Medicine and Health Sciences Commons^™

Syncope In A Population-Based Sample Of Elderly Persons: Prevalence, Predisposing Risk Factors, And Precipitating Events, Eric A. Gomes

Yale Medicine Thesis Digital Library

Syncope is a serious but potentially preventable occurrence commonly afflicting the elderly population. The objectives of this study were to estimate the incidence of syncope in the community-dwelling elderly population, to identify the clinical risk factors that predispose some elderly persons to syncope, and to describe situational factors and the morbidity associated with syncope. Study participants were members of the Project Safety cohort, representing a probability sample of non-institutionalized residents of New Haven, Connecticut aged 72 years or older. Age-restricted housing lists and utilities listings were used to generate an index of community dwellings from which 5,936 households were identified. …

The Nutritional Knowledge, Food Choices And Exercise Habits Of Students At Langston University, Preston Solomon

McCabe Thesis Collection

The process of nutritional assessment has long been used to identify specific nutritional problems that demand attention and correction. The major health problems in the United States and much of the industrialized world have nutrition at their root. The ten leading causes of death in the United States are in some way related to the lack of adequate knowledge, adequate nutrition, or both. Increasingly young people are experiencing obesity, high blood pressure, and high serum cholesterol. These conditions pose problems in nutrition and healthy lifestyles in general. Given that behavior is related positively to knowledge, good nutrition and medical knowledge …

The Nutritional Knowledge, Food Choices, And Exercise Habits Of Students At Langston University, Preston Solomon

McCabe Thesis Collection

The nutritional knowledge, food choice, and exercise habits of an individual determine his or her overall health and life expectancy. Information on these topics enables nutrition educators to develop strategies to improve knowledge and to tailor educational efforts which affect a large number of persons. Poor health in America today is an ever present reality. Heart disease, cancer, diabetes mellitus, cerebrovascular diseases, renal diseases, and pulmonary diseases are causes of death related in part to lack of nutritional knowledge and poor eating and exercise habits. A few of these diseases are chronic in nature and are the most deadly.

The …

The Impact Of A Health Education Program On The Attitudes Of African-American Hypertensive Clients Regarding Adherence To A Prescribed Medical Regimen, Teresa Y. Mcpherson

Theses & Dissertations

This quasi-experimental study examined the effect of an educational program on the attitudes of hypertensive African-American clients regarding their adherence to a prescribed medical regimen.

Despite increased public awareness and improved treatment in hypertension, poorly controlled hypertension continues to be a significant problem especially among blacks and other minority populations in the United States (Shea, Misra, Ehlich, Field, & Francis, 1991). On the basis of different experiences, people may form different beliefs and, therefore different attitudes about the consequences of performing or not performing a behavior (Ajzen & Fishbein, 1980). Studies have indicated that a variety of factors such as …

Program Evaluation: A Look At A Case Management Program Of Big Spring State Hospital Community Services, Sharon Root Treadway

Graduate Theses

Case management services are an expanding program in the Texas Department of Mental Health and Mental Retardation (TXMHMR) system's treatment for chronically mentally ill individuals (CMI). CMI’s are individuals who are unable to maintain a stable adjustment to community life because of persistent and serious emotional disabilities. Previous research findings as to the effectiveness of this type of service in other programs have been mixed, and because of differences in program guidelines are not directly applicable to the TXMHMR program. The hypotheses of this study, which was a program evaluation of one specific program of case management, were two-fold; one, …

Crisis Of Infertility: Effects Of Length Of Treatment On Emotional And Marital Adjustment, Christie L. Markestad

Graduate Theses

Twenty infertile couples participated in the present study to investigate whether infertile couples receiving medical treatment experience changes in their emotional, marital and sexual adjustment as a result of the length of time they have been in treatment. The couples were divided into three groups based on how long they had been seeking medical attention for infertility. The instruments administered were: SCL-90-R (Symptom Checklist), Dyadic Adjustment Scale (DAS) and Index of Sexual Satisfaction (ISS). It was predicted couples who were in the initial stages of treatment would experience increased levels of emotional, marital and sexual distress, however those levels would …

