Medicine and Health Sciences Commons^™

Microcirculation: Electrophysiological Basis For The Response Of Endothelial Cells To Inflammatory Mediators-Bradykinin, Kai Miao

Electronic Theses and Dissertations

Using conventional microelectrodes, I studied the electrical basis for determining the resting V$\sb{\rm m}$ in intact EC's from hamsters. The resting V$\sb{\rm m}$ were found to be $-$40 mV for aortic EC's and $-$43 mV for vena caval EC's. The contributions of ions to the resting V$\sb{\rm m}$ of aortic EC's were compared in terms of the transference number (t$\sb{\rm ion}$). To develop a technique for in situ monitoring changes in V$\sb{\rm m}$ of postcapillary venular EC's in the hamster mesentery, a voltage-sensitive fluorescent probe, bisoxonol, was used to load the cells and the fluorescence signals were analyzed under an …

Women’S-Perceived Quality In Postpartum Care, Maryland A. Hunter

Theses and Dissertations (ETD)

Increased competition among healthcare organizations for the obstetric consumer market has led to increased interest in women’s perceptions of their obstetric experience. This study explored women’s perceptions of quality and women’s perceptions of benefits for women who received family-centered postpartum care (FCPPC) and women who received traditional postpartum care (TPPC). The study also assessed the relationship between women’s-perceived quality (WPQ) and women’s-perceived benefit (WPB) for those receiving FCPPC and those receiving TPPC. Quality and beneficence are the two concepts of Larrabee’s (1992) model of quality operationalized in this study. The sample consisted of 60 postpartum women, 30 receiving care on …

"Well-Growness" Of The Newborn And Factors Contributing To Low Birth Weight, Diane Buck Kruse Dnsc

Dissertations

The problem of determining risk factors and antecedents of birth weight is multifactorial. The purpose of this study was to examine the effect of pre-pregnancy health status, prenatal care, stress, negative life style practices, nutritional status during pregnancy, and placental perfusion on the well-growness of the newborn (birth weight) in five time orderings and to examine the interaction of these variables on each other. The theoretical framework was a physiologic one centering on the effects of the proposed variables on the well-growness outcome. This prospective study used a correlational design with path analytic techniques. A sample of 160 pregnant women …

Nurse Practitioners In Rural Practice : Physicians' Perspective, James Stephen Boyte

MSN Research Projects

This study addressed the question: will primary care physicians from a rural Northern Louisiana area be accepting of the nurse practitioner role in a similar practice setting?

Psychosocial Determinants Of Age-Appropriate Immunizations Of Infants In Norfolk, Virginia, Hoda Youssef Atta

Health Services Research Dissertations

This study represents an investigation of psychosocial factors affecting age-appropriate immunizations of infants in Norfolk, Virginia. A household survey was conducted in Norfolk, Virginia, from 4/93-8/93, to assess immunization coverage of children 12-30 months of age. This survey included a total of 389 children in the target age range. A subset of 201 mothers were randomly selected and reinterviewed to assess their knowledge and attitudes and the relationships of these factors to age-appropriate immunizations at 12 months of age. Sixty-two percent of children were not age-appropriately immunized at 12 months of age. Almost all mothers (99%) considered vaccines to be …

Characterization Of An Antiviral Agent Based On Nonionic Surfactants And It's Effects On Human Dermal Fibroblasts, Ji Young Li

Biological Sciences Theses & Dissertations

The AIDS ·pandemic has directed various research endeavors towards finding an appropriate method for eliminating all potentially infectious material within bone allografts before implantation into a recipient. To that effect, Panavirocide was conceived by Medicine and Applied Science·s, Inc. This compound, in which three nonionic surfactants serve as the active agents, has been shown to inactivate HIV-1 particles within blood and blood products. Because Panavirocide has never been used with allografts, the purpose of the present research was to characterize the nonionic surfactants for the putative alteration of the formulation by determining the critical micelle concentration values and to determine …

Biofeedback Gait Training Auditory Vs. Visual Techniques, Timothy D. Hiemenz

Electrical & Computer Engineering Theses & Dissertations

Training lower extremity amputees to walk normally is quite a difficult task. Amputees must wear a prosthesis so they can walk at all. This allows them some mobility, but their walking pattern may be unnatural. If their gait is temporally asymmetric, they need to exert more energy to move about. This research was initiated to help lower extremity amputees to walk more efficiently using biofeedback gait training. Two types of feedback were developed and tested to determine which method gave the most understandable feedback, validating its use in a clinical setting.

