneath the anode generally increase in …

Effect Of Cvd Education On The Perception And Modifiable Health Behaviors Of College Students, Sanitha Douglas

Doctor of Nursing Practice Projects

Background

Research reports that cardiovascular disease (CVD) has been a national and global health problem for many years, and that knowledge has increased regarding its prevention (Hennekens, 2020). However, according to Hennekens (2020), CVD remains the number one cause of death in America and most developed countries worldwide. The lack of perception and knowledge of actual CVD risk in the young adult population may be contributing to this deadly disease. This project evaluated the effectiveness of education on CVD risk perception and modifiable health behaviors of college students.

Purpose

This project’s purpose was to assess college students' perception of their …

The Role Of Kinases Signaling In Organogenesis, Fatemeh Nasehi

All Dissertations

Kinases are crucial regulators of organ development and differentiation. This thesis investi- gates the roles of TAK1, TGFbeta-Activate Kinase 1 (TAK1/Map3K7), and Akt3 kinases in skeletal, cardiac muscle, and cartilage. TAK1 is pivotal for the differentiation of various organ systems, including sinoatrial node and cartilage, and is responsible for phosphorylat- ing a diverse array of downstream kinases. We identified several novel proteins, including phospho-Akts, that are upregulated in response to TAK1 activation. We discovered severe Dilated Cardiomyopathy (DCM) and cartilage defects in Akt3 mutant mice. Although this mouse mutant has been studied for over two decades, we are the first …

Evaluating The Use Of The Braden Scale For Predicting Pressure Sore Risk© In Residents Of A Short-Term Rehabilitation Facility, Amelia Simmons

All Dissertations

Background: Pressure injuries are significant health issues and one of the biggest challenges organizations face on a day-to-day basis. Aside from the high cost of treatment, pressure injuries also have a great impact on patients’ lives and on the provider’s ability to render appropriate care to patients The keys to preventing the development of pressure ulcers is to identify at-risk individuals as soon as possible so that measures can be implemented.

Objective: To evaluate use of the Braden Scale© on admission and weekly for three weeks in residents admitted to a short-term rehabilitation facility for two months immediately following a …

Neuroscience-Based Harm Reduction Education For College Students In Portland, Or, Catriona Swallow

University Honors Theses

Harm reduction (HR) is a movement focused on reducing the harms of the opioid overdose crisis through education, advocacy, and community engagement. A key component of HR is naloxone, a medication which reverses opioid overdoses when administered. Due to increased fentanyl contamination, opioid overdose deaths have been on the rise among adolescents in the U.S and HR practices are crucially important at this point in time. In recent years, alternative curricula of HR education have included a neuroscience-based approach to the topic of substance use. While both traditional and alternative programs have had success increasing substance use literacy among adolescents, …

Early Identification Of Autism Spectrum Disorder Markers In Infants Using The Infant And Motor Engagement Scale, Cesley L. Taft

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Implementation Of An Evidence-Based Hospital Acquired Pressure Injury Strategy In The Intensive Care Unit, Tonya C.W. Brigman

Student Scholarly Projects

Practice Problem: Hospital-acquired pressure injuries (HAPI) are a significant concern in healthcare with the most vulnerable group being the adult patients in ICUs leading to increased morbidity, longer hospital stays, and higher healthcare costs.

PICOT: In adult ICU patients (P) does the implementation of daily chlorhexidine gluconate (CHG) baths with post bath barrier cream combined with intentional turning every 2-hours (I) compared to standard skin care practices and nonintentional turning (C) reduce the incidence of hospital-acquired pressure injuries (HAPI) (O) within 10-weeks (T)?

Evidence: The project was based on the analysis of the literature published in the …

A Clinical Comparison With The Flattening Free Filter Technique For Lung Stereotactic Body Radiotherapy Using Functional Lung Planning, Addison Gucwa

Masters Projects

Abstract

Introduction

Lung cancer remains the leading cause of cancer incidence and mortality worldwide. Advances in stereotactic body radiation therapy have demonstrated survival rates comparable to surgery, however, they come with a higher risk of developing radiation pneumonitis. The aim of this study was to explore the possibility of minimizing the risk of lung toxicities after stereotactic body radiation therapy to lung tumors with the use of functional lung planning and flattening filter free beams.

Materials and Methods

This retrospective study analyzed treatment planning data from ten patients previously treated with SBRT for inoperable lung tumors. Functional lung volumes were …

Improving Parent And Nurse Communication Using The Lowline Model In The Cvicu, Nelli Hodorff Noor

DNP Projects

This project was designed to help improve family and nurse communication using the LOWLINE model in the CVICU to allow families and nurses to be on the same page and work as a team.

Implementation Of A Sickle Cell Disease Toolkit In The Emergency Department To Improve Provider Knowledge And Confidence, Kendra Paeper

DNP Projects

No abstract provided.