Persistent Oral Dyskinesias Induced By Long-Term Haloperidol Treatment Is Dissociated From Changes In Neostriatal B(Max) And Mrna Content For Dopamine D(2) Receptors, Nuoyu Huang

Electronic Theses and Dissertations

Due to the presumed associations of dopamine (DA) receptor supersensitivity phenomena in both long-term neuroleptic-treated tardive dyskinetic rats and neonatal 6-hydroxydopamine (n6-OHDA)-lesioned rats, we studied the influence of haloperidol on n6-OHDA-lesioned rats. At 3 days after birth rats received 6-OHDA-HBr (200 $\mu$g, bilateral intracerebroventricularly; desipramine pretreatment, 20 mg/kg, 1h) or vehicle. Two months later haloperidol (1.5/kg/day $\times$ 2 days/week for 4 weeks, then 1.5 mg/kg/day, every day for 10 months) was added to the drinking water. Spontaneous oral activity of intact and n6-OHDA-lesioned rats receiving haloperidol was reached and maintained at significantly higher levels after 15 weeks of haloperidol treatment. …

The Identification And Characterization Of Protein Tyrosine Phosphatases Expressed In The Developing Rat Brain, Mustafa Sahin

Yale Medicine Thesis Digital Library

Previous studies of the developing nervous system have shown that cell-cell and cell-matrix interactions are involved in a variety of processes such as the proliferation, migration and differentiation of neurons. While many cell surface molecules have been identified, the signal transduction mechanisms through which they alter cellular responses are poorly understood. Recent studies have described a new and large family of enzymes, protein tyrosine phosphatases (PTPases), that may play a key role in transduction of cell surface events. Opposing the actions of protein tyrosine kinases (PTKs), PTPases may determine the state of tyrosine phosphorylation of a protein and regulate its …

Patient Satisfaction Among Users Of The After Hours Program, Helen L. Larocco

Community & Environmental Health Theses & Dissertations

The problem of increasing health care costs and decreasing access to health care services is a major crisis in the U.S. today. One factor contributing to the rising cost of health care is the inappropriate use of emergency rooms, (ERs). In response to escalating costs a local health care corporation implemented a telephone triage program called the After Hours Program, (AHP). The goal of the program was to reduce inappropriate utilization of emergency rooms, and to educate patients to recognize and treat specific health problems independently, i.e., home treatment.

A program evaluation was completed in which different dimensions of patient …

Relationship Between The Menstrual Cycle, Mood And Overeating In Women, Veronica Lynne Broussard

Honors Capstones

No abstract provided.

The Relationship Among The Contributing Factors To Anorexia Nervosa, Stephanie S. Plunkett, David Stein

Undergraduate Honors Capstone Projects

Anorexia nervosa is now being viewed as a multidimensional disorder in terms of predisposing factors such as genetics, biology, and environment. Results from twin studies suggest that part of a susceptibility to AN may lie in genetic factors (Holland et al., 1984, 1988; Treasure and Holland, 1991). However, the nature of a genetic contribution, if any, remains unclear. Neurochemical alterations have been found to be associated with AN, but it is difficult to assess what role these neurochemical changes play in the etiology of the disorder since they may precipitate, accompany, or follow weight loss (Fava et al., 1989). Abnormal …

Moraxella (Branhamella) Catarrhalis: A Molecular Epidemiology Study, Lyndell R. Gill

Electronic Theses and Dissertations

Moraxella (Branhamella) catarrhalis is the third-most-frequently isolated microorganism associated with acute exacerbations of chronic bronchitis in patients during their stay at the Mountain Home VA Medical Center (MHVAMC). In order to develop a practical, epidemiologically-meaningful typing method for M. (B.) catarrhalis, we tested two methods based on analysis of chromosomal DNA for typeability, reproducibility, and ability to differentiate between unrelated strains (discriminatory power, D). M. (B.) catarrhalis isolants from MHVAMC from 7/1/87-6/30/88 were grown overnight in broth and embedded in agarose. DNA was isolated by standard methods. The DNA was subjected to: (1) restriction endonuclease digestion (with either Bgl II …

Indomethacin Reduces Splenic Red Pulp Macrophage Populations In Female New Zealand White Rabbits, Thane S. Thurmond