A normal gait cycle uses the lower limbs to …

A Retrospective Quantitative Assessment Of Trichloroethylene Exposure Of Workers At Aircraft Maintenance Facilities At Hill Air Force Base Through The Use Of Modeling, Anthony O. Copeland

Theses and Dissertations

Monte Carlo simulation and source-receptor modeling are used to estimate the TCE exposures encountered by select workers at aircraft maintenance facilities at Hill Air Force Base between 1955 and 1979. An epidemiological study of this group, a retrospective cohort study of 14,457 workers who were employed at the base for a minimum of one year between 1952 and 1956, was headed by Dr. R. Spirtas of the National Cancer Institute to evaluate mortality associated with occupational exposure. One of the major conclusions of the study was that TCE 'probably does not pose a strong carcinogenic risk for man.' In the …

A Comparative Pharmacokinetic Study Of The Role Of Gender And Developmental Differences In Occupational And Environmental Exposure To Benzene, Elizabeth A. Brown

Theses and Dissertations

The purpose of this study is two-fold. First, it shows that physiological differences between men and women result in gender-specific exposures with respect to benzene. Second, it assesses the potential for a lactating woman's occupational and personal benzene exposure to impact a nursing infant's exposure, highlighting the possibility of subjecting an infant to the effects of industrial chemicals via breast feeding. This study employs physiologically based pharmacokinetic (PBPK) modeling to investigate the influence of physiological parameters and to evaluate the ability of inhaled benzene to transfer from mother to infant through breastmilk. The models are run through scenarios that simulate …

A Comparative Study Of Activities Of Daily Living Levels Of Catholic Nuns In A Motherhouse Nursing Home And Mainstream Women In A Community Nursing Home, Betty Ann Ray Duke

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Education and Behavioral Sciences at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Arts by Betty Ann Ray Duke on August 31, 1994

Perceptions Of Nurse Practitioners In Primary Care Toward Rationing Of Health Care, Donna Baucum

MSN Research Projects

The United States has the highest cost of health care in the world. In an effort to control this continually escalating expense, the concept of rationing of health care has been offered as a solution. Health care providers, such as nurse practitioners, will be confronted with making decisions related to the allocation of health care. Thus, the purpose of this descriptive study was to explore the perceptions that nurse practitioners have regarding rationing of health care. Henderson's Model of Nursing served as the theoretical framework. The research question that guided this study was what are the perceptions of nurse practitioners …

The Effect Of Cardiac Rehabilitation On Quality Of Life, Anxiety, And Self-Care In Coronary Artery Disease Patients, Susan Susskind Wilkinson

Theses & Dissertations

This study was designed to explore the effect of cardiac rehabilitation program participation on anxiety, quality of life, and self-care among coronary artery disease patients.

Major lifestyle changes are required after a person experiences an acute coronary event. Rehabilitation programs for coronary artery disease patients are designed to assist the patient with these lifestyle changes by altering the survivor's self-care patterns and improve long-term physical and psychological outcomes. By coordinating education, counseling, and exercise programs, the nurse can help individuals move toward a maximal physiological, psychological, social and vocational recovery. This study was designed to explore the effect of cardiac …

External Locus Of Control And Negative Life Experiences In Persons With Chronic Fatigue And Immune Dysfunction Syndrome, Pamela Thomas Priebe

Graduate Theses

A review of related literature indicated a person's perception of negative life experiences may be unusually high prior to the onset of an illness. An external locus of control belief system may also be present prior to the onset of an illness. The present study used the Life Experiences Survey measure to compare the perception of life experiences of a group of people with CFIDS and a group of people without CFIDS. The present study also used the Locus of Control Scale to measure the locus of control belief system for the same two groups of people. The results of …

A Comparison Of Prenatal Help-Seeking Behavior Between Rural Native Americans And Anglo Women, Lasteffia Jan Todd

MSN Research Projects

The purpose of this descriptive study was to compare the prenatal help-seeking behaviors of two ethnic groups of rural women in a southeastern state. Three hypotheses guided the study: Ho^, There will be no relationship between selected demographic variables and help-seeking behaviors in Native Americans; HOg, There will be no relationship between selected demographic variables and help-seeking behaviors in Anglo women; and Ho^, There will be no difference in the factors predicting prenatal help- seeking behavior between Native Americans and Anglo women. This study replicated the work of Ide and Gill (1992). Leininger's Transcultural Nursing Theory was used as a …

The Acceptance Of The Role Of The Nurse Practitioner By Primary Care Physicians, Micki S. Raber

MSN Research Projects

The purpose of this study was to examine the acceptance of the role of the nurse practitioner by primary care physicians.