Feasibility Of Individualized Toolkits To Reduce Childhood Obesity In A Pediatric Primary Care Setting, Molly Sexe

DNP Projects

Background: Childhood obesity rates continue to rise, leading to comorbid conditions presenting in adolescence and adulthood (Durbin, 2018). Individualized toolkits focusing on various health habits have been identified as an effective intervention in pediatric primary care practices (Byrne et al., 2018; Henderson, 2021; Mead et al., 2017; Smith et al., 2021 & Wright et al., 2018). This project assessed barriers of the current obesity prevention program at a pediatric primary care clinic, Operation Get FIT. This project identified steps to revising Operation Get FIT to tailor it more to the needs and goals of the participating clinic, the providers, and …

Integration Of Depression And Anxiety Screening Among Uninsured And Underinsured Patients In A Mobile Nurse-Led Clinic, Samantha Hamm

DNP Projects

This quality improvement project sought to increase screening rates and referrals for pregnant and postpartum depression/ anxiety using the Edinburgh Postnatal Depression Scale (EPDS) and increase the rate of mental health referrals as a result of that screening in an underserved population /community health mobile clinic. Maternal mental health is a key public health concern. In the most recent community health needs assessment (2022-2025) in one Midwestern rural community, priority needs were identified with the top priority of building families with access to culturally competent healthcare, including access to mental health services (Central MN Alliance, 2022). Under-reporting anxiety and depression …

Knowledge And Attitudes Toward Baby-Led Weaning In Primary Care, Taylor Schreiner

DNP Projects

Objective

Adequate nutrition is critical for an infant’s growth and development. Around the age of six months, most infants can begin the process of being introduced to table foods. The debate is about what method is safest for the infant, spoon-led feeding or baby-led weaning (BLW).

Methods

This project explored the beliefs, attitudes, and knowledge of both parents of infants and primary care providers (PCP) on baby-led weaning. Data were obtained through the use of pre-and post-surveys following the implementation of specific education for parents and PCPs.

Results

The findings from parents who participated would suggest that most parents who …

Medical Imaging Dataset Management Leveraging Deep Learning Frameworks In Breast Cancer Screening, Inchan Hwang

Dissertations

In the domain of Computer-Aided Diagnosis (CADx) for breast cancer diagnosis through mammography, prevailing models have traditionally been trained and validated using old film-based mammography. However, contemporary U.S. hospital practices involve the utilization of Full Field Digital Mammography (FFDM), offering more detailed images captured at various angles than old film-scanned mammography. Despite this shift, the existing body of research predominantly focuses on old-film based datasets, the implications of FFDM for CADx systems have not been understood. This dissertation addresses the issues emerged from FFDM such as data augmentation between old film-based set and new FFDM whether they are more effective …

Sleep Rehabilitation Program For Military Members With Tbis & Scis, Hailey M. Cassidy

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Increasing Reading Comprehension And Accuracy By Enhancing Reading Mechanics In Preadolescence: The Role Of Occupational Therapy In Academia, Shireena Behel

Department of Occupational Therapy Entry-Level Capstone Projects

Reading comprehension and accuracy are critical components of academic success in preadolescence. Research suggests that traditional school systems utilize a unisensory approach to learning, however, recent studies have emphasized the successful impact a multisensory approach can have on academic performance. This doctoral capstone project aimed to develop a multisensory, occupation-based reading program for the Huntsville Learning Center (HLC) Christian Summer Camp under the guidance of Mariana D’Amico, EdD, OTR/L, FAOTA, and Susan Callaway, HLC Family Development Coordinator. This required conducting pretest and post-test measurements, implementing occupation-based reading activities, and administering a post-program evaluation survey to determine the effectiveness of a …

Implementing A Patient Education Bundle To Improve Patient Satisfaction, Madison Tyler

Student Scholarly Projects

Practice Problem: Patients on the intervention unit reported via HCAHPS surveys a lack of understanding of the nurse provided education on their medications’ side effects and purpose after discharge home from the hospital. Nurses at the intervention unit’s organization do not use any formal or standardized method of patient education to ensure patient comprehension.

PICOT: Among adult inpatients (18 years or older) on a step-down unit in an acute care facility (P), does implementing an education bundle related to patient medication education (I), compared to current practice of no formal education process (C), increase patient satisfaction as measured by HCAHPS …

Quality Improvement Project: Evaluating The Impact Of An Intrapreneurial Skill Enhancement Program On Enhancing Innovation Perspectives And Overcoming Obstacles Among Nurse Practitioners At A Midwestern Academic Medical Center, Michael Thorn

Doctor of Nursing Practice Projects

Nurse practitioners (NPs) face barriers to being innovative in healthcare because of a need for more resources, education, and cultural inclusion compared to physicians and researchers (Joseph et al., 2019). NPs are often disregarded from involvement in the innovation ecosystem and seen as solely end-users of new products and services (Davis & Glasgow, 2020). This Doctor of Nursing Practice project aimed to assess the impact of a 5-week innovation and intrapreneurship course on NPs' perceptions of their ability to innovate at a Midwest academic hospital. The aim was to address the known innovation education gap that NPs rarely receive. Using …

Nursing Shortage Crisis: Can Implementing Supplemental Instruction Impact Nursing Students' Success In Nursing Programs?, Lauren Smith