Electronic Theses and Dissertations

In an effort to elucidate the mechanism by which indomethacin (IN) attenuates the stimulatory effect of estradiol (E$\sb2$) on rabbit splenic red pulp macrophages (RPM), thirty-nine female New Zealand White rabbits were divided into 10 groups: ovariectomized (OVX), OVX/IN at 0.1 and 5.0 mg/kg body weight (bw)/day; sham OVX (SOVX), SOVX/IN at 0.1 and 5.0 mg/kg bw/day; OVX/25 mg E2, OVX/25 mg E$\sb2$/IN at 0.1 and 5.0 mg/kg bw/day; intact Control. Quantitative changes in RPM population in response to the treatments were measured using a 0 to 4 histologic grading scale. Estradiol treatment resulted in increased RPM grade when compared …

Care Of Aging Parents: The Experiences Of Middle-Aged Filipino Women, Carmen B. Toledo Galang Dnsc, Msn, Rn

Dissertations

The purpose of this study was to examine and analyze parent care as experienced by middle-aged Filipino women, particularly those who have resided in the United States for over 20 years. There is little information known about this topic; therefore, a grounded theory study design was utilized. Open-ended, semi-structured interviews of 29 Filipino women were conducted in English and/or Tagalog, and at times a combination of both languages. Data were transcribed verbatim from the audio-recorded interviews and analyzed using a constant comparative method of analytic induction. Field notes were kept and patterns of observation were analyzed according to their significance. …

A Model Of Patient Satisfaction And Behavioral Intention In Managed Care, Diane Sturdy Greeneich Dnsc, Ms, Rn

Dissertations

Determination of patient outcomes associated with new and return business is a primary objective of the managed care marketplace. Identification of variables which contribute to both positive and negative patient experience in managed care systems is crucial to their effectiveness. The purpose of this study was to test the functional relationships between the variables of nurse practitioner attributes and behaviors, patient perceptions of the managed care system, and outcomes of patient satisfaction and intention to return to and recommend the managed care system. Functional relationships were measured with the Patient Satisfaction Semantic Differential (Greeneich and Long, 1992), and the Service …

A History Of The Concept Of Creativity In Western Nursing: A Cultural Feminist Perspective, Karen K. Fritz Dnsc, Ms, Ba, Rn

Dissertations

Using historical methodology, this study examined the concept of creativity in Western nursing from a cultural feminist perspective. An exploration of the concept was accomplished by means of a review emanating from the English literature of Western nursing and its allied disciplines of education and psychology. Two distinct views of creativity were delineated--the classical and the contemporary. The classical understanding required the completion of a major product or attainment in order for creativity to be ascribed. In contrast, the contemporary view was that of a novel, unrestrained thought process. It required no creative work or attainment for its ascription. The …

Development In Drawings And Language Of Young Children With Hearing Impairments, Daniel Carey Nordenbrock

Masters Theses

The use of free choice drawings and contingent questions as prompts to enhance oral language development in young children with moderate to profound hearing losses was the focus of this descriptive and experimental study. The effects of contingent queries (scaffolding) on drawing and oral language were measured using a single subject experimental design in which a staggered baseline was followed by treatment replicated across two sets of students at two levels of language abilities. An extensive coding system for dependent drawing and language variables was developed and utilized for analysis.

The major findings of this study were that the use …

The Effects Of Interactive Songs On Syllable Production In A Child With Agenesis Of The Corpus Callosum, Kelly D. Beens

Masters Theses

Agenesis of the corpus callosum is a disorder which has been the focus of clinical research on various tasks involving interhemispheric transfer of information. However, therapeutic intervention for individuals with this disorder has not been located in the literature by this researcher. Speech-language therapy for a five-year-old male incorporating interaction with songs was employed to activate various portions of the congenitally separated cerebral hemispheres and to encourage information transfer through non-traditional ways to facilitate syllable production.