The Effects Of An Aids Educational Program On The Knowledge, Attitudes, And Behaviors Of Sixth-Grade Students, Jerrie L. Coleman-Sullivan

MSN Research Projects

The purpose of this study was to measure attitudes, knowledge, and behaviors of sixth-grade students before and after a teaching program.

Posttraumatic Stress Disorder In Sexually Abused Children And Implications For Therapy, Robbie Jones

Graduate Theses

This study examined the symptoms of posttraumatic stress disorder (PTSD) in sexually abused children. Sixty-seven children volunteered to participate in this study. Of the 67 children, 33 (26 female and 7 male) were sexually abused and 34 (22 female and 12 male) were non-sexually abused. Several instruments were employed to assess the severity of the symptoms of PTSD including the Children's PTSD Inventory, the Child Behavior Checklist, and the Children's Depression Inventory, as well as others. The results of this study showed that sexually abused children have more symptoms of PTSD than non-sexually abused children. Early diagnosis and treatment of …

A Comparative Analysis Of Prospective Nursing Patient Classification And Retrospective Nursing Patient Classification, Dana Larmore Hlusko

Ellmer School of Nursing Theses & Dissertations

Nursing patient classification systems have been in use in some form since Florence Nightingale first arranged her patients in wards (Giovanetti, 1978). Prospective classification systems which have been implemented in hospitals now generate billing information, staff budgets and long-range financial forecasts (Giovanetti, 1978; Alward, 1983; Edwardson and Giovanetti, 1987). Quantitative analysis using at-test indicated a significant difference in mean acuity scores in the prospective and retrospective data which pointed to a retrospective system as being more appropriate for billing, budgeting and finance decisions. Spearman's correlation analysis did not demonstrate a strong correlation between any indicators or with total acuity. Several …

Stab Wounds To Rat Brains : Demyelination, Remyelination And The Cellular Response, Particularly Of Oligodendrocytes, Xie Dangci

Loma Linda University Electronic Theses, Dissertations & Projects

The present body of knowledge concerning the results of central nervous system injury is incomplete and controversial. The role of oligodendrocytes, the cells involved in phagocytosis, the stages of demyelination, and the evidence for remyelination are of interest. Following stab wounds to rat brain cortex, corpus callosum and hippocampus, the animals were examined at 4,7,11,18,23,29,45,60 and 70 days postoperation (dpo). To help in the identification of cells immunocytochemical markers for astrocytes and immature oligodendrocytes were used. These were labels for glial fibrillary acidic protein (GFAP) and myelin/oligodendrocyte specific protein (MOSP) respectively. Light and electron microscopy were correlated using conventionally prepared …

The Relationship Of Dietary And Lifestyle Factors To Bone Mineral Density Of Healthy Singaporean Chinese Women, Ampai Dana Aimsiri

Loma Linda University Electronic Theses, Dissertations & Projects

Few studies have examined the risk factors associated with reduced bone mass in Asians, but none specifically investigated Singaporean Chinese women. The subjects in this study were 16 premenopausal, 8 perimenopausal and 13 postmenopausal women who participated in a larger study which began in 1986. Bone density was measured in 1986 and 1992. Dietary and lifestyle data were collected for this study by personal interview. Association between dietary and lifestyle factors and bone density variables and change in bone density at the end of the 6 year period were assessed by univariate regression analyses.

Postmenopausal women had significantly lower baseline …

The Production And Characterization Of A Monoclonal Antibody To A Naturally Occurring Aminomalonic Acid Epitope And A Comparison With An Antibody To A Synthetically Derived Aminomalonic Acid Epitope, James L. Gulley

Loma Linda University Electronic Theses, Dissertations & Projects

The goal for this project is to undertake the first step in the study of blocking metastasis by a monoclonal antibody. The long range goal of this line of research is to study a novel mechanism for the blocking of tumor metastasis in general and prostatic cancer metastasis in particular. The problem that this addresses is the growing number of cases of prostatic cancer in the increasingly aging male population. This cancer is not lethal unless it metastasizes, yet there is no cure for the metastatic disease. The inherent specificity of a monoclonal antibody combined with the uniqueness of the …