Doctor of Nursing Practice Projects

This quality improvement project (QI) aimed to provide nursing students in the traditional Bachelor of Science in Nursing (BSN) program with different forms of supplemental instruction (SI). The problem identified considered that nursing students' success rates have been dwindling for years, decreasing the number of nurses available. The purpose was to evaluate the effectiveness of SI in promoting student success throughout the semester. SI was first introduced at the University of Missouri-Kansas City in 1973 and is utilized primarily to improve student success in courses that are often considered "high-risk" for failure (Bowman et al., 2021). When SI is appropriately …

Evaluation Of A Peer Mentoring Program In Baccalaureate Nursing Students: A Quality Improvement Project, Leigh E. Swartzendruber

Doctor of Nursing Practice Projects

Nursing school can be rigorous, stressful, and anxiety-producing for students trying to progress to graduation, with students leaving the program if they encounter barriers. Academia must consider strategies to support students; peer mentoring is an evidence-based approach. The project evaluated an existing peer mentoring program to understand the benefits and barriers entry-level sophomore students experience with the program, comparing survey results from 2022 and 2024 cohorts—a mixed-methods descriptive statistical study was conducted with the spring 2024 peer mentoring program. Using a PDSA cycle, the program was transformed from an in-person to a hybrid format. At the end of the program, …

Associations Between Coping Style And Perceptions Of Web-Delivered Physical Activity Messages Among Women In Midlife With Cardiovascular Health Risks, Kristen Pasko

Theses and Dissertations

Midlife women are at unique risk for cardiovascular disease (CVD) and benefit from increasing physical activity (PA). Many PA interventions involve social support, though fail to address related processes such as social comparison. Desire for specific types of social support and comparison may represent emotion-focused versus problem-solving coping, though little is known about women’s preferences for/responses to these coping opportunities. The present study examined women’s selections of PA content in a digital environment. Over 7 days, women in midlife ≥1 CVD risk factor (N = 60, MAge = 50.70, SD = 5.89) wore a PA monitor and visited a proprietary …

A Retrospective Analysis Of Primary Breast Cancer Surgical Procedures (Mastectomy Versus Breast Conserving Surgery) Performed On Women Living In Rural And Urban Counties In South Carolina, Talitha M. Massaquoi

MUSC Theses and Dissertations

Women dealing with a diagnosis of breast cancer may be challenged when attempting to seek and obtain medical care while living in a rural community. It is not known whether geography impacts the decision-making process for women considering elective breast cancer surgery (mastectomy versus breast conserving surgery (BCS)) in South Carolina. We performed a retrospective analysis of breast cancer surgical options offered to women to examine if a difference exists in both rural and urban settings. Although there was a higher proportion of women in South Carolina who elected to undergo a mastectomy instead of BCS (4,416 [79.5%] vs. 1,139 …

Adaptive Immune Profiling Of Sin Nombre Hantavirus And Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Tonilynn M. Baranowski

Biomedical Sciences ETDs

Hantaviruses are causative agents of potentially fatal respiratory illness and/or organ failure in humans worldwide. In the United States, the predominant hantavirus species, Sin Nombre hantavirus (SNV), causes a severe disease pathology, called hantavirus cardiopulmonary syndrome (HCPS). Infection with SNV and subsequent clinical manifestations of HCPS lends itself to case fatality rates approaching 40%, even under supportive care. This is partially due to the lack of FDA-approved vaccines and antivirals, in addition to a deficit in our knowledge regarding the human immune response to SNV. Further investigation of the adaptive immune response may reveal key targets to mediate disease outcome. …

Empowering Patient Care Technicians To Reduce Non-Ventilated Hospital-Acquired Pneumonia In An Acute Care Hospital In Northern California, Barbra Pacatang

Master's Projects and Capstones

Abstract

Problem: Non-ventilator hospital-acquired pneumonia (nv-HAP) is increasingly becoming a significant concern in healthcare settings. Studies have indicated that nv-HAP accounts for a substantial portion of hospital-acquired pneumonia cases, with a high associated mortality rate. The prevalence of nv-HAP underscores the importance of implementing robust HAP prevention bundles. Prevention, early recognition, and appropriate management of nv-HAP are essential to improve patient outcomes and reduce the burden on healthcare facilities.

Context: A 28-bed capacity Stroke Telemetry Unit incurred six nv-HAP incidents in 2023. Patients needed to be more compliant with the nv-HAP prevention bundles. Patient care technicians (PCTs) are instrumental nurses’ …

Improving First Case On-Time Starts In The Operating Room, Lojy Koshy

Master's Projects and Capstones

Problem: A timely first-case start in the operating room (OR) is critical for optimizing departmental efficiency and resource utilization. Persistent delays in first-case start times disrupt the surgical schedule, leading to suboptimal OR use, diminished patient and staff satisfaction, reduced operational efficiency, and decreased overall productivity. Addressing these delays is essential to enhance the quality and efficiency of surgical services.

Context: The microsystem for this project is a Northern California operating room that handles a high volume of surgical procedures. There are 10 operating rooms, and the goal is to have 70% of first cases in the operating room on …