The child received speech-language therapy for 15, 30-minute sessions. He was prompted to participate physically (with actions or manipulation of props) and verbally in …

Protein-Tyrosine Phosphatase In Normal And Malignant Melanocytes, James H. Ahn

Yale Medicine Thesis Digital Library

We embarked on a study to define the role of protein-tyrosine phosphatases (PTPases) in both normal melanocytes and melanoma cells, searching for specific differences that might provide clues to the malignant transformation process in these cells and to the role of PTPases as possible tumor suppressor genes. We used Northern blotting and RNase protection assays to measure mRNA expression levels, immunoprecipitation and immunoblotting to measure protein expression, and a bioassay to measure protein PTPase activity in normal melanocyte and melanoma cell lines.

Our experiments showed that all major PTPases are equally expressed at both mRNA and protein levels, except for …

Mathematical Models Of Chemotherapy, John Carl Panetta

Mathematics & Statistics Theses & Dissertations

Several mathematical models are developed to describe the effects of chemotherapy on both cancerous and normal tissue. Each model is defined by either a single homogeneous equation or a system of heterogeneous equations which describe the states of the normal and/or cancer cells. Periodic terms are added to model the effects of the chemotherapy. What we obtain are regions, in parameter space (dose and period), of acceptable drug regimens.

The models take into account various aspects of chemotherapy. These include, interactions between the cancer and normal tissue, cell specific chemotherapeutic drug, the use of non-constant parameters to aid in modeling …

Structural Characterization Of A Novel Inhibitor Of Hiv Reverse Transcriptase (Hiv Rt), Greggory Jon Woitte

Chemistry & Biochemistry Theses & Dissertations

Human immunodeficiency virus (HIV) infections have become a leading cause of death among young people in the United States today. As the number of HIV infections increases, so too does the cost of treatment. Together, these numbers have prompted an increase in the development of pharmaceutical interventions. HIV reverse transcriptase (HIV RT) has become a suitable target for drug therapy because it is the sole enzyme responsible for HIV replication.

Fucoidan, a sulfated polysaccharide isolated from the brown algae Fucus vesiculosus, has been shown to block a variety of cell adhesion related events including metastasis. In addition, fucoidan has also …

The Kinetic Characterization Of Mutant L289p Of Recombinant Hiv-1 Reverse Transcriptase, Tryn Thomas Stimart

Chemistry & Biochemistry Theses & Dissertations

The Human Immunodeficiency Virus, type 1 (HIV-1) is the causative agent of the Acquired immunodeficiency Syndrome (AIDS). Currently, AIDS is the leading cause of death amongst young people in the United States. The large increase of HIV-1 infections over the past decade has spawned considerable research in fighting the spread of this disease. One area of intense HIV-1 research has focused on the enzyme Reverse Transcriptase (RT) which is an essential enzyme involved in the replication and life cycle of HIV-1. HIV-1 RT is composed of p66 and p51 subunits and is only active as a heterodimer in vivo. …

An Assessment Of The Descriptors And Determinants Of Academic Success Of Selected Allied Health Students In Virginia, Theodora Christine Gordon

Health Services Research Dissertations

This study assessed the relationship of cognitive and noncognitive variables in relationship to academic success of students from selected allied health majors: respiratory therapist (RTT), radiologic technology (RT), surgical technology (ST) and medical records technician (MRT) from hospital based and community college programs in Virginia. Student academic success was defined as academic (classroom) grade point average, clinical grade point average, cumulative grade point average and passing status. The cognitive variables were preclinical (high school) grade point average, academic, clinical and cumulative grade point averages. The noncognitive variables were character type, temperament type/preference for learning style, and the Sedlacek Noncognitive Questionnaire …

Effect Of Nutrition Intervention On The Outcomes Of Pregnancy: A Rural Urban Comparison, Ranjita Misra

Health Services Research Dissertations

The present study examines the effect of nutritional intervention on two outcomes of pregnancy: birth weight of the baby and gestational age. The study further examines the difference in nutritional intervention in rural and urban areas. The research method used is ex-post facto design. Data for the study is extracted from the health records and tracking sheets of women participating in the Nutrition Intervention Project in Virginia Department of Health. Path analysis and effects analysis are used to analyze the causal and direct effect of the independent variables and each of the outcome variables. A model has been developed grounded …

Effectiveness Of Dna Probe Technology In Distinguishing Among Gingival Health, Mild-Moderate Periodontitis, And Severe Periodontitis In Human Oral Sites, Juliana J. Kim