Effects Of Furosemide And Oleic Acid On Thyroxine Binding To Isolated Pairs Of Thyroxine Binding Serum Proteins, Deborah Hustead

Loma Linda University Electronic Theses, Dissertations & Projects

Dosage dependent binding inhibition and redistribution of thyroxine (T₄) between three pairs of thyroxine binding serum proteins, TBG-TTR, TBG-albumin and TTR-albumin, by furosemide (0.0 to 1.0 mol/L) and oleic acid (0.0 to 0.10 mol/L) were studied using equilibrium dialysis with purified binding proteins at concentrations 1/200 of levels in normal human sera, separated across the dialysis membrane and competing for T₄.

Furosemide (1.0 mol/L) reduced TBG bound T₄ in both the TBG-TTR system and TBG-albumin system (>90% decrease) and inhibited T₄ binding to TTR in the TTR-albumin system (68% decrease) and to albumin …

Short And Long Term Effects Of Proton Microbeam Irradiation : In The Lateral Geniculate Nucleus Of Felis Domesticus, Chad Sherwood Reder

Loma Linda University Electronic Theses, Dissertations & Projects

Little is known of the effects of proton irradiation on neural tissue. A 1.0 mm microbeam was used on the cat lateral geniculate nucleus (LGN) to quantify the short term (< 3 months) and long term (< 9 months) effects of radiation damage. The LGN is a large structure with well defined afferent, efferent, and receptive field properties.

Electrophysiological and histological techniques were used to examine the effects of the microbeam at 60, 40, and 16 Gy, administered as a single bolus. Recordings of light evoked responses in the LGN were obtained using microelectrodes in nine animals within 12 weeks of irradiation, and 6 animals within 36 weeks of irradiation. Receptive fields were mapped onto a tangent screen using standard receptive field techniques. Histological measures included afferent …

Integrating Chronic Illness Into One's Life: A Phenomenological Inquiry, Susan Rush Michael Dnsc, Ms, Rn

Dissertations

Chronic illness is currently the number one health problem facing the United States; however, little is known about the experience of making chronic illness a part of one's life, particularly from the perspective of the chronically ill person. If nurses are to assist people in living with chronic illness, then an understanding of this experience is essential. Therefore, the purpose of this phenomenological inquiry was to explore how chronically ill adults integrate chronic illness into their lives. Seventeen chronically ill adults were interviewed by the researcher, and asked to describe how they integrated chronic illness into their lives. Each interview …

The Environment: Alive, Whole, Interconnected And Interacting, Dorothy Kleffel Dnsc, Mph, Bsn, Rn

Dissertations

Nurses frequently care for individuals whose conditions are related to destructive environmental influences. Although the environment is a central construct in the nursing paradigm, its definition is client oriented, circumscribed, and does not adequately explain situations emanating from the larger physical, social, cultural, political, or economic spheres of the environment. This research described an expanded, ideal, environmental nursing domain derived from selected upstream scholars whose work has addressed broad environmental dimensions. Using the concept of future search, once this idealized environmental domain is envisioned, the nursing profession can begin to discover the knowledge base that is needed in order to …

Motivations For Initiation Of Early Prenatal Care For Women Of Poverty Level Residing In Mississippi, Bruce Giamalva

MSN Research Projects

This study was designed to determine what factors motivate women of poverty level residing in Mississippi to initiate early prenatal care.

Characteristics Of Nurse Entrepreneurs In Established Practice, Nancy M. Hurt

MSN Research Projects

The purpose of this study was to assess business knowledge/skills and characteristics of nurse entrepreneurs.

The Nurse Practitioner's Perception Of The Meaning Of Professional Accountability : A Qualitative Study, Patricia Flannery Pearce

MSN Research Projects

The purpose of this qualitative study was to investigate the meaning of professional accountability from the perspective of the nurse practitioner.

Correlation Of Attitudes And Values Of Nurse Practitioners And Levels Of Confidence, Janell Carter

MSN Research Projects

The purpose of this study was to correlate attitudes and values of nurse practitioners and levels of confidence in the role.

The Incidence Of Elevated Blood Lead Levels In Children Ages 1 To 6 Years Who Receive Care In A Military Health Care Facility, Christina Montague

MSN Research Projects

The purpose of this study was to investigate the incidence of elevated lead levels in children ages 1 to 6 years who received health care in a military facility.