Dental Hygiene Theses & Dissertations

The purpose of this investigation was to determine if there is a difference in the type of microorganisms found in oral sites classified as gingival health, mild-moderate periodontitis, or severe periodontitis as measured by the DMDx* Test. A purposive sample of one hundred oral sites was selected from adult patients. Subjects were excluded from the study based on: the presence of any systemic disorders, communicable diseases, diabetic conditions, blood dyscrasias, congenital heart disease, rheumatic heart disease, pregnancy, history of periodontal surgery, prosthetic joint replacement, hypertensive heart disease, or any medications that might alter the gingival tissues (e.g. antibiotics, hormonal therapy, …

A Comparison Of The Utilization Of Health Services In The Presence Or Absence Of Prescriptive Drug Insurance In A Managed Care Environment, Martha Groblewski

Health Services Research Dissertations

This study tested if the availability of third party payment for prescriptive drugs as part of employer sponsored health insurance was associated with a change in the utilization of four types of health services in an independent practice association (IPA). The study employed the individual determinants component of the Andersen-Newman theoretical framework for health services utilization. Groups of employees in companies that offered health insurance identical in all ways except for the presence or absence of the prescriptive rider were included in the study which resulted in a population of 122 companies (89 with prescriptive rider insurance and 33 without …

Personal Interviews Vs. Awareness: A Health Promotion Program For Behavior Change, Elizabeth Klein

Honors Theses

In the United States, heart disease is currently the number one cause of death in the adult population (U.S. Department of Health and Human Services, 1991). Unlike many of the major causes of death, heart disease is largely preventable through changes in health related behaviors. Although a portion of heart disease risk is attributed to genetics, the primary cause of heart disease development lies in the eating habits, exercise behaviors, and smoking habits of the individual.

Development And Testing Of An Explanatory Model Of Registered Nurse Empowerment, Marilyn D. Klakovich Dnsc, Msn, Rn, Cnaa

Dissertations

Recent innovations in patient care delivery and nursing governance require an empowered workforce. However, little is known about what combination of organizational, leadership, and personal characteristics maximize the prediction of registered nurse empowerment. The purpose of this study was to develop and test an explanatory model of registered nurse empowerment. The predictor variables included personal characteristics of registered nurses (age, experience, organizational tenure, education, and position level of clinical and/or management responsibility), perceptions of organizational culture, and connective leadership. The study was conducted in a tertiary-care hospital in Southern California. A total of 113 registered nurses completed the Organizational Culture …

Use Of A Structured Interview To Evaluate The Validity Of The Alcohol And Drug Dependence Scales Of The Millon Clinical Multiaxial Inventory Ii, Bert Van Hoek

Dissertations

This is an external validation study of the Alcohol and Drug dependence scales of the Millon Clinical Multiaxial Inventory II ([MCMI-II], Millon, 1987). The Structured Clinical Interview for the DSM-III-R ([SCID], Spitzer, Williams, Gibbon, & First, 1990) was administered to a sample of 73 adults who presented for treatment at a substance abuse facility to establish all possible substance abuse diagnoses based on the nosology of the revised Diagnostic Statistical Manual for Mental Disorders (3rd ed. [DSM-III], American Psychiatric Association, 1980). Subsequently, scores on the Alcohol and Drug Dependence scales of the MCMI-II for the present sample were compared to …

A Kinetic Investigation Of The Mechanism Of Muscle Contraction With A Series Of Nucleotides, Wei Jiang

Theses and Dissertations in Biomedical Sciences

Muscle contraction is thought to be accomplished by sliding of myosin filaments along actin filaments. Although actomyosin naturally uses ATP as an energy source, it can also use other nucleoside triphosphates (NTP) as substrates. In this work, the dependence of rate and equilibrium constants of the various steps in the muscle contraction mechanism upon nucleotide structure was investigated to unravel the dependence of the mechanical properties of the muscle upon changes in different biochemical steps of the mechanism.

The experiments measuring the dissociation of actomyosin by NTP (or mant-NTP) shows that both the rate constant of actomyosin-S1 dissociation and second …